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    Methods for Detection of Nucleotide Modification
    22.
    发明申请
    Methods for Detection of Nucleotide Modification 有权
    核苷酸修饰检测方法

    公开(公告)号：US20140178881A1

    公开(公告)日：2014-06-26

    申请号：US14235707

    申请日：2012-07-27

    Applicant: Michael John Booth ,  Shankar Balasubramanian

    Inventor： Michael John Booth ,  Shankar Balasubramanian

    IPC: C12Q1/68

    CPC classification number: C12Q1/6876 ,  C01G55/002 ,  C07H1/00 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q2600/154 ,  C12Q2523/115 ,  C12Q2523/125

    Abstract: This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods may comprise oxidising or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidised or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA.

    Abstract translation: 本发明涉及在样本核苷酸序列中鉴定与胞嘧啶（C）不同的修饰胞嘧啶残基如5-甲基胞嘧啶（5mC），5-羟甲基胞嘧啶（5hmC）和5-甲酰胞嘧啶（5fC）。 方法可以包括氧化或还原包含样品核苷酸序列的多核苷酸的第一部分; 用亚硫酸氢盐处理氧化或还原的第一部分和第二部分多核苷酸; 在步骤ii）和iii）之后对群体的第一和第二部分中的多核苷酸进行测序以分别产生第一和第二核苷酸序列; 识别与样品核苷酸序列中的胞嘧啶残基相对应的第一和第二核苷酸序列中的残基。 这些方法可能是有用的，例如在基因组DNA和/或RNA的分析中。

    Block based backup
    23.
    发明授权
    Block based backup 有权
    基于块的备份

    公开(公告)号：US08738870B1

    公开(公告)日：2014-05-27

    申请号：US13250637

    申请日：2011-09-30

    Applicant: Shankar Balasubramanian ,  Vladimir Mandic ,  Sriprasad Bhat Kasargod ,  Anand Raj

    Inventor： Shankar Balasubramanian ,  Vladimir Mandic ,  Sriprasad Bhat Kasargod ,  Anand Raj

    IPC: G06F12/00 ,  G06F12/16

    CPC classification number: G06F12/16 ,  G06F11/00 ,  G06F11/14

    Abstract: A method, article of manufacture, and apparatus for protecting data. In some embodiments, this includes taking a snapshot of a physical volume with a native snapshot program, reading the snapshot block by block, creating a blank virtual container on a deduplicated virtual storage device, and populating the blank virtual container block by block based on reading the snapshot.

    Abstract translation: 一种保护数据的方法，制品和装置。 在一些实施例中，这包括使用本机快照程序拍摄物理卷的快照，逐块读取快照块，在重复数据删除的虚拟存储设备上创建空白虚拟容器，以及基于读取来逐块填充空白虚拟容器 快照。

    Network security and applications to the fabric environment
    24.
    发明授权
    Network security and applications to the fabric environment 有权
    网络安全和应用到面料环境

    公开(公告)号：US08621567B2

    公开(公告)日：2013-12-31

    申请号：US11198834

    申请日：2005-08-05

    Applicant: James Kleinsteiber ,  Richard L. Hammons ,  Dilip Gunawardena ,  Hung Nguyen ,  Shankar Balasubramanian ,  Vidya Renganararayanan

    Inventor： James Kleinsteiber ,  Richard L. Hammons ,  Dilip Gunawardena ,  Hung Nguyen ,  Shankar Balasubramanian ,  Vidya Renganararayanan

    IPC: G06F21/00

    CPC classification number: H04L63/08 ,  H04L63/0428 ,  H04L63/0823 ,  H04L63/0869 ,  H04L63/104 ,  H04L63/20 ,  H04L2463/102

    Abstract: A method and apparatus for securing networks, focusing on application in Fibre Channel networks. A combination of unique security techniques are combined to provide overall network security. Responsibility for security in the network is assigned to one or more designated entities. The designated entities deploy management information throughout the network to enhance security by modifying the capabilities and operational permissions of the devices participating in the network. For example, through network control: logical management access or physical I/O access may be limited on a per device or per I/O basis; and all devices and ports in the network operate only with other approved devices and ports. These designated entities can better manage network security by exploiting a unique link authentication system as well as a unique push-model secure distributed time service. The link authentication involves a multi-phase nonce exchange exploiting various derivations of the nonce and other information such as hashes and encryptions. The push-model secure time distribution departs from the traditional Fibre Channel pull mode time distribution and provides for secure and reliable distributed time so that various security attacks may be defeated.

    Abstract translation: 一种用于保护网络的方法和设备，专注于光纤通道网络中的应用。 组合独特的安全技术，提供整体网络安全。 将网络中的安全责任分配给一个或多个指定实体。 指定实体在整个网络中部署管理信息，通过修改参与网络的设备的功能和操作许可来增强安全性。 例如，通过网络控制：逻辑管理访问或物理I / O访问可能在每个设备或每个I / O的基础上受到限制; 并且网络中的所有设备和端口仅与其他已批准的设备和端口一起工作。 这些指定实体可以通过利用独特的链路认证系统以及独特的推模型安全分发时间服务来更好地管理网络安全。 链路认证涉及利用随机数的各种推导和其他信息（如散列和加密）的多阶段随机交换。 推模型安全时间分配与传统的光纤通道拉模式时间分布不符，提供了安全可靠的分发时间，从而可能会破坏各种安全攻击。

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