公开(公告)号：US10710986B2

公开(公告)日：2020-07-14

申请号：US16274106

申请日：2019-02-12

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D403/14 ,  A61P31/20 ,  A61P35/02 ,  A61K31/496 ,  C07D519/00 ,  C07D241/20 ,  C07D487/10 ,  C07D405/14 ,  C07D487/08 ,  A61K31/497 ,  C07D491/107 ,  C07D241/18 ,  A61P35/00 ,  C07K16/28

Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US20180327437A1

公开(公告)日：2018-11-15

申请号：US16011055

申请日：2018-06-18

Applicant: GILEAD SCIENCES, INC.

Inventor： Thomas Butler ,  Aesop Cho ,  Benjamin R. Graetz ,  Choung U. Kim ,  Samuel E. Metobo ,  Oliver L. Saunders ,  Andrew W. Waltman ,  Jie Xu ,  Lijun Zhang

IPC: C07H1/00 ,  C07H19/23

CPC classification number: C07H1/00 ,  A61K31/7052 ,  A61K31/7056 ,  A61K31/706 ,  C07H19/23

Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.

公开(公告)号：US11932634B2

公开(公告)日：2024-03-19

申请号：US17845469

申请日：2022-06-21

Applicant: Gilead Sciences, Inc.

Inventor： Michael Graupe ,  Juan A. Guerrero ,  Stephen D. Holmbo ,  Jesse M. Jacobsen ,  Tetsuya Kobayashi ,  Leena B. Patel ,  Heath A. Weaver ,  Jie Xu ,  Suet C. Yeung

IPC: C07D413/14 ,  C07D239/95 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/04 ,  C07D417/12 ,  C07D471/04

CPC classification number: C07D413/14 ,  C07D239/95 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/04 ,  C07D417/12 ,  C07D471/04 ,  C07B2200/05

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

公开(公告)号：US20230060004A1

公开(公告)日：2023-02-23

申请号：US17845469

申请日：2022-06-21

Applicant: Gilead Sciences, Inc.

Inventor： Michael Graupe ,  Juan A. Guerrero ,  Stephen D. Holmbo ,  Jesse M. Jacobsen ,  Tetsuya Kobayashi ,  Leena B. Patel ,  Heath A. Weaver ,  Jie Xu ,  Suet C. Yeung

IPC: C07D413/14 ,  C07D239/95 ,  C07D401/12 ,  C07D417/12 ,  C07D403/12 ,  C07D401/04 ,  C07D471/04 ,  C07D413/04 ,  C07D401/14

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

公开(公告)号：US11555029B2

公开(公告)日：2023-01-17

申请号：US16891880

申请日：2020-06-03

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D403/14 ,  A61P31/20 ,  A61P35/02 ,  A61K31/496 ,  C07D519/00 ,  C07D241/20 ,  C07D487/10 ,  C07D405/14 ,  C07D487/08 ,  A61K31/497 ,  C07D491/107 ,  C07D241/18 ,  A61P35/00 ,  C07K16/28

Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US20210078959A1

公开(公告)日：2021-03-18

申请号：US16925096

申请日：2020-07-09

Applicant: Gilead Sciences, Inc.

Inventor： Zhenhong R. Cai ,  Aesop Cho ,  Ana Zurisadai Gonzalez Buenrostro ,  Xiaochun Han ,  Salman Y. Jabri ,  Ryan McFadden ,  Yingmei Qi ,  Johannes Voigt ,  Jie Xu ,  Lianhong Xu ,  Hong Yang

IPC: C07D247/00 ,  A61P31/18 ,  C07D401/10 ,  C07D403/14 ,  C07D233/88 ,  C07D487/04 ,  C07D417/10 ,  C07D471/04 ,  C07D417/14 ,  C07D491/107 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D403/10 ,  C07D413/10

Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

公开(公告)号：US20210053946A1

公开(公告)日：2021-02-25

申请号：US16891880

申请日：2020-06-03

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D403/14 ,  A61P31/20 ,  A61P35/02 ,  A61K31/496 ,  C07D519/00 ,  C07D241/20 ,  C07D487/10 ,  C07D405/14 ,  C07D487/08 ,  A61K31/497 ,  C07D491/107 ,  C07D241/18 ,  A61P35/00

Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US10899735B2

公开(公告)日：2021-01-26

申请号：US16388517

申请日：2019-04-18

Applicant: Gilead Sciences, Inc

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D401/10 ,  A61K31/444 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D487/10 ,  C07D519/00 ,  C07K16/28

Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US10774053B2

公开(公告)日：2020-09-15

申请号：US16158446

申请日：2018-10-12

Applicant: Gilead Sciences, Inc.

Inventor： Zhenhong R. Cai ,  Aesop Cho ,  Ana Zurisadai Gonzalez Buenrostro ,  Xiaochun Han ,  Salman Y. Jabri ,  Ryan McFadden ,  Yingmei Qi ,  Johannes Voigt ,  Hong Yang ,  Jie Xu ,  Lianhong Xu

IPC: A61K31/497 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/4196 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/422 ,  C07D247/00 ,  A61P31/18 ,  C07D401/10 ,  C07D403/14 ,  C07D233/88 ,  C07D487/04 ,  C07D417/10 ,  C07D471/04 ,  C07D417/14 ,  C07D491/107 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D403/10 ,  C07D413/10 ,  A61K45/06

Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

公开(公告)号：US20250042922A1

公开(公告)日：2025-02-06

申请号：US18756455

申请日：2024-06-27

Applicant: Gilead Sciences, Inc.

Inventor： Chaodi Dai ,  Julie Farand ,  Juan A. Guerrero ,  Tezcan Guney ,  Hongyan Guo ,  Jason R. Hudlicky ,  Darryl Kato ,  Irene N. Kiburu ,  Scott E. Lazerwith ,  Paulo A. Machicao Tello ,  James B.C. Mack ,  Erik P. McAuley ,  Jessica L. McKinley ,  Jonathan William Medley ,  Hyung-Jung Pyun ,  Thomas P. Stratton ,  Maoqun Tian ,  Jeremy R. Tuck ,  William J. Watkins ,  Jie Xu ,  Jennifer R. Zhang

IPC: C07D519/00 ,  A61K31/55 ,  C07D471/22

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.