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公开(公告)号：US10030228B2
公开(公告)日：2018-07-24
申请号：US13863364
申请日：2013-04-15
Applicant: Case Western Reserve University
Inventor： Eben Alsberg , Loran Solorio , Phuong Dang
IPC: C12N5/077
Abstract: A tissue construct comprising includes a self-assembled, scaffold-free, high-density cell aggregate. The cell aggregate includes a plurality of cells and a plurality of biocompatible and degradable nanoparticles and/or microparticles that are incorporated within the cell aggregate. The nanoparticles and/or microparticles act as a bulking agent and/or provide bioactive agents or signals within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate and/or regulate cell function within the aggregate allowing the cell aggregate to be readily manipulated and formed into tissue constructs with defined architectures and potential tissue specific functionality.
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公开(公告)号：US20160008475A1
公开(公告)日：2016-01-14
申请号：US14795569
申请日：2015-07-09
Applicant: Case Western Reserve University
Inventor： Eben Alsberg , Oju Jeon , David Wolfson
CPC classification number: A61K47/36 , A61K31/727 , A61K35/28 , A61K38/1875 , A61K47/42 , A61L27/26 , A61L27/38 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2430/02 , C12N5/0662 , C12N2533/54 , C12N2533/74 , C12N2537/00 , C12N2537/10 , C08L5/04 , C08L89/06
Abstract: A composition includes a plurality of coacervate micro and/or nanodroplets of oxidized alginate and a methacrylated gelatin.
Abstract translation: 组合物包括氧化藻酸盐和甲基丙烯酸酯化明胶的多个凝聚微晶和/或纳米质子。
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公开(公告)号：US20150267196A1
公开(公告)日：2015-09-24
申请号：US14435378
申请日：2013-10-15
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Eben Alsberg , Minh Khanh Nguyen , Cong Huynh , Alex Gilewski , Matt Levy , Vincent Rotello , Gulen Yesilbag , Oju Jeon
IPC: C12N15/113
CPC classification number: C12N15/113 , C08B37/0021 , C08J3/075 , C08J2305/02 , C08L5/02 , C08L29/04 , C08L33/14 , C08L79/02 , C08L85/02 , C08L2205/03 , C12N2310/14 , C12N2310/351
Abstract: A composition includes a biodegradable hydrogel that includes a hydrogel forming base polymer and a plurality of physiologically degradable ester linkages, amide linkages, azide-alkyne cycloaddition linkages, acrylate-thiol linkages, urethane linkages, and/or methacrylate-thiol linkages, a polynucleotide coupling polymeric molecule; and a polynucleotide. The polynucleotide is released under physiological conditions in a spatial and/or temporally controlled or predetermined manner from the composition.
Abstract translation: 组合物包括可生物降解的水凝胶，其包括形成水凝胶的基础聚合物和多个生理可降解酯键，酰胺键，叠氮炔环加成键，丙烯酸酯 - 硫醇键，氨基甲酸酯键和/或甲基丙烯酸酯 - 硫醇键，多核苷酸偶联 聚合物分子; 和多核苷酸。 多核苷酸在生理条件下以空间和/或时间控制或预定的方式从组合物释放。
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公开(公告)号：US12144906B2
公开(公告)日：2024-11-19
申请号：US17544492
申请日：2021-12-07
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Eben Alsberg , Oju Jeon
Abstract: A bioadhesive includes a crosslinked biodegradable hydrogel that includes a plurality of oxidized, acrylated or methacrylated, natural polymer.
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公开(公告)号：US20240157030A1
公开(公告)日：2024-05-16
申请号：US18370106
申请日：2023-09-19
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Eben Alsberg
IPC: A61L27/44 , A61L27/20 , A61L27/26 , A61L27/36 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , C08B37/00 , C08G65/00 , C08H1/06 , C08L5/04 , C08L89/06
CPC classification number: A61L27/44 , A61L27/20 , A61L27/26 , A61L27/3608 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/58 , C08B37/0084 , C08G65/002 , C08H1/06 , C08L5/04 , C08L89/06 , A61L2300/236 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2400/16 , A61L2430/40 , C08L2205/04 , C08L2312/00
Abstract: An interpenetrating polymer network (IPN) structured hydrogel includes a crosslinked first natural polymer macromer with a first elasticity and an interpenetrating network of crosslinked second natural polymer macromers having a second elasticity higher than the first elasticity, the IPN structured hydrogel being cytocompatible, and, upon degradation, produce substantially non-toxic products.
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Patent Agency Ranking
公开(公告)号：US20240075188A1
公开(公告)日：2024-03-07
申请号：US18367356
申请日：2023-09-12
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Eben Alsberg , Oju Jeon
IPC: A61L27/44 , A61L27/20 , A61L27/26 , A61L27/36 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , C08B37/00 , C08G65/00 , C08H1/06 , C08L5/04 , C08L89/06
CPC classification number: A61L27/44 , A61L27/20 , A61L27/26 , A61L27/3608 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/58 , C08B37/0084 , C08G65/002 , C08H1/06 , C08L5/04 , C08L89/06 , A61L2300/236 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2400/16 , A61L2430/40 , C08L2205/04 , C08L2312/00
Abstract: A method for forming a bioactive agent spatially patterned includes providing a photocrosslinkable hydrogel that includes a photocrosslinkable base polymer, photocrosslinkable bioactive agent coupling polymer macromers, and at least one bioactive agent that couples to the photocrosslinkable bioactive agent coupling polymer macromer, an selectively exposing discrete portions of the photocrosslinkable hydrogel to actinic radiation effective to initiate cross-linking of the base polymer and the bioactive agent coupling polymer macromers at the exposed portions.
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公开(公告)号：US11759549B2
公开(公告)日：2023-09-19
申请号：US16107708
申请日：2018-08-21
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Eben Alsberg
IPC: A61L27/44 , A61L27/36 , A61L27/52 , A61L27/54 , A61L27/58 , C08L89/06 , C08L5/04 , C08B37/00 , C08H1/06 , A61L27/26 , A61L27/38 , C08G65/00 , A61L27/20
CPC classification number: A61L27/44 , A61L27/20 , A61L27/26 , A61L27/3608 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/58 , C08B37/0084 , C08G65/002 , C08H1/06 , C08L5/04 , C08L89/06 , A61L2300/236 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2400/16 , A61L2430/40 , C08L2205/04 , C08L2312/00 , C08L5/04 , C08L89/06 , C08L89/06 , C08L5/04 , A61L27/26 , C08L89/06 , A61L27/26 , C08L5/08
Abstract: An interpenetrating polymer network (IPN) structured hydrogel includes a crosslinked first natural polymer macromer with a first elasticity and an interpenetrating network of crosslinked second natural polymer macromers having a second elasticity higher than the first elasticity, the IPN structured hydrogel being cytocompatible, and, upon degradation, produce substantially non-toxic products.
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公开(公告)号：US11191871B2
公开(公告)日：2021-12-07
申请号：US16371806
申请日：2019-04-01
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Eben Alsberg , Rui Tang
IPC: A61L27/24 , A61K9/50 , A61K47/02 , A61K47/42 , C07K14/78 , A61L27/54 , C12N5/00 , A61L27/36 , B82Y5/00 , B82Y40/00 , C08J3/075
Abstract: A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core.
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公开(公告)号：US11191867B2
公开(公告)日：2021-12-07
申请号：US16726375
申请日：2019-12-24
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Eben Alsberg , Oju Jeon
Abstract: A bioadhesive includes a crosslinked biodegradable hydrogel that includes a plurality of oxidized, acrylated or methacrylated, natural polymer.
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公开(公告)号：US20190105395A1
公开(公告)日：2019-04-11
申请号：US16153138
申请日：2018-10-05
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Eben Alsberg , Fangze Liu , Yuxuan Cheng , Katherine A. Coughlin
IPC: A61K47/34 , C12N15/113 , C08J3/075 , A61K35/28 , A61K9/06 , A61L27/52 , A61L27/54 , A61L27/58 , A61L27/26 , A61L27/18
Abstract: A cytocompatible hydrogel includes a plurality first polymer macromers linked to a plurality of second polymer macromers different than the first polymer macromers by a plurality of β-hydroxythio-ether linkages, and a plurality of cells encapsulated in the hydrogel.
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