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公开(公告)号:US10696944B2
公开(公告)日:2020-06-30
申请号:US14352354
申请日:2012-10-17
申请人: Massachusetts Institute of Technology , Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
摘要: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
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公开(公告)号:US20090209039A1
公开(公告)日:2009-08-20
申请号:US12370146
申请日:2009-02-12
申请人: Andrea Adamo , Luigi Adamo , Klavs F. Jensen
发明人: Andrea Adamo , Luigi Adamo , Klavs F. Jensen
CPC分类号: C12M35/02
摘要: A method and apparatus for producing a jet or droplet of liquid. An injector device may include a reservoir in fluid communication with a nozzle, and a pressure gradient may be produced in the reservoir (e.g., by a piezoelectric element in an initial direction that is transverse to the emission direction of the jet or droplet) to produce a jet of liquid from the nozzle. The jet or droplet of liquid may be introduced through a cell membrane and into the cell interior in such a way that damage to the cell membrane that would cause cell death is avoided. An electrode may be formed adjacent a fluid channel by conducting a liquid material, such as solder, from a reservoir and into an electrode portion of an electrode channel to a location adjacent the fluid channel. A passageway between the electrode channel and the fluid channel may prevent flow of the liquid electrode material into the fluid channel during electrode formation.
摘要翻译: 一种用于生产液体的射流或液滴的方法和装置。 注射器装置可以包括与喷嘴流体连通的储存器,并且可以在储存器中产生压力梯度(例如,通过横向于射流或液滴的排放方向的初始方向的压电元件)产生压力梯度,以产生 来自喷嘴的液体喷射。 液体的射流或液滴可以通过细胞膜引入细胞内部,从而避免细胞膜对细胞死亡的破坏。 可以通过将诸如焊料的液体材料从储存器引导到电极通道的电极部分到与流体通道相邻的位置而邻近流体通道形成电极。 在电极形成期间,电极通道和流体通道之间的通道可以防止液体电极材料流入流体通道。
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3.
公开(公告)号:US20090280518A1
公开(公告)日:2009-11-12
申请号:US12436814
申请日:2009-05-07
申请人: Andrea Adamo , Rangel P. Dokov , Klavs F. Jensen
发明人: Andrea Adamo , Rangel P. Dokov , Klavs F. Jensen
CPC分类号: G01N33/48728
摘要: A system for measuring a mechanical property of a cell is provided. The system includes a body having a channel therethrough with a first end and a second end, the channel including at least one cell deforming feature configured to deform a cell passing through the channel. A first sensor system is positioned on the first end side of the cell deforming feature and a second sensor system is positioned on the second end side of the cell deforming feature, and the first and second sensor systems are configured to detect information about a cell as the cell travels across the cell deforming feature. A controller communicating with the first and second sensor systems is adapted to receive data from the first and second sensor systems and calculate a mechanical property of the cell.
摘要翻译: 提供了一种用于测量电池的机械性能的系统。 该系统包括具有通道的主体,其具有第一端和第二端,该通道包括至少一个细胞变形特征,其被配置为使穿过通道的细胞变形。 第一传感器系统位于细胞变形特征的第一端侧,第二传感器系统位于细胞变形特征的第二端侧,并且第一和第二传感器系统被配置为检测关于细胞变形的信息 细胞穿过细胞变形特征。 与第一和第二传感器系统通信的控制器适于从第一传感器系统和第二传感器系统接收数据并且计算单元的机械特性。
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公开(公告)号:US08158193B2
公开(公告)日:2012-04-17
申请号:US12509869
申请日:2009-07-27
申请人: Moungi Bawendi , Klavs F. Jensen , Bashir O. Dabbousi , Javier Rodriguez-Viejo , Frederic Victor Mikulec
发明人: Moungi Bawendi , Klavs F. Jensen , Bashir O. Dabbousi , Javier Rodriguez-Viejo , Frederic Victor Mikulec
IPC分类号: B05D7/00
CPC分类号: C09K11/883 , B82Y20/00 , B82Y30/00 , C01B17/20 , C01B19/007 , C01P2002/72 , C01P2002/84 , C01P2004/04 , C01P2004/52 , C01P2004/64 , C01P2004/80 , C01P2004/86 , C01P2006/60 , C07F9/224 , C07F9/5304 , C09K11/02 , C09K11/565 , C09K11/885 , C09K11/892 , C30B7/00 , C30B7/14 , C30B29/46 , C30B29/48 , C30B29/60 , C30B29/605 , Y10S977/773 , Y10S977/774 , Y10S977/777 , Y10S977/813 , Y10S977/824 , Y10S977/832 , Y10T428/12035 , Y10T428/12049 , Y10T428/12181 , Y10T428/12986 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993
摘要: A nanocrystal capable of light emission includes a nanoparticle having photoluminescence having quantum yields of greater than 30%.
摘要翻译: 能够发光的纳米晶体包括具有大于30%的量子产率的光致发光的纳米颗粒。
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公开(公告)号:US08075778B2
公开(公告)日:2011-12-13
申请号:US10546911
申请日:2004-03-25
CPC分类号: B01L3/502784 , B01D17/045 , B01D17/048 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F13/0222 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2200/0673 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/161 , B01L2300/165 , B01L2400/0406 , B01L2400/0487 , B01L2400/0694 , F16K99/0001 , F16K99/0017 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , Y10T436/25375
摘要: A method of separating a first fluid from a second fluid may include prewetting with the first fluid at least one channel defined by a separation device, the at least one channel thereby containing a column of the first fluid along its length. A combined flow of the first fluid and the second fluid may be presented to the separation device, so that the at least one channel is in fluid communication with the combined flow. Fluid pressure may be applied across the combined flow and the separation device, but the applied pressure should not exceed the capillary pressure in the at least one channel. Otherwise, the combined flow may be forced through the separation device. In this manner, the first fluid flows through the at least one channel, and the second fluid is excluded from the at least one channel, thereby separating at least a portion of the first fluid from the second fluid.
摘要翻译: 从第二流体分离第一流体的方法可以包括用第一流体预润湿由分离装置限定的至少一个通道,因此至少一个通道沿其长度包含第一流体的柱。 可以将第一流体和第二流体的组合流体提供给分离装置,使得至少一个通道与组合流体流体连通。 流体压力可以跨过组合的流量和分离装置施加,但施加的压力不应超过至少一个通道中的毛细管压力。 否则,组合的流动可能被迫通过分离装置。 以这种方式,第一流体流过至少一个通道,并且第二流体从至少一个通道排除,从而将第一流体的至少一部分与第二流体分离。
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公开(公告)号:US20110284059A1
公开(公告)日:2011-11-24
申请号:US13112831
申请日:2011-05-20
申请人: Ivan Celanovic , Walker Chan , Peter Bermel , Adrian Y.X. Yeng , Christopher Marton , Michael Ghebrebrhan , Mohammad Araghchini , Klavs F. Jensen , Marin Soljacic , John D. Joannopoulos , Steven G. Johnson , Robert Pilawa-Podgurski , Peter Fisher
发明人: Ivan Celanovic , Walker Chan , Peter Bermel , Adrian Y.X. Yeng , Christopher Marton , Michael Ghebrebrhan , Mohammad Araghchini , Klavs F. Jensen , Marin Soljacic , John D. Joannopoulos , Steven G. Johnson , Robert Pilawa-Podgurski , Peter Fisher
CPC分类号: G05F1/67 , F23C2900/03001 , F23M2900/13004 , H02S10/30
摘要: Inventive systems and methods for the generation of energy using thermophotovoltaic cells are described. Also described are systems and methods for selectively emitting electromagnetic radiation from an emitter for use in thermophotovoltaic energy generation systems. In at least some of the inventive energy generation systems and methods, a voltage applied to the thermophotovoltaic cell (e.g., to enhance the power produced by the cell) can be adjusted to enhance system performance. Certain embodiments of the systems and methods described herein can be used to generate energy relatively efficiently.
摘要翻译: 描述了使用热光伏电池产生能量的本发明的系统和方法。 还描述了用于选择性地从用于热光伏能量产生系统的发射器发射电磁辐射的系统和方法。 在至少一些本发明的能量产生系统和方法中,可以调节施加到热光伏电池的电压(例如,以增强由电池产生的功率),以增强系统性能。 本文所述的系统和方法的某些实施例可以用于相对有效地产生能量。
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公开(公告)号:US20110263062A1
公开(公告)日:2011-10-27
申请号:US13157466
申请日:2011-06-10
申请人: Moungi G. Bawendi , Klavs F. Jensen , Bashir O. Dabbousi , Javier Rodriguez-Viejo , Frederic Victor Mikulec
发明人: Moungi G. Bawendi , Klavs F. Jensen , Bashir O. Dabbousi , Javier Rodriguez-Viejo , Frederic Victor Mikulec
CPC分类号: C09K11/883 , B82Y20/00 , B82Y30/00 , C01B17/20 , C01B19/007 , C01P2002/72 , C01P2002/84 , C01P2004/04 , C01P2004/52 , C01P2004/64 , C01P2004/80 , C01P2004/86 , C01P2006/60 , C07F9/224 , C07F9/5304 , C09K11/02 , C09K11/565 , C09K11/885 , C09K11/892 , C30B7/00 , C30B7/14 , C30B29/46 , C30B29/48 , C30B29/60 , C30B29/605 , Y10S977/773 , Y10S977/774 , Y10S977/777 , Y10S977/813 , Y10S977/824 , Y10S977/832 , Y10T428/12035 , Y10T428/12049 , Y10T428/12181 , Y10T428/12986 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993
摘要: A nanocrystal capable of light emission includes a nanoparticle having photoluminescence having quantum yields of greater than 30%.
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公开(公告)号:US20100298602A1
公开(公告)日:2010-11-25
申请号:US12468365
申请日:2009-05-19
申请人: Mahmooda Sultana , Klavs F. Jensen
发明人: Mahmooda Sultana , Klavs F. Jensen
IPC分类号: C07C229/08 , G01N15/00 , C07C229/06
CPC分类号: C07C227/42 , C07C229/08
摘要: Systems and methods for crystallization in microfluidic systems are generally described. Many applications require the collection of time-resolved data to determine advantageous conditions for crystallization. The present invention provides tools and related techniques which address this need, as well as a platform for the growth of crystals within microfluidic channels. The systems and methods described herein provide, in one aspect, tools that allow for controlled, stable crystallization of organic materials in microfluidic channels. The invention can interface not only with microfluidic/microscale equipment, but with macroscale equipment to allow for the easy injection of fluids (e.g., fluids containing crystal precursor), extraction of crystals, determination of one or more crystal properties (e.g., crystal size, size distribution among multiple crystals, morphology, etc.), etc.
摘要翻译: 通常描述微流体系统中用于结晶的系统和方法。 许多应用需要收集时间分辨数据来确定结晶的有利条件。 本发明提供了解决这一需求的工具和相关技术,以及用于在微流体通道内生长晶体的平台。 本文所述的系统和方法在一个方面提供允许有机材料在微流体通道中受控的稳定结晶的工具。 本发明不仅可以与微流体/微型设备接口,而且可以与宏观设备相接合,以便容易地注入流体(例如,含有晶体前体的流体),提取晶体,确定一种或多种晶体性质(例如晶体尺寸, 多晶体的大小分布,形态等)等
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公开(公告)号:US20100176715A1
公开(公告)日:2010-07-15
申请号:US12700713
申请日:2010-02-04
IPC分类号: H01J99/00
CPC分类号: H01L33/06 , B82Y10/00 , C09K11/02 , C09K11/565 , C09K11/883 , H01L33/502 , H01L33/504 , H01S3/169 , Y02B20/181 , Y10S977/95
摘要: A light-emitting device comprising a population of quantum dots (QDs) embedded in a host matrix and a primary light source which causes the QDs to emit secondary light and a method of making such a device. The size distribution of the QDs is chosen to allow light of a particular color to be emitted therefrom. The light emitted from the device may be of either a pure (monochromatic) color, or a mixed (polychromatic) color, and may consist solely of light emitted from the QDs themselves, or of a mixture of light emitted from the QDs and light emitted from the primary source. The QDs desirably are composed of an undoped semiconductor such as CdSe, and may optionally be overcoated to increase photoluminescence.
摘要翻译: 一种发光装置,包括嵌入在主矩阵中的量子点群(QD)和导致QD发出二次光的初级光源以及制造这种器件的方法。 选择量子点的尺寸分布以允许从其发射特定颜色的光。 从装置发射的光可以是纯(单色)或混合(多色)颜色,并且可以仅由QDs本身发出的光或者从QD发出的光的混合物和发射的光 从主要来源。 QD理想地由诸如CdSe的未掺杂的半导体组成,并且可以任选地被涂覆以增加光致发光。
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10.
公开(公告)号:US20100170572A1
公开(公告)日:2010-07-08
申请号:US12312348
申请日:2007-11-06
CPC分类号: B01L3/50273 , B01L2200/146 , B01L2300/0816 , B01L2300/14 , B01L2400/0487 , Y10T137/0396 , Y10T137/86485
摘要: The present invention generally relates to devices and methods for affecting the flow rate of fluid using pressure. The invention generally provides for controlled application of pressure to flowing fluids to control pressure and flow rates of those fluids, independent of location of the fluids relative to various devices. For example, in a series of devices, each connected to another via a conduit, pressure control units can be provided between devices to raise or lower pressure and/or flow rate of fluid flowing from one device to the next. In this way, a series of interconnected devices can be arranged such that inlet fluid pressure or flow rate of any individual device can be set independently of every other device.
摘要翻译: 本发明一般涉及使用压力影响流体流速的装置和方法。 本发明通常提供对流动流体的压力的受控应用,以控制这些流体的压力和流速,而与流体相对于各种装置的位置无关。 例如,在一系列装置中,每个装置通过管道连接到另一个装置,压力控制单元可以设置在装置之间以提高或降低从一个装置流向下一个装置的流体的压力和/或流速。 以这种方式,可以布置一系列互连的装置,使得任何单独装置的入口流体压力或流量可以独立于每个其他装置设定。
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