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31 条记录 (耗时 0.044 秒)

    PREVENTION AND ALLEVIATION OF STERIC HINDRANCE DURING SINGLE MOLECULE SYNTHESIS
    21.
    发明申请
    PREVENTION AND ALLEVIATION OF STERIC HINDRANCE DURING SINGLE MOLECULE SYNTHESIS 有权
    单分子合成期间的绝育情况的预防与评价

    公开(公告)号：US20100035269A1

    公开(公告)日：2010-02-11

    申请号：US12535385

    申请日：2009-08-04

    申请人： Congcong Ma ,  Paul Wyatt

    发明人： Congcong Ma ,  Paul Wyatt

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12P19/34 ,  C12Q1/686

    摘要： The present invention provides compositions and methods for reducing steric hindrance in the product of nucleic acid polymerase reaction. Methods and compositions of the invention encompass application of exonucleases, endonucleases, and uracil-DNA glycosylases to a nucleic acid polymerase reaction such that newly formed nucleic acid strands are modified (e.g., cleaved) while the polymerase reaction continues to proceed.

    摘要翻译： 本发明提供了降低核酸聚合酶反应产物中的空间位阻的组合物和方法。 本发明的方法和组合物包括将核酸外切酶，内切核酸酶和尿嘧啶-DNA糖基酶应用于核酸聚合酶反应，使得新聚合酶反应继续进行而修饰（例如，切割）。

    Image processor, method, and program
    22.
    发明申请
    Image processor, method, and program 审中-公开
    图像处理器，方法和程序

    公开(公告)号：US20070110319A1

    公开(公告)日：2007-05-17

    申请号：US11595902

    申请日：2006-11-13

    申请人： Paul Wyatt ,  Hiroaki Nakai

    发明人： Paul Wyatt ,  Hiroaki Nakai

    IPC分类号： G06K9/48

    CPC分类号： G06K9/40 ,  G06T7/13

    摘要： An image processor, method, and program are provided for detecting edges in an image. In one embodiment, an image processor detects edges from an image while suppressing the effects of noise. Brightness gradient values of each pixel of the image are found for each of a plurality of directions. An amount of noise in the image is estimated based on the brightness gradient values and edge intensities are normalized in order to suppress the effects of the noise.

    摘要翻译： 提供图像处理器，方法和程序用于检测图像中的边缘。 在一个实施例中，图像处理器在抑制噪声的影响的同时检测图像中的边缘。 针对多个方向中的每一个找到图像的每个像素的亮度梯度值。 基于亮度梯度值来估计图像中的噪声量，对边缘强度进行归一化以抑制噪声的影响。

    Hay cutting machine
    24.
    发明授权
    Hay cutting machine 失效
    干草切割机

    公开(公告)号：US5927625A

    公开(公告)日：1999-07-27

    申请号：US970167

    申请日：1997-11-12

    申请人： Bret A. Simpson ,  Paul Wyatt

    发明人： Bret A. Simpson ,  Paul Wyatt

    IPC分类号： A01F29/00 ,  B02C18/00

    CPC分类号： A01F29/00 ,  Y10S241/605

    摘要： An apparatus for cutting hay, straw, or other agricultural materials is provided with an intake hopper which directs a supply of material to be cut into a holding chamber. The material in the holding chamber is separated from the material remaining in the intake hopper by a pair of separating blades, while an advancement plate pushes the material in the holding chamber toward a cutting grid. A sliding panel is pulled behind the advancement plate to prevent the material remaining in the intake hopper from falling behind the advancement plate. The material in the holding chamber is cut into shorter lengths as it is pressed through horizontal and vertical slicing blades of the cutting grid.

    摘要翻译： 一种用于切割干草，秸秆或其他农用材料的装置设置有进料斗，其将要切割的材料供应引入保持室。 保持室中的材料通过一对分离叶片与残留在进料斗中的材料分离，而前进板将保持室中的材料推向切割格栅。 滑动面板被拉到推进板后面，以防止进料斗中剩余的材料落在前进板的后面。 当通过切割网格的水平和垂直切片刀片按压时，保持室中的材料被切割成更短的长度。

    Reaction mixtures for prevention and alleviation of steric hindrance during single molecule synthesis
    25.
    发明授权
    Reaction mixtures for prevention and alleviation of steric hindrance during single molecule synthesis 有权
    用于单分子合成期间预防和减轻空间位阻的反应混合物

    公开(公告)号：US08835135B2

    公开(公告)日：2014-09-16

    申请号：US13468365

    申请日：2012-05-10

    申请人： Congcong Ma ,  Paul Wyatt

    发明人： Congcong Ma ,  Paul Wyatt

    IPC分类号： C12P19/34 ,  C12Q1/68

    CPC分类号： C12P19/34 ,  C12Q1/686

    摘要： The present invention provides compositions and methods for reducing steric hindrance in the product of nucleic acid polymerase reaction. Methods and compositions of the invention encompass application of exonucleases, endonucleases, and uracil-DNA glycosylases to a nucleic acid polymerase reaction such that newly formed nucleic acid strands are modified (e.g., cleaved) while the polymerase reaction continues to proceed.

    摘要翻译： 本发明提供了降低核酸聚合酶反应产物中的空间位阻的组合物和方法。 本发明的方法和组合物包括将核酸外切酶，内切核酸酶和尿嘧啶-DNA糖基酶应用于核酸聚合酶反应，使得新聚合酶反应继续进行而修饰（例如，切割）。

    Image processing apparatus
    28.
    发明申请
    Image processing apparatus 有权
    图像处理装置

    公开(公告)号：US20070183667A1

    公开(公告)日：2007-08-09

    申请号：US11652501

    申请日：2007-01-12

    申请人： Paul Wyatt ,  Hiroaki Nakai

    发明人： Paul Wyatt ,  Hiroaki Nakai

    IPC分类号： G06K9/46

    CPC分类号： G06K9/48 ,  G06K9/4609 ,  G06T7/13

    摘要： An apparatus includes: a spatial differential value calculation unit that calculates a primary spatial differential value and a secondary spatial differential value of a brightness value with respect to each of a plurality of directions in each pixel of the image; a maximum and minimum direction estimation unit that estimates a maximum direction and a minimum direction for each pixel, the maximum direction being a direction with which the primary spatial differential value is a maximum value, the minimum direction being a direction with which the primary spatial differential value is a minimum value; and an evaluated value calculation unit that calculates a first evaluated value of each pixel using the primary spatial differential value in the maximum direction, the primary spatial differential value in the minimum direction, and the secondary spatial differential value in the maximum direction.

    摘要翻译： 一种装置，包括：空间微分值计算单元，其针对图像的每个像素中的多个方向中的每个方向计算亮度值的一次空间微分值和二次空间微分值; 估计每个像素的最大方向和最小方向的最大和最小方向估计单元，最大方向是主要空间微分值是最大值的方向，最小方向是主要空间差异的方向 值是最小值; 以及评估值计算单元，其使用最大方向上的一次空间差分值，最小方向上的一次空间微分值和最大方向上的二次空间微分值来计算每个像素的第一评估值。

    Synthesis and screening of ligands using x-ray crystallography
    29.
    发明申请
    Synthesis and screening of ligands using x-ray crystallography 失效
    使用x射线晶体学合成和筛选配体

    公开(公告)号：US20060159226A1

    公开(公告)日：2006-07-20

    申请号：US10539447

    申请日：2003-12-22

    申请人： Harren Jhoti ,  Miles Congreve ,  Marc O'Reilly ,  Paul Wyatt

    发明人： Harren Jhoti ,  Miles Congreve ,  Marc O'Reilly ,  Paul Wyatt

    IPC分类号： G01N23/207

    CPC分类号： C40B30/04 ,  G01N23/20 ,  G01N33/6803

    摘要： A method for identifying a ligand of a target macromolecule is disclosed, comprising the steps of: soaking one or more crystals of the target macromolecule in a solution containing a collection of compounds generated in situ or separate from the crystal, where the solution has been prepared without the purification of the synthesized collection of compounds; obtaining an X-ray crystal diffraction pattern of the soaked macromolecule crystal; and using said X-ray crystal diffraction pattern to identify any compound bound to the macromolecule crystal, said compound being a ligand of the target macromolecule.

    摘要翻译： 公开了一种用于鉴定目标大分子的配体的方法，包括以下步骤：将一种或多种目标大分子的晶体浸入含有原位生成或与晶体分离的化合物的溶液中，其中溶液已经被制备 无需纯化合成的化合物集合; 获得浸渍的大分子晶体的X射线晶体衍射图; 并且使用所述X射线晶体衍射图来鉴定与大分子晶体结合的任何化合物，所述化合物是目标大分子的配体。

    1h-Indazole-3-carboxamide compounds as cyclin dependent kinase (cdk) inhibitors
    30.
    发明申请
    1h-Indazole-3-carboxamide compounds as cyclin dependent kinase (cdk) inhibitors 审中-公开

    公开(公告)号：US20060135589A1

    公开(公告)日：2006-06-22

    申请号：US10524784

    申请日：2003-08-08

    申请人： Valerio Berdino ,  Alessandro Padova ,  Paul Wyatt ,  Gordon Saxty ,  Alison Woolford

    发明人： Valerio Berdino ,  Alessandro Padova ,  Paul Wyatt ,  Gordon Saxty ,  Alison Woolford

    IPC分类号： A61K31/416

    CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

    摘要： The invention provides a compound of the formula (I) for use in the prophylaxis or treatment of a disease state or condition mediated by a cyclin dependent kinase: wherein A is a group R2 or CH2—R2 where R2 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; B is a bond or an acyclic linker group having a linking chain length of up to 3 atoms selected from C, N, S and O; R1 is hydrogen or a group selected from SO2Rb, SO2NR7R8, CONR7R8, NR7R9 and carbocyclic and heterocyclic groups having from 3 to 7 ring members; R3, R4, R5 and R6 are the same or different and are each selected from hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, carbocyclic and heterocyclic groups having from 3 to 12 ring members; a group Ra—Rb wherein Ra is a bond, O, CO, X1C(X2), C(X2)X1, X1C(X2)X1, S, SO, SO2, NRc, SO2NRc or NRcSO2; and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, amino, mono- or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C1-8 hydrocarbyl group may optionally be replaced by O, S, SO, SO2, NRc, X1C(X2), C(X2)X1 or X1C(X2)X1; Rc is hydrogen or C1-4 hydrocarbyl; X1 is O, S or NRc and X2 is ═O, ═S or ═NRc; R7 is selected from hydrogen and a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, amino, mono- or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C1-8 hydrocarbyl group may optionally be replaced by O, S, SO, SO2, NRc, X1C(X2), C(X2)X1 or X1C(X2)X1; R8 is selected from R7 and carbocyclic and heterocyclic groups having from 3 to 12 ring members; R9 is selected from R8, COR8 and SO2R8; or NR7R8 or NR7R9 may each form a heterocyclic group having from 5 to 12 ring members; but excluding the compounds N-[(morpholin-4-yl)phenyl-1H-indazole-3-carboxamide and N-[4-(acetylaminosulphonyl)phenyl-1H-indazole-3-carboxamide.