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公开(公告)号：US20170281921A1
公开(公告)日：2017-10-05
申请号：US15625401
申请日：2017-06-16
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Eric Faldt , Klaus Gebauer
CPC classification number: A61M39/105 , A61M39/16 , A61M39/18 , F16L39/00 , F16L2201/44
Abstract: The invention relates to a An aseptic connector comprising a first connection unit (102; 202; 302; 402; 502) provided with a first terminal end surface (104; 204; 304; 404; 504) and a second connection unit (106; 206; 306; 406; 506) provided with a second terminal end surface (108; 208; 308; 408; 508); said first and second terminal end surfaces are each provided with at least one first and second opening (110, 112; 210, 212; 310, 312; 410, 412; 510, 512), which openings are orientated to substantially coincide when said first and second connection units are connected to each other; said first and second openings are sealed by at least one film (114; 214; 314; 414; 514) arranged on said first and second connection units, so that the contact between the film and each connection unit is aseptic; said at least one film is adapted to be mated with a corresponding film on the other connection unit when said first and second connection units are connected to each other; and said mated films are adapted to be pulled out together two and two after mating such that corresponding first and second openings in said first and second terminal end surfaces are mated aseptically. At least two first ports (116; 216; 316; 416; 516) are arranged on the first connection unit, which first ports have fluid connection with the at least one first opening (110; 210; 310; 410; 510) in the first terminal end surface; and in that at least one second port (118; 218; 318; 418; 518) is arranged on the second connection unit, which the at least one second port has a fluid connection with the at least one second opening (112; 212; 312; 412; 512) in the second terminal end surface.
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22.发明授权Systems and methods for status indication in a single-use biomedical and bioprocess system 有权一次性生物医学和生物过程系统中状态指示的系统和方法公开(公告)号：US09571904B2
公开(公告)日：2017-02-14
申请号：US14086117
申请日：2013-11-21
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Radislav A. Potyrailo , Klaus Gebauer , Kajsa Stridsberg-Friden , Timothy A. Wortley
IPC: H04Q9/00 , A61L2/24 , G01N27/327
CPC classification number: G08B21/18 , A61L2/24 , C12M41/48 , G01N27/3272 , G06K19/0702 , G06K19/0707 , G06K19/07745 , H04Q9/00 , H04Q2209/30 , H04Q2209/47
Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioproces sing platform including the component.
Abstract translation: 公开和描述了在生物处理环境中监测组件状态的方法，系统和装置。 某些实例提供了用于一次性生物处理组件的传感器装置。 示例性传感器设备包括附接到部件的第一部分，第一部分被配置为提供与部件相关联的标识符。 示例性传感器设备还包括被配置为基于组件的状态提供状态指示的第二部分。 示例性传感器设备被配置为将标识符和状态指示发送到与包括该组件的生物处理平台相关联的控制计算机。
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公开(公告)号：US20160235962A1
公开(公告)日：2016-08-18
申请号：US15032249
申请日：2014-11-05
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Klaus Gebauer
CPC classification number: A61M39/1055 , A61M39/10 , A61M39/16 , A61M39/165 , A61M39/18 , A61M2039/1027 , C12M37/04 , F16L2201/44
Abstract: The invention discloses a connector (1) for substantially aseptic connection of tubing, comprising: a) a central tubular stem member (2) with a line connection end (3) and a coupling end (5) having an annular gasket (6) arranged to engage a similar annular gasket (26) on a similar second connector (21) in sealing abutment and; b) a tubular socket member (7), concentrically arranged outside the stem member, having a flange (8) concentrically arranged outside the coupling end and comprising a cover film (9) releasably bonded to the flange and covering the coupling end of the stem member, the annular gasket and at least a portion of the flange; wherein the socket member is rotatable around the stem member and wherein the connector further comprises an annular seal member (10) in sealing abutment between an inside (11) of the socket member and an outside (12) of the stem member.
Abstract translation: 本发明公开了一种用于管道的基本上无菌连接的连接器（1），包括：a）具有线连接端（3）的中心管状杆件（2）和具有环形垫圈（6）的联接端部（5） 以在类似的第二连接器（21）上接合类似的环形垫圈（26），以密封抵接; b）同轴地布置在杆构件外部的管状插座构件（7），其具有同心地布置在联接端的外部的凸缘（8），并且包括可剥离地接合到凸缘并覆盖杆的联接端的覆盖膜 构件，环形垫圈和凸缘的至少一部分; 其中所述插座构件可围绕所述杆构件旋转，并且其中所述连接器还包括密封邻接所述插座构件的内部（11）和所述杆构件的外部（12）之间的环形密封构件（10）。
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公开(公告)号：US20150041009A1
公开(公告)日：2015-02-12
申请号：US14385516
申请日：2013-03-28
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Klaus Gebauer , Ekta Mahajan , Eric Faldt
IPC: F16K11/10
CPC classification number: F16K11/10 , A61M5/1408 , A61M2039/242 , B01D15/14 , F16K15/144 , F16K15/145 , F16K15/148 , F16K27/0209 , Y10T137/7838 , Y10T137/789 , Y10T137/87684 , G01N2030/328 , G01N2030/6056
Abstract: The present invention relates to a device (1) for delivery of fluid, said device comprising at least two fluid ducts (12-17) of flexible material, each of which in one end can be connected to a fluid source and in the opposite end is connected to a manifold (18) having an inlet end and an outlet end, each of said fluid ducts (12-17) comprising a pinch valve (19) for closing and opening the duct. According to the invention a check valve (20) is disposed in at least one of said fluid ducts (12-17) in the end thereof connected to the manifold (18).
Abstract translation: 本发明涉及一种用于输送流体的装置（1），所述装置包括至少两个柔性材料的流体管道（12-17），每个流体管道的一端可以连接到流体源并且在相对端 连接到具有入口端和出口端的歧管（18），每个所述流体管道（12-17）包括用于关闭和打开管道的夹紧阀（19）。 根据本发明，止回阀（20）设置在连接到歧管（18）的端部中的至少一个所述流体管道（12-17）中。
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公开(公告)号：US11846635B2
公开(公告)日：2023-12-19
申请号：US16470677
申请日：2017-12-21
Applicant: GE Healthcare Bio-Sciences AB
Inventor： Ola Lind , Klaus Gebauer , Eric Faldt , Nils Norrman , Ronnie Palmgren , Jesper Hedberg , Niklas Jungnelius , Karl Liderfelt , Anita Solbrand
IPC: G01N33/543 , C12M3/00 , C12M3/06 , C12M1/00 , C12M1/34 , C12N13/00 , B03C5/00 , B03C5/02 , B01D21/00 , B03C1/30 , B03C1/01 , B03C1/28
CPC classification number: G01N33/54326 , B01D21/0009 , B03C1/30 , B03C5/00 , B03C5/02 , C12M23/48 , C12M27/16 , C12M29/00 , C12M41/44 , C12M45/07 , C12M47/04 , C12M47/10 , C12N13/00 , G01N33/5436 , B03C1/01 , B03C1/288 , B03C2201/26 , G01N2333/31
Abstract: The invention discloses an immunoglobulin-binding magnetic bead, comprising a porous matrix and one or more magnetic particles embedded in said matrix, wherein said matrix comprises a porous polymer and at least 10 mg/ml Fc-binding proteinaceous ligands covalently coupled to said porous polymer.
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Patent Agency Ranking
公开(公告)号：US20200087605A1
公开(公告)日：2020-03-19
申请号：US16586272
申请日：2019-09-27
Applicant: GE Healthcare Bio-Sciences AB
Inventor： Klaus Gebauer , Andreas Castan , Camilla Estmer-Nilsson , Thomas Falkman , Anders Wilen , Michael Miller , Ralph Stankowski
Abstract: The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.
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公开(公告)号：US10451591B1
公开(公告)日：2019-10-22
申请号：US15188102
申请日：2016-06-21
Applicant: GE Healthcare Bio-Sciences AB
Inventor： Klaus Gebauer , Stefan Sjolander , Andreas Torbjorn Lundin
Abstract: The invention relates to valve system for controlling a process fluid within a liquid processing system. The valve system comprises a valve arrangement, a pneumatic or hydraulic control system, and a connector unit. When the valve arrangement is connected to the connector unit, two or more valves are formed, such that the pneumatic or hydraulic control system controls an open/close or pressure control mode of the valves. A pump diaphragm system is disclosed, as well as a system for purifying a biological material that comprises the valve system or the pump diaphragm system. Also discloses are methods of using the valve system or the pump diaphragm system in a process for the purification of a biological material.
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公开(公告)号：US10183236B2
公开(公告)日：2019-01-22
申请号：US15010565
申请日：2016-01-29
Applicant: GE Healthcare Bio-Sciences AB
Inventor： Klaus Gebauer
Abstract: A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the center of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs. The desired local effective channel height varies in accordance with a predetermined formula from the first radial position to the outer radial position. The transverse cross-sectional areas of the ribs or the channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between the first radial position and the outer radial position. The length of the portions correspond to at least 80% of the distance between the first and outer radial position and the outer radial position.
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公开(公告)号：US20190015799A1
公开(公告)日：2019-01-17
申请号：US16066209
申请日：2017-01-04
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Klaus Gebauer , Peter Toreheim , Patrik Akerstrom , Patrick Jonsson
Abstract: A rigid housing comprising a bottom part and at least one wall part, said bottom part and said at least one wall part together defining an internal volume when the bottom part is provided below the at least one wall part in a processing position, said rigid housing being arranged for holding a flexible bag within the internal volume, wherein the bottom part is rotatable about an axis of rotation, wherein said axis of rotation is substantially parallel to a longitudinal axis of said rigid housing such that the bottom part can be provided in a loading position in which the bottom part has been rotated out from the position below the at least one wall part.
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公开(公告)号：US10094481B2
公开(公告)日：2018-10-09
申请号：US14385516
申请日：2013-03-28
Applicant: GE HEALTHCARE BIO-SCIENCES AB
Inventor： Klaus Gebauer , Ekta Mahajan , Eric Faldt
Abstract: The present invention relates to a device (1) for delivery of fluid, said device comprising at least two fluid ducts (12-17) of flexible material, each of which in one end can be connected to a fluid source and in the opposite end is connected to a manifold (18) having an inlet end and an outlet end, each of said fluid ducts (12-17) comprising a pinch valve (19) for closing and opening the duct. According to the invention a check valve (20) is disposed in at least one of said fluid ducts (12-17) in the end thereof connected to the manifold (18).
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