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44 条记录 (耗时 0.03 秒)

    Method for producing light-alloy casting
    23.
    发明申请
    Method for producing light-alloy casting 审中-公开
    轻合金铸造方法

    公开(公告)号：US20050103407A1

    公开(公告)日：2005-05-19

    申请号：US10991603

    申请日：2004-11-18

    申请人： Tsutomu Masuda ,  Yasuhiro Fukumoto

    发明人： Tsutomu Masuda ,  Yasuhiro Fukumoto

    IPC分类号： F02F1/24 ,  B22C9/08 ,  B22C9/24 ,  B22D21/00 ,  B22D21/04 ,  B22D30/00 ,  C22C21/02 ,  C22C23/02 ,  C22F1/00 ,  C22F1/04 ,  C22F1/043 ,  C22F1/06

    CPC分类号： C22F1/04

    摘要： A light-alloy casting producing method is provided in which a T6 treatment can be given to a light-alloy casting without any heat treatment furnace (or aging furnace), so that its mechanical properties such as tensile strength can be adequately heightened. This method includes: a mold preparing process of preparing a mold which includes a sand mold part which is provided with a riser section, and a metal mold part which is disposed apart from the riser section, the sand mold part and the metal mold part forming a cavity section; a casting process of pouring a molten light-alloy into the cavity section of the mold; a metal mold part removing process of separating the metal mold part from a casting which is formed by pouring; a quenching process of bringing a cooling medium into contact with the surface of the casting from which the metal mold part is removed, and thereby, cooling the casting rapidly; an aging process of covering the metal mold part-removed section of the casting with a heat keeper, and keeping the whole casting which is surrounded with the sand mold part and the heat keeper at an aging temperature for a predetermined period of time, using the heat which is kept by a riser portion.

    摘要翻译： 提供了一种轻合金铸造生产方法，其中可以在没有任何热处理炉（或老化炉）的情况下对轻合金铸件进行T6处理，使得其机械性能如拉伸强度可以得到充分提高。 该方法包括：制备模具的模具制备方法，该模具包括设置有提升部分的砂模部分和与提升部分隔开的金属模具部分，模具部分和金属模具部分形成 空腔部分; 将熔融轻合金注入模具的空腔部分的铸造工艺; 将金属模具部件与通过倾倒形成的铸件分离的金属模具部件去除工艺; 使冷却介质与金属模具部分被去除的铸件的表面接触的淬火工艺，从而快速冷却铸件; 使用保温器覆盖铸件的金属模具部分去除部分的老化过程，并且使用砂模部件和保温器围绕的整个铸件在老化温度下保持预定时间段，使用 由提升部分保持的热量。

    Agglutination enhancer
    24.
    发明授权
    Agglutination enhancer 有权

    公开(公告)号：US09797886B2

    公开(公告)日：2017-10-24

    申请号：US14123899

    申请日：2012-06-04

    申请人： Naoyuki Yamamoto ,  Tsutomu Masuda

    发明人： Naoyuki Yamamoto ,  Tsutomu Masuda

    IPC分类号： G01N33/53 ,  C08F220/36 ,  C08F220/60 ,  G01N33/542

    CPC分类号： G01N33/5306 ,  C08F220/36 ,  C08F220/60 ,  G01N33/542

    摘要： The purpose of the present invention is to provide an agglutination enhancer which shows superior agglutination enhancing effect to those of conventional immunoagglutination enhancers, and the present invention relates to an agglutination enhancer for an immunoagglutination measurement method which comprises a polymer having a monomer unit shown by the following general formula [1]: (Wherein R1 represents a hydrogen atom or a methyl group; R2 and R3 independently represent a methyl group or an ethyl group, respectively; X represents —NH— or an oxygen atom; n represents an integer of 1 to 6; and m represents an integer of 1 to 3), and an immunoagglutination measurement method in which, in the coexistence of the above-described agglutination enhancer for immunoagglutination measurement method, an antibody against analyte or an antigen for the analyte is brought into contact with the analyte to cause an antigen-antibody reaction.

    Benzimidazolone derivatives as CB2 receptor ligands
    25.
    发明授权
    Benzimidazolone derivatives as CB2 receptor ligands 失效
    苯并咪唑酮衍生物作为CB2受体配体

    公开(公告)号：US08138177B2

    公开(公告)日：2012-03-20

    申请号：US11909763

    申请日：2006-03-02

    申请人： Kazuo Ando ,  Makoto Kawai ,  Tsutomu Masuda ,  Hirofumi Omura

    发明人： Kazuo Ando ,  Makoto Kawai ,  Tsutomu Masuda ,  Hirofumi Omura

    IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/454 ,  C07D413/02 ,  C07D211/32 ,  C07D471/02

    CPC分类号： C07D471/04 ,  C07D235/26 ,  C07D401/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/12 ,  C07D417/12

    摘要： This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by CB2 receptor binding activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, emesis such as cancer chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, gastroesophageal reflux disease (GERD), constipation, diarrhea, functional gastrointestinal disorder, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, chronic obstructive pulmonary disease (COPD), cryptogenic fibrosing alveolitis or bronchitis.

    摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中：A，B，R 1，R 2和R 3各自如本文所述，含有这些化合物的组合物和这些化合物在治疗 由CB2受体结合活性介导的病症，例如但不限于炎性疼痛，伤害性疼痛，神经性疼痛，纤维肌痛，慢性腰痛，内脏痛，急性脑缺血，疼痛，慢性疼痛，急性疼痛，疱疹后神经痛 ，神经病，神经痛，糖尿病性神经病，HIV相关神经病，神经损伤，类风湿性关节炎疼痛，骨关节炎疼痛，背痛，癌症疼痛，牙痛，纤维肌痛，神经炎，坐骨神经痛，炎症，神经变性疾病，咳嗽，支气管收缩，肠易激惹 综合征（IBS），炎性肠病（IBD），结肠炎，脑血管缺血，呕吐如癌症化疗诱发的呕吐，类风湿性关节炎，哮喘，克罗恩病，ul 结肠炎，哮喘，皮炎，季节性过敏性鼻炎，胃食管反流病（GERD），便秘，腹泻，功能性胃肠道疾病，皮肤T细胞淋巴瘤，多发性硬化症，骨关节炎，牛皮癣，系统性红斑狼疮，糖尿病，青光眼，骨质疏松症，肾小球性肾炎， 肾缺血，肾炎，肝炎，脑中风，血管炎，心肌梗死，脑缺血，可逆性气道阻塞，成人呼吸道疾病综合征，慢性阻塞性肺病（COPD），隐源性纤维化肺泡炎或支气管炎。

    Purified luciferase from luciola lateralis
    30.
    发明授权
    Purified luciferase from luciola lateralis 失效
    来自luciola lateralis的纯化萤光素酶

    公开(公告)号：US5352598A

    公开(公告)日：1994-10-04

    申请号：US759814

    申请日：1991-08-29

    申请人： Naoki Kajiyama ,  Tsutomu Masuda ,  Hiroki Tatsumi ,  Eiichi Nakano

    发明人： Naoki Kajiyama ,  Tsutomu Masuda ,  Hiroki Tatsumi ,  Eiichi Nakano

    IPC分类号： C12N9/02 ,  C12N1/00

    CPC分类号： C12N9/0069 ,  C12Y113/12007 ,  Y10S435/815 ,  Y10S435/816

    摘要： A purified luciferase from Luciola lateralis is disclosed. The enzyme is characterized by having properties including: an optimum pH range of 7.5 to 9.5, an optimum temperature range of 0.degree. C. to 50.degree. C., and that the enzyme does not act on ADP, CTP, UTP, and GTP. The enzyme is purified by using a process which includes: gel filtration chromatography, hydroxyapatite column chromatography, and a tris(hydroxy)aminomethane-hydro-chloric acid buffer.

    摘要翻译： 公开了一种来自Luciola lateralis的纯化的萤光素酶。 该酶的特征在于具有以下特性：最佳pH范围为7.5至9.5，最适温度范围为0℃至50℃，并且该酶不作用于ADP，CTP，UTP和GTP。 通过使用包括凝胶过滤色谱法，羟基磷灰石柱色谱法和三（羟基）氨基甲烷 - 氢氯酸缓冲液的方法纯化酶。