利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

50 条记录 (耗时 0.078 秒)

    Protection circuit for semiconductor integrated circuit that can discriminate between program voltage and static electricity
    21.
    发明授权
    Protection circuit for semiconductor integrated circuit that can discriminate between program voltage and static electricity 失效
    用于半导体集成电路的保护电路，可以区分编程电压和静电

    公开(公告)号：US06404017B1

    公开(公告)日：2002-06-11

    申请号：US09688384

    申请日：2000-10-17

    申请人： Toru Takizawa ,  Toshio Imai

    发明人： Toru Takizawa ,  Toshio Imai

    IPC分类号： H01L2362

    CPC分类号： H01L27/0266

    摘要： A current when static electricity intrudes is passed by a first circuit portion composed of a series circuit including a fuse element and a resistor until a program voltage is applied to a program voltage terminal, and the fuse element is fused when the program voltage is applied. A current for breaking the fuse element is passed when an N-type MOS transistor turns into a second breakdown state by a gate voltage from a second circuit portion.

    摘要翻译： 当由包括熔丝元件和电阻器的串联电路组成的第一电路部分通过静电导通的电流，直到编程电压被施加到编程电压端子，并且当施加编程电压时熔丝元件熔断。 当N型MOS晶体管通过来自第二电路部分的栅极电压变为第二击穿状态时，断开熔丝元件的电流通过。

    Methods For Detecting Th1 Cells
    24.
    发明申请
    Methods For Detecting Th1 Cells 审中-公开
    检测Th1细胞的方法

    公开(公告)号：US20110294986A1

    公开(公告)日：2011-12-01

    申请号：US13207837

    申请日：2011-08-11

    申请人： Keiko Yamaguchi ,  Toshio Imai ,  Kenzo Muramoto

    发明人： Keiko Yamaguchi ,  Toshio Imai ,  Kenzo Muramoto

    IPC分类号： C07K16/28

    CPC分类号： C07K16/18 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/569 ,  C07K2317/76 ,  G01N33/56972 ,  G01N2333/075 ,  G01N2333/085

    摘要： The inventors discovered that the adhesion molecule CAR, known to be localized in intracellular adhesion sites, functioned as an adhesion molecule for activated lymphocytes. Further, the inventors identified CARL, a novel CAR ligand expressed in lymphocytes, and clarified that the ligand was expressed selectively in Th1 cells. In addition, they found that anti-CAR antibodies could inhibit the adhesion of activated lymphocytes to CAR molecules. Thus, the present invention provides methods for detecting Th1 cells using CAR or anti-CARL antibodies, and methods of screening for inhibitors suppressing the adhesion of Th1 cells using the binding between CAR and CARL as an index. Furthermore, the present invention relates to methods of screening for inhibitors of the binding between CAR and CARL, antibodies that inhibit the binding between CAR and CARL, and therapeutic compositions comprising these antibodies. These are expected to be useful in diagnosing diseases, such as inflammation, in which infiltration of Th1 cells is involved, and in providing pharmaceutical agents for alleviating such diseases.

    摘要翻译： 本发明人发现已知局限在细胞内粘附位点的粘附分子CAR用作活化淋巴细胞的粘附分子。 此外，本发明人鉴定了CARL，一种在淋巴细胞中表达的新型CAR配体，并阐明了配体在Th1细胞中有选择性表达。 此外，他们发现抗CAR抗体可以抑制活化淋巴细胞对CAR分子的粘附。 因此，本发明提供了使用CAR或抗CARL抗体检测Th1细胞的方法，以及使用CAR和CARL之间的结合作为指标筛选抑制Th1细胞粘附的抑制剂的方法。 此外，本发明涉及筛选CAR和CARL之间的结合抑制剂的方法，抑制CAR和CARL之间的结合的抗体以及包含这些抗体的治疗组合物。 预期这些可用于诊断涉及Th1细胞浸润的疾病，例如炎症，以及提供减轻这些疾病的药物。

    Synthetic resin bottle
    25.
    发明授权
    Synthetic resin bottle 有权
    合成树脂瓶

    公开(公告)号：US08056746B2

    公开(公告)日：2011-11-15

    申请号：US12310163

    申请日：2007-08-20

    申请人： Toshio Imai

    发明人： Toshio Imai

    IPC分类号： B65D1/02

    CPC分类号： B65D23/02 ,  C23C16/006 ,  C23C16/045 ,  C23C16/26

    摘要： There is provided a synthetic resin bottle in which an amorphous carbon film having good appearance without forming the brown mottled pattern on the surface thereof is deposited.The present invention provides a bottle having a mouth portion, a shoulder portion, a body portion and a bottom portion in which an amorphous carbon film is deposited on the inner surfaces of the mouth portion, the shoulder portion, the body portion and the bottom portion by supplying C2H2 gas. When the height position of the shoulder portion in the direction toward the mouth portion along the bottle axis from the position at which the inner diameter of the shoulder portion is maximal is within the area whose height is not more than 70% the total height of the shoulder portion along the bottle axis, the amorphous carbon film on the shoulder portion within the above range of height position is formed so that the thickness thereof is not less than 0.9 times but not more than 1.1 times the thickness at the shoulder portion having maximum inner diameter.

    摘要翻译： 提供了一种合成树脂瓶，其中沉积具有良好外观的无定形碳膜，而在其表面上不形成棕色斑驳图案。 本发明提供一种具有口部，肩部，主体部和底部的瓶子，其中在口部，肩部，主体部和底部的内表面上沉积有非晶碳膜 通过供应C2H2气体。 当从肩部的内径最大的位置沿着瓶轴线朝向口部的方向的肩部的高度位置在高度不高于肩部的总高度的70％的区域内时 沿着瓶轴线的肩部，在上述高度位置范围内的肩部上的无定形碳膜的厚度形成为不小于具有最大内侧的肩部的厚度的0.9倍以上1.1倍以下 直径。

    Methods for detecting Th1 cells
    26.
    发明授权
    Methods for detecting Th1 cells 有权
    检测Th1细胞的方法

    公开(公告)号：US08017344B2

    公开(公告)日：2011-09-13

    申请号：US11568435

    申请日：2005-04-28

    申请人： Keiko Yamaguchi ,  Toshio Imai ,  Kenzo Muramoto

    发明人： Keiko Yamaguchi ,  Toshio Imai ,  Kenzo Muramoto

    IPC分类号： G01N33/53

    CPC分类号： C07K16/18 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/569 ,  C07K2317/76 ,  G01N33/56972 ,  G01N2333/075 ,  G01N2333/085

    摘要： The inventors discovered that the adhesion molecule CAR, known to be localized in intracellular adhesion sites, functioned as an adhesion molecule for activated lymphocytes. Further, the inventors identified CARL, a novel CAR ligand expressed in lymphocytes, and clarified that the ligand was expressed selectively in Th1 cells. In addition, they found that anti-CAR antibodies could inhibit the adhesion of activated lymphocytes to CAR molecules. Thus, the present invention provides methods for detecting Th1 cells using CAR or anti-CARL antibodies, and methods of screening for inhibitors suppressing the adhesion of Th1 cells using the binding between CAR and CARL as an index. Furthermore, the present invention relates to methods of screening for inhibitors of the binding between CAR and CARL, antibodies that inhibit the binding between CAR and CARL, and therapeutic compositions comprising these antibodies. These are expected to be useful in diagnosing diseases, such as inflammation, in which infiltration of Th1 cells is involved, and in providing pharmaceutical agents for alleviating such diseases.

    摘要翻译： 本发明人发现已知局限在细胞内粘附位点的粘附分子CAR用作活化淋巴细胞的粘附分子。 此外，本发明人鉴定了CARL，一种在淋巴细胞中表达的新型CAR配体，并阐明了配体在Th1细胞中有选择性表达。 此外，他们发现抗CAR抗体可以抑制活化淋巴细胞对CAR分子的粘附。 因此，本发明提供了使用CAR或抗CARL抗体检测Th1细胞的方法，以及使用CAR和CARL之间的结合作为指标筛选抑制Th1细胞粘附的抑制剂的方法。 此外，本发明涉及筛选CAR和CARL之间的结合抑制剂的方法，抑制CAR和CARL之间的结合的抗体以及包含这些抗体的治疗组合物。 预期这些可用于诊断涉及Th1细胞浸润的疾病，例如炎症，以及提供减轻这些疾病的药物。

    Synthetic resin bottle
    27.
    发明授权
    Synthetic resin bottle 有权

    公开(公告)号：US07992736B2

    公开(公告)日：2011-08-09

    申请号：US12310163

    申请日：2007-08-20

    申请人： Toshio Imai

    发明人： Toshio Imai

    IPC分类号： B65D1/02

    摘要： There is provided a synthetic resin bottle in which an amorphous carbon film having good appearance without forming the brown mottled pattern on the surface thereof is deposited.The present invention provides a bottle having a mouth portion, a shoulder portion, a body portion and a bottom portion in which an amorphous carbon film is deposited on the inner surfaces of the mouth portion, the shoulder portion, the body portion and the bottom portion by supplying C2H2 gas. When the height position of the shoulder portion in the direction toward the mouth portion along the bottle axis from the position at which the inner diameter of the shoulder portion is maximal is within the area whose height is not more than 70% the total height of the shoulder portion along the bottle axis, the amorphous carbon film on the shoulder portion within the above range of height position is formed so that the thickness thereof is not less than 0.9 times but not more than 1.1 times the thickness at the shoulder portion having maximum inner diameter.

    Illuminated switch device
    28.
    发明授权
    Illuminated switch device 有权
    照明开关装置

    公开(公告)号：US07989722B2

    公开(公告)日：2011-08-02

    申请号：US12246049

    申请日：2008-10-06

    申请人： Anthony McCurdy ,  Takayoshi Hoshi ,  Toshio Imai

    发明人： Anthony McCurdy ,  Takayoshi Hoshi ,  Toshio Imai

    IPC分类号： H01H9/00

    CPC分类号： H01H13/023 ,  H01H9/182 ,  H01H2013/026 ,  H01H2219/062 ,  H01H2219/064 ,  H01H2221/016

    摘要： Disclosed is an illuminated switch device capable of effectively preventing light leakage between different light sources, thereby obtaining a good lighting quality, while reducing the overall size of the switch device. The illuminated switch device includes: a casing that has an open upper end and a partition wall provided therein and is formed on a bottom plate member having light sources and a push switch mounted thereon; and an operating body that has a light-shielding wall provided on the rear surface of an upper plate, is arranged so as to close the open end, and can be pressed. First and second illuminated regions to which light components are emitted from first and second light sources are provided on the upper plate. A protruding portion is formed at a leading end portion of a light-shielding wall, and a concave groove is provided at a leading end portion of a partition wall. The leading end portions are opposite to each other such that they can approach or separate from each other. At least a part of the protruding portion is arranged in the concave groove, and a gap is formed between the leading ends of the protruding portion and the concave portion.

    摘要翻译： 公开了一种照明开关装置，其能够有效地防止不同光源之间的光泄漏，从而在减小开关装置的整体尺寸的同时获得良好的照明质量。 照明开关装置包括：壳体，其具有设置在其中的敞开的上端和分隔壁，并且形成在具有光源的底板构件和安装在其上的推动开关; 并且具有设置在上板的后表面上的遮光壁的操作体被布置成闭合开口端，并且可以被按压。 在上板上设置有从第一和第二光源发射光分量的第一和第二照明区域。 在遮光壁的前端部形成有突出部，在分隔壁的前端部设置有凹槽。 前端部彼此相对，使得它们可以彼此接近或分离。 突出部的至少一部分配置在凹槽内，在突出部的前端与凹部之间形成间隙。