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公开(公告)号:US20080090846A1
公开(公告)日:2008-04-17
申请号:US11956190
申请日:2007-12-13
申请人: Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Rosaria Di Fluri
发明人: Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Rosaria Di Fluri
IPC分类号: A61K31/436 , A61K31/47 , A61K31/506 , C07D215/38 , C07D401/14 , C07D491/052
CPC分类号: C07D213/38 , C07D213/65 , C07D213/81 , C07D215/40 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04
摘要: Tertiary amines containing a multiplicity of heteroaromatic substituents are useful as chemokine receptor modulators.
摘要翻译: 含有多个杂芳族取代基的叔胺可用作趋化因子受体调节剂。
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公开(公告)号:US07491735B2
公开(公告)日:2009-02-17
申请号:US11012002
申请日:2004-12-13
申请人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
发明人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
IPC分类号: A61K31/4468
CPC分类号: C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号:US20060100240A1
公开(公告)日:2006-05-11
申请号:US11301725
申请日:2005-12-13
申请人: Gary Bridger , Ai Kaller , Curtis Harwig , Renato Skerlj , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Maria Di Fluri
发明人: Gary Bridger , Ai Kaller , Curtis Harwig , Renato Skerlj , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Maria Di Fluri
IPC分类号: A61K31/4709 , C07D403/02 , C07D403/14
CPC分类号: C07D401/14 , C07D235/14 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04
摘要: The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号:US07790747B2
公开(公告)日:2010-09-07
申请号:US11453221
申请日:2006-06-14
申请人: Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
发明人: Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
IPC分类号: A61K31/4545 , C07D409/14
CPC分类号: C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译: 本发明涉及趋化因子受体结合化合物,药物组合物及其用途。 更具体地,本发明涉及趋化因子受体活性的调节剂,优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒(HIV)感染靶细胞的保护作用。
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公开(公告)号:US20090099205A1
公开(公告)日:2009-04-16
申请号:US11453221
申请日:2006-06-14
申请人: Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
发明人: Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
IPC分类号: A61K31/506 , C07D403/12 , A61K31/4545 , C07D409/14 , C12N5/06
CPC分类号: C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号:US07498346B2
公开(公告)日:2009-03-03
申请号:US11152589
申请日:2005-06-14
申请人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
发明人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
IPC分类号: A61K31/4453 , C07D211/58
CPC分类号: C07D417/14 , C07D401/12 , C07D401/14 , C07D413/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译: 本发明涉及趋化因子受体结合化合物,药物组合物及其用途。 更具体地,本发明涉及趋化因子受体活性的调节剂,优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒(HIV)感染靶细胞的保护作用。
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公开(公告)号:US20050277670A1
公开(公告)日:2005-12-15
申请号:US11012002
申请日:2004-12-13
申请人: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
发明人: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
IPC分类号: A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C12N20060101 , C07D43/02
CPC分类号: C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号:US09718854B2
公开(公告)日:2017-08-01
申请号:US14008388
申请日:2012-03-20
申请人: Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
发明人: Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
IPC分类号: C07H19/24 , C07D513/04 , A61K31/429 , C12N9/99 , C12Q1/34 , C07H9/06 , C07H11/00 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/203 , C07H15/207 , C07H17/02 , C07H17/04 , A61K31/7056
CPC分类号: C07H19/24 , A61K31/7056 , C07D513/04 , C07H9/06 , C07H11/00 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/203 , C07H15/207 , C07H17/02 , C07H17/04 , C12N9/99 , C12Q1/34 , C12Y302/01169
摘要: The invention provides compounds of formula (I) with substituents as specified in claim 1 for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to over-expression of O-GlcNAcase or accumulation of O-GlcNac.
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公开(公告)号:US20140296205A1
公开(公告)日:2014-10-02
申请号:US14129177
申请日:2012-06-27
申请人: Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
发明人: Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
IPC分类号: C07D513/04 , G01N33/50 , C12Q1/34
CPC分类号: C07D513/04 , C07H9/06 , C12Q1/34 , C12Q1/37 , G01N33/5038 , G01N2333/924 , G01N2500/04
摘要: The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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公开(公告)号:US09120781B2
公开(公告)日:2015-09-01
申请号:US13697179
申请日:2011-05-10
申请人: Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
发明人: Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
IPC分类号: C07D263/56 , C07D263/58 , C07D277/82 , C07D413/04 , C07D417/04 , C07D277/64 , C07D263/52 , C07D277/60
CPC分类号: C07D417/04 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D277/64 , C07D277/82 , C07D413/04
摘要: The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
摘要翻译: 本发明提供了用于选择性抑制糖苷酶的化合物(I)的化合物,以及化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法,O-GlcNAc的积累或缺乏。
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