公开(公告)号：US07927362B2

公开(公告)日：2011-04-19

申请号：US11186370

申请日：2005-07-21

Applicant: James Lee Shippy, III ,  Karl Alan Jagger

Inventor： James Lee Shippy, III ,  Karl Alan Jagger

IPC: A61F2/06

CPC classification number: A61F2/958 ,  A61F2002/9583

Abstract: The stent placement dilation balloon assembly comprises a catheter having a distal end, a distal end portion, and a proximal end, a balloon mounted to, about, and around the distal end portion of the catheter. The assembly further includes an elastic sheath positioned about and around the balloon. The outer surface of the sheath includes a profile which encourages stent securement. A stent is mounted on the sleeve for placement in a vessel in a human body.

Abstract translation: 支架放置扩张气囊组件包括具有远端，远端部分和近端的导管，安装到导管的远端部分周围和周围的气囊。 组件还包括围绕和围绕气球定位的弹性护套。 护套的外表面包括鼓励支架固定的轮廓。 将支架安装在套筒上以放置在人体内的容器中。

公开(公告)号：US20090318848A1

公开(公告)日：2009-12-24

申请号：US12487203

申请日：2009-06-18

Applicant: James Lee Shippy III ,  Jan Weber ,  Karl Jagger ,  Tracee Eidenschink ,  Liliana Atanasoska

Inventor： James Lee Shippy III ,  Jan Weber ,  Karl Jagger ,  Tracee Eidenschink ,  Liliana Atanasoska

IPC: A61N1/30

CPC classification number: A61M25/1029 ,  A61F2002/0081 ,  A61F2250/0068 ,  A61K9/0009 ,  A61K31/00 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/52 ,  A61L27/50 ,  A61L27/54 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/0057 ,  A61M2025/0058 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/1088 ,  A61M2025/1093

Abstract: In accordance with one aspect, the invention relates to medical devices which comprise at least one reservoir, a therapeutic-agent-containing region disposed within the reservoir and an electrode comprising a conductive polymer. The devices of the invention are configured such that a rate of release of the therapeutic agent from the reservoir changes upon a change in the oxidation state of the conductive polymer.

Abstract translation: 根据一个方面，本发明涉及包括至少一个贮存器，设置在储存器内的含治疗剂的区域和包含导电聚合物的电极的医疗装置。 本发明的装置被配置成使得治疗剂从贮存器释放的速率随着导电聚合物的氧化态的变化而变化。

公开(公告)号：US20090226598A1

公开(公告)日：2009-09-10

申请号：US12363979

申请日：2009-02-02

Applicant: James Feng ,  Frank Genovese ,  James Lee Shippy

Inventor： James Feng ,  Frank Genovese ,  James Lee Shippy

IPC: B05D3/10 ,  B05C9/08

CPC classification number: B05D1/02 ,  B01L3/502707 ,  B05B7/066 ,  B05B15/50 ,  B05B15/55 ,  B05C5/001 ,  B05D3/0486

Abstract: An apparatus for depositing coating onto a substrate including a housing having a nozzle including a nozzle orifice, a fluid source configured to deliver coating fluid to the nozzle, and a solvent vapor emitter. The solvent vapor emitter can be located proximate to the nozzle, for example, such as behind the nozzle orifice and/or in a direction substantially parallel to a central axis of the housing. During coating, coating fluid may exit the nozzle and is deposited onto the substrate while the solvent vapor emitter emits solvent vapor proximate to the nozzle orifice.

Abstract translation: 一种用于将涂层沉积到基底上的装置，包括具有喷嘴的壳体，所述喷嘴包括喷嘴孔，被配置为将喷射流体输送到喷嘴的流体源和溶剂蒸气发射器。 溶剂蒸汽发射器可以位于喷嘴附近，例如位于喷嘴孔的后面和/或基本上平行于壳体的中心轴线的方向上。 在涂覆期间，涂布流体可以离开喷嘴并沉积到衬底上，同时溶剂蒸汽发射器在喷嘴孔附近发射溶剂蒸气。

公开(公告)号：US20080004691A1

公开(公告)日：2008-01-03

申请号：US11763770

申请日：2007-06-15

Applicant: Jan Weber ,  Liliana Atanasoska ,  James Lee Shippy ,  Edward E. Parsonage

Inventor： Jan Weber ,  Liliana Atanasoska ,  James Lee Shippy ,  Edward E. Parsonage

IPC: A61F2/06

CPC classification number: A61F2/82 ,  A61F2/91 ,  A61F2002/30322 ,  A61F2250/0026 ,  A61F2250/0056 ,  A61F2310/00616 ,  A61F2310/0097 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  B05D1/32

Abstract: Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway. The inner luminal wall surface and side wall surface of the bands and connectors forming transverse passageways through the elongated tubular structure can bear a coating of hydrophilic material and the outer abluminal wall surface of the tubular structure can bear a coating of hydrophobic material.

Abstract translation: 描述医疗装置，例如内用假体，以及制造装置的方法。 在一些实施例中，医疗装置包括互连带的主体和形成细长管状结构的连接器，其具有内管腔壁表面和外侧腔壁表面，并限定中央腔或通道。 形成穿过细长管状结构的横向通道的带和连接件的内腔壁表面和侧壁表面可以承受亲水材料的涂层，并且管状结构的外侧壁面可承受疏水材料的涂层。

公开(公告)号：US08267992B2

公开(公告)日：2012-09-18

申请号：US12715577

申请日：2010-03-02

Applicant: Liliana Atanasoska ,  James Lee Shippy, III ,  Tom Holman ,  Michael S. Arney ,  Victor Schoenle ,  Frank Genovese ,  James Q. Feng ,  Aiden Flanagan ,  Jan Weber

Inventor： Liliana Atanasoska ,  James Lee Shippy, III ,  Tom Holman ,  Michael S. Arney ,  Victor Schoenle ,  Frank Genovese ,  James Q. Feng ,  Aiden Flanagan ,  Jan Weber

IPC: A61F2/06

CPC classification number: A61L31/148 ,  A61L27/34 ,  A61L27/446 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/128 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2400/12 ,  A61L2420/04 ,  C08L67/04

Abstract: A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.

Abstract translation: 医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。 生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。 生物腐蚀金属在生理条件下降解形成碱性降解产物。 酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。 在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。 在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。

公开(公告)号：US20110245905A1

公开(公告)日：2011-10-06

申请号：US13051496

申请日：2011-03-18

Applicant: Jan Weber ,  Liliana Atanasoska ,  James Lee Shippy, III ,  Torsten Scheuermann ,  Daniel J. Gregorich ,  Michael P. Meyer

Inventor： Jan Weber ,  Liliana Atanasoska ,  James Lee Shippy, III ,  Torsten Scheuermann ,  Daniel J. Gregorich ,  Michael P. Meyer

IPC: A61F2/82 ,  B05D3/00 ,  B44C1/22 ,  B23P11/00

CPC classification number: A61L31/088 ,  A61L31/044 ,  A61L31/06 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  Y10T29/49826 ,  C08L67/04

Abstract: Among other things, a bio-erodible implantable endoprosthesis comprises a member that includes (a) a core having a surface, and (b) a bio-erodible metal on a least a portion of the surface of the core, wherein the bio-erodible metal erodes more slowly than the core and includes openings through which physiological fluids can access the core upon implantation.

Abstract translation: 除其他之外，生物可蚀刻的可植入内用假体包括一种构件，其包括（a）具有表面的芯，和（b）所述芯的表面的至少一部分上的生物可侵蚀金属，其中所述生物可蚀刻 金属腐蚀比核心更慢，并且包括生理流体在植入时可通过其进入核心的开口。

公开(公告)号：US20110224770A1

公开(公告)日：2011-09-15

申请号：US13046970

申请日：2011-03-14

Applicant: Pu Zhou ,  James Feng ,  Benjamin Arcand ,  James Lee Shippy

Inventor： Pu Zhou ,  James Feng ,  Benjamin Arcand ,  James Lee Shippy

IPC: A61F2/82 ,  B29C35/02

CPC classification number: A61F2/82 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/04 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  C08L67/04

Abstract: A stent formed from a bioabsorbable polymer matrix including at least one bioabsorbable polymer and at least one therapeutic agent dispersed therein, and methods of making the same.

Abstract translation: 由包含至少一种生物可吸收聚合物和分散在其中的至少一种治疗剂的生物可吸收聚合物基质形成的支架及其制备方法。

公开(公告)号：US20100008970A1

公开(公告)日：2010-01-14

申请号：US12334113

申请日：2008-12-12

Applicant: Barry O'Brien ,  Ben Arcand ,  James Lee Shippy, III ,  Liliana Atanasoska ,  Aiden Flanagan ,  John T. Clarke ,  Tim O'Connor ,  Yixin Xu ,  Dave McMorrow ,  Jan Weber ,  John Kremer ,  Michael Kuehling ,  Dominique Seidel

Inventor： Barry O'Brien ,  Ben Arcand ,  James Lee Shippy, III ,  Liliana Atanasoska ,  Aiden Flanagan ,  John T. Clarke ,  Tim O'Connor ,  Yixin Xu ,  Dave McMorrow ,  Jan Weber ,  John Kremer ,  Michael Kuehling ,  Dominique Seidel

IPC: A61K31/337 ,  A61F2/00 ,  B05D1/02

CPC classification number: A61L31/088 ,  A61L31/16 ,  A61L2300/45 ,  A61L2300/61

Abstract: A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.

Abstract translation: 包括生物腐蚀性金属部分和治疗剂的药物洗脱内用假体。 在一些方面，内假体包括多个离散沉积物和多个覆盖层，每个覆盖层覆盖多个离散沉积物之一。 每个离散沉积物包括一种或多种治疗剂，并且每个上覆层包括一种或多种生物可腐蚀金属。 在其他方面，生物腐蚀性金属部分包括具有不同电负性的至少两个生物可腐蚀金属区域。 所述至少两个生物浸渍金属区域彼此电接触。 生物腐蚀性金属在生理环境中侵蚀以释放治疗剂。

公开(公告)号：US20090324684A1

公开(公告)日：2009-12-31

申请号：US12489996

申请日：2009-06-23

Applicant: Liliana Atanasoska ,  James Lee Shippy, III ,  Benjamin Arcand ,  Robert W. Warner

Inventor： Liliana Atanasoska ,  James Lee Shippy, III ,  Benjamin Arcand ,  Robert W. Warner

IPC: A61L27/54 ,  A61L27/58

CPC classification number: A61L31/022 ,  A61L31/08

Abstract: According to an aspect of the present invention, medical devices are provided which comprise a metallic region and a coating on all or part of the metallic region that comprises a multivalent acid.

Abstract translation: 根据本发明的一个方面，提供了包括金属区域和包含多价酸的全部或部分金属区域上的涂层的医疗装置。