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21.
公开(公告)号:US20120214796A1
公开(公告)日:2012-08-23
申请号:US13458968
申请日:2012-04-27
申请人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
发明人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
IPC分类号: A61K31/18 , A61K31/495 , A61K31/55 , A61K31/439 , A61K31/5377 , A61K31/496 , A61P35/00 , A61K31/451
CPC分类号: C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号:US07504512B2
公开(公告)日:2009-03-17
申请号:US10820097
申请日:2004-04-07
申请人: David J. Augeri , Steven A. Baumeister , Milan Bruncko , Daniel A. Dickman , Hong Ding , Jurgen Dinges , Stephen W. Fesik , Philip J. Hajduk , Aaron R. Kunzer , William McClellan , David G. Nettesheim , Thorsten Oost , Andrew M. Petros , Saul H. Rosenberg , Wang Shen , Sheela A. Thomas , Xilu Wang , Michael D. Wendt
发明人: David J. Augeri , Steven A. Baumeister , Milan Bruncko , Daniel A. Dickman , Hong Ding , Jurgen Dinges , Stephen W. Fesik , Philip J. Hajduk , Aaron R. Kunzer , William McClellan , David G. Nettesheim , Thorsten Oost , Andrew M. Petros , Saul H. Rosenberg , Wang Shen , Sheela A. Thomas , Xilu Wang , Michael D. Wendt
IPC分类号: C07C211/00 , A61K31/445
CPC分类号: C07D207/27 , A61K31/18 , A61K31/4015 , A61K31/44 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , C07C311/51 , C07C323/30 , C07C323/37 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D203/26 , C07D207/06 , C07D209/08 , C07D209/52 , C07D209/54 , C07D211/22 , C07D211/74 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/78 , C07D215/12 , C07D221/20 , C07D231/12 , C07D235/08 , C07D235/26 , C07D239/26 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/56 , C07D277/64 , C07D295/205 , C07D295/26 , C07D317/60 , C07D333/28 , C07D333/56 , C07D333/70 , C07D417/12 , C07D451/02
摘要: N-Benzoyl arylsulfonamides having the formula are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.
摘要翻译: 具有下式的N-苯甲酰基芳基磺酰胺是BCL-X1抑制剂,可用于促进凋亡。 还公开了BCL-X1抑制组合物和促进哺乳动物细胞凋亡的方法。
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公开(公告)号:US20090137585A1
公开(公告)日:2009-05-28
申请号:US12364987
申请日:2009-02-03
申请人: David J. Augeri , Steven A. Baumeister , Milan Bruncko , Daniel A. Dickman , Hong Ding , Jurgen Dinges , Stephen W. Fesik , Philip J. Hajduk , Aaron R. Kunzer , William Mcclellan , David G. Nettesheim , Thorsten Oost , Andrew M. Petros , Saul H. Rosenberg , Wang Shen , Sheela A. Thomas , Xilu Wang , Michael D. Wendt
发明人: David J. Augeri , Steven A. Baumeister , Milan Bruncko , Daniel A. Dickman , Hong Ding , Jurgen Dinges , Stephen W. Fesik , Philip J. Hajduk , Aaron R. Kunzer , William Mcclellan , David G. Nettesheim , Thorsten Oost , Andrew M. Petros , Saul H. Rosenberg , Wang Shen , Sheela A. Thomas , Xilu Wang , Michael D. Wendt
IPC分类号: A61K31/445 , C07D211/60 , C07D241/04 , A61K31/5375 , A61P35/00 , A61K31/495 , C07D413/02
CPC分类号: C07D207/27 , A61K31/18 , A61K31/4015 , A61K31/44 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , C07C311/51 , C07C323/30 , C07C323/37 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D203/26 , C07D207/06 , C07D209/08 , C07D209/52 , C07D209/54 , C07D211/22 , C07D211/74 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/78 , C07D215/12 , C07D221/20 , C07D231/12 , C07D235/08 , C07D235/26 , C07D239/26 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/56 , C07D277/64 , C07D295/205 , C07D295/26 , C07D317/60 , C07D333/28 , C07D333/56 , C07D333/70 , C07D417/12 , C07D451/02
摘要: N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
摘要翻译: 具有下式的N-苯甲酰基芳基磺酰胺是BCL-X1抑制剂,可用于促进凋亡。 还公开了BCL-X1抑制组合物和促进哺乳动物细胞凋亡的方法。
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公开(公告)号:US06720338B2
公开(公告)日:2004-04-13
申请号:US09957276
申请日:2001-09-20
申请人: David J. Augeri , Steven A. Baumeister , Milan Bruncko , Daniel A. Dickman , Hong Ding , Jurgen Dinges , Stephen W. Fesik , Philip J. Hajduk , Aaron R. Kunzer , William McClellan , David G. Nettesheim , Thorsten Oost , Andrew M. Petros , Saul H. Rosenberg , Wang Shen , Sheela A. Thomas , Xilu Wang , Michael D. Wendt
发明人: David J. Augeri , Steven A. Baumeister , Milan Bruncko , Daniel A. Dickman , Hong Ding , Jurgen Dinges , Stephen W. Fesik , Philip J. Hajduk , Aaron R. Kunzer , William McClellan , David G. Nettesheim , Thorsten Oost , Andrew M. Petros , Saul H. Rosenberg , Wang Shen , Sheela A. Thomas , Xilu Wang , Michael D. Wendt
IPC分类号: A61K31445
CPC分类号: C07D207/27 , A61K31/18 , A61K31/4015 , A61K31/44 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , C07C311/51 , C07C323/30 , C07C323/37 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D203/26 , C07D207/06 , C07D209/08 , C07D209/52 , C07D209/54 , C07D211/22 , C07D211/74 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/78 , C07D215/12 , C07D221/20 , C07D231/12 , C07D235/08 , C07D235/26 , C07D239/26 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/56 , C07D277/64 , C07D295/205 , C07D295/26 , C07D317/60 , C07D333/28 , C07D333/56 , C07D333/70 , C07D417/12 , C07D451/02
摘要: N-Benzoyl arylsulfonamides having the formula: are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.
摘要翻译: 具有下式的N-苯甲酰基芳基磺酰胺是BCL-X1抑制剂,可用于促进细胞凋亡。 还公开了BCL-X1抑制组合物和促进哺乳动物细胞凋亡的方法。
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公开(公告)号:US20100234456A1
公开(公告)日:2010-09-16
申请号:US12787140
申请日:2010-05-25
申请人: Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri
发明人: Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri
IPC分类号: A61K31/255 , C07C39/24 , A61K31/055 , C07C39/04 , A61K31/05 , C07C305/22 , C07C47/52 , A61K31/11 , C07C63/00 , A61K31/192 , C07C211/44 , A61K31/135 , A61P35/00
CPC分类号: C07C311/41 , C07C63/48 , C07C63/49 , C07C65/26 , C07C65/28 , C07C205/58 , C07C229/52 , C07C229/56 , C07C233/81 , C07C311/13 , C07C311/18 , C07C311/21 , C07C311/37 , C07C311/44 , C07C323/20 , C07C323/25 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/18 , C07C2603/74 , C07D207/30 , C07D213/53 , C07D215/12 , C07D215/48 , C07D333/34
摘要: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
摘要翻译: 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物,含有该化合物的组合物和治疗疾病的方法,其表达为Mcl-1蛋白。
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公开(公告)号:US07989656B2
公开(公告)日:2011-08-02
申请号:US12787140
申请日:2010-05-25
申请人: Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri
发明人: Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri
IPC分类号: C07C63/00
CPC分类号: C07C311/41 , C07C63/48 , C07C63/49 , C07C65/26 , C07C65/28 , C07C205/58 , C07C229/52 , C07C229/56 , C07C233/81 , C07C311/13 , C07C311/18 , C07C311/21 , C07C311/37 , C07C311/44 , C07C323/20 , C07C323/25 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/18 , C07C2603/74 , C07D207/30 , C07D213/53 , C07D215/12 , C07D215/48 , C07D333/34
摘要: The present invention relates to biaryl carboxylic acid compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing these compounds and methods of treating diseases which express the Mcl-1 protein.
摘要翻译: 本发明涉及抑制抗细胞凋亡Mcl-1蛋白活性的联芳羧酸化合物,含有这些化合物的组合物和治疗表达Mcl-1蛋白的疾病的方法。
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公开(公告)号:US07750004B2
公开(公告)日:2010-07-06
申请号:US11482458
申请日:2006-07-07
申请人: Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri
发明人: Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri
IPC分类号: A61K31/5375 , C07D265/30
CPC分类号: C07C311/41 , C07C63/48 , C07C63/49 , C07C65/26 , C07C65/28 , C07C205/58 , C07C229/52 , C07C229/56 , C07C233/81 , C07C311/13 , C07C311/18 , C07C311/21 , C07C311/37 , C07C311/44 , C07C323/20 , C07C323/25 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/18 , C07C2603/74 , C07D207/30 , C07D213/53 , C07D215/12 , C07D215/48 , C07D333/34
摘要: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
摘要翻译: 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物,含有该化合物的组合物和治疗疾病的方法,其表达为Mcl-1蛋白。
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公开(公告)号:US07910742B2
公开(公告)日:2011-03-22
申请号:US11529845
申请日:2006-09-29
IPC分类号: C07D401/12
CPC分类号: C07D213/85 , C07D213/64 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/12
摘要: Compounds that inhibit survivin, compositions containing the compounds and methods of treating diseases in which survivin is unregulated or overexpressed are disclosed.
摘要翻译: 公开了抑制存活蛋白的化合物,含有化合物的组合物和治疗存活蛋白不受调节或过表达的疾病的方法。
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29.Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists 失效
标题翻译: 三环取代六氢苯并[e]异吲哚α-1肾上腺素能拮抗剂公开(公告)号:US5597823A
公开(公告)日:1997-01-28
申请号:US463528
申请日:1995-06-05
申请人: Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , Steven W. Elmore , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Michael D. Wendt
发明人: Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , Steven W. Elmore , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Michael D. Wendt
IPC分类号: A61K31/437 , A61K31/519 , A61P13/00 , A61P13/08 , A61P43/00 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147 , C07D495/04 , C07D495/14 , A61K31/505
CPC分类号: C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要: The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an .alpha.-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
摘要翻译: 本发明涉及式IMA的化合物及其药学上可接受的盐,其中W是三环杂环体系; 其是α-1肾上腺素能拮抗剂,可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。
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公开(公告)号:US06284796B1
公开(公告)日:2001-09-04
申请号:US09236254
申请日:1999-01-25
申请人: Andrew G. Geyer , William J. McClellan , Todd W. Rockway , Kent D. Stewart , Moshe Weitzberg , Michael D. Wendt
发明人: Andrew G. Geyer , William J. McClellan , Todd W. Rockway , Kent D. Stewart , Moshe Weitzberg , Michael D. Wendt
IPC分类号: A61K31165
CPC分类号: C07D213/74 , C07B2200/07 , C07B2200/09 , C07C257/18 , C07C259/18 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/64 , C07C275/40 , C07C275/42 , C07C275/64 , C07C311/13 , C07C311/16 , C07C323/60 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07D217/02 , C07D231/12 , C07D239/42 , C07D241/18 , C07D277/30 , C07D295/088 , C07D295/155 , C07D307/18 , C07D307/54 , C07D307/64 , C07D307/79 , C07D333/24
摘要: Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
摘要翻译: 具有该化学式的化合物是尿激酶的抑制剂,并且可用于治疗尿激酶起作用的疾病。 还公开了尿激酶抑制组合物和抑制哺乳动物尿激酶的方法。
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