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21.发明授权公开(公告)号：US09809528B2
公开(公告)日：2017-11-07
申请号：US15207822
申请日：2016-07-12
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Marat Orazov , Mark E. Davis
Abstract: The present disclosure is directed to methods and composition used in the preparation of alpha-hydroxy carboxylic acids and esters from higher sugars using a tandem catalyst system comprising retro-aldol catalysts and Lewis acid catalysts. In some embodiments, these alpha-hydroxy carboxylic acids may be prepared from pentoses and hexoses. The retro-aldol and Lewis catalysts may be characterized by their respective ability to catalyze a 1,2-carbon shift reaction and a 1,2-hydride shift reaction on an aldose or ketose substrate.
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公开(公告)号：US09255120B2
公开(公告)日：2016-02-09
申请号：US14197511
申请日：2014-03-05
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Mark E. Davis , Rajamani Gounder
IPC: C07B37/08 , C07H3/02 , C07D307/62
CPC classification number: C07H3/02 , C07D307/62
Abstract: The present invention is directed to methods for preparing sorbose from glucose, said method comprising: (a) contacting the glucose with a silica-containing structure comprising a zeolite having a topology of a 12 membered-ring or larger, an ordered mesoporous silica material, or an amorphous silica, said structure containing Lewis acidic Ti4+ or Zr4+ or both Ti4+ and Zr4+ framework centers, said contacting conducted under reaction conditions sufficient to isomerize the glucose to sorbose. The sorbose may be (b) separated or isolated; or (c) converted to ascorbic acid.
Abstract translation: 本发明涉及从葡萄糖制备山梨糖的方法，所述方法包括：（a）使葡萄糖与包含具有12元环以上拓扑的沸石的二氧化硅结构物接触，有序介孔二氧化硅材料， 或无定形二氧化硅，所述结构含有Lewis酸性Ti4 +或Zr4 +或Ti4 +和Zr4 +骨架中心，所述接触在足以使葡萄糖异构化为山梨糖的反应条件下进行。 山梨糖可以是（b）分离或分离; 或（c）转化为抗坏血酸。
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23.发明授权Diels-alder reactions catalyzed by lewis acid containing solids: renewable production of bio-plastics 有权由含有固体的路易斯酸催化的鳗鱼反应：可再生生物生物塑料公开(公告)号：US09108982B2
公开(公告)日：2015-08-18
申请号：US14561351
申请日：2014-12-05
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Mark E. Davis , Joshua J. Pacheco
IPC: C07D493/08
CPC classification number: C07D493/08 , B01J29/0341 , B01J29/035 , B01J29/047 , B01J29/405 , B01J29/7057 , B01J29/89 , B01J2229/183 , C07C2/862 , C07C2/865 , C07C29/32 , C07C45/70 , C07C51/353 , C07C67/343 , C07C67/347 , C07C2529/00 , C07C2529/70 , C07C2529/89 , Y02P20/52 , C07C69/76 , C07C65/01 , C07C65/21 , C07C63/04 , C07C63/26 , C07C47/542 , C07C33/26 , C07C47/56 , C07C69/82 , C07C63/06 , C07C15/08
Abstract: The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and dehydrative aromatization of dienes and dienophiles containing oxygenated substituents to form substituted benzene products. In some embodiments, the processes comprise contacting biomass-derived substrates with ethylene to form terephthalic acid and its derivatives.
Abstract translation: 本公开涉及基本上没有强布朗斯台德酸性质的二氧化硅基路易斯酸催化剂，以及它们对含有氧化取代基的二烯和亲烯体的[4 + 2]环加成和脱水芳构化的能力，以形成取代的苯产物。 在一些实施方案中，该方法包括使生物质衍生的底物与乙烯接触以形成对苯二甲酸及其衍生物。
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公开(公告)号：US20150203634A1
公开(公告)日：2015-07-23
申请号：US14476655
申请日：2014-09-03
Applicant: California Institute of Technology
Inventor： Mark E. Davis , Hector Gonzalez , Suzie Hwang Pun
CPC classification number: C08G75/06 , A61K47/6951 , B82Y5/00 , C08B37/0012 , C08G69/40 , C08G69/48 , C08G73/02 , C08G73/06
Abstract: Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.
Abstract translation: 描述了包含整合到聚合物主链中的未氧化和/或氧化的环糊精部分的线性环糊精共聚物和线性氧化环糊精共聚物。 还描述了制备这种共聚物的方法。 本发明的线性环糊精共聚物和线性氧化环糊精共聚物可以用作各种治疗剂的递送载体。
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公开(公告)号：US20150050233A1
公开(公告)日：2015-02-19
申请号：US14196954
申请日：2014-03-04
Inventor： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
CPC classification number: A61K48/0041 , A61K38/44 , A61K47/555 , A61K47/6949 , A61K47/6951 , B82Y5/00 , C08B37/0012 , C08B37/0015 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12N15/87 , C12Y113/12007
Abstract: The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
Abstract translation: 本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。 该组合物还含有络合剂。 聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。 本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。 颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。 本发明还涉及制备组合物的方法。 该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。 络合剂与聚合物形成包合络合物。 本发明还涉及递送治疗剂的方法。 根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。 还公开了具有下式的化合物：
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Patent Agency Ranking
公开(公告)号：US20140249202A1
公开(公告)日：2014-09-04
申请号：US13782458
申请日：2013-03-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Mark E. Davis , Han Han
IPC: A61K47/34 , A61K45/06 , A61K31/713
CPC classification number: A61K45/06 , A61K9/5161 , A61K31/337 , A61K31/4745 , A61K31/727 , A61K47/60 , A61K47/6935 , A61K2300/00
Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.
Abstract translation: 本文描述了载体纳米颗粒，其包含含有与包含硼酸的聚合物偶联的多元醇的聚合物，其被配置为将含有硼酸的聚合物存在于纳米颗粒外部的环境中。 还描述了所描述的纳米颗粒的目标形式，以及相关的组合物，方法和系统。
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公开(公告)号：US20130211012A1
公开(公告)日：2013-08-15
申请号：US13852303
申请日：2013-03-28
Applicant: California Institute of Technology
Inventor： Mark E. Davis , Christopher A. Alabi
IPC: A61K47/48
CPC classification number: A61K47/6935 , A61K9/14 , A61K9/5146 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K31/713 , A61K47/545 , A61K47/549 , A61K47/595 , A61K47/644 , C08G59/4078 , C08G65/337 , C08G69/40 , C08G69/48 , C12N15/113 , C12N2310/14 , C12N2310/351
Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.
Abstract translation: 载体纳米颗粒包含含有与包含硼酸的聚合物偶联的多元醇的聚合物，其被配置为将含有硼酸的聚合物呈现到纳米颗粒外部的环境以及相关组合物，方法和系统。
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公开(公告)号：US20130209448A1
公开(公告)日：2013-08-15
申请号：US13852397
申请日：2013-03-28
Applicant: California Institute of Technology
Inventor： Mark E. Davis , Akinleye Alabi
IPC: A61K9/14
CPC classification number: A61K47/6935 , A61K9/14 , A61K9/5146 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K31/713 , A61K47/545 , A61K47/549 , A61K47/595 , A61K47/644 , C08G59/4078 , C08G65/337 , C08G69/40 , C08G69/48 , C12N15/113 , C12N2310/14 , C12N2310/351
Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.
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公开(公告)号：US20240207831A1
公开(公告)日：2024-06-27
申请号：US18534042
申请日：2023-12-08
Applicant: California Institute of Technology
Inventor： Jong Hun Kang , Faisal H. Alshafei , Mark E. Davis
CPC classification number: B01J29/85 , B01J37/0018 , B01J37/0045 , B01J37/04 , B01J37/06 , B01J37/08 , C01B39/54 , C07C1/24 , B01J2229/183 , C01P2002/72 , C01P2002/76 , C01P2002/77 , C01P2002/85 , C01P2002/86 , C01P2002/88 , C01P2004/03 , C01P2006/14
Abstract: The disclosure provides a novel silicoaluminophosphate molecular sieve, referred to as CIT-16P, that comprises a silicoaluminophosphate framework with an occluded OSDA that is DiQ-C4 or DiQ-C3. The synthesis of CIT-16P, its conversion to SAPO-17, and the use of the so-derived SAPO-17 in the MTO reaction are also disclosed.
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公开(公告)号：US20220274088A1
公开(公告)日：2022-09-01
申请号：US17681267
申请日：2022-02-25
Applicant: California Institute of Technology
Inventor： Donglong Fu , Mark E. Davis
Abstract: The present disclosure is directed to metal ion-containing zeolitic compositions, preferably transition metal ion-containing, more preferably zinc ion containing zeolitic compositions, that are useful for reversibly scavenging water from humid gaseous feed streams, including air, and method of making and using the same. In some embodiments, the compositions comprise zinc-ion-doped zeolites have LTA, FAU, or EMT topologies.
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