中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

46 records (took 0.02 seconds)

    Wavy interface mixer
    22.
    发明授权
    Wavy interface mixer 失效
    波纹接口搅拌机

    公开(公告)号：US07416903B2

    公开(公告)日：2008-08-26

    申请号：US10428931

    申请日：2003-05-05

    Applicant: Larry A. Sklar ,  Andrea A. Mammoli ,  Richard A. Truesdell ,  Peter V. Vorobieff

    Inventor： Larry A. Sklar ,  Andrea A. Mammoli ,  Richard A. Truesdell ,  Peter V. Vorobieff

    IPC: G01N1/10 ,  G01N1/00 ,  G01N1/68 ,  G01N15/06 ,  C12Q33/00

    CPC classification number: B01L3/502776 ,  B01F13/0059 ,  B01F15/024 ,  B01F2215/0459 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0655 ,  Y10T137/2496 ,  Y10T137/2499 ,  Y10T137/2559 ,  Y10T137/2562 ,  Y10T137/2564 ,  Y10T137/2567 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: The present invention provides methods and apparatus for mixing samples in-line in a microfluidic system, comprising methods of and means for introducing a first fluid sample into a flow-tube at a first end at a first velocity via a first conduit; methods of and means for introducing a second fluid sample into the flow-tube at the first end at a second velocity, the second velocity different from the first velocity, via a second conduit, wherein the first fluid sample and the second fluid sample converge in the flow tube to form an interface; whereby the first fluid sample and the second fluid sample mix at the interface within the flow-tube, wherein fluid flow at the first end of the flow-tube is laminar and fluid flow at a second end of the flow-tube is laminar, and wherein the flow-tube has a constant diameter between the first end and the second end of the flow-tube.

    Abstract translation: 本发明提供了在微流体系统中在线混合样品的方法和装置，包括用于经由第一导管以第一速度在第一端将第一流体样品引入流管的方法和装置; 通过第二导管以第二速度（第二速度不同于第一速度）将第二流体样品引入流管中的方法和装置，其中第一流体样品和第二流体样品收敛于 流管形成界面; 由此所述第一流体样品和所述第二流体样品在所述流动管内的界面处混合，其中在所述流动管的所述第一端处的流体流是层流的，并且在所述流动管的第二端的流体流是层流的，以及 其中所述流管在所述流管的所述第一端和所述第二端之间具有恒定的直径。

    Method for induction of L-selectin shedding
    24.
    发明授权
    Method for induction of L-selectin shedding 失效
    诱导L-选择蛋白脱落的方法

    公开(公告)号：US06943268B2

    公开(公告)日：2005-09-13

    申请号：US10284321

    申请日：2002-10-31

    Applicant: Snezna Rogelj ,  Teresa A. Bennett ,  Larry A. Sklar

    Inventor： Snezna Rogelj ,  Teresa A. Bennett ,  Larry A. Sklar

    IPC: A61K31/285 ,  C07C309/05

    CPC classification number: A61K31/285

    Abstract: The invention provides anti-thiol reagents which inhibit enzyme activity of cell-associated protein disulfide isomerase (PDI) by oxidizing or blocking PDI active site vicinal thiol groups which normally participate in disulfide bond rearrangement of PDI substrates. Inhibition of this PDI function is particularly useful in blocking PDI-mediated entry of HIV or other virions into a host cell, as well as inhibiting lymphocyte traffic through the lymph nodes. The invention further provides an assay for the identification of such PDI inhibitors based on the discovery that inhibitors of the invention also induce shedding of the leucocyte L-selectin adhesion molecule. The invention additionally provides for suppression of inflammation and of lymph node entry by calmodulin antagonists that, like PDI inhibition, cause leukocyte L-selectin shedding.

    Abstract translation: 本发明提供通过氧化或阻断通常参与PDI底物的二硫键重排的PDI活性位点连位硫醇基团来抑制细胞相关蛋白二硫键异构酶（PDI）的酶活性的抗硫醇试剂。 该PDI功能的抑制特别可用于阻断PDI介导的HIV或其它病毒体进入宿主细胞，以及抑制通过淋巴结的淋巴细胞流量。 基于本发明的抑制剂还诱导白细胞L-选择素粘附分子的脱落的发现，本发明还提供了用于鉴定这种PDI抑制剂的测定法。 本发明另外提供抑制钙调素拮抗剂的炎症和淋巴结进入，其像PDI抑制一样导致白细胞L-选择蛋白脱落。

    Controlled sheath flow injection cytometry
    27.
    发明授权
    Controlled sheath flow injection cytometry 失效
    控制鞘流注射细胞计数

    公开(公告)号：US5895764A

    公开(公告)日：1999-04-20

    申请号：US976637

    申请日：1997-11-24

    Applicant: Larry A. Sklar ,  Larry C. Seamer

    Inventor： Larry A. Sklar ,  Larry C. Seamer

    IPC: G01N15/14 ,  G01N33/48

    CPC classification number: G01N15/1404 ,  Y10T436/117497 ,  Y10T436/118339

    Abstract: A flow cytometry method and system to regulate both the sheath and sample streams during the period of sample injection. The period of turbulence between the streams is reduced to approximately 100 milliseconds thereby allowing for focused measurement of cell associated fluorescence.

    Abstract translation: 流式细胞术方法和系统，用于在注射期间调节鞘和样品流。 流之间的湍流周期减少到大约100毫秒，从而允许聚焦测量细胞相关荧光。

    METHODS FOR TREATING BACTERIAL INFECTION
    29.
    发明申请
    METHODS FOR TREATING BACTERIAL INFECTION 有权
    治疗细菌感染的方法

    公开(公告)号：US20150190408A1

    公开(公告)日：2015-07-09

    申请号：US14561787

    申请日：2014-12-05

    Applicant: Susan A. McDowell ,  Robert E. Sammelson ,  Larry A. Sklar ,  Mark K. Haynes

    Inventor： Susan A. McDowell ,  Robert E. Sammelson ,  Larry A. Sklar ,  Mark K. Haynes

    IPC: A61K31/635

    CPC classification number: A61K31/635

    Abstract: The present disclosure relates to molecules which function as selective modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases and, in particular, CDC42 GTPase, and their use to treat bacterial infection including systemic infection from sources such as Staphylococcus aureus and Streptococcus pyogenes.

    Abstract translation: 本公开内容涉及用作小GTP酶的Ras同源（Rho）家族，特别是CDC42GTP酶的选择性调节剂（即抑制剂和激动剂）的分子及其用于治疗细菌感染的用途，包括来源的全身感染 如金黄色葡萄球菌和化脓性链球菌。

    NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONS AND METHODS OF TREATMENT OF CANCER
    30.
    发明申请
    NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONS AND METHODS OF TREATMENT OF CANCER 有权
    新型双功能蛋白酶/终止抑制剂及相关组合物及治疗癌症的方法

    公开(公告)号：US20120302582A1

    公开(公告)日：2012-11-29

    申请号：US13574941

    申请日：2011-01-26

    Applicant: Robert Hromas ,  Andrei Leitao ,  Tudor I. Oprea ,  Larry A. Sklar ,  Elizabeth A. Williamson ,  Justin Wray ,  Wei Wang

    Inventor： Robert Hromas ,  Andrei Leitao ,  Tudor I. Oprea ,  Larry A. Sklar ,  Elizabeth A. Williamson ,  Justin Wray ,  Wei Wang

    IPC: A61K31/496 ,  C07D401/10 ,  A61N5/10 ,  C07D401/14 ,  A61P35/00 ,  A61P35/02 ,  A61K31/47 ,  C07D215/56

    CPC classification number: C07D215/56 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/475 ,  A61K31/496 ,  A61K31/7048 ,  A61K45/06 ,  A61N5/1001 ,  A61N5/1045 ,  A61N2005/1087 ,  A61N2005/1098 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  A61K2300/00

    Abstract: This invention relates to novel cancer treatment compositions and associated therapeutic methods. More particularly, this invention relates in part to small chemical bifunctional inhibitors of DNA replication and repair proteins Metnase and/or Intnase (also termed Gypsy Integrase, Gypsy Integrease-1, Gypsy Retransposon Integrase 1, or GIN-I) that simultaneously damage DNA, and to a therapeutic method that utilizes the inhibitors to increase the effectiveness of cancer treatment protocols, including radiation therapy. In preferred embodiments, compounds, compositions and methods of treatment of the invention are used to treat a patient suffering from leukemia (e.g. acute myeloid leukemia (AML) and related cancers. In certain aspects of such treatments, compounds, compositions and methods of treatment of the invention are administered as a monotherapy (in some cases, to patients who have exhibited resistance to Topo IIalpha inhibitors such as VP-16), or are co-administered with a Topo IIalpha inhibitor or other anti-cancer agents as otherwise described herein or in combination with radiation therapy.

    Abstract translation: 本发明涉及新的癌症治疗组合物和相关的治疗方法。 更具体地说，本发明部分涉及同时损伤DNA的DNA复制和修复蛋白质Metnase和/或Intnase（也称为Gypsy整合酶，Gypsy Integrease-1，Gypsy Retransposon Integrase 1或GIN-1）的小型化学双功能抑制剂， 以及利用抑制剂增加包括放射治疗在内的癌症治疗方案的有效性的治疗方法。 在优选的实施方案中，本发明的化合物，组合物和治疗方法用于治疗患有白血病的患者（例如急性骨髓性白血病（AML）和相关的癌症）。在这些治疗的某些方面，化合物，组合物和治疗方法 本发明作为单一疗法（在某些情况下，对已显示出对Topo IIalpha抑制剂如VP-16具有抗性的患者）施用，或者与本文另有描述的Topo IIal抑制剂或其它抗癌剂共同施用，或 结合放射治疗。

Patent Agency Ranking