公开(公告)号：US09568741B2

公开(公告)日：2017-02-14

申请号：US13640453

申请日：2011-04-13

Applicant: Kishan Dholakia ,  Jorg Baumgartl ,  Michael Mazilu ,  Anna Chiara De Luca

Inventor： Kishan Dholakia ,  Jorg Baumgartl ,  Michael Mazilu ,  Anna Chiara De Luca

IPC: G06F17/11 ,  G02B27/58

CPC classification number: G02B27/58 ,  G02B2207/125

Abstract: A method of optimising at least one measure that is a quadratic function of a wavefunction, such as the spot size of a laser, the method comprising: superimposing a plurality of wavefunctions; determining a relationship between the superimposed wavefunctions and the quadratic measure, and using the determined relationship to identify the superimposed wavefunctions that provide a desired or optimised quadratic measure.

Abstract translation: 一种优化作为波函数的二次函数的至少一个度量的方法，例如激光器的光斑尺寸，该方法包括：叠加多个波函数; 确定叠加的波函数和二次测量之间的关系，并且使用确定的关系来识别提供期望或优化的二次方法的叠加波函数。

公开(公告)号：US20140239149A1

公开(公告)日：2014-08-28

申请号：US14233105

申请日：2012-09-13

Applicant: Kishan Dholakia ,  Tomas Cimar

Inventor： Kishan Dholakia ,  Tomas Cimar

IPC: G02B27/00 ,  G01J1/02

CPC classification number: G02B27/0025 ,  G01J1/02 ,  G02B26/06 ,  G02B27/0933

Abstract: Methods for controlling light transmission through a medium by transmitting light from a single spatial portion of an input optical field through the medium creating an output optical field, superposing the output optical field with a reference optical field creating an optical interference field, detecting an intensity of a spatial portion of a polarization component of the optical interference field and using the detected intensity to determine a value of an optical field amplitude and of an optical field phase for each of a plurality of spatial portions of the input optical field and for each of first and second orthogonal input polarization states of transmitted light entering the medium. The method may be used in the control of the transmission of light 1) through a medium, which is randomizing in amplitude, phase and/or polarization or 2) through a multi-mode fiber or for beam shaping, optical trapping and/or optical manipulation.

Abstract translation: 用于通过从输入光场的单个空间部分传输光通过介质来控制光传输的方法，其创建输出光场，将输出光场与参考光场叠加，产生光学干涉场，检测光强 光学干涉场的偏振分量的空间部分，并且使用所检测的强度来确定输入光场的多个空间部分中的每一个的光场振幅和光场相位的值，并且对于第一 以及进入介质的透射光的第二正交输入极化状态。 该方法可以用于控制通过介质的光的传输1），该介质在幅度，相位和/或极化上是随机化的，或者2）通过多模光纤或用于光束成形，光学俘获和/或光学 操纵。

公开(公告)号：US08638431B2

公开(公告)日：2014-01-28

申请号：US12892640

申请日：2010-09-28

Applicant: Praveen Cheriyan Ashok ,  Gajendra Pratap Singh ,  Kishan Dholakia ,  Khay Tan

Inventor： Praveen Cheriyan Ashok ,  Gajendra Pratap Singh ,  Kishan Dholakia ,  Khay Tan

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2201/08

Abstract: A microfluidic device comprising at least one microfluidic channel with an input and an output for allowing fluid flow; and at least one Raman fiber based probe having an excitation fiber probe and/or a collection fiber probe positioned so that one end of the probe is in the microfluidic channel.

Abstract translation: 一种微流体装置，包括至少一个具有输入的微流体通道和用于允许流体流动的输出; 以及至少一个具有激发纤维探针和/或收集纤维探针的拉曼光纤探针，其定位使得探针的一端在微流体通道中。

公开(公告)号：US20130164828A1

公开(公告)日：2013-06-27

申请号：US13643279

申请日：2011-06-10

Applicant: Kishan Dholakia ,  Na Ma ,  Praveen Cheriyan Ashok ,  David Stevenson ,  Francis James Gunn-Moore

Inventor： Kishan Dholakia ,  Na Ma ,  Praveen Cheriyan Ashok ,  David Stevenson ,  Francis James Gunn-Moore

IPC: C12N15/85

CPC classification number: C12M35/02 ,  C12N15/87 ,  G02B21/32

Abstract: An integrated fibre based device for transfecting material into a cell comprising an optical fiber that has a lens formed at its end for directing light to a surface of the cell, and a channel for delivery of the material for transfection into the cell.

Abstract translation: 一种用于将材料转染到细胞中的集成的基于纤维的装置，包括具有在其端部形成的用于将光引导到细胞表面的透镜的光纤，以及用于将所述材料输送到细胞中的通道。

公开(公告)号：US08269962B2

公开(公告)日：2012-09-18

申请号：US12532723

申请日：2008-03-10

Applicant: Kishan Dholakia ,  Iain Cormack ,  Michael Mazilu

Inventor： Kishan Dholakia ,  Iain Cormack ,  Michael Mazilu

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/10 ,  G01J2003/4424

Abstract: A Raman spectrometer comprising means for illuminating a sample with a shaped laser beam and a detector that is operable to detect light that is reflected from or transmitted through a sample. Preferably, the shaped laser beam has a dark spot at its center.

Abstract translation: 拉曼光谱仪，其包括用成形激光束照射样品的装置和可操作以检测从样品反射或透过样品的光的检测器。 优选地，成形激光束在其中心处具有黑点。

公开(公告)号：US20110133104A1

公开(公告)日：2011-06-09

申请号：US13057706

申请日：2009-08-28

Applicant: Kishan Dholakia ,  Michael Mazilu ,  Jorg Baumgartl

Inventor： Kishan Dholakia ,  Michael Mazilu ,  Jorg Baumgartl

IPC: G21K1/00

CPC classification number: G02B21/32

Abstract: A method for manipulating one or more particles comprising exposing the particle(s) to a beam of radiation that is able to lift and or impart an acceleration to the particle(s) to cause it to move in a curved trajectory.

Abstract translation: 一种用于操纵一种或多种颗粒的方法，包括将颗粒暴露于辐射束，所述辐射束能够提升和/或赋予颗粒加速度以使其在弯曲的轨迹中移动。

公开(公告)号：US20100047761A1

公开(公告)日：2010-02-25

申请号：US12442327

申请日：2007-09-20

Applicant: Michael MacDonald ,  Kishan Dholakia ,  Igor Andreev

Inventor： Michael MacDonald ,  Kishan Dholakia ,  Igor Andreev

IPC: C12N5/078 ,  C12M1/00 ,  C12M1/34

CPC classification number: C12M47/04 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2400/0454 ,  G01N15/1484 ,  G01N2015/149

Abstract: A method for sorting particles, in particular cells A and B. The method uses a single channel with only one input and only one output. A particle mix A and B in a fluid is introduced into the channel and particles within the channel are sorted.

Abstract translation: 一种用于排序粒子的方法，特别是单元A和B.该方法使用单个通道，只有一个输入，只有一个输出。 将流体中的颗粒混合物A和B引入通道中，并且分配通道内的颗粒。

公开(公告)号：US20100014078A1

公开(公告)日：2010-01-21

申请号：US12303526

申请日：2007-06-08

Applicant: Kishan Dholakia ,  Phillip Ronald Thomas Jess ,  Michael Mazilu

Inventor： Kishan Dholakia ,  Phillip Ronald Thomas Jess ,  Michael Mazilu

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/433

CPC classification number: G01J3/0297 ,  B01L3/5027 ,  G01J3/28 ,  G01J3/433 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/65 ,  G01N2021/651 ,  G01N2021/656

Abstract: A micro-fluidic system comprising means for optically trapping a particle and a Raman excitation source for causing Raman scatter from the particle whilst it is in the optical trap.

Abstract translation: 微流体系统包括用于光学捕获颗粒和拉曼激发源的装置，用于在颗粒处于光阱中时引起来自颗粒的拉曼散射。

公开(公告)号：US20080274529A1

公开(公告)日：2008-11-06

申请号：US11720488

申请日：2005-11-29

Applicant: Kishan Dholakia ,  Christian Thomas Alcuin Brown ,  Lynn Paterson

Inventor： Kishan Dholakia ,  Christian Thomas Alcuin Brown ,  Lynn Paterson

IPC: C12N13/00

CPC classification number: C12N15/87 ,  C12M35/02

Abstract: An opening is formed in a cell using laser radiation. A Bessel beam is formed using the laser radiation and the Bessel beam is directed onto the cell to form an opening. The guiding of material towards the opening may be involved using optical trapping/manipulation. The material may change cellular function or analyse cell behaviour. Both pulsed laser radiation and continuous wave radiation may be formed using the same laser.

Abstract translation: 在使用激光辐射的电池中形成开口。 使用激光辐射形成贝塞尔光束，并且贝塞尔光束被引导到细胞上以形成开口。 材料向开口的引导可能涉及使用光学捕获/操纵。 该物质可能改变细胞功能或分析细胞行为。 可以使用相同的激光器来形成脉冲激光辐射和连续波辐射。

公开(公告)号：US20080017808A1

公开(公告)日：2008-01-24

申请号：US11596490

申请日：2005-05-10

Applicant: Kishan Dholakia ,  Thomas Krauss ,  Simon Cran-McGreehin

Inventor： Kishan Dholakia ,  Thomas Krauss ,  Simon Cran-McGreehin

IPC: G01N21/01

CPC classification number: G21K1/006 ,  B01L3/5027

Abstract: An on-chip micro-fluidic device (10) fabricated using a semiconductor material. The device has a micro-fluidic channel or chamber (14) defined within the material and one or more monolithically integrated semiconductor lasers (12) operate to form an optical trap in the channel or chamber (14).

Abstract translation: 使用半导体材料制造的片上微流体装置（10）。 所述装置具有限定在所述材料内的微流体通道或室（14），并且一个或多个单片集成半导体激光器（12）操作以在所述通道或室（14）中形成光阱。