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公开(公告)号：US20100331864A1
公开(公告)日：2010-12-30
申请号：US12494887
申请日：2009-06-30
IPC分类号： A61B17/08
CPC分类号： A61F2/0063 , A61F2/042 , A61F2002/0068 , A61L27/18 , A61L27/48 , A61L27/58 , A61L2430/22 , C08L67/04
摘要： A tissue engineering construct made from a nonwoven fabric. The fabric is made from first and second staple fibers. The first staple fibers are made from a first biocompatible, bioabsorbable material, and the second staple fibers are made from a second biocompatible, bioabsorbable material. The first material has a melting temperature lower than the second material. The fabric is formed into a three-dimensional construct suitable for the repair of urinary tract structures.
摘要翻译： 由非织造织物制成的组织工程结构。 织物由第一和第二短纤维制成。 第一短纤维由第一生物相容的生物可吸收材料制成，第二短纤维由第二生物相容的生物可吸收材料制成。 第一种材料的熔融温度低于第二种材料。 该织物形成适于修复尿道结构的三维结构。
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公开(公告)号：US20090275129A1
公开(公告)日：2009-11-05
申请号：US12432994
申请日：2009-04-30
申请人： Kevin Cooper , Iksoo Chun , David C. Colter , Sridevi Dhanaraj , Anna Gosiewska , Agnieszka Seyda , Carrie H. Fang , Chunlin Yang
发明人： Kevin Cooper , Iksoo Chun , David C. Colter , Sridevi Dhanaraj , Anna Gosiewska , Agnieszka Seyda , Carrie H. Fang , Chunlin Yang
CPC分类号： C12N5/0691 , A61L27/18 , A61L27/3604 , A61L27/38 , A61L27/507 , C12M21/08 , C12M25/14 , C08L67/04
摘要： Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.
摘要翻译： 公开了使用组织工程化血管修复和再生血管疾病患者血管的组合物和方法。
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公开(公告)号：US20090263484A1
公开(公告)日：2009-10-22
申请号：US12107408
申请日：2008-04-22
申请人： Joseph J. Hammer , Dhanuraj Shetty , Sridevi Dhanaraj , Ziwei Wang , Jeffrey C. Geesin , Daniel J. Keeley
发明人： Joseph J. Hammer , Dhanuraj Shetty , Sridevi Dhanaraj , Ziwei Wang , Jeffrey C. Geesin , Daniel J. Keeley
CPC分类号： A61K35/34 , A61K35/22 , A61K38/00 , A61L27/3604 , A61L27/3834 , A61K2300/00
摘要： Tissue engineering devices and methods are provided for the reconstruction, repair, augmentation, or replacement of a luminal organ or tissue structure involving the use of a biodegradable polymer matrix conforming to a portion of a laminarly arranged luminal organ, the processing of autologous, allogeneic or xenogeneic tissue comprising multiple cell populations to obtain a minced tissue composition, the seeding of the matrix with the composition, and the implanting of the seeded polymer matrix into a patient.
摘要翻译： 提供组织工程装置和方法用于重建，修复，增加或更换腔内器官或组织结构，其涉及使用符合层状布置的器官器官的一部分的生物可降解聚合物基质，自体，异基因或 包含多个细胞群体的异种组织以获得切碎的组织组合物，用组合物接种基质，以及将接种的聚合物基质植入患者体内。
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公开(公告)号：US20060084930A1
公开(公告)日：2006-04-20
申请号：US11252176
申请日：2005-10-17
申请人： Sridevi Dhanaraj , Dhanuraj Shetty , Hiep Do , Sanyog Pendharkar
发明人： Sridevi Dhanaraj , Dhanuraj Shetty , Hiep Do , Sanyog Pendharkar
IPC分类号： A61F13/00
CPC分类号： A61L31/042 , A61F2/0063 , A61F13/00 , A61F2013/00604 , A61F2013/00927 , A61L15/26 , A61L15/28 , A61L27/18 , A61L27/20 , A61L27/48 , A61L27/58 , A61L31/06 , A61L2430/06 , A61L2430/10 , A61L2430/24 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/06 , B32B5/10 , B32B5/26 , B32B9/04 , B32B2250/02 , B32B2250/20 , B32B2262/0276 , B32B2262/04 , B32B2262/06 , B32B2307/726 , B32B2459/00 , B32B2535/00 , D04H1/435 , D04H1/4374 , Y10T442/3707 , Y10T442/494 , C08L67/04 , C08L1/00 , C08L1/24 , C08L1/04
摘要： The present invention is directed to a method of using a multilayered fabric comprising a first absorbable nonwoven fabric and a second absorbable woven or knitted fabric in tissue repair and regeneration.
摘要翻译： 本发明涉及一种在组织修复和再生中使用包含第一可吸收性无纺布和第二可吸收编织物或针织物的多层织物的方法。
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公开(公告)号：US08137686B2
公开(公告)日：2012-03-20
申请号：US10828838
申请日：2004-04-20
IPC分类号： A61F2/00
CPC分类号： A61L27/56 , A61F2/3872 , A61L27/18 , A61L2430/06 , C08L67/04
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
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26.发明授权Reinforced absorbable multilayered fabric for use in tissue repair and regeneration 有权用于组织修复和再生的增强可吸收多层织物公开(公告)号：US07749204B2
公开(公告)日：2010-07-06
申请号：US11252176
申请日：2005-10-17
CPC分类号： A61L31/042 , A61F2/0063 , A61F13/00 , A61F2013/00604 , A61F2013/00927 , A61L15/26 , A61L15/28 , A61L27/18 , A61L27/20 , A61L27/48 , A61L27/58 , A61L31/06 , A61L2430/06 , A61L2430/10 , A61L2430/24 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/06 , B32B5/10 , B32B5/26 , B32B9/04 , B32B2250/02 , B32B2250/20 , B32B2262/0276 , B32B2262/04 , B32B2262/06 , B32B2307/726 , B32B2459/00 , B32B2535/00 , D04H1/435 , D04H1/4374 , Y10T442/3707 , Y10T442/494 , C08L67/04 , C08L1/00 , C08L1/24 , C08L1/04
摘要： The present invention is directed to a method of using a multilayered fabric comprising a first absorbable nonwoven fabric and a second absorbable woven or knitted fabric in tissue repair and regeneration.
摘要翻译： 本发明涉及一种在组织修复和再生中使用包含第一可吸收性无纺布和第二可吸收编织物或针织物的多层织物的方法。
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公开(公告)号：US20090148495A1
公开(公告)日：2009-06-11
申请号：US11954100
申请日：2007-12-11
CPC分类号： A61F2/30756 , A61F2/30907 , A61F2002/30062 , A61F2002/30766 , A61F2210/0004 , A61F2310/00329 , A61L27/18 , A61L27/38 , A61L27/56 , C08L67/04
摘要： An implantable biodegradable porous fibrous matrix is disclosed, the fibrous matrix being constructed of fibers arranged in a nonwoven array. The density of the nonwoven array is adjusted in the manufacturing process to obtain an optimum density of the array for tissue ingrowth. When implanted, the optimum density fibrous matrix provides for a superior biological response of the host in terms of tissue growth, especially for tissues containing glycosaminoglycans (GAGs). The optimum density fibrous matrix is therefore provided with properties useful in repair and/or regeneration of mammalian tissue.
摘要翻译： 公开了可植入的可生物降解的多孔纤维基质，所述纤维基质由布置成无纺布阵列的纤维构成。 在制造过程中调节非织造布阵列的密度以获得用于组织向内生长的阵列的最佳密度。 当植入时，最佳密度纤维基质在组织生长方面提供了优异的宿主生物反应，特别是对于含有糖胺聚糖（GAG）的组织。 因此，最佳密度纤维基质具有可用于哺乳动物组织的修复和/或再生的性质。
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公开(公告)号：US20080081362A1
公开(公告)日：2008-04-03
申请号：US11856741
申请日：2007-09-18
申请人： Daniel Keeley , Dhanuraj Shetty , Sridevi Dhanaraj , Ziwei Wang
发明人： Daniel Keeley , Dhanuraj Shetty , Sridevi Dhanaraj , Ziwei Wang
IPC分类号： C12M1/00
CPC分类号： C12M21/08 , A61L27/3604 , A61L27/38 , A61L27/3882 , A61L27/58 , A61L2430/22 , C12M25/14
摘要： The present invention relates to devices and methods for tissue augmentation or regeneration and specifically, to a composite of bioabsorbable scaffold material and autologous tissue, suitable for implantation in tissue or organs.
摘要翻译： 本发明涉及用于组织增强或再生的装置和方法，具体涉及适于植入组织或器官的生物可吸收支架材料和自体组织的复合材料。
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公开(公告)号：US20070071840A1
公开(公告)日：2007-03-29
申请号：US11235850
申请日：2005-09-27
申请人： Sridevi Dhanaraj , Carrie Fang
发明人： Sridevi Dhanaraj , Carrie Fang
IPC分类号： A61K36/28
CPC分类号： A61K36/23 , A61K9/0019
摘要： The invention is a method for the treatment of mammalian articular cartilage disorders, inflammatory joint disease, trauma-related cartilage injuries, and degenerative disc disease. The method involves treating the affected area with a composition containing a therapeutically effective dose of Centella extract. The composition is delivered locally by parenteral administration to the affected site.
摘要翻译： 本发明是一种治疗哺乳动物关节软骨疾病，炎性关节疾病，创伤相关软骨损伤和退行性椎间盘疾病的方法。 该方法包括用含有治疗有效剂量的Centella提取物的组合物治疗受影响的区域。 组合物通过肠胃外给药局部递送至受影响部位。
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30.发明申请公开(公告)号：US20060153815A1
公开(公告)日：2006-07-13
申请号：US11304091
申请日：2005-12-15
申请人： Agnieszka Seyda , David Colter , Charito Buensuceso , Sridevi Dhanaraj , Anna Gosiewska , Jeffrey Geesin , Angelo Scopelianos
发明人： Agnieszka Seyda , David Colter , Charito Buensuceso , Sridevi Dhanaraj , Anna Gosiewska , Jeffrey Geesin , Angelo Scopelianos
CPC分类号： C12N5/0068 , A61L27/3604 , A61L27/38 , C12N2533/40
摘要： Tissue engineering devices for use in the repair or regeneration of tissue made of support scaffolds and cell sheets.
摘要翻译： 用于修复或再生由支撑支架和细胞片组成的组织的组织工程装置。
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