公开(公告)号：US08987531B2

公开(公告)日：2015-03-24

申请号：US13785101

申请日：2013-03-05

Applicant: California Institute of Technology

Inventor： Robert H. Grubbs ,  Myles B. Herbert ,  Zachary K. Wickens ,  Vanessa M. Marx ,  Benjamin K. Keitz ,  Koji Endo

IPC: C07C27/00 ,  C07C45/00 ,  C07C67/02 ,  C07C29/00 ,  C07C67/28 ,  C07C45/30 ,  C07C67/08 ,  C07C29/32 ,  C07C67/293 ,  C07C67/343

CPC classification number: C07C29/00 ,  C07C29/32 ,  C07C45/30 ,  C07C67/08 ,  C07C67/28 ,  C07C67/293 ,  C07C67/343 ,  C07C33/025 ,  C07C47/21 ,  C07C69/145 ,  C07C33/02 ,  C07C49/203

Abstract: The present invention is directed to methods of synthesizing insect pheromones, particularly lepidopteran insect pheromones, their precursors and derivatives from inexpensive, readily available starting materials using olefin metathesis catalysis.

Abstract translation: 本发明涉及使用烯烃复分解催化合成昆虫信息素，特别是鳞翅目昆虫信息素，它们的前体和廉价，易得的原料的衍生物的方法。

公开(公告)号：US08871879B2

公开(公告)日：2014-10-28

申请号：US13779190

申请日：2013-02-27

Applicant: Materia, Inc. ,  California Institute of Technology

Inventor： Thay Ung ,  Yann Schrodi ,  Mark S. Trimmer ,  Andrew Hejl ,  Daniel Sanders ,  Robert H. Grubbs

IPC: C08F132/08 ,  C07C67/333 ,  B01J31/22

CPC classification number: C08G61/02 ,  C07C67/333 ,  C07D493/10 ,  C07F15/0046 ,  C08F132/08 ,  C08G61/06 ,  C08G2261/11 ,  C08G2261/3325 ,  C08G2261/418

Abstract: The invention provides novel organometallic complexes useful as olefin metathesis catalysts. The complexes have an N-heterocyclic carbene ligand and a chelating carbene ligand associated with a Group 8 transition metal center. The molecular structure of the complexes can be altered so as to provide a substantial latency period. The complexes are particularly useful in catalyzing ring closing metathesis of acyclic olefins and ring opening metathesis polymerization of cyclic olefins.

Abstract translation: 本发明提供了用作烯烃复分解催化剂的新型有机金属络合物。 络合物具有与8族过渡金属中心相关的N-杂环卡宾配体和螯合卡宾配体。 可以改变配合物的分子结构，以便提供大量潜伏期。 该络合物特别可用于催化环烯烃的闭环复分解和环烯烃的开环易位聚合。

公开(公告)号：US20140005036A1

公开(公告)日：2014-01-02

申请号：US13928155

申请日：2013-06-26

Applicant: California Institute of Technology

Inventor： Raymond Weitekamp ,  Robert H. Grubbs

IPC: B01J31/22

CPC classification number: B01J31/22 ,  B01J31/0259 ,  B01J31/1625 ,  B01J31/2273 ,  B01J2231/543 ,  B01J2531/17 ,  B01J2531/18 ,  B01J2531/821 ,  B01J2540/64 ,  C07F9/6506 ,  Y02P20/582

Abstract: An efficient method for the preparation of backbone-substituted imidazolinium salts for use as N-heterocyclic carbene ligands, e.g., for organometallic catalysts is provided. These functionalized N-heterocyclic carbene ligands are used to prepare solid-supported catalysts, e.g., for olefin metathesis.

Abstract translation: 提供了用于制备用作N-杂环卡宾配体的骨架取代的咪唑啉鎓盐的有效方法，例如用于有机金属催化剂。 这些官能化的N-杂环卡宾配体用于制备固体负载的催化剂，例如用于烯烃复分解。

公开(公告)号：US11830983B2

公开(公告)日：2023-11-28

申请号：US17217428

申请日：2021-03-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  HONDA MOTOR CO., LTD.

Inventor： Simon C. Jones ,  Victoria K. Davis ,  Christopher M. Bates ,  Nebojsa Momcilovic ,  Brett M. Savoie ,  Michael A. Webb ,  Thomas F. Miller, III ,  Robert H. Grubbs ,  Christopher Brooks ,  Kaoru Omichi

IPC: H01M10/0568 ,  H01M10/0525 ,  H01M10/0569 ,  H01M10/054 ,  C07C209/68

CPC classification number: H01M10/0568 ,  C07C209/68 ,  H01M10/054 ,  H01M10/0525 ,  H01M10/0569 ,  H01M2300/0025

Abstract: Electrolyte solutions including at least one anhydrous fluoride salt and at least one non-aqueous solvent are presented. The fluoride salt includes an organic cation having a charge center (e.g., N, P, S, or O) that does not possess a carbon in the β-position or does not possess a carbon in the β-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. Combining these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents. The solvent may be a mixture of at least one non-aqueous, fluorine-containing solvent and at least one other non-aqueous, fluorine or non-fluorine containing solvent (e.g., BTFE and propionitrile or dimethoxyethane). The electrolyte solutions may be employed in electrochemical cells, such as batteries, fuel cells, electrolysis systems, and capacitors.

公开(公告)号：US11779912B2

公开(公告)日：2023-10-10

申请号：US17459089

申请日：2021-08-27

Applicant: Umicore AG & Co. KG ,  California Institute of Technology

Inventor： Adam M. Johns ,  Jessica R. Herron ,  Richard L. Pederson ,  Bryan A. Fiamengo ,  Jennifer A. Beerman ,  Tzu-Pin Lin ,  Crystal K. Chu ,  Robert H. Grubbs

IPC: B01J31/24 ,  B01J31/22 ,  C07F15/00

CPC classification number: B01J31/2414 ,  B01J31/2208 ,  B01J31/2273 ,  B01J31/2278 ,  B01J31/2295 ,  B01J31/2404 ,  B01J31/2409 ,  C07F15/0046 ,  B01J2231/543 ,  B01J2531/821

Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.

公开(公告)号：US11642410B2

公开(公告)日：2023-05-09

申请号：US17544630

申请日：2021-12-07

Applicant: California Institute of Technology ,  The Regents of the University of California

Inventor： Robert H. Grubbs ,  Marshall L. Stoller ,  Hoyong Chung ,  Alissa M. Fitzgerald ,  Thomas W. Kenny ,  Renee M. Thomas

IPC: A61K41/00 ,  A61K9/00 ,  A61K9/107 ,  A61K47/69 ,  A61B17/22 ,  A61K31/663 ,  A61K47/24 ,  A61N7/00

CPC classification number: A61K41/0028 ,  A61B17/2202 ,  A61B17/22004 ,  A61B17/22022 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/663 ,  A61K41/0033 ,  A61K47/24 ,  A61K47/6911 ,  A61N7/00 ,  A61B2017/22007 ,  A61B2017/22008 ,  A61N2007/0039

Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

公开(公告)号：US11154639B2

公开(公告)日：2021-10-26

申请号：US16222918

申请日：2018-12-17

Applicant: University of Southern California ,  California Institute of Technology ,  The Regents of the University of California

Inventor： Mark S. Humayun ,  Ashish Ahuja ,  Yu-Chong Tai ,  David R. Hinton ,  Robert H. Grubbs ,  Dennis O. Clegg ,  Lincoln Vallance Johnson ,  Sherry T. Hikita

IPC: A61K47/34 ,  A61L27/18 ,  A61K35/30 ,  A61L27/38 ,  A61K35/545 ,  A61P27/00 ,  C12N5/079 ,  A61L27/34 ,  A61K9/00 ,  A61L27/56

Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

公开(公告)号：US11123722B2

公开(公告)日：2021-09-21

申请号：US16919704

申请日：2020-07-02

Applicant: Umicore AG & Co. KG ,  California Institute of Technology

Inventor： Adam M. Johns ,  Jessica R. Herron ,  Richard L. Pederson ,  Bryan A. Fiamengo ,  Jennifer A. Beerman ,  Tzu-Pin Lin ,  Crystal K. Chu ,  Robert H. Grubbs

IPC: B01J31/24 ,  B01J31/22 ,  C07F15/00

Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.

公开(公告)号：US20210122701A1

公开(公告)日：2021-04-29

申请号：US17142751

申请日：2021-01-06

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Robert H. Grubbs ,  Alexey Federov ,  Anton Toutov ,  Kerry N. Betz

IPC: C07C209/28 ,  C07C37/50 ,  C07C1/22 ,  C07F7/08 ,  C07C37/055 ,  C07C209/62 ,  C07C319/06

Abstract: The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.

公开(公告)号：US10945946B2

公开(公告)日：2021-03-16

申请号：US16831781

申请日：2020-03-26

Applicant: California Institute of Technology

Inventor： Vanessa M. Marx ,  Robert H. Grubbs

IPC: A61K9/00 ,  C07F9/38 ,  A61K9/107 ,  A61K31/663 ,  A61K9/12 ,  A61N5/02 ,  A61N7/02 ,  C07B41/12 ,  C07B43/06 ,  A61N7/00

Abstract: The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further include pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy.