公开(公告)号：US20210386335A1

公开(公告)日：2021-12-16

申请号：US17458643

申请日：2021-08-27

Applicant: Medtronic MiniMed, Inc.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20210174960A1

公开(公告)日：2021-06-10

申请号：US16848710

申请日：2020-04-14

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Elaine Gee ,  Peter Ajemba ,  Bahman Engheta ,  Jeffrey Nishida ,  Andrea Varsavsky ,  Keith Nogueira

IPC: G16H50/20 ,  A61B5/145 ,  A61M5/172 ,  A61B5/00 ,  G16H50/30 ,  G16H70/60 ,  G16H40/67 ,  G16H50/50 ,  G16H20/17 ,  G06N3/08 ,  G06N3/04

Abstract: Medical devices and related systems and methods are provided. A method of estimating a physiological condition involves obtaining reference measurement data for the physiological condition, obtaining first measurement data corresponding to the reference measurement data from one or more instances of the first sensing arrangement, determining a generative model associated with the first sensing arrangement based on relationships between the first measurement data and the reference measurement data, obtaining second reference measurement data for the physiological condition, generating simulated measurement data corresponding to the second reference measurement data by applying the generative model to the second reference measurement data, and determining an estimation model for the physiological condition based on relationships between the simulated measurement data and the second reference measurement data, wherein the estimation model is applied to subsequent measurement output provided by an instance of the first sensing arrangement to obtain an estimated value for the physiological condition.

公开(公告)号：US20210170103A1

公开(公告)日：2021-06-10

申请号：US16848695

申请日：2020-04-14

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Elaine Gee ,  Peter Ajemba ,  Bahman Engheta ,  Jeffrey Nishida ,  Andrea Varsavsky ,  Keith Nogueira

IPC: A61M5/172 ,  A61B5/145 ,  A61B5/00 ,  G16H50/50 ,  G16H20/17

Abstract: Medical devices and related systems and methods are provided. A method of estimating a physiological condition using a first sensing arrangement involves obtaining a sensor translation model associated with a relationship between the first sensing arrangement and a second sensing arrangement, wherein the second sensing arrangement is different from the first sensing arrangement, obtaining one or more measurements from a sensing element coupled to the processing system of the first sensing arrangement, determining simulated measurement data for the second sensing arrangement by applying the sensor translation model to the one or more measurements from the sensing element of the first sensing arrangement, and determining an estimated value for the physiological condition by applying an estimation model associated with the second sensing arrangement to the simulated measurement data.

公开(公告)号：US10952651B2

公开(公告)日：2021-03-23

申请号：US15903332

申请日：2018-02-23

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US10478557B2

公开(公告)日：2019-11-19

申请号：US15240726

申请日：2016-08-18

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Yunfeng Lu ,  Keith Nogueira ,  Jeffrey Nishida

IPC: G01N33/48 ,  A61M5/172 ,  G06F19/00 ,  A61B5/145 ,  A61B5/00 ,  G16H10/60 ,  G16H50/50 ,  G16H40/63 ,  G16H40/40 ,  G16H50/20 ,  A61B5/024 ,  A61M5/142 ,  G16H15/00

Abstract: Medical devices and related patient management systems and parameter modeling methods are provided. An exemplary method of operating a sensing device associated with a patient involves obtaining current operational context information associated with the sensing device, obtaining a parameter model associated with the patient, calculating a current parameter value based on the parameter model and the current operational context information, obtaining one or more signals from a sensing element configured to measure a condition in a body of the patient, and providing an output that is influenced by the calculated current parameter value and the one or more signals.

公开(公告)号：US10426385B2

公开(公告)日：2019-10-01

申请号：US15481868

申请日：2017-04-07

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  A61B5/145 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US09649059B2

公开(公告)日：2017-05-16

申请号：US14261043

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20150300969A1

公开(公告)日：2015-10-22

申请号：US14256229

申请日：2014-04-18

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Benyamin Grosman ,  Desmond Barry Keenan ,  John J. Mastrototaro ,  Rajiv Shah ,  Andrea Varsavsky ,  Ning Yang

IPC: G01N27/02

CPC classification number: G01N27/026

Abstract: A method of measuring blood glucose of a patient is presented here. In accordance with certain embodiments, the method applies a constant voltage potential to a glucose sensor and obtains a constant potential sensor current from the glucose sensor, wherein the constant potential sensor current is generated in response to applying the constant voltage potential to the glucose sensor. The method continues by performing an electrochemical impedance spectroscopy (EIS) procedure for the glucose sensor to obtain EIS output measurements. The method also performs a nonlinear mapping operation on the constant potential sensor current and the EIS output measurements to generate a blood glucose value.

Abstract translation: 这里给出了测量患者血糖的方法。 根据某些实施例，该方法向葡萄糖传感器施加恒定电压电位，并从葡萄糖传感器获得恒定的电位传感器电流，其中响应于向葡萄糖传感器施加恒定电压电位而产生恒定电位传感器电流。 该方法通过对葡萄糖传感器执行电化学阻抗谱（EIS）程序来获得EIS输出测量结果。 该方法还对恒定电位传感器电流和EIS输出测量执行非线性映射操作以产生血糖值。

公开(公告)号：US20150164389A1

公开(公告)日：2015-06-18

申请号：US14261043

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/145 ,  A61M5/172 ,  A61B5/1495 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1468

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20240358294A1

公开(公告)日：2024-10-31

申请号：US18763620

申请日：2024-07-03

Applicant: Medtronic MiniMed, Inc.

Inventor： Jia Yao ,  Daniel E. Pesantez ,  Anuradha Biswas Bhatia ,  Akhil Srinivasan ,  Guangping Zhang ,  Andrea Varsavsky ,  Raghavendhar Gautham

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145 ,  A61L31/04 ,  A61L31/14 ,  C09D5/16 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/54

CPC classification number: A61B5/14865 ,  A61B5/1451 ,  A61B5/14532 ,  A61L31/04 ,  A61L31/14 ,  C09D5/1681 ,  C12Q1/006 ,  C12Q1/26 ,  C12Q1/54 ,  A61B5/41 ,  A61L2400/18

Abstract: Embodiments of the invention provide optimized polymeric surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These polymer surfaces have a constellation of features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a polymer surface with the disclosed constellation of features.