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公开(公告)号：US20210188901A1
公开(公告)日：2021-06-24
申请号：US17086196
申请日：2020-10-30
Applicant: Massachusetts Institute of Technology
Inventor： Dale Arlington Thomas, III , Alexander James Mijalis , Bradley L. Pentelute , Mark David Simon , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.
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公开(公告)号：US10988504B2
公开(公告)日：2021-04-27
申请号：US15695795
申请日：2017-09-05
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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23.发明申请公开(公告)号：US20200368710A1
公开(公告)日：2020-11-26
申请号：US16988827
申请日：2020-08-10
Applicant: Massachusetts Institute of Technology
Inventor： Klavs F. Jensen , Timothy F. Jamison , Allan S. Myerson , Jean-Christophe M. Monbaliu , Mohsen Behnam , Shin Yee Wong , Nopphon Weeranoppanant , Eve Marie Revalor , Torsten Stelzer , Jie Chen , Andrea Adamo , David R. Snead , Ping Zhang
Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
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公开(公告)号：US20180057525A1
公开(公告)日：2018-03-01
申请号：US15602056
申请日：2017-05-22
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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公开(公告)号：US09695214B2
公开(公告)日：2017-07-04
申请号：US14776870
申请日：2014-02-24
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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Patent Agency Ranking
公开(公告)号：US09169287B2
公开(公告)日：2015-10-27
申请号：US13833745
申请日：2013-03-15
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
Abstract translation: 通常描述用于进行固相肽合成的系统和方法。 固相肽合成是将已经固定在固体支持物上的肽加入氨基酸残基的已知方法。 在某些实施方案中，本发明的系统和方法可用于快速进行固相肽合成，同时保持高产率。 某些实施方案涉及可用于以减少进行固相肽合成所需时间量的方式加热，运输和/或混合试剂的方法和系统。
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公开(公告)号：US20140275481A1
公开(公告)日：2014-09-18
申请号：US13833745
申请日：2013-03-15
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
Abstract translation: 通常描述用于进行固相肽合成的系统和方法。 固相肽合成是将已经固定在固体支持物上的肽加入氨基酸残基的已知方法。 在某些实施方案中，本发明的系统和方法可用于快速进行固相肽合成，同时保持高产率。 某些实施方案涉及可用于以减少进行固相肽合成所需时间量的方式加热，运输和/或混合试剂的方法和系统。
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28.发明授权公开(公告)号：US11565230B2
公开(公告)日：2023-01-31
申请号：US16988827
申请日：2020-08-10
Applicant: Massachusetts Institute of Technology
Inventor： Klavs F. Jensen , Timothy F. Jamison , Allan S. Myerson , Jean-Christophe M. Monbaliu , Mohsen Behnam , Shin Yee Wong , Nopphon Weeranoppanant , Eve Marie Revalor , Torsten Stelzer , Jie Chen , Andrea Adamo , David R. Snead , Ping Zhang
IPC: B01J19/00 , B01J19/18 , A61K31/14 , A61K31/167
Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
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公开(公告)号：US10696944B2
公开(公告)日：2020-06-30
申请号：US14352354
申请日：2012-10-17
Applicant: Massachusetts Institute of Technology , Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
Inventor： Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
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公开(公告)号：US20190093073A1
公开(公告)日：2019-03-28
申请号：US16141107
申请日：2018-09-25
Applicant: Massachusetts Institute of Technology
Inventor： Armon R Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
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