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    Method and apparatus for calibrating a particle emissions monitor
    22.
    发明授权
    Method and apparatus for calibrating a particle emissions monitor 失效
    用于校准颗粒物排放监测器的方法和装置

    公开(公告)号：US5777734A

    公开(公告)日：1998-07-07

    申请号：US585341

    申请日：1996-01-11

    申请人： William L. Flower ,  Ronald F. Renzi

    发明人： William L. Flower ,  Ronald F. Renzi

    IPC分类号： G01N15/10 ,  G01N21/73 ,  G01N21/00

    CPC分类号： G01N21/73 ,  G01N15/1012 ,  G01N21/85

    摘要： The instant invention discloses method and apparatus for calibrating particulate emissions monitors, in particular, and sampling probes, in general, without removing the instrument from the system being monitored. A source of one or more specific metals in aerosol (either solid or liquid) or vapor form is housed in the instrument. The calibration operation is initiated by moving a focusing lens, used to focus a light beam onto an analysis location and collect the output light response, from an operating position to a calibration position such that the focal point of the focusing lens is now within a calibration stream issuing from a calibration source. The output light response from the calibration stream can be compared to that derived from an analysis location in the operating position to more accurately monitor emissions within the emissions flow stream.

    摘要翻译： 本发明公开了一种用于校准颗粒物排放监测器，特别是采样探头的方法和装置，一般而言，不将仪器从被监测的系统中移除。 气溶胶（固体或液体）或蒸汽形式的一种或多种特定金属的来源被容纳在仪器中。 通过移动用于将光束聚焦到分析位置并且将输出光响应从操作位置收集到校准位置的聚焦透镜开始，使得聚焦透镜的焦点现在处于校准 流从校准源发出。 来自校准流的输出光响应可以与从操作位置的分析位置得到的输出光响应进行比较，以更准确地监测排放流内的排放。

    Ion chamber based neutron detectors
    23.
    发明授权
    Ion chamber based neutron detectors 有权
    基于离子室的中子探测器

    公开(公告)号：US08912502B2

    公开(公告)日：2014-12-16

    申请号：US13559370

    申请日：2012-07-26

    申请人： Mark S. Derzon ,  Paul C. Galambos ,  Ronald F. Renzi

    发明人： Mark S. Derzon ,  Paul C. Galambos ,  Ronald F. Renzi

    IPC分类号： G01T3/00 ,  H01J47/02

    CPC分类号： G01T3/008 ,  G01T3/00 ,  H01J47/02

    摘要： A neutron detector with monolithically integrated readout circuitry, including: a bonded semiconductor die; an ion chamber formed in the bonded semiconductor die; a first electrode and a second electrode formed in the ion chamber; a neutron absorbing material filling the ion chamber; and the readout circuitry which is electrically coupled to the first and second electrodes. The bonded semiconductor die includes an etched semiconductor substrate bonded to an active semiconductor substrate. The readout circuitry is formed in a portion of the active semiconductor substrate. The ion chamber has a substantially planar first surface on which the first electrode is formed and a substantially planar second surface, parallel to the first surface, on which the second electrode is formed. The distance between the first electrode and the second electrode may be equal to or less than the 50% attenuation length for neutrons in the neutron absorbing material filling the ion chamber.

    摘要翻译： 一种具有单片集成读出电路的中子检测器，包括：键合半导体管芯; 形成在所述键合半导体管芯中的离子室; 形成在所述离子室中的第一电极和第二电极; 填充离子室的中子吸收材料; 以及电耦合到第一和第二电极的读出电路。 键合的半导体管芯包括结合到有源半导体衬底的蚀刻半导体衬底。 读出电路形成在有源半导体衬底的一部分中。 离子室具有基本上平面的第一表面，第一电极形成在其上，并且平行于第一表面的基本平坦的第二表面，在其上形成第二电极。 第一电极和第二电极之间的距离可以等于或小于填充离子室的中子吸收材料中的中子的50％衰减长度。

    Multidimensional bioseparation with modular microfluidics
    24.
    发明授权
    Multidimensional bioseparation with modular microfluidics 有权
    具有模块化微流体的多维生物分离

    公开(公告)号：US08518346B1

    公开(公告)日：2013-08-27

    申请号：US12157601

    申请日：2008-06-11

    申请人： Gabriela S. Chirica ,  Ronald F. Renzi

    发明人： Gabriela S. Chirica ,  Ronald F. Renzi

    IPC分类号： B01L3/02

    CPC分类号： B01J19/0093 ,  B01J2219/0081 ,  B01L3/502715 ,  B01L3/563 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/028 ,  Y10T436/25375

    摘要： A multidimensional chemical separation and analysis system is described including a prototyping platform and modular microfluidic components capable of rapid and convenient assembly, alteration and disassembly of numerous candidate separation systems. Partial or total computer control of the separation system is possible. Single or multiple alternative processing trains can be tested, optimized and/or run in parallel. Examples related to the separation and analysis of human bodily fluids are given.

    摘要翻译： 描述了一个多维化学分离和分析系统，包括原型平台和模块化微流体部件，能够快速方便地组装，更改和拆卸许多候选分离系统。 分离系统的部分或全部计算机控制是可能的。 可以对单个或多个替代的处理列进行测试，优化和/或并行运行。 给出与人体液分离和分析有关的实例。

    Micromanifold assembly
    26.
    发明授权
    Micromanifold assembly 有权
    Micromanifold组装

    公开(公告)号：US07553455B1

    公开(公告)日：2009-06-30

    申请号：US10405842

    申请日：2003-04-02

    申请人： Ronald F. Renzi ,  Scott Ferko

    发明人： Ronald F. Renzi ,  Scott Ferko

    IPC分类号： B01L11/00

    CPC分类号： B01L3/502715 ,  B01L3/565 ,  B01L9/527 ,  B01L2200/027 ,  G01N30/6026 ,  G01N30/6095

    摘要： A micromanifold for connecting external capillaries to the inlet and/or outlet ports of a microfluidic device can employ a ferrule/capillary assembly that includes: (a) a ferrule comprising an elongated member and having a bore traversing from a proximal end to a distal end of the member, wherein the bore has an inner surface and wherein the distal end of the ferrule has a tapered, threaded exterior surface, and (b) a capillary that is positioned within the bore wherein the capillary's outer surface is in direct contact with the bore's inner surface. No mating sleeve is required for the one-piece ferrule. Alternatively, the capillaries can be bonded to channels that traverse the manifold and therefore obviate the need for a ferrule.

    摘要翻译： 用于将外部毛细管连接到微流体装置的入口和/或出口的微型歧管可以采用套圈/毛细管组件，其包括：（a）套圈，其包括细长构件，并且具有从近端到远端的孔 ，其中所述孔具有内表面，并且其中所述套圈的远端具有锥形的带螺纹的外表面，以及（b）位于所述孔内的毛细管，其中所述毛细管的外表面与所述毛细管的外表面直接接触 孔的内表面。 单件套圈不需要配套套管。 或者，毛细管可以结合到穿过歧管的通道，因此避免了对套圈的需要。

    Edge compression manifold apparatus
    28.
    发明授权
    Edge compression manifold apparatus 有权
    边缘压缩歧管装置

    公开(公告)号：US07182371B1

    公开(公告)日：2007-02-27

    申请号：US10999828

    申请日：2004-11-30

    申请人： Ronald F. Renzi

    发明人： Ronald F. Renzi

    IPC分类号： F16L39/00

    CPC分类号： F16L41/03 ,  B01J2219/0081 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0689

    摘要： A manifold for connecting external capillaries to the inlet and/or outlet ports of a microfluidic device for high pressure applications is provided. The fluid connector for coupling at least one fluid conduit to a corresponding port of a substrate that includes: (i) a manifold comprising one or more channels extending therethrough wherein each channel is at least partially threaded, (ii) one or more threaded ferrules each defining a bore extending therethrough with each ferrule supporting a fluid conduit wherein each ferrule is threaded into a channel of the manifold, (iii) a substrate having one or more ports on its upper surface wherein the substrate is positioned below the manifold so that the one or more ports is aligned with the one or more channels of the manifold, and (iv) device to apply an axial compressive force to the substrate to couple the one or more ports of the substrate to a corresponding proximal end of a fluid conduit.

    摘要翻译： 提供了用于将外部毛细管连接到用于高压应用的微流体装置的入口和/或出口端口的歧管。 用于将至少一个流体导管联接到基板的对应端口的流体连接器，其包括：（i）包括一个或多个延伸穿过其中的通道的歧管，其中每个通道至少部分地具有螺纹，（ii）一个或多个螺纹套圈 限定一个延伸穿过其中的孔，其中每个套圈支撑流体导管，其中每个套圈拧入歧管的通道中，（iii）在其上表面上具有一个或多个端口的衬底，其中衬底位于歧管下方， 或更多的端口与歧管的一个或多个通道对准，以及（iv）向衬底施加轴向压缩力以将衬底的一个或多个端口耦合到流体导管的相应近端的装置。

    Microvalve
    29.
    发明授权
    Microvalve 有权
    微型阀门

    公开(公告)号：US06918573B1

    公开(公告)日：2005-07-19

    申请号：US10351714

    申请日：2003-01-27

    申请人： Ronald F. Renzi

    发明人： Ronald F. Renzi

    IPC分类号： B01L3/00 ,  F15C5/00 ,  F16K3/08 ,  F16K99/00 ,  F16K5/00

    CPC分类号： F16K3/085 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/563 ,  B01L3/567 ,  B01L2200/027 ,  F16K99/0001 ,  F16K99/0017 ,  F16K2099/0076

    摘要： A high pressure microvalve for connecting a first fluid-bearing conduit to a second fluid-bearing conduit is provided. The microvalve includes (a) a first body having a first interior surface and at least one port outlet at the first interior surface that is in fluid communication with at least one first channel wherein each port outlet is surrounded by a first seal with an upper surface that is at a level above that of the first interior surface (b) a second body having a second interior surface and at least one port inlet at the second interior surface that is in fluid communication with at least one second channel, and wherein each port inlet is surrounded by a second seal with an upper surface that is at a level above that of the second interior surface, wherein the first interior surface is substantially planar and is slidably secured to the second interior surface which is also substantially planar, and (c) means for aligning a port outlet in the first body to a port inlet in the second body to permit fluid flow and/or control from a first channel into a second channel.

    摘要翻译： 提供了用于将第一流体承载导管连接到第二流体承载导管的高压微型阀。 微型阀包括（a）具有第一内表面的第一主体和在第一内表面处与至少一个第一通道流体连通的至少一个端口出口，其中每个端口出口被第一密封件包围，上表面 其高度高于第一内表面（b）的水平，第二主体具有第二内表面和在第二内表面处与至少一个第二通道流体连通的至少一个端口入口，并且其中每个端口 进口被第二密封件包围，上表面的高度高于第二内表面的上表面，其中第一内表面基本上是平面的并且可滑动地固定到也基本上平面的第二内表面，（c ）用于将第一主体中的出口与第二主体中的端口入口对准，以允许流体流动和/或从第一通道进入第二通道。

    Edge compression manifold apparatus
    30.
    发明授权
    Edge compression manifold apparatus 有权
    边缘压缩歧管装置

    公开(公告)号：US06832787B1

    公开(公告)日：2004-12-21

    申请号：US10350628

    申请日：2003-01-24

    申请人： Ronald F. Renzi

    发明人： Ronald F. Renzi

    IPC分类号： F16L3900

    CPC分类号： F16L41/03 ,  B01J2219/0081 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0689

    摘要： A manifold for connecting external capillaries to the inlet and/or outlet ports of a microfluidic device for high pressure applications is provided. The fluid connector for coupling at least one fluid conduit to a corresponding port of a substrate that includes: (i) a manifold comprising one or more channels extending therethrough wherein each channel is at least partially threaded, (ii) one or more threaded ferrules each defining a bore extending therethrough with each ferrule supporting a fluid conduit wherein each ferrule is threaded into a channel of the manifold, (iii) a substrate having one or more ports on its upper surface wherein the substrate is positioned below the manifold so that the one or more ports is aligned with the one or more channels of the manifold, and (iv) device to apply an axial compressive force to the substrate to couple the one or more ports of the substrate to a corresponding proximal end of a fluid conduit.

    摘要翻译： 提供了用于将外部毛细管连接到用于高压应用的微流体装置的入口和/或出口端口的歧管。 用于将至少一个流体导管联接到基板的对应端口的流体连接器，其包括：（i）包括一个或多个延伸穿过其中的通道的歧管，其中每个通道至少部分地具有螺纹，（ii）一个或多个螺纹套圈 限定一个延伸穿过其中的孔，其中每个套圈支撑流体导管，其中每个套圈拧入歧管的通道中，（iii）在其上表面上具有一个或多个端口的衬底，其中衬底位于歧管下方， 或更多的端口与歧管的一个或多个通道对准，以及（iv）向衬底施加轴向压缩力以将衬底的一个或多个端口耦合到流体导管的相应近端的装置。