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公开(公告)号：US07402161B2
公开(公告)日：2008-07-22
申请号：US11219646
申请日：2005-09-07
Applicant: Roni Zvuloni , Shaike Schatzberger
Inventor： Roni Zvuloni , Shaike Schatzberger
IPC: A61B18/02
CPC classification number: A61B18/02 , A61B8/0833 , A61B8/445 , A61B34/10 , A61B90/37 , A61B2017/00274 , A61B2018/00041 , A61B2018/00547 , A61B2018/0262 , A61B2034/104 , A61B2090/374
Abstract: Systems and methods for planning a cryoablation procedure and for facilitating a cryoablation procedure utilize integrated images displaying, in a common virtual space, a three-dimensional model of a surgical intervention site based on digitized preparatory images of the site from first imaging modalities, simulation images of cryoprobes used according to an operator-planned cryoablation procedure at the site, and real-time images provided by second imaging modalities during cryoablation. The system supplies recommendations for and evaluations of the planned cryoablation procedure, feedback to an operator during cryoablation, and guidance and control signals for operating a cryosurgery tool during cryoablation. Methods are provided for generating a nearly-uniform cold field among a plurality of cryoprobes, for cryoablating a volume with smooth and well-defined borders, thereby minimizing damage to healthy tissues.
Abstract translation: 用于规划冷冻消融程序和促进冷冻消融过程的系统和方法利用在共同虚拟空间中基于来自第一成像模态的站点的数字化预备图像显示外科手术部位的三维模型的综合图像，模拟图像 根据运营商计划的冷冻消融程序在现场使用的低温球，以及在冷冻消融期间由第二成像模式提供的实时图像。 该系统提供计划的冷冻消融程序的建议和评估，冷冻消融期间对操作者的反馈，以及冷冻消融期间操作冷冻手术工具的指导和控制信号。 提供了用于在多个冷冻探针之间产生几乎均匀的冷场的方法，用于冷却具有平滑且明确限定的边界的体积，从而最小化对健康组织的损伤。
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公开(公告)号：US20070167938A1
公开(公告)日：2007-07-19
申请号：US11640309
申请日：2006-12-18
Applicant: Roni Zvuloni , Shaike Schatzberger
Inventor： Roni Zvuloni , Shaike Schatzberger
IPC: A61B18/02
CPC classification number: A61B18/02 , A61B90/11 , A61B90/36 , A61B2017/00092 , A61B2017/00867 , A61B2018/00041 , A61B2018/00101 , A61B2018/0262 , A61B2018/0268 , A61B2018/0287 , A61B2018/0293
Abstract: A cryosurgery apparatus is disclosed. The cryosurgery apparatus an introducer having a hollow and a distal portion, the distal portion being sufficiently sharp so as to penetrate into a body, the hollow of the introducer being designed and constructed for containing a plurality of cryoprobes each of the cryoprobes being for effecting cryoablation, such that each of the plurality of cryoprobes is deployable through the distal portion of the introducer when the distal portion is positioned with respect to a tissue to be cryoablated.
Abstract translation: 公开了一种冷冻手术装置。 所述冷冻手术装置具有中空和远端部分的导引器，所述远端部分足够锋利以便穿透入体内，导引器的中空部被设计和构造成用于容纳多个冷冻探针，每个冷冻探针用于进行冷冻消融 使得当远侧部分相对于要冷冻的组织定位时，多个冷冻探针中的每一个可以通过导引器的远端部分展开。
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公开(公告)号：US20060079867A1
公开(公告)日：2006-04-13
申请号：US11240556
申请日：2005-10-03
Applicant: Nir Berzak , Roni Zvuloni , Uri Amir
Inventor： Nir Berzak , Roni Zvuloni , Uri Amir
IPC: A61B18/02
CPC classification number: A61B18/02 , A61B90/11 , A61B2018/00041 , A61B2018/0262 , A61B2018/0287 , A61B2018/0293
Abstract: The present invention is of a system and method for accurate cryoablation, useable to enhance a surgeon's ability to accurately cryoablate a selected cryoablation target and to limit cryoablation to that selected target. Presented are apparatus and method for accurately delimiting a cryoablation volume, for minimizing damage to tissues surrounding a cryoablation volume, and for real-time visualization of a border of a cryoablation volume during cryoablation. Also presented are a method for mildly heating tissues during cryoablation, cryoprobes operable to simultaneously cool first tissues while heating second tissues, and cryoprobes operable to cool tissues extending in a first lateral direction from those probes while not substantially cooling tissues extending in a second lateral direction from those probes.
Abstract translation: 本发明是一种用于精确冷冻消融的系统和方法，可用于增强外科医生准确地冷冻选定的冷冻消融靶的能力，并将冷冻消融限制到所选择的靶。 提出了用于精确地限定冷冻消融体积的装置和方法，用于最小化对冷冻消融体周围的组织的损伤，以及用于在冷冻消融期间对冷冻消融体积的边界的实时可视化。 还提出了一种用于在冷冻消融期间轻度加热组织的方法，可操作地同时冷却第一组织同时冷却第二组织的冷冻手段，以及可操作以冷冻从那些探针沿第一横向延伸的组织的冷冻杆，同时基本上不冷却在第二横向方向上延伸的组织 从那些探针。
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公开(公告)号：US09198791B2
公开(公告)日：2015-12-01
申请号：US13811333
申请日：2011-07-20
Applicant: Pierre Sharvit , Chen Porat , Dan Kinarty , Roni Zvuloni
Inventor： Pierre Sharvit , Chen Porat , Dan Kinarty , Roni Zvuloni
CPC classification number: A61F5/0036 , A61F2/04 , A61F2/848 , A61F2/88 , A61F5/0003 , A61F5/0013 , A61F5/0076 , A61F5/0079 , A61F2002/041 , A61F2002/044 , A61F2002/045 , A61M27/002 , A61M2210/1042 , A61M2210/1053 , A61M2210/1057 , A61M2210/106
Abstract: Apparatus (20) for use with pancreaticobiliary secretions that enter a gastrointestinal tract of a subject at an anatomical entry location, the apparatus (20) comprising: a pancreaticobiliary secretion-diversion guide (30) configured to collect the pancreaticobiliary secretions from the anatomical entry location and deliver the pancreaticobiliary secretions to a location in the gastrointestinal tract that is distal to the anatomical entry location; and an anchoring system (40) comprising one or more helical anchors (80) located within the gastrointestinal tract and configured to apply pressure to a wall of the gastrointestinal tract in order to maintain the pancreaticobiliary secretion-diversion guide in place.
Abstract translation: 用于在解剖学进入位置进入受试者的胃肠道的胰胆管分泌物的装置（20），所述装置（20）包括：胰胆管分泌分流引导件（30），其构造成从解剖入口位置收集胰胆管分泌物 并将胰胆管分泌物输送到解剖进入位置远端的胃肠道中的位置; 以及锚定系统（40），其包括位于胃肠道内的一个或多个螺旋锚（80）并且构造成向胃肠道的壁施加压力，以便将胰胆管分泌分流引导件保持在适当位置。
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公开(公告)号：US20130090554A1
公开(公告)日：2013-04-11
申请号：US13805535
申请日：2011-06-23
Applicant: Roni Zvuloni , Shaike Schatzberger
Inventor： Roni Zvuloni , Shaike Schatzberger
CPC classification number: A61B5/061 , A61B8/12 , A61B10/0241 , A61B34/25 , A61B2017/00274 , A61B2018/00547 , A61B2034/105 , A61B2034/2051 , A61B2034/2072 , A61B2090/378
Abstract: Systems and methods for locating lesions in a prostate or other organ during a first intervention session, and for using that lesion location information during a second intervention session are presented. A module for detecting and reporting the position of a prostate in real time is disclosed. The module comprises a sensor which detects and electronic signal. An image registration system for mapping first-session 3D model information to a second-session 3D model is also presented, as is a prostate modeling facilitation tool which comprises a set of predefined 3D models of the prostate.
Abstract translation: 呈现在第一次干预会话期间用于定位前列腺或其他器官中的病变的系统和方法，以及在第二次干预期间期间使用该病变位置信息。 公开了一种用于实时检测和报告前列腺位置的模块。 该模块包括检测和电子信号的传感器。 还提出了用于将第一会话3D模型信息映射到第二会话3D模型的图像注册系统，前列腺建模促进工具还包括一组前列腺的预定3D模型。
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Patent Agency Ranking
26.发明授权公开(公告)号：US07407501B2
公开(公告)日：2008-08-05
申请号：US11055597
申请日：2005-02-11
Applicant: Roni Zvuloni
Inventor： Roni Zvuloni
IPC: A61B18/02
CPC classification number: A61B18/02 , A61B90/36 , A61B2017/00092 , A61B2017/00867 , A61B2018/00041 , A61B2018/0262 , A61B2018/0268 , A61B2018/0287 , F17C2201/018 , F17C2201/0185 , F17C2201/019
Abstract: An apparatus for compressing a gas and its uses are disclosed. The apparatus comprises a fixed-volume container having a hollow and a moveable element subdividing said hollow into a first variable-volume portion and a second variable-volume portion, the second variable-volume portion having an opening for introducing therein a hydraulic and/or pneumatic fluid under pressure, for causing an increase in the volume of said second variable-portion by moving said moveable element, thereby, consequently, decreasing the volume of the first variable-volume portion and compressing a gas contained therein.
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公开(公告)号：US07402160B2
公开(公告)日：2008-07-22
申请号：US11066294
申请日：2005-02-28
Applicant: Roni Zvuloni , Shaike Schatzberger
Inventor： Roni Zvuloni , Shaike Schatzberger
IPC: A61B18/18
CPC classification number: A61B18/02 , A61B8/0833 , A61B8/445 , A61B34/10 , A61B90/37 , A61B2017/00274 , A61B2018/00041 , A61B2018/00547 , A61B2018/0262 , A61B2034/104 , A61B2090/374
Abstract: Systems and methods for planning a cryoablation procedure and for facilitating a cryoablation procedure utilize integrated images displaying, in a common virtual space, a three-dimensional model of a surgical intervention site based on digitized preparatory images of the site from first imaging modalities, simulation images of cryoprobes used according to an operator-planned cryoablation procedure at the site, and real-time images provided by second imaging modalities during cryoablation. The system supplies recommendations for and evaluations of the planned cryoablation procedure, feedback to an operator during cryoablation, and guidance and control signals for operating a cryosurgery tool during cryoablation. Methods are provided for generating a nearly-uniform cold field among a plurality of cryoprobes, for cryoablating a volume with smooth and well-defined borders, thereby minimizing damage to healthy tissues.
Abstract translation: 用于规划冷冻消融程序和促进冷冻消融过程的系统和方法利用在共同虚拟空间中基于来自第一成像模态的站点的数字化预备图像显示外科手术部位的三维模型的综合图像，模拟图像 根据运营商计划的冷冻消融程序在现场使用的低温球，以及在冷冻消融期间由第二成像模式提供的实时图像。 该系统提供计划的冷冻消融程序的建议和评估，冷冻消融期间对操作者的反馈，以及冷冻消融期间操作冷冻手术工具的指导和控制信号。 提供了用于在多个冷冻探针之间产生几乎均匀的冷场的方法，用于冷却具有平滑且明确限定的边界的体积，从而最小化对健康组织的损伤。
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公开(公告)号：US07399298B2
公开(公告)日：2008-07-15
申请号：US11219648
申请日：2005-09-07
Applicant: Roni Zvuloni , Shaike Schatzberger
Inventor： Roni Zvuloni , Shaike Schatzberger
IPC: A61B18/02
CPC classification number: A61B18/02 , A61B8/0833 , A61B8/445 , A61B34/10 , A61B90/37 , A61B2017/00274 , A61B2018/00041 , A61B2018/00547 , A61B2018/0262 , A61B2034/104 , A61B2090/374
Abstract: Systems and methods for planning a cryoablation procedure and for facilitating a cryoablation procedure utilize integrated images displaying, in a common virtual space, a three-dimensional model of a surgical intervention site based on digitized preparatory images of the site from first imaging modalities, simulation images of cryoprobes used according to an operator-planned cryoablation procedure at the site, and real-time images provided by second imaging modalities during cryoablation. The system supplies recommendations for and evaluations of the planned cryoablation procedure, feedback to an operator during cryoablation, and guidance and control signals for operating a cryosurgery tool during cryoablation. Methods are provided for generating a nearly-uniform cold field among a plurality of cryoprobes, for cryoablating a volume with smooth and well-defined borders, thereby minimizing damage to healthy tissues.
Abstract translation: 用于规划冷冻消融程序和促进冷冻消融过程的系统和方法利用在共同虚拟空间中基于来自第一成像模态的站点的数字化预备图像显示外科手术部位的三维模型的综合图像，模拟图像 根据运营商计划的冷冻消融程序在现场使用的低温球，以及在冷冻消融期间由第二成像模式提供的实时图像。 该系统提供计划的冷冻消融程序的建议和评估，冷冻消融期间对操作者的反馈，以及冷冻消融期间操作冷冻手术工具的指导和控制信号。 提供了用于在多个冷冻探针之间产生几乎均匀的冷场的方法，用于冷却具有平滑且明确限定的边界的体积，从而最小化对健康组织的损伤。
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公开(公告)号：US20070088247A1
公开(公告)日：2007-04-19
申请号：US11637095
申请日：2006-12-12
Applicant: Mordechai Bliweis , Nir Berzak , Shimon Livneh , Yaron Hefetz , Yaron Tal , Roni Zvuloni
Inventor： Mordechai Bliweis , Nir Berzak , Shimon Livneh , Yaron Hefetz , Yaron Tal , Roni Zvuloni
CPC classification number: A61B1/018 , A61B1/00073 , A61B1/00098 , A61B1/00135 , A61B1/00154 , A61B1/303 , A61B17/3421 , A61B17/42 , A61B18/02 , A61B2017/3445 , A61B2017/3447 , A61B2017/4216 , A61B2018/00101 , A61B2018/0262 , A61B2018/1495 , A61B2090/0463
Abstract: The present invention relates to apparatus and methods for thermally ablating uterine fibroids. More particularly, the present invention relates to a conduit having a plurality of channels for delivering a plurality of thermal ablation probes to an organic target such as a uterine fibroid, the probes being delivered in such configuration and orientation as to enable efficient and thorough ablation of the fibroid. In a preferred embodiment, the conduit is formed as a sleeve having a large central lumen sized to accommodate a hysteroscope, channels sized to accommodate cryoprobes are used as thermal ablation probes, and comprises thermal insulation materials serving to protect the cervix from damage by cold. The present invention further relates to bent cryoprobes usable in conjunction with such a conduit and designed to exit therefrom in a desired configuration useful for ablating a large fibroid.
Abstract translation: 本发明涉及用于热消融子宫肌瘤的装置和方法。 更具体地，本发明涉及一种具有多个通道以用于将多个热消融探针输送到诸如子宫肌瘤的有机靶的导管，所述探针以这种构造和取向被递送以使得能够有效和彻底地消融 肌瘤。 在优选实施例中，导管形成为具有尺寸适于容纳宫腔镜的大中心腔的套管，尺寸适于容纳冷冻探针的通道用作热消融探针，并且包括用于保护子宫颈免受寒冷伤害的保温材料。 本发明还涉及可与这种导管结合使用的设计成以可用于消融大的纤维瘤的所需构型从其中退出的弯曲的冷冻探针。
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30.发明申请Device, system, and Method for detecting and localizing obstruction within a blood vessel 失效用于检测和定位血管内梗阻的装置，系统和方法公开(公告)号：US20060149166A1
公开(公告)日：2006-07-06
申请号：US10542386
申请日：2004-01-15
Applicant: Roni Zvuloni
Inventor： Roni Zvuloni
IPC: A61B5/103
CPC classification number: A61B5/103 , A61B5/02007 , A61B5/1076 , A61B5/6853 , A61B6/12 , A61B6/5247 , A61B8/0841 , A61B8/5238 , A61B17/22 , A61B90/06 , A61B2017/22065 , A61B2090/064 , A61B2562/0261 , A61B2562/046
Abstract: The present invention is of system, device, and method for detecting and localizing obstruction in a blood vessel. More particularly, the present invention is of a balloon catheter having an expandable balloon which comprises a plurality of strain gauges operable to report relative degrees of expansion of local portions of a wall of the expandable balloon. Incomplete expansion of a local portion of the balloon, under common pressure within the balloon, indicates presence of an obstruction, such as a region of plaque, within the blood vessel.
Abstract translation: 本发明是用于检测和定位血管中的梗阻的系统，装置和方法。 更具体地说，本发明是一种具有可膨胀气囊的球囊导管，其包括多个应变仪，其可操作以报告可膨胀气囊的壁的局部部分的相对膨胀程度。 在气囊内的共同压力下球囊的局部部分的不完全膨胀表示在血管内存在障碍物，例如斑块区域。
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