公开(公告)号：US20230242411A1

公开(公告)日：2023-08-03

申请号：US18003507

申请日：2021-07-05

Applicant: Universiteit van Amsterdam

Inventor： Hong Zhang ,  Yansong Feng

IPC: C01F17/36 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: C01F17/36 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01P2004/84 ,  C01P2004/04 ,  C01P2002/72 ,  C01P2002/82 ,  C01P2002/84

Abstract: In accordance with the present invention there is provided a nanoparticle, comprising—a core, —an outer layer, and —a buffer layer located between said core and said outer layer, wherein the buffer layer prevents energy transfer between the core and the outer layer. In another aspect of the invention there is provided a nanoparticle as described herein for use in therapy, a nanoparticle according as described herein for use in treatment of a tumor, and a nanoparticle as used herein for use in in vivo imaging According to another aspect of the invention there is provided a method for the production of a nanoparticle as described herein, comprising the steps of—heating of a solution comprising core precursors, followed by—injection of a dispersion comprising buffer layer precursors, followed by—injection of a dispersion comprising outer layer precursors. Another aspect of the invention is a method for in vivo imaging or treatment or both of a human or animal, comprising the steps of: —administering nanoparticles as described herein to a patient, —irradiating at least part of the patient's body with one or more types of radiation. According to yet another aspect of the invention there is provided the use of a nanoparticle as described herein for therapy, in vivo imaging, or both.

公开(公告)号：US20210171413A1

公开(公告)日：2021-06-10

申请号：US17253816

申请日：2019-06-21

Applicant: Algae Innovations Netherlands B.V. ,  Universiteit van Amsterdam

Inventor： Robert BAARD ,  Wishwas ABHYANKAR ,  Stanley BRUL

IPC: C05F11/00 ,  C05G5/23 ,  A01G33/00

Abstract: The present invention relates to a liquid composition comprising living green microalgae for improving plant growth. The liquid composition is prepared by growing green microalgae at a pH of 10-12 in the presence of hydrogen carbonate as the inorganic carbon source. The liquid composition may be stored at 4 to 25 degrees C. until use. The liquid composition may be used to improve fertilizers.

公开(公告)号：US20200232931A1

公开(公告)日：2020-07-23

申请号：US16751104

申请日：2020-01-23

Applicant: ASML Netherlands B.V. ,  Stichting Nederlandse Wetenschappelijk Onderzoek Instituten ,  Stichting VU ,  Universiteit van Amsterdam

Inventor： Stefan Michiel WITTE ,  Gijsbert Simon Matthijs JANSEN ,  Lars Christian FREISEM ,  Kjeld Sijbrand Eduard EIKEMA ,  Simon Gijsbert Josephus MATHIJSSEN

IPC: G01N21/88 ,  G03F7/20 ,  G01J9/00 ,  G01J1/42 ,  G01N21/95

Abstract: A metrology apparatus (302) includes a higher harmonic generation (HHG) radiation source for generating (310) EUV radiation. Operation of the HHG source is monitored using a wavefront sensor (420) which comprises an aperture array (424, 702) and an image sensor (426). A grating (706) disperses the radiation passing through each aperture so that the image detector captures positions and intensities of higher diffraction orders for different spectral components and different locations across the beam. In this way, the wavefront sensor can be arranged to measure a wavefront tilt for multiple harmonics at each location in said array. In one embodiment, the apertures are divided into two subsets (A) and (B), the gratings (706) of each subset having a different direction of dispersion. The spectrally resolved wavefront information (430) is used in feedback control (432) to stabilize operation of the HGG source, and/or to improve accuracy of metrology results.

公开(公告)号：US20190107781A1

公开(公告)日：2019-04-11

申请号：US16150879

申请日：2018-10-03

Applicant: Stichting VU ,  Stichting Nederlandse Wetenschappelijk Onderzoek Instituten ,  Universiteit van Amsterdam ,  ASML Netherlands B.V.

Inventor： Patricius Aloysius Jacobus TINNEMANS ,  Arie Jeffrey Den Boef ,  Armand Eugene Albert Koolen ,  Nitesh Pandey ,  Vasco Tomas Tenner ,  Willem Marie Julia Marcel Coene ,  Patrick Warnaar

IPC: G03F7/20 ,  G03F9/00 ,  G01N21/47 ,  G01N21/95

Abstract: Described is a metrology system for determining a characteristic of interest relating to at least one structure on a substrate, and associated method. The metrology system comprises a processor being configured to computationally determine phase and amplitude information from a detected characteristic of scattered radiation having been reflected or scattered by the at least one structure as a result of illumination of said at least one structure with illumination radiation in a measurement acquisition, and use the determined phase and amplitude to determine the characteristic of interest.

公开(公告)号：US20170269482A1

公开(公告)日：2017-09-21

申请号：US15453049

申请日：2017-03-08

Applicant: Stichting VU ,  Universiteit van Amsterdam ,  Stichting voor Fundamenteel Onderzoek der Materie ,  ASML Netherlands B.V.

Inventor： Dirk Ewoud Boonzajer Flaes ,  Stefan Michiel Witte ,  Kjeld Sijbrand Eduard Eikema

IPC: G03F7/20 ,  G01B11/00 ,  G01N21/956 ,  G01N21/47

CPC classification number: G03F7/7065 ,  G01B11/00 ,  G01N21/4788 ,  G01N21/956 ,  G01N2201/061 ,  G01N2201/0635 ,  G02B21/16 ,  G03F7/70625 ,  G03F7/70633 ,  H05G2/003 ,  H05G2/008

Abstract: In an inspection apparatus, a target on the surface is illuminated with illuminating radiation that comprises first and second illuminating components. The illuminating components form one or more periodic illuminating patterns on the surface. A plurality of scattered radiation patterns formed by the illuminating radiation after scattering by the target is captured at a detector for a number of values of a controllable characteristic of at least one of the illuminating components. The captured radiation is then used to reconstruct data describing the target.

公开(公告)号：US20170007118A1

公开(公告)日：2017-01-12

申请号：US15100228

申请日：2014-11-28

Applicant: UNIVERSITEIT VAN AMSTERDAM ,  SIGHTCORP B.V.

Inventor： Fares ALNAJAR ,  Roberto VALENTI ,  Theo GEVERS

IPC: A61B3/113 ,  G06F17/18 ,  G06F3/01

CPC classification number: A61B3/113 ,  G06F3/013 ,  G06F17/18

Abstract: Some embodiments are directed to a system and a method for estimating gaze from a set of eye measurement points that are indicative of a gaze pattern of a user viewing a scene. Some other embodiments are directed to obtaining sets of eye measurement points from different users viewing the same scene. In another embodiment, the different sets of eye measurement points are mapped to a common coordinate system for reciprocal calibration. In yet another embodiment, a scene transformation for mapping the common coordinate system to a coordinate system associated with the scene can be calculated by matching eye measurement points from the common coordinate system to interest points of the scene. The scene transformation is thereby calculated more accurately than individually calculated scene transformations, thereby providing a more accurate estimate of the gaze points.

Abstract translation: 一些实施例涉及用于从指示观看场景的用户的注视图案的一组眼睛测量点估计注视的系统和方法。 一些其他实施例旨在从观看相同场景的不同用户获得一组眼睛测量点。 在另一个实施例中，将不同组的眼睛测量点映射到用于相互校准的公共坐标系。 在另一个实施例中，可以通过将来自公共坐标系的眼睛测量点与场景的兴趣点相匹配来计算用于将公共坐标系映射到与场景相关联的坐标系的场景变换。 因此，比单独计算的场景变换更精确地计算场景变换，从而提供更精确的凝视点估计。

公开(公告)号：US20160152647A1

公开(公告)日：2016-06-02

申请号：US14901394

申请日：2014-06-26

Applicant: IFP ENERGIES NOUVELLES ,  UNIVERSITEIT VAN AMSTERDAM

Inventor： Pierre-Alain BREUIL ,  Pierre BOULENS ,  Joost REEK ,  Helene OLIVIER-BOURBIGOU

IPC: C07F15/04 ,  C07C2/32 ,  B01J31/18

CPC classification number: C07F15/045 ,  B01J31/00 ,  B01J31/188 ,  B01J2231/20 ,  B01J2531/847 ,  C07C2/32 ,  C07C2/36 ,  C07C2531/14 ,  C07C2531/22 ,  C07C2531/24 ,  C08F4/80 ,  C08F110/02 ,  C08F2500/02 ,  C08F110/06 ,  C07C11/107 ,  C07C11/08

Abstract: The invention describes a novel dissymmetric nickel-based complex and the method of preparation thereof from at least one diphosphinamine ligand B1 of formula (R1)(R′1)P—N(R3)—P(R2)(R′2), or an iminobisphosphine ligand B2 of formula (R3)N═P(R1)(R′1)—P(R2)(R′2). The invention also concerns the use of said complex in a method for oligomerisation of olefins.

Abstract translation: 本发明描述了一种新的不对称镍基络合物及其由式（R1）（R'1）P-N（R3）-P（R2）（R'2）的至少一种二磷酸胞嘧啶配体B1制备的方法， 或式（R3）N = P（R1）（R'1）-P（R2）（R'2）的亚氨基双膦配体B2。 本发明还涉及在烯烃低聚方法中使用所述络合物。

公开(公告)号：US09283554B2

公开(公告)日：2016-03-15

申请号：US14694052

申请日：2015-04-23

Applicant: IFP Energies nouvelles ,  UNIVERSITEIT VAN AMSTERDAM

Inventor： Pierre Boulens ,  Pierre-Alain Breuil ,  Joost Reek ,  Helene Olivier-Bourbigou

IPC: C07F15/00 ,  B01J31/00 ,  C07C2/02 ,  B01J31/18 ,  C07C2/32 ,  C07F15/04 ,  B01J31/14 ,  B01J31/02 ,  B01J31/22

CPC classification number: B01J31/1845 ,  B01J31/0267 ,  B01J31/143 ,  B01J31/2247 ,  B01J2231/20 ,  B01J2531/0213 ,  B01J2531/847 ,  C07C2/32 ,  C07C2/34 ,  C07C2527/02 ,  C07C2531/18 ,  C07C2531/24 ,  C07F15/045 ,  C07C11/08

Abstract: The invention describes a nickel-based composition. The invention also concerns the use of said composition as a catalytic composition in an olefin oligomerization process.

Abstract translation: 本发明描述了一种镍基组合物。 本发明还涉及在烯烃低聚方法中使用所述组合物作为催化组合物。

公开(公告)号：US20150203816A1

公开(公告)日：2015-07-23

申请号：US14669916

申请日：2015-03-26

Applicant: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ,  AIMM THERAPEUTICS B.V.

Inventor： Hergen SPITS

IPC: C12N5/0781 ,  C07K16/00

CPC classification number: C12N5/0635 ,  C07K16/00 ,  C12N2501/23 ,  C12N2501/60

Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines arc also provided, as well as methods for producing antibodies using such cells and/or cell lines.

Abstract translation: 本发明提供了影响抗体产生细胞的稳定性的方法，其包括直接或间接地影响所述抗体产生细胞内的BCL6和/或Blimp1表达产物的量。 还提供了稳定的抗体产生细胞和细胞系，以及使用这种细胞和/或细胞系产生抗体的方法。

公开(公告)号：US20250000429A1

公开(公告)日：2025-01-02

申请号：US18883987

申请日：2024-09-12

Applicant: Universiteit van Amsterdam ,  Okazolab Ltd

Inventor： Lucia Maddalena TALAMINI ,  Ilia Korjoukov

IPC: A61B5/374 ,  A61B5/00 ,  A61B5/316 ,  A61B5/378 ,  A61B5/38

Abstract: The invention provides an assembly comprising: a recording assembly for recording a time-based brain-related signal; a stimulus generator for providing a stimulus, and a computer assembly, functionally coupled to said recording assembly and to said stimulus generator, said computer assembly comprising: a memory for storing at least a data segment of said time-based brain-related signal during recording of said time-based brain-related signal, and a computer program which, when running on said computer assembly, functionally real-time performs: retrieving a most-recent data segment of said stored data segment of said time-based brain-related signal; fitting at least one curve to said retrieved most-recent data segment; predicting a future continuation of said most-recent data segment using said at least one curve fitted to said most-recent data segment; detecting a predefined pattern in said predicted future continuation for predicting occurrence of said predefined pattern, and defining a predicted event time of said predefined pattern, said predicted event time being in the future with respect to said most-recent data segment, and actuating said stimulus generator for providing a stimulus within a predefined event time window of said predicted event time.