Abstract:
This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P). This invention also provides for internal calibration and for co-registration over time of the scanner's and tracking system's reference frames to compensate for drift and other inaccuracies that may arise over time.
Abstract:
Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of treating cancer using the compounds.
Abstract:
An infant sleep pod providing passive and/or active safety features. The infant sleep pod provides a safe sleeping environment for infants sharing sleep areas with adults. The infant sleep pod provides a firm, flat, separate, portable, and dedicated sleep space for an infant. The infant sleep pod includes a base with a bed and sidewall, and a bridge extending across the bed. The bridge covers a head portion of the bed, while a foot portion of the bed is left open for inserting and removing the infant. The bridge prevents pillows and blankets from covering the bed and infant. The infant sleep pod also includes electronics for monitoring the sleep pod. The electronics include a sensor unit in the bridge and a control unit in communication with the sensor unit. The control unit and sensor unit are operable to detect unsafe conditions and, in response, generate alerts.
Abstract:
Disclosed herein are methods of making an electrode. The method includes contacting an electrode material with a mixture that includes an alkali metal, an organic solvent, and an aromatic compound. Also disclosed herein are methods of making a battery that includes an electrode provided by the disclosed methods.
Abstract:
Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them.
Abstract:
A medical tubing organizer includes a base defining a longitudinal direction, a lateral direction being defined as substantially orthogonal to the longitudinal direction, and a vertical direction being defined as substantially orthogonal to the longitudinal and lateral directions. A tube retainer is positioned on a top of the base and configured to receive a medical tube that extends along the lateral direction. The tube retainer is further configured to adjust between a free flow state and a retention state, wherein, in the free flow state, the tube retainer is configured to enable movement of the medical tube in the lateral direction and resist movement in the longitudinal direction, and in the retention state, the tube retainer is configured to resist movement in the lateral, longitudinal, and vertical directions. A connector is positioned on the base for selectively coupling the medical tubing organizer to a structure.
Abstract:
An antimicrobial composition comprising lithocholic acid, zinc pyrithione, cinnamaldehyde and a matrix forming compound. The composition is particularly suitable for treatment of microbial contamination and the formation of biofilms.
Abstract:
Substituted benzo[f]imidazo[1,5-α][1,4]diazepines of formula (I′) target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
Abstract:
A coating composition comprises a functionalized epoxy resin and a fluoroalkyl-modified particle, such as activated carbon or silica. The functionalized epoxy resin is a ternary polymer composition comprising one or more epoxy resin moieties linked to a polyethylene backbone through an oxygen atom, fluoroalkyl(poly)propionyl groups being grafted to the polyethylene backbone. The coating compositions have superhydrophobic properties useful for self-cleaning surfaces and bubble release from sensors.
Abstract:
Sensors for detecting and distinguishing metals in a sample comprise phenol group-containing azo dyes, the phenol group having one hydroxy involved in reversible metal ion binding and a second hydroxy alkylated to an optically transparent substrate. The sensors have utility for detecting chromium, calcium, magnesium, copper, mercury, nickel, zinc, cobalt, manganese, cadmium, lead, tin, aluminum, potassium, sodium, or arsenic ions in a sample.