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21.发明申请公开(公告)号：US20190218250A1
公开(公告)日：2019-07-18
申请号：US16358845
申请日：2019-03-20
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak
IPC: C07K1/36 , B01J20/20 , B01D15/12 , B01D15/36 , C07K16/00 , B01J47/04 , B01J43/00 , B01J41/20 , B01J39/26 , C07K1/20 , C07K1/16 , B01J20/282
CPC classification number: C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J20/20 , B01J20/282 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , C07K1/16 , C07K1/20 , C07K16/00 , C07K2317/10
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely affecting the yield of the desired protein product.
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公开(公告)号：US10350518B2
公开(公告)日：2019-07-16
申请号：US14839852
申请日：2015-08-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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23.发明申请公开(公告)号：US20190099702A1
公开(公告)日：2019-04-04
申请号：US16208018
申请日：2018-12-03
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US20180169593A1
公开(公告)日：2018-06-21
申请号：US15575596
申请日：2016-08-12
Applicant: EMD Millipore Corporation
Inventor： Jad Jaber , Wilson Moya , Mikhail Kozlov
CPC classification number: B01D71/08 , B01D61/145 , B01D67/0006 , B01D67/0011 , B01D67/0013 , B01D67/0016 , B01D69/02 , B01D69/10 , B01D69/125 , B01D2323/30 , B01D2325/02 , B01D2325/04 , B01D2325/36
Abstract: The embodiments described herein relate to agarose ultrafiltration membrane composites and methods for making and using the same.
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公开(公告)号：US09943616B2
公开(公告)日：2018-04-17
申请号：US15691369
申请日：2017-08-30
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Gabriel Tkacik
CPC classification number: A61L2/0017 , B01D39/1623 , B01D67/0004 , B01D67/002 , B01D69/00 , B01D2239/025 , B01D2323/39 , C02F1/444 , C02F2303/04
Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
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Patent Agency Ranking
公开(公告)号：US20170320909A1
公开(公告)日：2017-11-09
申请号：US15654876
申请日：2017-07-20
Applicant: EMD Millipore Corporation
Inventor： Alex Xenopoulos , Michael Phillips , Wilson Moya , Jad Jaber , Mikhail Kozlov , Ajish Potty , Matthew T. Stone , William Cataldo , Christopher Gillespie
CPC classification number: C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01D15/3847 , C07K16/00 , C07K2317/14 , C12M29/04 , C12M43/00 , C12M47/12 , C12N7/00
Abstract: The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.
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27.发明申请Processes for Filtering Liquids Using Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems with Recirculation of Retentate 审中-公开使用单道切向流过滤系统过滤液体的过程和具有再渗透的切向流过滤系统公开(公告)号：US20160059160A1
公开(公告)日：2016-03-03
申请号：US14839852
申请日：2015-08-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
CPC classification number: B01D29/908 , B01D29/52 , B01D29/603 , B01D61/142 , B01D61/145 , B01D61/147 , B01D63/04 , B01D63/12 , B01D2313/105 , B01D2313/125 , B01D2313/21 , B01D2313/44 , B01D2315/10
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
Abstract translation: 公开了过滤液体进料的方法。 在一个版本中，该方法包括使液体进料通过单通道切向流过滤（SPTFF）系统，并且在分离的容器中从系统中回收渗余物和渗透物，而不通过SPTFF系统再循环。 在另一个版本中，过滤液体进料的方法包括使液体进料通过切向流过滤（TFF）系统，在分离的容器中从体系中回收渗透物和一部分滞留物，而不通过TFF系统再循环 剩余的残留物通过TFF系统至少一次。 该方法可以使用包括歧管段的SPTFF或TFF系统来执行，以串行化进料和滞留物的流动路径，而不需要转向板。
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公开(公告)号：US20150133636A1
公开(公告)日：2015-05-14
申请号：US14400389
申请日：2013-06-21
Applicant: EMD Millipore Corporation
Inventor： Alex Xenopoulos , Michael Phillips , Wilson Moya , Jad Jaber , Mikhail Kozlov , Ajish Potty , Matthew T. Stone , William Cataldo , Christopher Gillespie
CPC classification number: C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01D15/3847 , C07K16/00 , C07K2317/14 , C12M29/04 , C12M43/00 , C12M47/12 , C12N7/00
Abstract: The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.
Abstract translation: 本发明涉及用于纯化生物分子的改进方法和系统，其中所述方法可以以连续的方式进行。
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公开(公告)号：US20230123639A1
公开(公告)日：2023-04-20
申请号：US18066610
申请日：2022-12-15
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Gabriel Tkacik , Onur Y. Kas , Ajish Potty , Jigneshkumar Patel
Abstract: A porous electrospun polymeric nanofiber liquid filtration medium, such as an electrospun mats, used for the removal of viral particles (e.g., parvovirus) and other particles in the 18 nm to 30 nm size range from fluid streams, having a mean flow bubble point measured with perfluorohexane above 100 psi. The electrospun medium includes nanofibers having an average fiber diameter of about 6 nm to about 13 nm, and the nanofiber liquid filtration medium has a mean pore size ranging from about 0.01 μm to about 0.03 μm, a porosity ranging from about 80% to about 95%, a thickness ranging from about 1 μm to about 100 μm, and a liquid permeability greater than about 10 LMH/psi. The high porosity of the electrospun mats enable much higher water fluxes, thus reducing the time required to complete virus filtration steps on a fluid stream.
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公开(公告)号：US11358102B2
公开(公告)日：2022-06-14
申请号：US16918431
申请日：2020-07-01
Applicant: EMD Millipore Corporation
Inventor： Jad Jaber , Wilson Moya , Mikhail Kozlov
Abstract: The embodiments described herein relate to agarose ultrafiltration membrane composites and methods for making and using the same.
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