公开(公告)号：US20120296348A1

公开(公告)日：2012-11-22

申请号：US13491273

申请日：2012-06-07

Applicant: Vahid Saadat ,  Richard C. Ewers ,  Cang C. Laduca ,  Robert A. Vaughan ,  Chris Rothe ,  Kenneth J. Michlitsch

Inventor： Vahid Saadat ,  Richard C. Ewers ,  Cang C. Laduca ,  Robert A. Vaughan ,  Chris Rothe ,  Kenneth J. Michlitsch

IPC: A61B17/04

CPC classification number: A61F5/0086 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0483 ,  A61B17/0487 ,  A61B17/06 ,  A61B17/06066 ,  A61B17/064 ,  A61B17/08 ,  A61B17/10 ,  A61B17/12013 ,  A61B17/1285 ,  A61B17/29 ,  A61B2017/00867 ,  A61B2017/0404 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0445 ,  A61B2017/0446 ,  A61B2017/045 ,  A61B2017/0451 ,  A61B2017/0454 ,  A61B2017/0456 ,  A61B2017/0458 ,  A61B2017/0459 ,  A61B2017/0461 ,  A61B2017/0462 ,  A61B2017/0464 ,  A61B2017/0475 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/081 ,  A61B2017/3488

Abstract: Apparatus for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably dispose through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.

Abstract translation: 本文描述了用于操纵和固定组织的装置。 在组织折叠在患者身体内部时，组织操作组件通常可以具有细长的管状构件，可滑动地配置穿过管状构件的接合构件和适于经由螺旋构件接合组织的远端，组织稳定构件 所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。 稳定构件可以适于相对于细长管状构件的纵向轴线成角度。 此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

公开(公告)号：US20120165924A1

公开(公告)日：2012-06-28

申请号：US13366540

申请日：2012-02-06

Applicant: Jan Otto Solem ,  Per-Ola Kimblad ,  Randolf von Oepen ,  Bodo Quint ,  Gerd Seibold ,  Kenneth J. Michlitsch ,  Suk-Woo Ha ,  Karl-Ludwig Eckert ,  Ib Joergensen ,  Stevan Nielsen

Inventor： Jan Otto Solem ,  Per-Ola Kimblad ,  Randolf von Oepen ,  Bodo Quint ,  Gerd Seibold ,  Kenneth J. Michlitsch ,  Suk-Woo Ha ,  Karl-Ludwig Eckert ,  Ib Joergensen ,  Stevan Nielsen

IPC: A61F2/24

CPC classification number: A61F2/2451 ,  A61F2/07 ,  A61F2/88 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2002/8483 ,  A61F2210/0004

Abstract: A device for treatment of mitral annulus dilation is disclosed, wherein the device comprises two states. In a first of these states the device is insertable into the coronary sinus and has a shape of the coronary sinus. When positioned in the coronary sinus, the device is transferable to the second state assuming a reduced radius of curvature, whereby the radius of curvature of the coronary sinus and the radius of curvature as well as the circumference of the mitral annulus is reduced.

Abstract translation: 公开了一种用于治疗二尖瓣环扩张的装置，其中该装置包括两种状态。 在这些状态中的第一个状态下，该装置可插入冠状窦并具有冠状窦的形状。 当定位在冠状窦中时，假设曲率半径减小，装置可转移到第二状态，由此降低冠状窦的曲率半径和曲率半径以及二尖瓣环的圆周。

公开(公告)号：US08118833B2

公开(公告)日：2012-02-21

申请号：US10523166

申请日：2003-07-25

Applicant: Gerd Seibold ,  Kenneth J. Michlitsch ,  Randolf Von Oepen ,  Bodo Quint ,  Ib Erling Joergensen ,  Stevan Nielsen ,  Tommy Conzelmann

Inventor： Gerd Seibold ,  Kenneth J. Michlitsch ,  Randolf Von Oepen ,  Bodo Quint ,  Ib Erling Joergensen ,  Stevan Nielsen ,  Tommy Conzelmann

IPC: A61B17/08

CPC classification number: A61B17/0057 ,  A61B17/0643 ,  A61B2017/00004 ,  A61B2017/00477 ,  A61B2017/00659

Abstract: Apparatus is provided for sealing a puncture within a vessel or tissue to provide hemostasis, comprising a first disk coupled to either a second disk or a spring, and sealingly engaged to the vessel or tissue surrounding the puncture. At least the first disk is preferably configured to substantially conform to the profile of the vessel or tissue when deployed. In one embodiment, the disks may be released from engagement with the vessel or tissue to reposition the disks after deployment.

Abstract translation: 提供了用于密封容器或组织内的穿刺以提供止血的装置，包括联接到第二盘或弹簧的第一盘，并密封地接合到围绕穿刺的容器或组织。 至少第一盘优选地构造成在展开时基本上符合血管或组织的轮廓。 在一个实施例中，盘可以从与血管或组织的接合中释放，以在部署之后重新定位椎间盘。

公开(公告)号：US08075616B2

公开(公告)日：2011-12-13

申请号：US10500188

申请日：2002-12-20

Applicant: Jan Otto Solem ,  Per Ola Kimblad ,  Randolf von Oepen ,  Bodo Quint ,  Gerd Seibold ,  Kenneth J. Michlitsch ,  Suk-Woo Ha ,  Karl-Ludwig Eckert ,  Ib Joergensen ,  Stevan Nielsen

Inventor： Jan Otto Solem ,  Per Ola Kimblad ,  Randolf von Oepen ,  Bodo Quint ,  Gerd Seibold ,  Kenneth J. Michlitsch ,  Suk-Woo Ha ,  Karl-Ludwig Eckert ,  Ib Joergensen ,  Stevan Nielsen

IPC: A61F2/24

CPC classification number: A61F2/2451 ,  A61F2/07 ,  A61F2/2481 ,  A61F2/26 ,  A61F2002/043 ,  A61F2002/072 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2002/8483 ,  A61F2210/0004

Abstract: A device for reshaping a cardiac valve (26), which is elongate and has such dimensions as to be insertable into a cardiac vessel (24). The device has two states, in a first state (K) of which the device has a shape that is adaptable to the shape of the vessel (24), and to the second state (k′) of which the device is transferable from said first state (K). Further, the device comprises a fixing means (22,23;22a,23a) for fixing the ends of the device within the vessel (24), when the device is first positioned therein, a shape-changing member (20;20a) for transferring the device to the second state (K′) by reshaping it, and a delay means (21;21a) for delaying said reshaping until the fixing of the ends of the device has been reinforced by keeping said device in said first state (K) until the delay means (21;21a) is resorbed.

Abstract translation: 一种用于整形心脏瓣膜（26）的装置，其是细长的并且具有可插入心脏容器（24）的尺寸。 该装置具有两种状态，其处于第一状态（K），其装置具有适应于容器（24）的形状的形状，以及第二状态（k'），其中装置可从所述第二状态 第一个状态（K）。 此外，该装置包括固定装置（22,23; 22a，23a），用于当装置首先定位在容器（24）内时将装置的端部固定，形状改变构件（20; 20a） 通过重新形成将装置转移到第二状态（K'），以及用于延迟所述重新成形的延迟装置（21; 21a），直到通过将所述装置保持在所述第一状态（K ），直到延迟装置（21; 21a）被再吸收。

公开(公告)号：US20110200171A1

公开(公告)日：2011-08-18

申请号：US13009748

申请日：2011-01-19

Applicant: Robert J. Beetel ,  Neil C. Barman ,  Benjamin J. Clark ,  Paul Friedrichs ,  Kenneth J. Michlitsch ,  Karun D. Naga ,  Andrew Wu ,  Denise Zarins

Inventor： Robert J. Beetel ,  Neil C. Barman ,  Benjamin J. Clark ,  Paul Friedrichs ,  Kenneth J. Michlitsch ,  Karun D. Naga ,  Andrew Wu ,  Denise Zarins

IPC: A61N5/10

CPC classification number: A61N5/1042 ,  A61B6/506 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61N5/1067 ,  A61N7/02 ,  A61N2005/1061

Abstract: The present disclosure describes methods and apparatus for renal neuromodulation via stereotactic radiotherapy for the treatment of hypertension, heart failure, chronic kidney disease, diabetes, insulin resistance, metabolic disorder or other ailments. Renal neuromodulation may be achieved by locating renal nerves and then utilizing stereotactic radiotherapy to expose the renal nerves to a radiation dose sufficient to reduce neural activity. A neural location element may be provided for locating target renal nerves, and a stereotactic radiotherapy system may be provided for exposing the located renal nerves to a radiation dose sufficient to reduce the neural activity, with reduced or minimized radiation exposure in adjacent tissue. Renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as at pre-ganglionic positions.

Abstract translation: 本公开描述了通过立体定向放射治疗高血压，心力衰竭，慢性肾脏疾病，糖尿病，胰岛素抵抗，代谢紊乱或其它疾病的肾神经调节的方法和装置。 肾神经调节可以通过定位肾神经，然后利用立体定向放射治疗来将肾神经暴露于足以减少神经活动的辐射剂量来实现。 可以提供用于定位目标肾神经的神经定位元件，并且可以提供立体定向放射治疗系统，用于将位于所述肾神经的辐射剂量暴露于足以减少或最小化相邻组织中的辐射暴露的神经活动的辐射剂量。 肾神经可能位于神经节水平和/或神经节后位置以及神经节前位置。

公开(公告)号：US20100249773A1

公开(公告)日：2010-09-30

申请号：US12759641

申请日：2010-04-13

Applicant: Benjamin J. Clark ,  William R. George ,  Kenneth J. Michlitsch ,  John Paul Sam ,  Erik Thai ,  Andrew Wu

Inventor： Benjamin J. Clark ,  William R. George ,  Kenneth J. Michlitsch ,  John Paul Sam ,  Erik Thai ,  Andrew Wu

IPC: A61F7/12 ,  A61B18/08

CPC classification number: A61B18/08 ,  A61B34/74 ,  A61B2017/003 ,  A61B2018/00916

Abstract: The present disclosure comprises handle assemblies for intravascular treatment devices. In one embodiment, a handle assembly comprises an actuator for deflecting a distal region of an intravascular treatment device. In one embodiment, a handle assembly comprises a rotator for rotating an intravascular treatment device independently of the handle assembly. In one embodiment, a handle assembly comprises a rotation limiting element for limiting independent rotation of an intravascular treatment device relative to the handle assembly. Methods and systems for intravascular delivery, deflection and placement of an intravascular treatment device via a handle assembly of the present invention are also provided.

Abstract translation: 本公开包括用于血管内治疗装置的手柄组件。 在一个实施例中，手柄组件包括用于偏转血管内治疗装置的远侧区域的致动器。 在一个实施例中，手柄组件包括用于独立于手柄组件旋转血管内治疗装置的旋转器。 在一个实施例中，手柄组件包括用于限制血管内治疗装置相对于手柄组件的独立旋转的旋转限制元件。 还提供了通过本发明的手柄组件进行血管内递送，偏转和放置血管内治疗装置的方法和系统。

公开(公告)号：US07695493B2

公开(公告)日：2010-04-13

申请号：US10865736

申请日：2004-06-09

Applicant: Vahid Saadat ,  Richard C. Ewers ,  Tracy D. Maahs ,  Alexander Khairkhahan ,  Kenneth J. Michlitsch

Inventor： Vahid Saadat ,  Richard C. Ewers ,  Tracy D. Maahs ,  Alexander Khairkhahan ,  Kenneth J. Michlitsch

IPC: A61B17/08 ,  A61D1/00

CPC classification number: A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0644 ,  A61B2017/00867 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2090/037

Abstract: Systems for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.

Abstract translation: 这里描述了用于优化锚固力的系统。 在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。 当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。 可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。 此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

公开(公告)号：US06497722B1

公开(公告)日：2002-12-24

申请号：US09718589

申请日：2000-11-22

Applicant: Randolf Von Oepen ,  Kenneth J. Michlitsch

Inventor： Randolf Von Oepen ,  Kenneth J. Michlitsch

IPC: A61F206

CPC classification number: A61F2/07 ,  A61F2/856 ,  A61F2/86 ,  A61F2/90 ,  A61F2002/061 ,  A61F2002/075 ,  A61F2210/0019

Abstract: Apparatus and methods for stenting are provided comprising a self-expandable stent that is at least partially covered with a biocompatible material configured to prevent dynamic self-expansion of the stent. The biocompatible material is irreversibly expandable by suitable means, for example, a balloon. Thus, the apparatus may be tailored in-vivo to a vessel profile, in a manner similar to a balloon-expandable stent, but maintains the flexibility required for use in tortuous anatomy and in vessels that undergo temporary deformation, in a manner similar to a self-expandable stent. Apparatus is also provided for stenting at a vessel branching, and for localized delivery of therapeutic agents.

Abstract translation: 提供了用于支架置入的装置和方法，其包括至少部分地覆盖有构造成防止支架的动态自膨胀的生物相容性材料的自扩张支架。 生物相容性材料通过合适的方式，例如气球不可逆地扩张。 因此，该装置可以以类似于球囊可扩张支架的方式体内适应血管分布，但是以类似于球囊扩张支架的方式保持用于弯曲解剖结构和在经历临时变形的血管中所需的柔性 自扩张支架 还提供了用于在分支的血管支架置入并用于治疗剂的局部递送的装置。

公开(公告)号：US20160068896A1

公开(公告)日：2016-03-10

申请号：US14941170

申请日：2015-11-13

Applicant: Jane P. BEARINGER ,  Scott CASTANON ,  Kenneth J. MICHLITSCH

Inventor： Jane P. BEARINGER ,  Scott CASTANON ,  Kenneth J. MICHLITSCH

IPC: C12Q1/68 ,  B01L3/00 ,  B01L7/00

CPC classification number: C12Q1/6844 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502738 ,  B01L7/00 ,  B01L2300/0861 ,  B01L2300/18 ,  B01L2400/06 ,  C12Q1/6825 ,  C12Q1/6846 ,  C12Q2547/101 ,  C12Q2563/173 ,  C12Q2565/607 ,  C12Q2527/101 ,  C12Q2563/107 ,  C12Q2565/629

Abstract: Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction. Such detection may be performed visually by an operator or may be achieved utilizing an imaging technique, e.g., spectrophotometric imaging.

Abstract translation: 提供了用于点对点核酸扩增和检测的方法和装置。 本发明的一个实施方案包括完全整合的样品至答复分子诊断仪器，其可任选地以多路复用方式使用以检测目标的多个靶核酸序列，并且可任选地配置为在一次使用后进行处置。 该仪器优选使用等温核酸扩增技术，例如环介导的等温扩增（LAMP），以减少与核酸扩增相关的仪器要求。 靶扩增的检测可以例如通过检测添加到扩增反应中的染料中的色移或荧光来实现。 这种检测可以由操作者视觉执行，或者可以使用成像技术（例如分光光度成像）来实现。

公开(公告)号：US20160000498A1

公开(公告)日：2016-01-07

申请号：US14676649

申请日：2015-04-01

Applicant: Denise Zarins ,  Hanson Gifford, III ,  Mark Deem ,  Nicolas Zadno ,  Benjamin J. Clark ,  Andrew Wu ,  Kenneth J. Michlitsch

Inventor： Denise Zarins ,  Hanson Gifford, III ,  Mark Deem ,  Nicolas Zadno ,  Benjamin J. Clark ,  Andrew Wu ,  Kenneth J. Michlitsch

IPC: A61B18/14 ,  A61B18/12

CPC classification number: A61B18/1492 ,  A61B18/1206 ,  A61B18/18 ,  A61B2018/00023 ,  A61B2018/00077 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00648 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/124 ,  A61B2018/1435 ,  A61B2018/1465 ,  A61N1/0551 ,  A61N1/32 ,  A61N1/327 ,  A61N1/36007 ,  A61N7/022

Abstract: Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.

Abstract translation: 提供了用于不间断地周围处理体腔的方法和装置。 装置可以定位在患者的体腔内，并且可以在第一纵向和角位置处递送能量，以在第一位置处产生小于整个圆周的处理区域。 该装置还可以在体腔内的一个或多个附加的纵向和角度位置处递送能量，以在一个或多个附加位置处创建小于整个圆周处理区域，该一个或多个附加位置从第一处理区域纵向和角度偏移 。 第一处理区和一个或多个另外的处理区的叠置限定非连续的圆周处理区而不形成连续的周向损伤。 提供了用于实现这种非连续圆周处理的方法和装置的各种实施例。