公开(公告)号：US08354123B2

公开(公告)日：2013-01-15

申请号：US13166433

申请日：2011-06-22

Applicant: Valerio Ditizio ,  Frank Dicosmo ,  Yuehua Xiao

Inventor： Valerio Ditizio ,  Frank Dicosmo ,  Yuehua Xiao

IPC: A61K9/70

CPC classification number: A61K47/42 ,  A61K9/7007 ,  A61K47/10 ,  A61K47/36 ,  A61L15/225 ,  A61L15/325 ,  A61L15/425 ,  A61L31/041 ,  A61L31/045 ,  A61L31/146 ,  C08L5/00 ,  C08L5/04 ,  C08L5/08 ,  C08L71/00 ,  C08L89/00 ,  C08L89/06 ,  C08L2205/02 ,  C08L2666/26 ,  C08L2666/14 ,  C08L2666/02

Abstract: The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.

Abstract translation: 本发明是基本上不粘的弹性明胶基体。 基质既不与伤口，组织和器官粘合，也具有弹性，使其柔韧。 基质是蛋白质，聚合物，交联剂和任选的增塑剂的冻干混合物。 本发明还提供了制造非粘性弹性明胶基质的方法。

公开(公告)号：US20110311629A1

公开(公告)日：2011-12-22

申请号：US13166433

申请日：2011-06-22

Applicant: Valerio DiTizio ,  Frank Dicosmo ,  Yuehua Xiao

Inventor： Valerio DiTizio ,  Frank Dicosmo ,  Yuehua Xiao

IPC: A61K47/42 ,  A61K31/09 ,  A61K31/4015 ,  A61K33/00 ,  A61K33/38 ,  A61K33/34 ,  A61K33/24 ,  A61K31/167 ,  A61K9/00 ,  A61K9/70 ,  A61K31/436 ,  A61P31/00 ,  A61P31/12 ,  A61P37/06 ,  A61P29/00 ,  A61P23/00 ,  A61K31/155

CPC classification number: A61K47/42 ,  A61K9/7007 ,  A61K47/10 ,  A61K47/36 ,  A61L15/225 ,  A61L15/325 ,  A61L15/425 ,  A61L31/041 ,  A61L31/045 ,  A61L31/146 ,  C08L5/00 ,  C08L5/04 ,  C08L5/08 ,  C08L71/00 ,  C08L89/00 ,  C08L89/06 ,  C08L2205/02 ,  C08L2666/26 ,  C08L2666/14 ,  C08L2666/02

Abstract: The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.

公开(公告)号：US20110256185A1

公开(公告)日：2011-10-20

申请号：US13087920

申请日：2011-04-15

Applicant: Liu Yang ,  Valerio DiTizio

Inventor： Liu Yang ,  Valerio DiTizio

IPC: A61K9/00 ,  A61K33/38 ,  A61F13/00 ,  A61P17/02 ,  A61P31/00 ,  A61K31/722 ,  A61P27/02

CPC classification number: A61K33/38 ,  A61K9/0051 ,  A61K31/722 ,  A61K47/36 ,  A61K47/42 ,  A61L15/28 ,  A61L15/44 ,  A61L27/20 ,  A61L27/54 ,  A61L2430/16 ,  C08L5/08

Abstract: Self-reinforced tissue shields are useful as ophthalmic shields, wound dressings, wound barriers, nerve repair, therapeutic drug delivery devices and the like. The self-reinforced tissue protective shields comprise gelatin, chitosan and reinforce and are made by a method comprising forming inter-molecular locking within a solution through electrostatic forces, eliminating the use of extra cross-linking methods, the solution mainly comprising natural existing polymers that are biodegradable and biocompatible.

Abstract translation: 自增强组织护罩可用作眼科护理，伤口敷料，伤口障碍，神经修复，治疗药物递送装置等。 自增强组织保护罩包括明胶，壳聚糖和增强剂，并且通过包括通过静电力在溶液中形成分子间锁定的方法制成，消除了使用额外的交联方法，该溶液主要包含天然存在的聚合物， 是可生物降解和生物兼容的。

公开(公告)号：US20110104390A1

公开(公告)日：2011-05-05

申请号：US12892770

申请日：2010-09-28

Applicant: Hamed Abbasian ,  Pamela Chan ,  Valerio Ditizio ,  Vyacheslav Dudnyk ,  Zhaopeng Li ,  Said Loloie ,  Natali Yakeemovich ,  Frank Dicosmo

Inventor： Hamed Abbasian ,  Pamela Chan ,  Valerio Ditizio ,  Vyacheslav Dudnyk ,  Zhaopeng Li ,  Said Loloie ,  Natali Yakeemovich ,  Frank Dicosmo

IPC: C08J7/18

CPC classification number: C08F2/48 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2400/10 ,  A61L2420/02 ,  C08J7/18 ,  C08L33/08 ,  C09D4/00 ,  C09D133/08

Abstract: A system and method for photo-grafting a coating polymer onto the surface of a medical device are provided. The system comprises a plurality of stations including a novel grafting station. The system and method of the invention are both time- and resource-efficient. The system includes several stations, each station including a dipping tank. The system allows for the automated, semi-automated, or manual dipping of medical devices into the dipping tanks in a specified order, as desired, wherein at least one of the stations is a grafting station for photo-grafting the coating polymer onto the surface of the medical device. The system is modular, which allows for modification of the process as required, depending on the needs of the user. The system may comprise stations for incorporating an antimicrobial agent into the coating, and/or for rendering the coating lubricious.

公开(公告)号：US06808738B2

公开(公告)日：2004-10-26

申请号：US10083737

申请日：2002-02-27

Applicant: Valerio DiTizio ,  Frank DiCosmo

Inventor： Valerio DiTizio ,  Frank DiCosmo

IPC: C08J704

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/606

Abstract: The present invention is a method for the modification of the surfaces of polymeric materials with polymer coatings that may be subsequently treated to be lubricious and anti-microbial. The method comprises incubating a photo-initiator-coated polymeric material with an aqueous monomer that is capable of free radical polymerization and exposing the incubating polymeric material to UV light creating a modified surface on said polymeric material. The method may additionally comprise adding a silver component to the modified surface. The silver component may be provided as a silver salt coating or a silver salt contained within a hydrogel bonded to the acrylate modified polymeric material surface.

Abstract translation: 本发明是一种用聚合物涂层改性聚合物材料的表面的方法，聚合物涂层可以随后被处理成润滑和抗微生物。 该方法包括将光引发剂涂覆的聚合物材料与能够进行自由基聚合的水性单体一起孵育，并将孵育的聚合物材料暴露于UV光，从而在所述聚合物材料上产生改性的表面。 该方法可另外包括向改性表面添加银组分。 银组分可以作为银盐包衣或包含在与丙烯酸酯改性的聚合物材料表面结合的水凝胶中的银盐提供。

公开(公告)号：US6132765A

公开(公告)日：2000-10-17

申请号：US843342

申请日：1997-04-15

Applicant: Frank DiCosmo ,  Valerio DiTizio

Inventor： Frank DiCosmo ,  Valerio DiTizio

IPC: A61K9/127 ,  A61L27/00 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/00 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61M25/00

CPC classification number: A61L27/52 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/145 ,  A61L29/16 ,  A61K9/127 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/436 ,  A61L2300/626

Abstract: The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.