公开(公告)号：US11186830B2

公开(公告)日：2021-11-30

申请号：US16166523

申请日：2018-10-22

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Hiroki Ando ,  Sebastien Lemire

IPC: C12N7/00 ,  C12N7/02 ,  C12N15/81

Abstract: Disclosed here are recombinant bacteriophages with tail fibers encoded by at least two subsets of genomic fragments from different bacteriophage having different host ranges.

公开(公告)号：US20210347823A1

公开(公告)日：2021-11-11

申请号：US17277783

申请日：2019-09-19

Applicant: Massachusetts Institute of Technology ,  Fundação Universidade Federal do ABC - UFABC (Federal University of ABC Foundation)

Inventor： Timothy Kuan-Ta Lu ,  Cesar de la Fuente Nunez ,  Vani Xavier de Oliveira Junior ,  Marcelo Der Torossian Torres

IPC: C07K7/08 ,  A61P31/04 ,  A61P31/10

Abstract: Described herein are methods of physicochemical-guided peptide design that utilize specific functional determinants to a protein's property of interest. Also described herein are novel synthetic peptide antibiotics that have increased potency and/or decreased toxicity relative to the template peptide from which they were derived, and methods of use thereof in treating microbial infections.

公开(公告)号：US20210183469A9

公开(公告)日：2021-06-17

申请号：US16299641

申请日：2019-03-12

Applicant: Massachusetts Institute of Technology ,  Universidade Católica de Brasília

Inventor： Timothy Kuan-Ta Lu ,  Cesar De la Fuente Nunez ,  William Porto ,  Octavio Franco

IPC: G16B35/10 ,  C07K14/00 ,  A61P31/04

Abstract: Disclosed herein are methods of designing peptides having at least one property of interest, such as α-helical propensity, higher net charge, hydrophobicity, and/or hydrophobic moment. Also disclosed herein are novel artificially evolved peptides (e.g., antimicrobial peptides), which may be designed according to the methods described herein, and methods of use thereof.

公开(公告)号：US20210071159A1

公开(公告)日：2021-03-11

申请号：US16936881

申请日：2020-07-23

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Robert James Citorik ,  Mark K. Mimee

IPC: C12N9/22 ,  A61K38/46 ,  C12N15/74

Abstract: Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest.

公开(公告)号：US20200066375A1

公开(公告)日：2020-02-27

申请号：US16441647

申请日：2019-06-14

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Manolis Kellis ,  Jicong Cao ,  Eva Maria Novoa Pardo ,  Zhizhuo Zhang

IPC: G16B20/50 ,  G16B40/00 ,  C12N15/10 ,  C12N15/11

Abstract: Disclosed herein are novel 5′ UTR sequences that can be used to control gene expression in various contexts. Also disclosed herein are methods of engineering 5′ UTR sequences and methods and kits for screening 5′ UTR sequences for a property of interest.

公开(公告)号：US20200063127A1

公开(公告)日：2020-02-27

申请号：US16485822

申请日：2018-02-14

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Fahim Farzadfard

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/62 ,  C12N9/78

Abstract: Provided herein are compositions, systems, and methods for continuous and accumulative modification of a target site.

公开(公告)号：US10449267B2

公开(公告)日：2019-10-22

申请号：US14540872

申请日：2014-11-13

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Chao Zhong

IPC: C07K14/78 ,  C08H1/00 ,  C09J189/00 ,  A61L24/10 ,  C07K14/245 ,  C07K14/435 ,  D01F4/00 ,  C09J5/00 ,  A61L24/00

Abstract: Compositions, methods, and kits are provided which involve novel fusion protein-based adhesives for use in medical and marine applications. In some aspects, the novel fusion proteins comprise an adhesive domain (e.g., derived from an adhesive protein of a marine organism) and an amyloid domain (e.g., derived from a bacterial amyloid protein). Also provided are copolymers and fibers of the fusion proteins.

公开(公告)号：US10385102B2

公开(公告)日：2019-08-20

申请号：US15436259

申请日：2017-02-17

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Allen Yuyin Chen

IPC: B82Y5/00 ,  B82Y40/00 ,  C07K14/47 ,  C07K14/245

Abstract: Aspects of the invention relate to the engineering of biological nanostructures and materials.

公开(公告)号：US20190002912A1

公开(公告)日：2019-01-03

申请号：US15737829

申请日：2016-06-17

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Lior Nissim ,  Ming-Ru Wu

IPC: C12N15/85 ,  C07K14/47 ,  C07K16/32 ,  C07K16/28

Abstract: Aspects of the present disclosure provide a platform that triggers potent and effective immunotherapy against tumors from within tumors themselves, thus overcoming limitations of existing cancer immunotherapies and tumor-detecting gene circuits.

公开(公告)号：US10073087B2

公开(公告)日：2018-09-11

申请号：US14597575

申请日：2015-01-15

Applicant: Massachusetts Institute of Technology

Inventor： Zhengtao Deng ,  Timothy Kuan-Ta Lu

IPC: G01N33/52 ,  A61K49/00

CPC classification number: G01N33/521 ,  A61K49/0093

Abstract: Various aspects and embodiments provided herein are directed to compositions that include at least one nanoparticle linked to a first polypeptide, and a biologically synthesizable polymer linked to at least one second polypeptide that binds covalently to the first polypeptide. Other aspects and embodiments provided herein are directed to methods of producing the foregoing compositions and components therein.