公开(公告)号：US20120115783A1

公开(公告)日：2012-05-10

申请号：US13120376

申请日：2009-09-22

申请人： Huw M. Nash ,  Rosana Kapeller-Libermann ,  Jiawen Han ,  Tomi K. Sawyer ,  Justin Noehre

发明人： Huw M. Nash ,  Rosana Kapeller-Libermann ,  Jiawen Han ,  Tomi K. Sawyer ,  Justin Noehre

IPC分类号： A61K38/12 ,  A61P27/02 ,  A61P35/00 ,  C07K7/56 ,  C07K14/00

CPC分类号： C07K14/4702 ,  C07K7/56

摘要： The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.

摘要翻译： 本发明提供新颖的拟肽大环化合物和使用这种大环化合物治疗疾病的方法。

公开(公告)号：US07910346B2

公开(公告)日：2011-03-22

申请号：US12378703

申请日：2009-02-17

申请人： Ruth E. Gimeno ,  Rosana Kapeller-Libermann ,  Zhidan Wu ,  Brian K. Hubbard

发明人： Ruth E. Gimeno ,  Rosana Kapeller-Libermann ,  Zhidan Wu ,  Brian K. Hubbard

IPC分类号： C12N9/10 ,  C12N1/20 ,  C12P7/64 ,  C12P15/70 ,  C07H21/04

CPC分类号： C12N9/1029 ,  A01K2217/05 ,  C07K16/40 ,  C12Q1/48 ,  C12Y203/0102 ,  G01N33/573 ,  G01N2333/91051 ,  G01N2800/044

摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.

摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。

公开(公告)号：US20100009384A1

公开(公告)日：2010-01-14

申请号：US12217258

申请日：2008-07-02

申请人： Rosana Kapeller-Libermann ,  Thomas Joseph Logan

发明人： Rosana Kapeller-Libermann ,  Thomas Joseph Logan

IPC分类号： G01N33/53 ,  C07H21/00 ,  C12N5/00 ,  C12N9/10 ,  C07K16/00 ,  C12P21/00 ,  C12N9/99

CPC分类号： C12N9/1029 ,  A61K38/00 ,  C12Y203/01015

摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

公开(公告)号：US20080234468A1

公开(公告)日：2008-09-25

申请号：US11981466

申请日：2007-10-31

申请人： Rachel E. Meyers ,  Joseph M. Carroll ,  William James Cook ,  Rosana Kapeller-Libermann ,  Nadine S. Weich ,  Rajasekhar Bandaru

发明人： Rachel E. Meyers ,  Joseph M. Carroll ,  William James Cook ,  Rosana Kapeller-Libermann ,  Nadine S. Weich ,  Rajasekhar Bandaru

IPC分类号： C07K14/00

CPC分类号： A61K38/16 ,  A01K2217/05 ,  A61K38/4813 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/0008 ,  C12N9/12 ,  C12N9/16 ,  C12N9/20 ,  C12N9/6416 ,  C12N9/6424 ,  C12N9/6491 ,  C12N9/93 ,  C12Q1/25 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y603/02019 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/573 ,  G01N33/68 ,  G01N2500/10 ,  Y10T436/143333 ,  A61K2300/00

摘要： The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。 本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及 已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。 本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20070212728A1

公开(公告)日：2007-09-13

申请号：US11800457

申请日：2007-05-04

申请人： Rachel Meyers ,  Laura Rudolph-Owen ,  Rosana Kapeller-Libermann

发明人： Rachel Meyers ,  Laura Rudolph-Owen ,  Rosana Kapeller-Libermann

IPC分类号： C12P21/00 ,  C07H21/04 ,  C07K14/00 ,  C07K16/00 ,  G01N33/53 ,  C12Q1/68 ,  C12N15/00 ,  C12N5/06

CPC分类号： C12N9/0022 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/16 ,  C12N9/20 ,  C12N9/6421 ,  C12N9/88 ,  C12N15/52 ,  C12Q1/008 ,  C12Q1/25 ,  C12Q1/527

摘要： The invention provides isolated nucleic acids molecules, designated BRE nucleic acid molecules, which encode novel biotin enzyme-related molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BRE nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a BRE gene has been introduced or disrupted. The invention still further provides isolated BRE proteins, fusion proteins, antigenic peptides and anti-BRE antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为BRE核酸分子，其编码新的生物素酶相关分子。 本发明还提供了反义核酸分子，含有BRE核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及引入或破坏BRE基因的非人类转基因动物。 本发明还进一步提供了分离的BRE蛋白，融合蛋白，抗原肽和抗BRE抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US20070166748A1

公开(公告)日：2007-07-19

申请号：US11684365

申请日：2007-03-09

申请人： Ruth GIMENO ,  Zhidan WU ,  Rosana Kapeller-Libermann ,  Brian Hubbard

发明人： Ruth GIMENO ,  Zhidan WU ,  Rosana Kapeller-Libermann ,  Brian Hubbard

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12Q1/48 ,  C07H21/04 ,  C12P21/06 ,  C12N9/10

CPC分类号： C12N9/1029 ,  A01K2217/05 ,  C07K16/40 ,  C12Q1/48 ,  C12Y203/0102 ,  G01N33/573 ,  G01N2333/91051 ,  G01N2800/044

摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection, with obesity disorders are also disclosed.

摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。

公开(公告)号：US07241585B2

公开(公告)日：2007-07-10

申请号：US10658904

申请日：2003-09-10

申请人： Rosana Kapeller-Libermann

发明人： Rosana Kapeller-Libermann

IPC分类号： C12Q1/48 ,  C12N1/20 ,  C12N15/00 ,  C12N9/20 ,  C07K1/00

CPC分类号： C12N9/1205

摘要： The invention relates to a novel kinase nucleic acid sequence and protein. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.

摘要翻译： 本发明涉及一种新的激酶核酸序列和蛋白质。 还提供了用于制备和使用新分子的载体，宿主细胞和重组方法。

公开(公告)号：US07235634B2

公开(公告)日：2007-06-26

申请号：US10767308

申请日：2004-01-29

申请人： Rosana Kapeller-Libermann ,  David White ,  Kyle J. MacBeth

发明人： Rosana Kapeller-Libermann ,  David White ,  Kyle J. MacBeth

IPC分类号： C07K14/00

CPC分类号： C12N9/48

摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.

摘要翻译： 本发明涉及新鉴定的人类氨基肽酶。 本发明还涉及编码氨基肽酶的多核苷酸。 本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。

公开(公告)号：US20060240464A1

公开(公告)日：2006-10-26

申请号：US11429599

申请日：2006-05-05

申请人： Rachel Meyers ,  Joseph Carroll ,  William Cook ,  Rosana Kapeller-Libermann ,  Nadine Weich ,  Rajasekhar Bandaru

发明人： Rachel Meyers ,  Joseph Carroll ,  William Cook ,  Rosana Kapeller-Libermann ,  Nadine Weich ,  Rajasekhar Bandaru

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： A61K38/16 ,  A01K2217/05 ,  A61K38/4813 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/0008 ,  C12N9/12 ,  C12N9/16 ,  C12N9/20 ,  C12N9/6416 ,  C12N9/6424 ,  C12N9/6491 ,  C12N9/93 ,  C12Q1/25 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y603/02019 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/573 ,  G01N33/68 ,  G01N2500/10 ,  Y10T436/143333 ,  A61K2300/00

摘要： The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。 本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及 已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。 本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US07094587B2

公开(公告)日：2006-08-22

申请号：US10391364

申请日：2003-03-18

申请人： Rachel E. Meyers ,  Joseph M. Carroll ,  William James Cook ,  Rosana Kapeller-Libermann ,  Nadine S. Weich ,  Rajasekhar Bandaru

发明人： Rachel E. Meyers ,  Joseph M. Carroll ,  William James Cook ,  Rosana Kapeller-Libermann ,  Nadine S. Weich ,  Rajasekhar Bandaru

IPC分类号： C12N9/12

CPC分类号： A61K38/16 ,  A01K2217/05 ,  A61K38/4813 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/0008 ,  C12N9/12 ,  C12N9/16 ,  C12N9/20 ,  C12N9/6416 ,  C12N9/6424 ,  C12N9/6491 ,  C12N9/93 ,  C12Q1/25 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y603/02019 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/573 ,  G01N33/68 ,  G01N2500/10 ,  Y10T436/143333 ,  A61K2300/00

摘要： The invention provides isolated nucleic acids molecules, designated 16002 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16002 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16002 gene has been introduced or disrupted. The invention still further provides isolated 16002 proteins, fusion proteins, antigenic peptides and anti-16002 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供了分离的核酸分子，命名为16002核酸分子。 本发明还提供反义核酸分子，含有16002个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及16002基因导入或破坏的非人转基因动物。 本发明还进一步提供了分离的16002蛋白，融合蛋白，抗原肽和抗-16002抗体。 还提供了利用本发明组合物的诊断和治疗方法。