Abstract:
The present invention relates to a new class of heterocyclic compounds and pharmaceutically acceptable salts thereof, process for preparing the same, pharmaceutical composition containing these compounds and to their use in treatment of diseases caused due to formation and accumulation of AGEs (Advanced Glycation end products). The compounds of the present invention are useful for the treatment of diabetic and aging-related complications caused by formation and accumulation of AGEs, such as neuropathy, nephropathy, microangiopathy, retinopathy, hypertension, heart failure, atherosclerosis, Alzheimer's disease & dermatological disorders.
Abstract:
The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.
Abstract:
Methods, systems, software arrangements and storage medium for measuring the magnetic field correlation function (“MFC”), and more particularly, to methods for measuring the magnetic field correlation function utilizing asymmetric spin echoes. Asymmetric Dual Spin Echo Sequences (“ADSE”) and Echo Planar Imaging Asymmetric Dual Spin Echo Sequences (“EPI-ADSE”) may be employed to apply multiple echoes to a sample and acquire data from which the MFC may be determined.
Abstract:
9-Chloro-nos, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-chloro-nos, and methods of preparation and use thereof are disclosed. 9-Chloro-nos is a noscapine analog that can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, by binding tubulin and inducing apoptosis selectively in tumor cells (ovarian and T-cell lymphoma) resistant to paclitaxel, vinblastine and teniposide. 9-Chloro-nos can perturb the progression of cell cycle by mitotic arrest, followed by apoptotic cell death associated with increased caspase-3 activation and appearance of TUNEL-positive cells. Thus, 9-chloro-nos is a novel therapeutic agents for a variety of cancers, including ovarian and T-cell lymphoma cancers, even those that have become drug-resistant to currently available chemotherapeutic drugs.
Abstract:
Methods, systems, software arrangements and storage medium for measuring the magnetic field correlation function (“MFC”), and more particularly, to methods for measuring the magnetic field correlation function utilizing asymmetric spin echoes. Asymmetric Dual Spin Echo Sequences (“ADSE”) and Echo Planar Imaging Asymmetric Dual Spin Echo Sequences (“EPI-ADSE”) may be employed to apply multiple echoes to a sample and acquire data from which the MFC may be determined.
Abstract:
Methods and systems for energy management system for a vehicle are provided. The system includes a first power source configured for cranking an engine wherein the first power source includes a switch configured to electrically couple the first power source to a starter for the engine and wherein the first power source is electrically isolated from auxiliary onboard loads. The system further includes a second power source configured for supplying auxiliary on board loads, a charging subsystem electrically coupled to the first and the second power sources. The charging subsystem is configured to supply charging current to the first and the second power sources. The system further includes a controller configured to maintain the first power source in a substantially fully charged condition and supply the auxiliary loads from the second power source.
Abstract:
Methods, systems, and apparatus, including computer program apparatus, implementing techniques for publishing, subscribing to, or playing live appliances. A live appliance includes a current virtual machine image. In publishing, a proxy file of a live appliance file type is provided to the publisher. The type is mapped to a live appliance player; so that when a proxy file is opened, the current virtual machine image is run. The player automatically binds a writeable file system external to the virtual machine image to the image to provide file storage that is accessible from within the virtual machine image and from a host operating system. The player also creates a subscription to the live appliance on the host computer if one does not exist when the proxy file is run. With the subscription, the player runs the then-current virtual machine image whenever the live appliance is run.
Abstract:
Methods, systems, and apparatus, including computer program apparatus, implementing techniques for publishing, subscribing to, or playing live appliances. A live appliance includes a current virtual machine image. In publishing, a proxy file of a live appliance file type is provided to the publisher. The type is mapped to a live appliance player; so that when a proxy file is opened, the current virtual machine image is run. The player automatically binds a writeable file system external to the virtual machine image to the image to provide file storage that is accessible from within the virtual machine image and from a host operating system. The player also creates a subscription to the live appliance on the host computer if one does not exist when the proxy file is run. With the subscription, the player runs the then-current virtual machine image whenever the live appliance is run.
Abstract:
Methods, systems, and apparatus, including computer program apparatus, implementing techniques for publishing, subscribing to, or playing live appliances. A live appliance includes a current virtual machine image. In publishing, a proxy file of a live appliance file type is provided to the publisher. The type is mapped to a live appliance player; so that when a proxy file is opened, the current virtual machine image is run. The player automatically binds a writeable file system external to the virtual machine image to the image to provide file storage that is accessible from within the virtual machine image and from a host operating system. The player also creates a subscription to the live appliance on the host computer if one does not exist when the proxy file is run. With the subscription, the player runs the then-current virtual machine image whenever the live appliance is run.
Abstract:
The present invention provides a novel saponin tigogenin penta glycoside isolated from the aerial parts of Chlorophytum nimonii and a process for the isolation thereof as well as its use in anti-hyperglycemic and hypolipidemic activities.