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    Triple antimicrobial composition
    23.
    发明授权
    Triple antimicrobial composition 失效
    三重抗菌组成

    公开(公告)号：US06503952B2

    公开(公告)日：2003-01-07

    申请号：US09758930

    申请日：2001-01-11

    Applicant: Shanta Modak ,  Lester Sampath ,  Lauserpina A. Caraos

    Inventor： Shanta Modak ,  Lester Sampath ,  Lauserpina A. Caraos

    IPC: A61K31155

    CPC classification number: A01N47/44 ,  A01N2300/00

    Abstract: An antimicrobial composition comprising (i) between 0.025 and 2 percent of an antimicrobial agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, polyhexamethylene biguanide, and alexidine; (ii) between 0.005 and 0.1 percent of a quaternary ammonium compound; and (iii) between 0.025 and 2 percent of a chlorinated phenol compound.

    Abstract translation: 一种抗微生物组合物，其包含（i）0.025％至2％的选自氯己定游离碱，氯己定盐，聚六亚甲基双胍和脒基的抗微生物剂; （ii）0.005〜0.1％的季铵化合物; 和（iii）0.025％至2％的氯化酚化合物。

    Gentle-Acting Skin-Disinfectants and Hydroalcoholic Gel Formulations
    26.
    发明申请
    Gentle-Acting Skin-Disinfectants and Hydroalcoholic Gel Formulations 有权
    温和的皮肤消毒剂和水醇凝胶制剂

    公开(公告)号：US20100305211A1

    公开(公告)日：2010-12-02

    申请号：US12853977

    申请日：2010-08-10

    Applicant: Shanta Modak ,  Trupti A. Gaonkar ,  Lauser Caraos ,  Lester Sampath

    Inventor： Shanta Modak ,  Trupti A. Gaonkar ,  Lauser Caraos ,  Lester Sampath

    IPC: A61K31/155 ,  A61K31/14 ,  A61P31/00

    CPC classification number: A61K8/042 ,  A61K8/347 ,  A61K8/416 ,  A61K8/43 ,  A61K31/79 ,  A61K2800/75 ,  A61Q17/005

    Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C. This skin-friendly hydroalcoholic gel composition, which can be further combined with silicone polymer, emollient solvent, thickening agent and antimicrobial agent, enhances rapid and long-term antimicrobial efficacy.

    Abstract translation: 在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。 在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。 优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。 不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。 含有醇，水，水凝胶和软化剂或乳化剂的水醇凝胶组合物，其中组合物在20和40℃之间的粘度低于2000厘泊。该皮肤友好的水醇凝胶组合物可以与硅氧烷聚合物进一步组合， 润肤溶剂，增稠剂和抗菌剂，可提高快速和长期的抗菌功效。

    Chlorhexidine-containing medical devices
    29.
    发明授权
    Chlorhexidine-containing medical devices 失效
    含洗必泰的医疗器械

    公开(公告)号：US06872195B2

    公开(公告)日：2005-03-29

    申请号：US10647740

    申请日：2003-08-25

    Applicant: Shanta Modak ,  Lester Sampath

    Inventor： Shanta Modak ,  Lester Sampath

    IPC: A61L15/44 ,  A61L27/00 ,  A61L27/34 ,  A61L27/54 ,  A61L29/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61M5/32

    CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/104 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/45 ,  Y10T428/1331 ,  Y10T428/1352 ,  A61L29/06 ,  C08L83/04 ,  C08L75/04 ,  A61L27/507

    Abstract: The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of anti-infective agent, for example into the bloodstream of a subject.

    Abstract translation: 本发明涉及包含抗感染剂氯己定和三氯生的聚合物医疗制品。 至少部分地基于以下发现：这些化合物之间的协同关系允许使用相对低水平的两种试剂，并且发现当这些化合物包括在亲水性或亲水性中时，可以实现有效的抗微生物活性 疏水聚合物。 也是基于以下发现：一起使用氯己定游离碱和三氯生，更有效地掺入到聚合物医疗用品中。 根据本发明制备的医疗制品提供了预防或抑制感染的优点，同时避免了抗感染剂的不期望的高释放，例如进入受试者的血液中。

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