公开(公告)号：US11445952B2

公开(公告)日：2022-09-20

申请号：US16388794

申请日：2019-04-18

Applicant: Medtronic MiniMed, Inc.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/1473 ,  A61M5/142 ,  A61M5/172 ,  A61B5/053

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20190246960A1

公开(公告)日：2019-08-15

申请号：US16388794

申请日：2019-04-18

Applicant: Medtronic MiniMed, Inc.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/1473 ,  A61M5/142 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/145 ,  A61M5/172

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4836 ,  A61B5/6848 ,  A61B5/6849 ,  A61B5/7225 ,  A61B5/7271 ,  A61B2560/0276 ,  A61B2560/029 ,  A61M5/142 ,  A61M5/1723

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US10327686B2

公开(公告)日：2019-06-25

申请号：US14980241

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/053

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US10258264B2

公开(公告)日：2019-04-16

申请号：US15483404

申请日：2017-04-10

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/00 ,  A61B5/145 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  C12Q1/00 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N33/49 ,  G01N33/66 ,  G01N27/327 ,  G01N27/416

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20170181673A1

公开(公告)日：2017-06-29

申请号：US14980241

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/6848 ,  A61B5/6868 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/742 ,  A61B2560/0204

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20170181672A1

公开(公告)日：2017-06-29

申请号：US14980152

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61M5/172 ,  A61B5/00 ,  A61M5/142 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4836 ,  A61B5/6848 ,  A61B5/6849 ,  A61B5/7225 ,  A61B5/7271 ,  A61B2560/0276 ,  A61B2560/029 ,  A61M5/142 ,  A61M5/1723

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US09649058B2

公开(公告)日：2017-05-16

申请号：US14261011

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20240345011A1

公开(公告)日：2024-10-17

申请号：US18735347

申请日：2024-06-06

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai ,  Andrea Varsavsky ,  Fei Yu

IPC: G01N27/02 ,  G01N33/487 ,  G01N33/49

CPC classification number: G01N27/026 ,  G01N33/48707 ,  G01N33/49

Abstract: A method of optimizing operation of a glucose sensor includes performing an electrochemical impedance spectroscopy (EIS) procedure to obtain imaginary impedance values for an electrode of a glucose sensor, calculating a change value as a difference between a threshold reference for the imaginary impedance values and a most-recent imaginary impedance value, and obtaining measurements of the calibration factor for the glucose sensor. The method also includes comparing the change value to a first threshold and the calibration factor to a second threshold and determining, based on the comparison, whether sensor data from the glucose sensor is valid.

公开(公告)号：US11974844B2

公开(公告)日：2024-05-07

申请号：US16397156

申请日：2019-04-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/7221 ,  A61B5/1451 ,  A61B5/6848 ,  A61B5/6868 ,  A61B5/7225 ,  A61B5/742 ,  A61B2560/0204

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20220354394A1

公开(公告)日：2022-11-10

申请号：US17859427

申请日：2022-07-07

Applicant: Medtronic MiniMed, Inc.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: The disclosed techniques include obtaining a first signal generated by an electrochemical glucose sensor and a second signal generated by an optical glucose sensor, and obtaining a glucose value indicative of a user's blood glucose level, where the glucose value and the second signal are obtained at different times. The disclosed techniques further cause calculating a mapped value for the second signal based on the first signal, and calibrating the mapped value of the second signal based on the glucose value.