公开(公告)号：US20110028862A1

公开(公告)日：2011-02-03

申请号：US12901290

申请日：2010-10-08

申请人： Heinz-Michael Hein ,  Reto Abt ,  Stephan Korner ,  Irio Giuseppe Calasso ,  Emad Sarofim ,  Patrick Griss ,  Rainer Jaeggi

发明人： Heinz-Michael Hein ,  Reto Abt ,  Stephan Korner ,  Irio Giuseppe Calasso ,  Emad Sarofim ,  Patrick Griss ,  Rainer Jaeggi

IPC分类号： A61B5/151

CPC分类号： A61B5/150503 ,  A61B5/0531 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15186

摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.

摘要翻译： 本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。 穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。 随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。 在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。 在等待期开始和结束后的正向相位之后检测穿刺元件与体液之间的接触。

公开(公告)号：US07819822B2

公开(公告)日：2010-10-26

申请号：US11470368

申请日：2006-09-06

申请人： Irio Guiseppe Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer ,  Wilfried Schmid ,  Otto Fuerst ,  Hans List ,  Hans-Peter Haar ,  Theo Arnitz ,  Steven N. Roe

发明人： Irio Guiseppe Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer ,  Wilfried Schmid ,  Otto Fuerst ,  Hans List ,  Hans-Peter Haar ,  Theo Arnitz ,  Steven N. Roe

IPC分类号： A61B5/00

CPC分类号： A61B5/1411 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150396 ,  A61B5/150419 ,  A61B5/150427 ,  A61B5/15045 ,  A61B5/150503 ,  A61B5/15151 ,  A61B5/15163

摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid, and the device further comprising a fluid receiving means remote spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially. The collection zone takes up a very small volume of body fluid of about 10 to 500 nl in a very short time period of less than 0.5 seconds. The fluid receiving means may have a test zone for performing an analytical reaction. Fluid sample from the collection zone is automatically or manually transported to the fluid receiving means to contact the fluid with the test zone.

摘要翻译： 体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件，并且该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液不会接触流体接收装置 原来。 收集区在小于0.5秒的非常短的时间段内占据非常小体积的体液约10至500nl。 流体接收装置可以具有用于进行分析反应的测试区域。 来自收集区的流体样品被自动或手动地输送到流体接收装置以使流体与测试区接触。

公开(公告)号：US08087141B2

公开(公告)日：2012-01-03

申请号：US11763266

申请日：2007-06-14

申请人： Patrick Griss ,  Marzellinus Zipfel ,  Angel Lopez

发明人： Patrick Griss ,  Marzellinus Zipfel ,  Angel Lopez

IPC分类号： B21D53/00

CPC分类号： A61M37/00 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150419 ,  A61B5/15105 ,  A61B5/15142 ,  Y10T29/302 ,  Y10T29/304 ,  Y10T29/49812 ,  Y10T29/49995 ,  Y10T29/53339 ,  Y10T428/12188

摘要： The sheet metal or substrate material 22 is constructed by a photo-chemical machining or milling method. In this exemplary process, an etching mask 24 is applied to both sides of the substrate 22 and covers the structure of the flat-shaped member 12, which is to be uncovered in a subsequent etching step. The mask 24 is formed by coating the substrate 22 with a photoresist and is exposed through a photomask having the desired pattern that is arranged in front of the mask, whereby the photoresist is polymerized or hardened in the covered areas while the other areas are rinsed away after development.

摘要翻译： 金属板或基板材料22通过光化学加工或研磨方法构成。 在该示例性工艺中，将蚀刻掩模24施加到基板22的两侧，并且覆盖在随后的蚀刻步骤中未被覆盖的平坦形构件12的结构。 掩模24通过用光致抗蚀剂涂覆基板22而形成，并且通过布置在掩模前面的具有所需图案的光掩模曝光，由此光致抗蚀剂在覆盖区域聚合或硬化，而其它区域被冲洗掉 后发展。

公开(公告)号：US20090311796A1

公开(公告)日：2009-12-17

申请号：US12482707

申请日：2009-06-11

申请人： Patrick Griss ,  Rainer Jaeggi ,  Goran Savatic ,  Vuk Siljegovic

发明人： Patrick Griss ,  Rainer Jaeggi ,  Goran Savatic ,  Vuk Siljegovic

IPC分类号： G01N21/75 ,  G01N33/00 ,  G01N9/30

CPC分类号： B01L3/50273 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2300/0887 ,  B01L2300/168 ,  B01L2400/0409 ,  B01L2400/0688 ,  C12Q1/54 ,  G01N21/07 ,  G01N33/491 ,  Y10T436/144444 ,  Y10T436/146666 ,  Y10T436/15 ,  Y10T436/166666 ,  Y10T436/171538 ,  Y10T436/175383 ,  Y10T436/201666 ,  Y10T436/204165

摘要： An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.

摘要翻译： 公开了用于分析化学或生物样品的分析装置，基于装置的旋转，集成的样品计量和光学检测使用这种装置的方法，以及包括这种装置的系统。 分析装置包括具有液体处理单元的装置主体。 液体处理单元包括用于将样品与试剂混合的混合室，用于将限定体积的样品输送到混合室的样品计量室，以及用于输送要与样品混合的试剂的试剂通道，其中 混合室也用作检测室。

公开(公告)号：US20070255205A1

公开(公告)日：2007-11-01

申请号：US11661113

申请日：2005-08-30

申请人： Patrick Griss ,  Goran Stemme

发明人： Patrick Griss ,  Goran Stemme

IPC分类号： A61M37/00

CPC分类号： B29C45/2628 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C2045/0094 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C99/0085 ,  B81C2201/034

摘要： Method of hollow micro-projections having side walls and at least one opening in a side wall, by a molding technique. The hollow micro-projections are defined by a first, negative mold defining the exterior shape of the micro-projections and a second, positive mold defining the hollow interior shape of the micro-projections. The method includes injecting a moldable material into the space between the two molds, in a state where they have been brought together. The positive and negative molds each have an essentially cylindrical geometry. In the process of bringing the molds together, the mold halves are laterally off-set with respect to each other, such that the distance between an inner wall of the negative mold and the positive mold in the area, ranges from zero to a finite distance. Micro-projections and arrays of micro-projections are also disclosed.

摘要翻译： 通过成型技术的具有侧壁和侧壁中的至少一个开口的中空微型突起的方法。 中空微突起由限定微突起的外部形状的第一负模具和限定微突起的中空内部形状的第二正模定义。 该方法包括将可模塑材料注入到两个模具之间的空间中，并将它们合并在一起。 正负模具各自具有基本上圆柱形的几何形状。 在将模具合在一起的过程中，半模相对于彼此横向偏移，使得阴模的内壁和该区域中的正模之间的距离从零到有限距离 。 还公开了微突起和微突起的阵列。

公开(公告)号：US07258805B2

公开(公告)日：2007-08-21

申请号：US10486541

申请日：2002-08-14

申请人： Göran Stemme ,  Patrick Griss

发明人： Göran Stemme ,  Patrick Griss

IPC分类号： A61M5/00

CPC分类号： A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053

摘要： A micro-needle protrudes from a support member. The needle has a needle body portion, a closed pointed tip portion, and an inner lumen extending through the support member and into the protruding needle. The needle body portion has at least one side opening communicating with the inner lumen. The method of making the needle comprises providing a mask on the front side of an etchable wafer such that the vertical projection of the mask at least partially covers the extension of a hole made in the back side. The mask is isotropically underetched to remove wafer material. An anisotropic etch forms a protruding structure. Optionally a second isotropic etch on the protruding structure exposes the blind hole. Optionally a final anisotropic etch extends the needle without forming side openings.

摘要翻译： 微针从支撑构件突出。 针具有针体部分，封闭的尖端部分和延伸穿过支撑部件并进入突出针的内腔。 针体部具有与内腔连通的至少一个侧开口。 制造针的方法包括在可蚀刻晶片的正面上设置掩模，使得掩模的垂直投影至少部分地覆盖在后侧形成的孔的延伸部。 掩模各向同性地去除晶片材料。 各向异性蚀刻形成突出结构。 可选地，突出结构上的第二各向同性蚀刻暴露盲孔。 可选地，最终的各向异性蚀刻使针不会形成侧面开口。

公开(公告)号：US07981346B2

公开(公告)日：2011-07-19

申请号：US11661113

申请日：2005-08-30

申请人： Patrick Griss ,  Göran Stemme

发明人： Patrick Griss ,  Göran Stemme

IPC分类号： B28B1/14 ,  B28B1/48 ,  A61M35/00

CPC分类号： B29C45/2628 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C2045/0094 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C99/0085 ,  B81C2201/034

摘要： Method of hollow micro-projections having side walls and at least one opening in a side wall, by a molding technique. The hollow micro-projections are defined by a first, negative mold defining the exterior shape of the micro-projections and a second, positive mold defining the hollow interior shape of the micro-projections. The method includes injecting a moldable material into the space between the two molds, in a state where they have been brought together. The positive and negative molds each have an essentially cylindrical geometry. In the process of bringing the molds together, the mold halves are laterally off-set with respect to each other, such that the distance between an inner wall of the negative mold and the positive mold in the area, ranges from zero to a finite distance. Micro-projections and arrays of micro-projections are also disclosed.

摘要翻译： 通过成型技术的具有侧壁和侧壁中的至少一个开口的中空微型突起的方法。 中空微突起由限定微突起的外部形状的第一负模具和限定微突起的中空内部形状的第二正模定义。 该方法包括将可模塑材料注入到两个模具之间的空间中，并将它们合并在一起。 正负模具各自具有基本上圆柱形的几何形状。 在将模具合在一起的过程中，半模相对于彼此横向偏移，使得阴模的内壁和该区域中的正模之间的距离从零到有限距离 。 还公开了微突起和微突起的阵列。

公开(公告)号：US20080290048A1

公开(公告)日：2008-11-27

申请号：US12131512

申请日：2008-06-02

申请人： Rainer Jaeggi ,  Patrick Griss ,  Hans-Peter Wahl

发明人： Rainer Jaeggi ,  Patrick Griss ,  Hans-Peter Wahl

IPC分类号： B04B3/00 ,  B01D33/15 ,  G01N21/07 ,  G01N33/48

CPC分类号： G01N21/07 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/086 ,  G01N33/491

摘要： A device and method thereof for at least partially fractioning or separating fluid from higher density and/or solid particles contained in liquid samples are disclosed. The present invention provides a movable or drivable device having a flow path defined by inner and outer wall surfaces and arranged such that the flow velocity of the liquid sample along the outer wall surface is higher than the flow velocity along the opposite inner wall surface. The flow path provides elements to at least delay the flow of the liquid sample along the outer wall surface. The device is, e.g., suitable for the separation of blood, e.g., of plasma from at least red blood cells, and from red and white blood cells to achieve blood plasma with high purity for analytical reasons.

摘要翻译： 公开了一种用于至少部分地分馏或分离液体样品中包含的较高密度和/或固体颗粒的流体的装置及其方法。 本发明提供了一种可移动或可驱动的装置，其具有由内壁和外壁表面限定的流动路径，并且布置成使得液体样品沿着外壁表面的流速高于沿着相对的内壁表面的流速。 流动路径提供元件以至少延迟液体样品沿着外壁表面的流动。 例如，该装置适于从至少红细胞和红细胞和白细胞分离血液，例如血浆，以实现高纯度的血浆，用于分析的原因。

公开(公告)号：US08506906B2

公开(公告)日：2013-08-13

申请号：US12092446

申请日：2006-11-24

申请人： Patrick Griss ,  Björn Samel ,  Goran Stemme ,  Frédéric Neftel ,  Laurent-Dominique Piveteau

发明人： Patrick Griss ,  Björn Samel ,  Goran Stemme ,  Frédéric Neftel ,  Laurent-Dominique Piveteau

IPC分类号： B81B7/00

CPC分类号： B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/0672 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0026 ,  F16K99/0036 ,  F16K99/004 ,  F16K99/0061 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0086 ,  G01N27/3271 ,  G01N33/4905 ,  Y10T137/2191 ,  Y10T137/2196

摘要： A microfluidic system comprises a first portion and a second portion. The first portion comprises a material which is able to change its volume when activated by an exciting factor, characterized by the fact that the first portion and the second portion define a zone which, when the first portion is not yet activated by the exciting factor, shows a first topography devoid of any fluidic pathway and which, after activation by the exciting factor, shows a second topography which is adapted to contain at least one fluidic pathway. The microfluidic system further comprises a tight cover surface situated above the first portion and the second portion.

摘要翻译： 微流体系统包括第一部分和第二部分。 第一部分包括当由激励因素激活时能够改变其体积的材料，其特征在于第一部分和第二部分限定了当第一部分尚未被激励因子激活时的区域， 显示没有任何流体通路的第一形貌，并且在由激发因子激活之后，显示适于包含至少一个流体路径的第二形貌。 微流体系统还包括位于第一部分和第二部分上方的紧密覆盖表面。

公开(公告)号：US20090044875A1

公开(公告)日：2009-02-19

申请号：US12092446

申请日：2006-11-24

申请人： Patrick Griss ,  Bjorn Samel ,  Goran Stemme ,  Frederic Neftel ,  Laurent-Dominique Piveteau

发明人： Patrick Griss ,  Bjorn Samel ,  Goran Stemme ,  Frederic Neftel ,  Laurent-Dominique Piveteau

IPC分类号： B81B7/02 ,  B01J19/00 ,  F15C3/00

CPC分类号： B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/0672 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0026 ,  F16K99/0036 ,  F16K99/004 ,  F16K99/0061 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0086 ,  G01N27/3271 ,  G01N33/4905 ,  Y10T137/2191 ,  Y10T137/2196

摘要： Microfluidic system (1, 2, 10, 11, 16) comprising a first portion (3, 4, 24, 25) and a second portion (5-7), said first portion (3, 4) comprising a material which is able to change its volume when activated by an exciting factor, characterized by the fact that said first portion (3, 4) and said second portion (5-7) define a zone (3-7) which, when said first portion (3,4) is not yet activated by said exciting factor, shows a first topography devoid of any fluidic pathway and which, after activation by said exciting factor, shows a second topography (9, 14) which is adapted to contain at least one fluidic pathway, said microfluidic system furthermore comprising a tight cover surface (20) situated above said first portion (3, 4) and said second portion (5-7).

摘要翻译： 包括第一部分（3,4,24,25）和第二部分（5-7）的微流体系统（1,2,10,11,16），所述第一部分（3,4）包括能够 当由激励因素激活时改变其体积，其特征在于所述第一部分（3,4）和所述第二部分（5-7）限定区域（3-7），当所述第一部分（3） 4）尚未被所述激发因子激活，显示没有任何流体通路的第一形貌，并且在由所述激发因子激活之后，显示适于包含至少一个流体路径的第二形貌（9,14） 所述微流体系统还包括位于所述第一部分（3,4）和所述第二部分（5-7）上方的紧密覆盖表面（20）。