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公开(公告)号：US20130306356A1
公开(公告)日：2013-11-21
申请号：US13873961
申请日：2013-04-30
Applicant: Mark G. Allen , Seong-O Choi , Jung-Hwan Pauk , Xiaosong Wu , Yanzhu Zhao , Yong-Kyu Yoon , Swaminathan Rajaraman
Inventor： Mark G. Allen , Seong-O Choi , Jung-Hwan Pauk , Xiaosong Wu , Yanzhu Zhao , Yong-Kyu Yoon , Swaminathan Rajaraman
CPC classification number: B32B3/30 , A61B5/685 , A61B2562/125 , A61M37/0015 , A61M2037/0053 , A61N1/327 , C25D1/003 , C25D1/10 , C25D5/022 , H01B13/00 , H05K1/02 , H05K3/20 , H05K3/4007 , H05K2201/0367 , H05K2201/09045 , H05K2201/09118 , H05K2203/0113 , Y10T428/2958 , Y10T428/298
Abstract: Methods are provided for fabricating three-dimensional electrically conductive structures. Three-dimensional electrically conductive microstructures are also provided. The method may include providing a mold having at least one microdepression which defines a three-dimensional structure; filling the microdepression of the mold with at least one substrate material; molding the at least one substrate material to form a substrate; and depositing and patterning of at least one electrically conductive layer either during the molding process or subsequent to the molding process to form an electrically conductive structure. In one embodiment, the three-dimensional electrically conductive microstructure comprises an electrically functional microneedle array comprising two or more microneedles, each including a high aspect ratio, polymeric three dimensional substrate structure which is at least substantially coated by an electrically conductive layer.
Abstract translation: 提供用于制造三维导电结构的方法。 还提供三维导电微结构。 该方法可以包括提供具有限定三维结构的至少一个微压缩的模具; 用至少一种基底材料填充模具的微压; 模制所述至少一种基底材料以形成基底; 以及在模制过程期间或在模制过程之后沉积和图案化至少一个导电层以形成导电结构。 在一个实施例中，三维导电微结构包括电功能微针阵列，其包括两个或更多个微针，每个微针包括高纵横比，至少基本上被导电层涂覆的聚合物三维衬底结构。
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公开(公告)号：US20120016207A1
公开(公告)日：2012-01-19
申请号：US13245565
申请日：2011-09-26
Applicant: MARK G. ALLEN
Inventor： MARK G. ALLEN
Abstract: An electromagnetically coupled hermetic chamber includes a body defining a hermetic chamber. A distributed LC circuit is disposed within the hermetic chamber and a second conductive structure is attached to the body outside of the hermetic chamber. The distributed LC circuit is electromagnetically coupled to the second conductive structure without direct electrical paths thereby allowing coupling of the distributed LC circuit to external electronics without the need for electrical feedthroughs or vias that could compromise the integrity of the hermetic chamber.
Abstract translation: 电磁耦合密封室包括限定密封室的主体。 分布式LC电路设置在密封室内，第二导电结构附着到密封室外部的本体。 分布式LC电路电磁耦合到第二导电结构而没有直接的电气路径，从而允许将分布式LC电路耦合到外部电子器件，而不需要可能危及密封室的完整性的电馈通或通孔。
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公开(公告)号：US20100316327A1
公开(公告)日：2010-12-16
申请号：US12704174
申请日：2010-02-11
Applicant: Juan Montoya , Mark G. Allen , Joel M. Hensley , Krishnan R. Parameswaran , Rajeev Ram
Inventor： Juan Montoya , Mark G. Allen , Joel M. Hensley , Krishnan R. Parameswaran , Rajeev Ram
CPC classification number: G02B6/1226 , B82Y20/00 , G02B2006/12097 , G02F1/011 , G02F1/0955 , G02F2203/10
Abstract: An optical device for integrated photonic applications includes a substrate, a dielectric waveguide and a surface plasmon waveguide. The dielectric waveguide includes a dielectric waveguide core disposed relative to a dielectric waveguide cladding and a common cladding. The surface plasmon waveguide includes a surface plasmon waveguide core disposed relative to the common cladding and a surface plasmon waveguide cladding. The common cladding couples the dielectric waveguide and the surface plasmon waveguide.
Abstract translation: 用于集成光子应用的光学装置包括基板，电介质波导和表面等离子体波导。 电介质波导包括相对于电介质波导包层和公共包层设置的电介质波导芯。 表面等离子体激元波导包括相对于公共包层设置的表面等离子体波导芯和表面等离子体激元波导包层。 公共覆层耦合介质波导和表面等离子体波导。
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24.发明申请公开(公告)号：US20100195082A1
公开(公告)日：2010-08-05
申请号：US12694936
申请日：2010-01-27
Applicant: Yong-Kyu Yoon , JungKwun Kim , Mark G. Allen
Inventor： Yong-Kyu Yoon , JungKwun Kim , Mark G. Allen
CPC classification number: G03F7/201
Abstract: A system according to an embodiment of the present invention comprises a movable stage having a top surface. A photosensitive material may be deposited on the top surface and a mask may be placed on the photosensitive material. A vessel, having a top portion, one or more flexible sides, and a transparent base, is configured to be placed adjacent to the mask. The base is configured to be movable relative to the top portion of the vessel. In this way, the movable stage, photosensitive material, and mask may move in conjunction with the base of the vessel.
Abstract translation: 根据本发明的实施例的系统包括具有顶表面的可移动台。 感光材料可以沉积在顶表面上，并且掩模可以放置在感光材料上。 具有顶部，一个或多个柔性侧面和透明基底的容器构造成邻近掩模放置。 基部构造成相对于容器的顶部可移动。 以这种方式，可移动台，感光材料和面罩可以与容器的底部一起移动。
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公开(公告)号：US07683357B2
公开(公告)日：2010-03-23
申请号：US12166222
申请日：2008-07-01
Applicant: William A. Von Drasek , Shawn D. Wehe , Mark G. Allen
Inventor： William A. Von Drasek , Shawn D. Wehe , Mark G. Allen
CPC classification number: G01N21/39 , G01N2201/12
Abstract: A gas species monitoring system includes a laser, a fiber amplifier configured to receive an input signal from the laser and generate an amplified signal, and a variable optical attenuation system configured to receive at least a portion of the amplified signal and generate an attenuated signal for delivery to a measurement point, where the measurement point includes a gaseous fluid. The system further includes a detector configured to receive and process a signal from the measurement point so as to obtain a measured signal that correlates with the presence of a gas species within the gaseous fluid at the measurement point, and a processor in communication with at least the variable optical attenuation system and the detector. The processor controls the variable optical attenuation system based upon the measured signal.
Abstract translation: 气体种类监测系统包括激光器，被配置为从激光器接收输入信号并产生放大信号的光纤放大器，以及可变光衰减系统，被配置为接收放大信号的至少一部分并产生衰减信号 输送到测量点，其中测量点包括气态流体。 该系统还包括检测器，其被配置为接收并处理来自测量点的信号，以便获得与测量点处的气态流体内的气体种类的存在相关的测量信号，以及至少与 可变光衰减系统和检测器。 处理器基于测量信号控制可变光衰减系统。
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Patent Agency Ranking
26.发明申请公开(公告)号：US20100070864A1
公开(公告)日：2010-03-18
申请号：US12425163
申请日：2009-04-16
Applicant: Mark G. ALLEN , Matthew L. Brunett , David L. Wilkerson
Inventor： Mark G. ALLEN , Matthew L. Brunett , David L. Wilkerson
IPC: G06F3/01
CPC classification number: G06Q50/10 , G06F16/29 , G06F16/958 , G06Q30/02 , G06Q30/0205 , G06Q30/0241 , G06Q50/01 , G06Q50/205
Abstract: A system and method links one or more disparate community awareness management (CAM) datasets for a community awareness program (CAP) with one or more spatial layers to create linked CAM datasets. One or more data attributes common to a CAM dataset and a spatial layer are identified, and the link is defined between the CAM dataset and the spatial layer. The spatial layer and the linked CAM dataset then may be queried using a single input query. Features from the spatial layer and features from the linked CAM dataset that match the query are generated for display. In one embodiment, a system and method manage CAP assets, transactions, interest areas for the CAP, and buffer areas for the CAP. An audience utility enables entering and maintaining audience data for the CAP. A journal utility enables making journal entries for one or more audience members, CAP assets, transactions, and/or other CAM data. A link document utility enables linking one or more documents to CAM data.
Abstract translation: 系统和方法将一个或多个不同的社区意识管理（CAM）数据集链接到具有一个或多个空间层的社区感知程序（CAP）以创建链接的CAM数据集。 识别CAM数据集和空间层通用的一个或多个数据属性，并且在CAM数据集和空间层之间定义链接。 然后可以使用单个输入查询查询空间层和链接的CAM数据集。 来自空间层的特征和与查询匹配的链接的CAM数据集的特征被生成用于显示。 在一个实施例中，管理CAP资产，交易，CAP的兴趣区域和CAP的缓冲区域的系统和方法。 观众实用程序可以输入和维护CAP的受众数据。 日记实用程序可以为一个或多个受众成员，CAP资产，交易和/或其他CAM数据制作日记帐分录。 链接文档实用程序可以将一个或多个文档链接到CAM数据。
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公开(公告)号：US20090318846A1
公开(公告)日：2009-12-24
申请号：US12130728
申请日：2008-05-30
Applicant: Mark R. Prausnitz , Mark G. Allen , Jung-Hwan Park , Jeong Woo Lee , Priya D. Gadiraju
Inventor： Mark R. Prausnitz , Mark G. Allen , Jung-Hwan Park , Jeong Woo Lee , Priya D. Gadiraju
CPC classification number: A61B17/3203 , A61B2017/00765 , A61B2018/00613 , A61N1/0412 , A61N1/0428 , A61N1/30 , A61N1/325 , A61N1/327 , A61N1/328
Abstract: The various embodiments of the present invention relate generally to methods and apparatus for surface ablation. More particularly, various embodiments of the present invention are related to methods and apparatus for ablation of barrier surfaces, such as skin, to increase the permeability of the barrier surface. Embodiments of the present invention comprise rapid thermo-mechanical ablation of the skin by a microfluidic jet generated by an arc discharge to produce micron-scale holes localized to the stratum corneum, which increases skin permeability.
Abstract translation: 本发明的各种实施例一般涉及用于表面消融的方法和装置。 更具体地，本发明的各种实施例涉及用于消除阻挡表面（例如皮肤）的方法和装置，以增加阻挡表面的渗透性。 本发明的实施例包括通过由电弧放电产生的微流体射流对皮肤进行快速热机械消融，以产生定位于角质层的微米级孔，这增加了皮肤渗透性。
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公开(公告)号：US20090131905A1
公开(公告)日：2009-05-21
申请号：US12150945
申请日：2008-05-01
Applicant: Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
Inventor： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
CPC classification number: B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B33Y80/00 , B81B2201/055
Abstract: Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.
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29.发明申请公开(公告)号：US20080275848A1
公开(公告)日：2008-11-06
申请号：US11927553
申请日：2007-10-29
Applicant: Mark G. ALLEN , Matthew L. BRUNETT , David L. WILKERSON , Scott A. EVANS , Robert L. Marshall , Brett A. Lester , Larry D. Miley
Inventor： Mark G. ALLEN , Matthew L. BRUNETT , David L. WILKERSON , Scott A. EVANS , Robert L. Marshall , Brett A. Lester , Larry D. Miley
IPC: G06F17/30
CPC classification number: G06Q50/10 , G06F16/29 , G06F16/958 , G06Q30/02 , G06Q30/0205 , G06Q30/0241 , G06Q50/01 , G06Q50/205
Abstract: A system and method links one or more disparate community awareness management (CAM) datasets for a community awareness program (CAP) with one or more spatial layers to create linked CAM datasets. One or more data attributes common to a CAM dataset and a spatial layer are identified, and the link is defined between the CAM dataset and the spatial layer. The spatial layer and the linked CAM dataset then may be queried using a single input query. Features from the spatial layer and features from the linked CAM dataset that match the query are generated for display. In one embodiment, a system and method manage CAP assets, transactions, interest areas for the CAP, and buffer areas for the CAP. An audience utility enables entering and maintaining audience data for the CAP. A journal utility enables making journal entries for one or more audience members, CAP assets, transactions, and/or other CAM data. A link document utility enables linking one or more documents to CAM data.
Abstract translation: 系统和方法将一个或多个不同的社区意识管理（CAM）数据集链接到具有一个或多个空间层的社区感知程序（CAP）以创建链接的CAM数据集。 识别CAM数据集和空间层通用的一个或多个数据属性，并且在CAM数据集和空间层之间定义链接。 然后可以使用单个输入查询查询空间层和链接的CAM数据集。 来自空间层的特征和与查询匹配的链接的CAM数据集的特征被生成用于显示。 在一个实施例中，管理CAP资产，交易，CAP的兴趣区域和CAP的缓冲区域的系统和方法。 观众实用程序可以输入和维护CAP的受众数据。 日记实用程序可以为一个或多个受众成员，CAP资产，交易和/或其他CAM数据制作日记帐分录。 链接文档实用程序可以将一个或多个文档链接到CAM数据。
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公开(公告)号：US07226439B2
公开(公告)日：2007-06-05
申请号：US10454973
申请日：2003-06-04
Applicant: Mark R. Prausnitz , Mark G. Allen , Inder-Jeet Gujral
Inventor： Mark R. Prausnitz , Mark G. Allen , Inder-Jeet Gujral
IPC: A61M31/00
CPC classification number: A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150969 , A61B5/150984 , A61B17/205 , A61B2090/0814 , A61M5/422 , A61M2037/0023 , A61M2037/003 , B33Y80/00
Abstract: Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which a plurality of hollow microneedles are attached or integrated, and at least one reservoir, containing the drug, selectably in communication with the microneedles, wherein the volume or amount of drug to be delivered can be selectively altered. The reservoir can be formed of a deformable, preferably elastic, material. The device typically includes a means, such as a plunger, for compressing the reservoir to drive the drug from the reservoir through the microneedles. In one embodiment, the reservoir is a syringe or pump connected to the substrate.
Abstract translation: 提供用于在生物组织中或在生物组织中递送药物的简单微针装置，其允许以临床相关的速率穿过或进入皮肤或其它组织屏障的药物递送，对组织进行最小的或没有损伤，疼痛或刺激。 所述装置包括多个中空微针连接或整合到其上的基底，以及容纳药物的至少一个储存器，可选择地与微针连通，其中可以选择性地改变要递送的药物的体积或量。 储存器可以由可变形的，优选弹性的材料形成。 该装置通常包括用于压缩储存器以通过微针从储存器驱动药物的装置，例如柱塞。 在一个实施例中，储存器是连接到基板的注射器或泵。
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