中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

128 records (took 0.024 seconds)

    TRIGGERABLE SHAPE MEMORY INDUCTION DEVICES
    22.
    发明申请
    TRIGGERABLE SHAPE MEMORY INDUCTION DEVICES 审中-公开
    可触发形状记忆感应装置

    公开(公告)号：US20160317796A1

    公开(公告)日：2016-11-03

    申请号：US15143230

    申请日：2016-04-29

    Applicant: Massachusetts Institute of Technology

    Inventor： Shiyi Zhang ,  Yida Zhao ,  Carlo Giovanni Traverso ,  Robert S. Langer

    IPC: A61M37/00 ,  A61D7/00 ,  A61L31/06

    CPC classification number: A61M37/00 ,  A61L27/26 ,  A61L27/446 ,  A61L27/50 ,  A61L31/041 ,  A61L31/06 ,  A61L31/128 ,  A61L31/14 ,  A61L2400/16 ,  A61M2205/0266

    Abstract: In accordance with the invention, compositions, devices, and related methods have been developed for medical-related and other applications. In some embodiments, the devices and compositions described herein comprise a triggerable shape memory polymer network. In certain embodiments, the polymer network comprises a covalently crosslinked polymeric material and a non-crosslinked polymeric material associated with the crosslinked polymeric material. In some cases, the polymer network has a first configuration (e.g., as polymerized), and a second configuration (e.g., upon heating and deformation), such that the polymer network can be triggered to recover the first configuration upon heating the polymeric material above a softening temperature of the polymeric material. In certain embodiments, the polymer network comprises a plurality of particles capable of increasing the temperature of the polymer network (e.g., above the softening temperature) in the presence of an external stimulus such as induction, radio frequency, or magnetic resonance, such that the polymer network changes configuration. The polymeric material may be molded into any suitable shape.

    Abstract translation: 根据本发明，已经开发了用于医疗相关和其它应用的组合物，装置和相关方法。 在一些实施例中，本文所述的装置和组合物包括可触发的形状记忆聚合物网络。 在某些实施方案中，聚合物网络包括共价交联的聚合物材料和与交联的聚合物材料相关的非交联聚合材料。 在一些情况下，聚合物网络具有第一构型（例如，聚合）和第二构型（例如，在加热和变形时），使得聚合物网络可以在加热上述聚合物材料时被触发以恢复第一构型 聚合材料的软化温度。 在某些实施方案中，聚合物网络包括能够在诸如感应，射频或磁共振的外部刺激的存在下能够增加聚合物网络的温度（例如高于软化温度）的多个颗粒，使得 聚合物网络改变配置。 聚合物材料可以模制成任何合适的形状。

    RESIDENCE STRUCTURES AND RELATED METHODS
    30.
    发明申请
    RESIDENCE STRUCTURES AND RELATED METHODS 有权

    公开(公告)号：US20230039421A1

    公开(公告)日：2023-02-09

    申请号：US17836972

    申请日：2022-06-09

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Lowell L. Wood, JR. ,  Philip A. Eckhoff

    IPC: A61K9/00 ,  C08G18/73 ,  C08G63/08 ,  C08G18/42 ,  A61K47/58 ,  A61K47/69 ,  A61K9/48 ,  A61K31/357 ,  A61K31/65 ,  A61K31/7048 ,  C08G83/00 ,  A61K47/32 ,  C08L33/02 ,  C08L33/08 ,  C08L33/14 ,  A61K47/10 ,  A61K47/34 ,  A61K47/40 ,  A61K47/42 ,  A61M31/00

    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

Patent Agency Ranking