Staple type oligonucleotide and drug comprising the same
    22.
    发明申请
    Staple type oligonucleotide and drug comprising the same 有权
    短链型寡核苷酸和包含其的药物

    公开(公告)号:US20060276421A1

    公开(公告)日:2006-12-07

    申请号:US10568226

    申请日:2004-09-29

    IPC分类号: A61K48/00 C07H21/02

    摘要: Conventional oligonucleotides are opened at both ends and thereby unstable. The stability of them against catabolic enzymes is increased by phosphorothioate modification, but such phosphorothioate causes toxicity. The present invention provides oligonucleotides and medicaments in which these problems are improved. That is, it provides a staple oligonucleotides and medicaments containing the same as the active ingredient. Specifically, it provides transcription factor inhibitors, antisense oligonucleotides and siRNAs. More specifically, it provides agents for preventing, treating or improving inflammation, autoimmune diseases, central diseases, reperfusion injury in ischaemic diseases, worsened prognosis after organ transplantation or organ surgery, or restenosis after PTCA. Further specifically, it provides agents for preventing, treating or improving arthritis, dermatitis, nephritis, hepatitis, renal failure, cystitis, prostatitis, urethritis, ulcerative colitis, Crohn disease, chronic rheumatoid arthritis, osteoarthritis, atopic dermatitis, contact dermatitis, psoriasis, cutaneous ulcer or decubitus.

    摘要翻译: 常规寡核苷酸在两端开放,从而不稳定。 它们对分解代谢酶的稳定性被硫代磷酸酯修饰增加,但是这种硫代磷酸酯引起毒性。 本发明提供了改善这些问题的寡核苷酸和药物。 也就是说,它提供了含有与活性成分相同的主要寡核苷酸和药物。 具体来说,它提供转录因子抑制剂,反义寡核苷酸和siRNA。 更具体地说,它提供用于预防,治疗或改善炎症,自身免疫性疾病,中枢性疾病,缺血性疾病中的再灌注损伤,器官移植或器官手术后的预后恶化或PTCA后的再狭窄的药剂。 更具体地说,它提供预防,治疗或改善关节炎,皮炎,肾炎,肝炎,肾衰竭,膀胱炎,前列腺炎,尿道炎,溃疡性结肠炎,克罗恩病,慢性类风湿性关节炎,骨关节炎,特应性皮炎,接触性皮炎,牛皮癣,皮肤 溃疡或褥疮。

    Method for manufacture of multilayer ceramic substrate and multilayer ceramic substrate
    24.
    发明申请
    Method for manufacture of multilayer ceramic substrate and multilayer ceramic substrate 失效
    多层陶瓷基板和多层陶瓷基板的制造方法

    公开(公告)号:US20050219774A1

    公开(公告)日:2005-10-06

    申请号:US11082970

    申请日:2005-03-18

    摘要: A method for manufacturing a multilayer ceramic substrate including the steps of providing multilayers of ceramic green sheets each having an electrode layer formed on a dielectric layer such that, after firing, at least one electrode layer which is separated by the dielectric layer from the adjacent electrode layer in the substrate has an overlapping area of 0.4 mm2 or smaller with the adjacent electrode; and firing the multilayers of the ceramic green sheets at a selected temperature such that, after firing, an interface between the dielectric layer and the electrode layer in the substrate has irregularities with a roughness Rmax of 6 μm or less per 100 μm standard length and the dielectric layer has a saturation sintered density.

    摘要翻译: 一种制造多层陶瓷基板的方法,包括以下步骤:提供陶瓷生片的多层,每层陶瓷生片均具有在电介质层上形成的电极层,使得在烧制之后,至少一个由电介质层与相邻电极隔开的电极层 衬底中的层与相邻电极具有0.4mm 2或更小的重叠面积; 并且在选定的温度下烧制陶瓷生片的多层,使得在烧结之后,介电层和基板中的电极层之间的界面具有不规则性,每100mum标准长度的粗糙度Rmax为6μm或更小,并且 电介质层具有饱和烧结密度。

    Ultrasonic diagnosis apparatus and method for constructing distribution image of blood flow dynamic state
    25.
    发明授权
    Ultrasonic diagnosis apparatus and method for constructing distribution image of blood flow dynamic state 有权
    用于构建血流动态分布图的超声诊断装置及方法

    公开(公告)号:US08971600B2

    公开(公告)日:2015-03-03

    申请号:US13263184

    申请日:2010-04-07

    摘要: An ultrasonic diagnostic apparatus is provided for displaying a color map on which a difference in blood flow dynamics is reflected. Setting a test subject who is administered a contrast agent is assumed as an imaging target, and a probe transmits and receives ultrasonic waves to and from the target for contrast imaging. Image data is constructed based on signals received by the probe and a time-intensity curve is generated from intensity values of the image data. According to the time-intensity curve, a value of a predetermined parameter is calculated for producing a distribution image of blood flow dynamics. The distribution image (color map) of the blood flow dynamics is produced from the parameter value. The color map is a two-dimensional or a three-dimensional image being color-coded according to the parameter value. At least one of the followings may be used as the parameter; a contrast agent inflow start time, a balanced intensity arrival time, a contrast agent disappearance start time, a contrast agent duration, a preset threshold arrival time, an intensity increase rate, an intensity decrease rate, intensity of balanced state, and a total flow amount.

    摘要翻译: 提供超声波诊断装置,用于显示反映血流动力学差异的色图。 设置施用造影剂的测试对象被认为是成像对象,并且探针向对象成像的目标发送和接收超声波。 图像数据是基于由探头接收的信号构成的,并且由图像数据的强度值产生时间 - 强度曲线。 根据时间 - 强度曲线,计算用于产生血流动力学分布图像的预定参数的值。 从参数值产生血流动力学的分布图像(颜色图)。 彩色图是根据参数值进行颜色编码的二维或三维图像。 可以使用以下中的至少一个作为参数; 造影剂流入开始时间,平衡强度到达时间,造影剂消失开始时间,造影剂持续时间,预设阈值到达时间,强度增加率,强度降低率,平衡状态强度和总流量 量。

    Ultrasonic imaging apparatus
    26.
    发明授权
    Ultrasonic imaging apparatus 有权
    超声波成像装置

    公开(公告)号:US08861812B2

    公开(公告)日:2014-10-14

    申请号:US12866712

    申请日:2009-02-17

    摘要: Provided is an ultrasonic imaging apparatus including: a time-gain controller (TGC) that compensates an amplitude fading occurring in the process of propagation inside a living body; a scan converter (SC) that constructs image data; a TIC measurement unit that measures a TIC of each pixel; an evaluation index input unit that inputs an index for evaluating hemodynamics on the basis of a TIC; a mapping parameter estimation unit that estimates a mapping parameter comparable to an evaluation index; a TIC image construction unit that constructs a two-dimensional image on the basis of the mapping parameter; and a pixel detection unit that extracts a region corresponding to a color map from a TIC image, and utilizing a TIC measured with each pixel so as to measure a difference in hemodynamics.

    摘要翻译: 提供一种超声波成像装置,包括:补偿在生物体内传播过程中发生的振幅衰落的时间增益控制器(TGC); 构建图像数据的扫描转换器(SC); TIC测量单元,测量每个像素的TIC; 评估指标输入单元,其输入用于基于TIC评估血液动力学的指标; 映射参数估计单元,其估计与评估指标相当的映射参数; TIC图像构造单元,其基于映射参数构建二维图像; 以及像素检测单元,其从TIC图像提取与颜色映射相对应的区域,并且利用用每个像素测量的TIC来测量血液动力学的差异。

    Medical digital X-ray imaging apparatus and medical digital X-ray sensor
    27.
    发明授权
    Medical digital X-ray imaging apparatus and medical digital X-ray sensor 有权
    医用数字X射线成像仪和医用数字X射线传感器

    公开(公告)号:US08005187B2

    公开(公告)日:2011-08-23

    申请号:US12083661

    申请日:2006-10-17

    IPC分类号: A61B6/14

    摘要: In a medical digital X-ray imaging apparatus having a plurality of imaging modes including computed tomography mode, a supporter supports an X-ray source and a digital X-ray sensor having a two-dimensional detection plane for detecting X-rays, while interposing an object between them. An image reconstructor acquires data from the digital X-ray sensor and reconstructs an image based on the acquired data. An operator selects one of a first imaging mode and a second imaging mode. The second imaging mode has an irradiation field different from the first imaging mode and has an area to be read in the digital X-ray sensor smaller than that in the first imaging mode.

    摘要翻译: 在具有包括计算机断层摄影模式的多种成像模式的医用数字X射线成像设备中,支持者支持X射线源和具有用于检测X射线的二维检测平面的数字X射线传感器,同时插入 他们之间的对象。 图像重构器从数字X射线传感器获取数据,并且基于获取的数据重建图像。 操作者选择第一成像模式和第二成像模式之一。 第二成像模式具有与第一成像模式不同的照射场,并且在数字X射线传感器中要具有要读取的区域小于第一成像模式中的区域。

    Radiography Apparatus With Scout View Function
    28.
    发明申请
    Radiography Apparatus With Scout View Function 有权
    具有侦察侦察功能的射线照相装置

    公开(公告)号:US20090041191A1

    公开(公告)日:2009-02-12

    申请号:US11918184

    申请日:2006-04-11

    IPC分类号: H05G1/64

    摘要: An X-ray detecting section (13) comprises a first imaging means (S1) to generate an X-ray image in response to the X-ray slit beam (B) and a second imaging means (S2) to generate an X-ray image in response to the X-ray broad beam (BB). The radiography apparatus (M) displays a first X-ray image generated by the X-ray slit beam (B) and said first imaging means (S1), specifies a desired interested area (R) on the first X-ray image, and generates a predetermined sectional image as a second X-ray image by using the X-ray broad beam (BB) and the second imaging means (S2) with respect to the specified interested area (R).

    摘要翻译: X射线检测部(13)包括响应于X射线狭缝光束(B)产生X射线图像的第一成像装置(S1)和第二成像装置(S2),以产生X射线 响应于X射线宽光束(BB)的图像。 射线照相设备(M)显示由X射线狭缝光束(B)和所述第一成像装置(S1)产生的第一X射线图像,指定第一X射线图像上期望的感兴趣区域(R),以及 通过使用X射线宽波束(BB)和第二成像装置(S2)相对于指定的感兴趣区域(R)产生作为第二X射线图像的预定截面图像。

    ULTRASONIC APPARATUS
    30.
    发明申请
    ULTRASONIC APPARATUS 审中-公开
    超声波设备

    公开(公告)号:US20080077011A1

    公开(公告)日:2008-03-27

    申请号:US11838263

    申请日:2007-08-14

    IPC分类号: A61B8/08

    摘要: An edge between a tumor and a normal tissue is detected even when acoustic impedance and elasticity of those are not changed. An edge position of tissue is estimated by setting a plurality of estimation regions of an inspection object, detecting direction of motion of the inspection object within each estimation region, and computing the point of inflexion in the direction of motion. Moreover, these edge positions are overlapped on the cross-sectional images and thereby an operator can easily detect the edge lines.

    摘要翻译: 即使在没有改变声阻抗和弹性的情况下,也检测肿瘤与正常组织之间的边缘。 通过设置检查对象的多个估计区域,检测检查对象在各估计区域内的运动方向,并计算运动方向的拐点来估计组织的边缘位置。 此外,这些边缘位置在横截面图像上重叠,从而操作者可以容易地检测边缘线。