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公开(公告)号：US08258266B2
公开(公告)日：2012-09-04
申请号：US12472877
申请日：2009-05-27
申请人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David B. Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
发明人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David B. Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。
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公开(公告)号：US08097703B2
公开(公告)日：2012-01-17
申请号：US11917750
申请日：2006-06-20
申请人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
发明人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
CPC分类号： C07K16/2803 , A61K47/6817 , A61K47/6825 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/732 , C07K2317/77 , Y02A50/412
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。 还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。 还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。 公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。
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公开(公告)号：US20100092484A1
公开(公告)日：2010-04-15
申请号：US12518856
申请日：2007-12-20
申请人： Xu Xu , Vahe Bedian , Erika Meaddough , Haichun Huang , Lan Yang , Kristopher Toy , Mohan Srinivasan , Advait V. Badkar
发明人： Xu Xu , Vahe Bedian , Erika Meaddough , Haichun Huang , Lan Yang , Kristopher Toy , Mohan Srinivasan , Advait V. Badkar
IPC分类号： A61K39/395 , C07K16/18 , A61P29/00 , A61P37/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12N5/12
CPC分类号： C07K16/2884 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to CD44, and that function to inhibit CD44. The invention also relates to heavy and light chain immunoglobulins derived from human CD44 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human CD44 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions or medicaments for treatment.
摘要翻译： 本发明涉及结合CD44的人抗体及其抗原结合部分的抗体，其功能是抑制CD44。 本发明还涉及衍生自人CD44抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人CD44抗体的方法，包含这些抗体的组合物和使用抗体和组合物或药物用于治疗的方法。
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24.发明申请Human Monoclonal Antibodies to Prostate Specific Membrane Antigen (PSMA) 审中-公开用于前列腺特异性膜抗原（PSMA）的人类单克隆抗体公开(公告)号：US20090297438A1
公开(公告)日：2009-12-03
申请号：US11918153
申请日：2006-02-17
IPC分类号： A61K51/10 , C07K16/28 , A61K39/395 , C07H21/00 , C12N15/63 , C12N5/00 , A01K67/027 , C07K1/107 , A61K38/20 , C12Q1/02 , A61P35/00
CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/21
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PSMA with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating cancer.
摘要翻译： 本发明提供以高亲和力特异性结合PSMA的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了治疗癌症的方法。
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25.发明授权Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors 有权人抗NGF中和抗体作为选择性NGF途径抑制剂公开(公告)号：US07601818B2
公开(公告)日：2009-10-13
申请号：US10891658
申请日：2004-07-15
申请人： Kenneth D. Wild, Jr. , James J. S. Treanor , Haichun Huang , Heather Inoue , Tie J. Zhang , Frank Martin
发明人： Kenneth D. Wild, Jr. , James J. S. Treanor , Haichun Huang , Heather Inoue , Tie J. Zhang , Frank Martin
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/48 , G01N2800/2842
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
摘要翻译： 本发明提供与人神经生长因子（NGF）相互作用或结合的抗体，从而中和NGF的功能。 本发明还提供了所述抗体的药物组合物和中和NGF功能的方法，特别是通过施用药学上有效量的抗NGF抗体来治疗NGF相关疾病（例如慢性疼痛）。 还提供了使用抗NGF抗体检测样品中NGF量的方法。
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公开(公告)号：US20090214559A1
公开(公告)日：2009-08-27
申请号：US12210313
申请日：2008-09-15
申请人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
发明人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译： 描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。 描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。 描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。
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公开(公告)号：US20080279868A1
公开(公告)日：2008-11-13
申请号：US12088066
申请日：2006-09-26
申请人： Sharon Elaine Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Kilian Horgan , Bilal Sufi , Haichun Huang , David John King , Chin Pan , Josephine M. Cardarelli
发明人： Sharon Elaine Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Kilian Horgan , Bilal Sufi , Haichun Huang , David John King , Chin Pan , Josephine M. Cardarelli
CPC分类号： C07K5/06052 , A61K38/00 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6869 , A61K47/6889 , B82Y30/00
摘要： The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.
摘要翻译： 本公开提供了抗体 - 药物偶联物，其是有效的细胞毒素，其中药物通过接头与抗体连接。 本公开还涉及含有抗体 - 药物共轭物的组合物，以及使用它们的治疗方法。
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公开(公告)号：US20080166352A1
公开(公告)日：2008-07-10
申请号：US11458260
申请日：2006-07-18
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53 , C07H21/00 , C12N1/00 , C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61P37/00 , A61P29/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RP1 antibodies Methods of detecting the amount of B7RP1 in a sample using anti-B7RP1 antibodies are also provided.
摘要翻译： 本发明提供了与人B7相关蛋白-1（B7RP1）相互作用或与之结合的抗体以及结合并中和B7RP1功能的抗体。本发明还提供所述抗体的药物组合物和中和B7RP1功能的方法，特别是用于 通过施用药物有效量的抗B7RP1抗体来治疗免疫疾病（例如，不适当的免疫应答）也提供使用抗B7RP1抗体检测样品中B7RP1的量的方法。
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公开(公告)号：US20050191293A1
公开(公告)日：2005-09-01
申请号：US11009731
申请日：2004-12-10
申请人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine Cardarelli , Changyu Wang , David Passmore , Vangipuram Rangan , Thomas Lane , Hans Keirstead , Michael Liu
发明人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine Cardarelli , Changyu Wang , David Passmore , Vangipuram Rangan , Thomas Lane , Hans Keirstead , Michael Liu
IPC分类号： A61K39/395 , C07D20060101 , C07K14/52 , C07K16/24 , C07K16/28
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。
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公开(公告)号：US08680247B2
公开(公告)日：2014-03-25
申请号：US12668965
申请日：2008-07-17
申请人： Jonathan Alexander Terrett , Li-Sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
发明人： Jonathan Alexander Terrett , Li-Sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
IPC分类号： C07K16/30 , A61K39/395 , A61K39/44 , C07K16/46
CPC分类号： C07K16/28 , A61K39/00 , C07K16/303 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合磷脂酰肌醇蛋白聚糖-3的人单克隆抗体。 还提供了编码磷脂酰肌醇蛋白聚糖-3抗体的核酸分子，表达载体，宿主细胞和用于表达糖蛋白聚糖-3抗体的方法。 还提供了免疫偶联物，双特异性分子和包含磷脂酰肌醇蛋白聚糖-3抗体的药物组合物。 公开了检测磷酸三钙-3的方法，以及用于治疗各种磷酸三钙3相关病症（包括肝细胞癌）的方法。
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