公开(公告)号：US20120225124A1

公开(公告)日：2012-09-06

申请号：US13471175

申请日：2012-05-14

申请人： Muhammad Safadi ,  Daniella Licht ,  Ioana Lovinger ,  Aharon M. Eyal ,  Tomas Fristedt ,  Karl Jansson

发明人： Muhammad Safadi ,  Daniella Licht ,  Ioana Lovinger ,  Aharon M. Eyal ,  Tomas Fristedt ,  Karl Jansson

IPC分类号： A61K31/4704 ,  A61K9/36 ,  G01N33/98 ,  A61P37/00 ,  G01N33/50 ,  A61K9/28 ,  C07D209/34

CPC分类号： B65B25/00 ,  A61K9/1623 ,  A61K9/2004 ,  A61K9/2018 ,  A61K31/438 ,  A61K31/4704 ,  C07D209/34 ,  C07D209/42 ,  C07D471/10 ,  Y10T436/145555

摘要： The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido)benzoic acid, 1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3′-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4-tetrahydro-quinoline-3-carboxamide.

摘要翻译： 本发明提供了包含N-乙基-N-苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺或其盐的药物组合物; 药学上可接受的载体; 并且相对于2-氯 - 苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺，相对于N-乙基-N-苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺为0.5％w / 6-（1-乙基-N-甲基-2-氧代二氢吲哚-3-甲酰氨基）苯甲酸，1H，3H-螺[5-氯-1-甲基喹啉-2,4-二酮-3,3' - [1] 乙醛基 - [2] - 酮]或5-氯-N-乙基-3-羟基-1-甲基-2,4-二氧代-N-苯基-1,2,3,4-四氢 - 甲酰胺。

公开(公告)号：US08178127B2

公开(公告)日：2012-05-15

申请号：US12317104

申请日：2008-12-19

申请人： Muhammad Safadi ,  Daniella Licht ,  Ioana Lovinger ,  Aharon M. Eyal ,  Tomas Fristedt ,  Karl Jansson

发明人： Muhammad Safadi ,  Daniella Licht ,  Ioana Lovinger ,  Aharon M. Eyal ,  Tomas Fristedt ,  Karl Jansson

IPC分类号： A61K9/20

CPC分类号： B65B25/00 ,  A61K9/1623 ,  A61K9/2004 ,  A61K9/2018 ,  A61K31/438 ,  A61K31/4704 ,  C07D209/34 ,  C07D209/42 ,  C07D471/10 ,  Y10T436/145555

摘要： The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido)benzoic acid, 1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3′-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4-tetrahydro-quinoline-3-carboxamide.

摘要翻译： 本发明提供了包含N-乙基-N-苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺或其盐的药物组合物; 药学上可接受的载体; 并且相对于2-氯 - 苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺，相对于N-乙基-N-苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺为0.5％w / 6-（1-乙基-N-甲基-2-氧代二氢吲哚-3-甲酰氨基）苯甲酸，1H，3H-螺[5-氯-1-甲基喹啉-2,4-二酮-3,3' - [1] 乙醛基 - [2] - 酮]或5-氯-N-乙基-3-羟基-1-甲基-2,4-二氧代-N-苯基-1,2,3,4-四氢 - 甲酰胺。

公开(公告)号：US20120107891A1

公开(公告)日：2012-05-03

申请号：US13344464

申请日：2012-01-05

申请人： William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

发明人： William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

IPC分类号： C12P7/16

CPC分类号： C12M43/00 ,  C07C29/80 ,  C07C29/86 ,  C12C11/11 ,  C12M45/20 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17 ,  Y10T29/49826 ,  C07C31/12

摘要： This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.

公开(公告)号：US20120107890A1

公开(公告)日：2012-05-03

申请号：US13344460

申请日：2012-01-05

申请人： William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

发明人： William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

IPC分类号： C12P7/16

CPC分类号： C12M43/00 ,  C07C29/80 ,  C07C29/86 ,  C12C11/11 ,  C12M45/20 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17 ,  Y10T29/49826 ,  C07C31/12

摘要： This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.

公开(公告)号：US06320077B1

公开(公告)日：2001-11-20

申请号：US09132720

申请日：1998-08-12

申请人： Aharon M. Eyal ,  John N. Starr ,  Rod Fisher ,  Betty Hazan ,  Riki Canari ,  David R. Witzke ,  Patrick R. Gruber ,  Jeffrey J. Kolstad

发明人： Aharon M. Eyal ,  John N. Starr ,  Rod Fisher ,  Betty Hazan ,  Riki Canari ,  David R. Witzke ,  Patrick R. Gruber ,  Jeffrey J. Kolstad

IPC分类号： C07C5908

CPC分类号： C07C51/48 ,  C07C67/08 ,  C12P7/56 ,  Y02P20/582 ,  C07C59/08 ,  C07C69/68

摘要： The techniques for processing lactic acid/lactate salt mixtures are provided. Preferred mixtures for processing are obtained from fermentation broths, preferably from fermentation processes conducted at a pH of 4.8 or lower. The techniques generally concern the provision of separated lactic acid and lactate streams, from the mixtures. Preferred techniques of separation and processing of each of the streams are provided.

摘要翻译： 提供了乳酸/乳酸盐混合物的加工技术。 优选的用于加工的混合物从发酵液中获得，优选在pH4.8或更低的条件下进行发酵。 这些技术通常涉及从混合物中提供分离的乳酸和乳酸盐流。 提供了每种流的分离和处理的优选技术。

公开(公告)号：US5510526A

公开(公告)日：1996-04-23

申请号：US207773

申请日：1994-03-08

申请人： Abraham M. Baniel ,  Aharon M. Eyal ,  Joseph Mizrahi ,  Betty Hazan ,  Rod R. Fisher ,  Jeffrey J. Kolstad ,  Brenda F. Stewart

发明人： Abraham M. Baniel ,  Aharon M. Eyal ,  Joseph Mizrahi ,  Betty Hazan ,  Rod R. Fisher ,  Jeffrey J. Kolstad ,  Brenda F. Stewart

IPC分类号： C12P7/56 ,  C07C51/48 ,  C07C51/42

CPC分类号： C12P7/56

摘要： A process for the production of lactic acid and for the separation and/or recovery of lactic acid from a lactate feed solution. A lactate feed solution preferably obtained from a fermentation broth is combined with and extracted by a water immiscible trialkyl amine in the presence of carbon dioxide. Lactic acid is recovered from the resulting organic phase. Recovered carbonate or bicarbonate from the aqueous phase is preferably recycled to the fermentor and regenerated extractant is preferably recycled for use in the extraction.

公开(公告)号：US20120064590A1

公开(公告)日：2012-03-15

申请号：US13302775

申请日：2011-11-22

申请人： William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

发明人： William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

IPC分类号： C12P7/16

CPC分类号： C12M43/00 ,  C07C29/80 ,  C07C29/86 ,  C12C11/11 ,  C12M45/20 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17 ,  Y10T29/49826 ,  C07C31/12

摘要： This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.

摘要翻译： 本发明涉及从稀释的水溶液如发酵液中回收C3-C6醇的方法。 这样的方法提供了用于发酵的改进的体积生产率并允许酒精回收。 由于通过同时发酵和回收过程增加了醇产物的有效浓度，所以这种方法还允许在用过的发酵液的生产和干燥中减少能量消耗，这增加了每一批发酵液干燥产生和回收的醇的量。 因此，本发明允许以低资本生产和回收C3-C6醇，降低运行成本。

公开(公告)号：US20090162432A1

公开(公告)日：2009-06-25

申请号：US12317104

申请日：2008-12-19

申请人： Muhammad Safadi ,  Daniella Licht ,  Ioana Lovinger ,  Aharon M. Eyal ,  Tomas Fristedt ,  Karl Jansson

发明人： Muhammad Safadi ,  Daniella Licht ,  Ioana Lovinger ,  Aharon M. Eyal ,  Tomas Fristedt ,  Karl Jansson

IPC分类号： A61K9/28 ,  A61K31/4704 ,  G01N33/15 ,  C07D471/10 ,  C07D209/34 ,  A61K31/438

CPC分类号： B65B25/00 ,  A61K9/1623 ,  A61K9/2004 ,  A61K9/2018 ,  A61K31/438 ,  A61K31/4704 ,  C07D209/34 ,  C07D209/42 ,  C07D471/10 ,  Y10T436/145555

摘要： The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido)benzoic acid,1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3′-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4-tetrahydro-quinoline-3-carboxamide.

摘要翻译： 本发明提供了包含N-乙基-N-苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺或其盐的药物组合物; 药学上可接受的载体; 并且相对于2-氯 - 苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺，相对于N-乙基-N-苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺为0.5％w / 6-（1-乙基-N-甲基-2-氧代二氢吲哚-3-甲酰氨基）苯甲酸，1H，3H-螺[5-氯-1-甲基喹啉-2,4-二酮-3,3' - [1] 乙醛基 - [2] - 酮]或5-氯-N-乙基-3-羟基-1-甲基-2,4-二氧代-N-苯基-1,2,3,4-四氢 - 甲酰胺。

公开(公告)号：US20080260902A1

公开(公告)日：2008-10-23

申请号：US11587258

申请日：2005-04-14

申请人： Michael Van Houten ,  Michael J. Beaver ,  Aharon M. Eyal ,  Eugene J. Fox ,  Joel Ingvalson ,  Neal T. Jakel ,  Douglas C. Kotowski ,  Paul J. McWilliams ,  Alexander Patist ,  Michael J. Tupy ,  Troy T. Lohrmann

发明人： Michael Van Houten ,  Michael J. Beaver ,  Aharon M. Eyal ,  Eugene J. Fox ,  Joel Ingvalson ,  Neal T. Jakel ,  Douglas C. Kotowski ,  Paul J. McWilliams ,  Alexander Patist ,  Michael J. Tupy ,  Troy T. Lohrmann

IPC分类号： A23L1/105 ,  A23D9/00 ,  A23L1/10 ,  C10L5/44

CPC分类号： C08L99/00 ,  A23D9/00 ,  A23K10/37 ,  A23K20/158 ,  A23K40/20 ,  A23K40/25 ,  A23K50/10 ,  A23K50/20 ,  A23K50/30 ,  A23K50/40 ,  A23K50/75 ,  A23K50/80 ,  A23L7/198 ,  A23L33/115 ,  A61K8/922 ,  A61K8/97 ,  A61Q1/06 ,  A61Q1/10 ,  B02B1/00 ,  B02B5/02 ,  C08B30/02 ,  C08H99/00 ,  C10L1/026 ,  C11B1/04 ,  C11B1/06 ,  C11B1/10 ,  C11B1/104 ,  D21H17/02 ,  Y02A40/818 ,  Y02E50/10 ,  Y02E50/13 ,  Y02E50/30 ,  Y02P60/877

摘要： Corn oil is extracted from corn to form a corn meal. Processing the corn grain to obtain the oil, meal, and other product streams generally includes dividing the corn kernel by fractionating to create a higher oil fraction and a lower oil fraction, forming a solvent extractable structure from the higher oil fraction, and extracting the oil from the higher oil fraction. The extracted corn oil is useful for making nutritionally enhanced edible oil or cooking oil, lubricants, biodiesel, fuel, cosmetics and oil-based or oil-containing chemical products. The extracted corn meal is useful for making enhanced animal feed rations, snack food, blended food products, cosmetics, and fermentation broth additive. The lower oil fraction is useful for one or more processes such as fermentation, wet-milling, animal feed production, sweetener production, and starch production, making enhanced animal feed rations, snack food, blended food products, and cosmetics.

摘要翻译： 从玉米中提取玉米油，形成玉米粉。 加工玉米粒以获得油，粕和其他产品流通常包括通过分馏分离玉米粒以产生较高的油馏分和较低的油馏分，从较高的油馏分形成溶剂可萃取的结构，并提取油 从较高的油分。 提取的玉米油可用于制备营养增强的食用油或食用油，润滑剂，生物柴油，燃料，化妆品和油基或含油化学产品。 提取的玉米粉可用于制造增强的动物饲料配给，小吃食品，混合食品，化妆品和发酵肉汤添加剂。 较低的油馏分可用于发酵，湿磨，动物饲料生产，甜味剂生产和淀粉生产等一个或多个过程，增强动物饲料配给，零食，混合食品和化妆品。

公开(公告)号：US06472559B2

公开(公告)日：2002-10-29

申请号：US09768078

申请日：2001-01-23

申请人： Avraham M. Baniel ,  Aharon M. Eyal ,  Joseph Mizrahi ,  Betty Hazan ,  Rod R. Fisher ,  Jeffrey J. Kolstad ,  Brenda F. Stewart

发明人： Avraham M. Baniel ,  Aharon M. Eyal ,  Joseph Mizrahi ,  Betty Hazan ,  Rod R. Fisher ,  Jeffrey J. Kolstad ,  Brenda F. Stewart

IPC分类号： C07C5142

CPC分类号： C12P7/56

摘要： A process for the production and isolation of lactic acid is provided. A lactate feed solution, preferably obtained from a fermentation broth is combined with and extracted by a water-immiscible base in the presence of an acidifying agent. Lactic acid is recovered from the resulting organic phase. Recovered carbonate or bicarbonate from the aqueous phase can be recycled to the fermentor and regenerated extractant can be recycled for use in the extraction.

摘要翻译： 提供了生产和分离乳酸的方法。 在酸性剂的存在下，优选从发酵液中获得的乳酸盐进料溶液与水不混溶的碱组合并提取。 从所得有机相中回收乳酸。 从水相中回收的碳酸盐或碳酸氢盐可以再循环到发酵罐中，再生的萃取剂可以再循环用于萃取。