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21.发明授权Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 有权用作逆转录病毒蛋白酶抑制剂的磺酰基烷酰氨基羟乙基氨基磺酰胺
公开(公告)号：US6147117A
公开(公告)日：2000-11-14
申请号：US352215
申请日：1999-07-13
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： A61K31/225 , A61K31/18 , A61K31/63 , A61P31/12 , C07C311/18 , C07C317/44 , C07C327/38 , C07D307/79 , C07D319/16 , A61K31/415 , A61K31/44 , A61K31/535
CPC分类号： A61K31/63 , A61K31/18 , C07C317/44
摘要： Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译： 含磺酰胺的羟乙基胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。
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22.发明授权
公开(公告)号：US5521219A
公开(公告)日：1996-05-28
申请号：US110913
申请日：1993-08-24
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： A61K31/225 , A61K31/18 , A61K31/63 , A61P31/12 , C07C311/18 , C07C317/44 , C07C327/38 , C07D307/79 , C07D319/16 , A61K31/38 , A61K31/44
CPC分类号： A61K31/63 , A61K31/18 , C07C317/44
摘要： Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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23.发明申请Alpha- and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效可用作逆转录病毒蛋白酶抑制剂的α-氨基酸和β-氨基酸羟乙基氨基磺酰胺公开(公告)号：US20070078173A1
公开(公告)日：2007-04-05
申请号：US11526101
申请日：2006-09-25
申请人： Michael Vazquez , Richard Mueller , John Talley , Daniel Getman , Gary DeCrescenzo , John Freskos , Robert Heintz , Deborah Bertenshaw
发明人： Michael Vazquez , Richard Mueller , John Talley , Daniel Getman , Gary DeCrescenzo , John Freskos , Robert Heintz , Deborah Bertenshaw
IPC分类号： A61K31/44 , A61K31/18 , C07D213/24 , C07C311/45
CPC分类号： C07C311/05 , A61K38/00 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D213/30 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D233/64 , C07D239/26 , C07D277/24 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D317/62 , C07D333/34 , C07D405/12 , C07D417/12 , C07K5/06026 , C07K5/06139
摘要： α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译： α-和β-氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。
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公开(公告)号：US20060264483A1
公开(公告)日：2006-11-23
申请号：US11397055
申请日：2006-04-04
申请人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , Joseph McDonald
发明人： Daniel Getman , Gary DeCrescenzo , John Freskos , Michael Vazquez , James Sikorski , Balekudru Devadas , Srinivasan Nagarajan , Joseph McDonald
IPC分类号： A61K31/428 , A61K31/423 , A61K31/4184 , A61K31/343 , C07D417/02 , C07D277/62 , C07D263/60 , C07D235/04
CPC分类号： C07D263/56 , C07C317/44 , C07D215/36 , C07D217/02 , C07D217/04 , C07D235/30 , C07D235/32 , C07D249/20 , C07D277/62 , C07D277/82 , C07D307/79 , C07D307/82 , C07D311/58 , C07D317/62 , C07D319/18
摘要： Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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公开(公告)号：US20060166895A1
公开(公告)日：2006-07-27
申请号：US11331344
申请日：2006-01-13
申请人： John Talley , Daniel Getman , Gary DeCrescenzo , Kathryn Reed , Ko-Chung Lin , John Freskos , Michael Clare , Donald Rogier , Robert Heintz , Michael Vazquez , Richard Mueller
发明人： John Talley , Daniel Getman , Gary DeCrescenzo , Kathryn Reed , Ko-Chung Lin , John Freskos , Michael Clare , Donald Rogier , Robert Heintz , Michael Vazquez , Richard Mueller
CPC分类号： C07D401/12 , C07D207/16 , C07D211/60 , C07D217/26
摘要： N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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公开(公告)号：US20060040974A1
公开(公告)日：2006-02-23
申请号：US11199571
申请日：2005-08-09
申请人： Richard Mueller , Daniel Getman
发明人： Richard Mueller , Daniel Getman
IPC分类号： A61K31/47 , C07D217/12
CPC分类号： C07D401/12 , C07D217/26
摘要： HIV protease inhibitors are disclosed which are characterized as having both hydroxyethylamine and N-heterocyclic moieties.
摘要翻译： 公开了HIV蛋白酶抑制剂，其特征在于具有羟基胺和N-杂环部分。
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27.发明申请Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效用作逆转录病毒蛋白酶抑制剂的琥珀酰氨基羟基氨基磺酰脲衍生物公开(公告)号：US20060020009A1
公开(公告)日：2006-01-26
申请号：US11183230
申请日：2005-07-18
申请人： Michael Vazquez , Richard Mueller , John Talley , Daniel Getman , Gary DeCrescenzo , Eric Sun
发明人： Michael Vazquez , Richard Mueller , John Talley , Daniel Getman , Gary DeCrescenzo , Eric Sun
IPC分类号： C07D233/61 , A61K31/4172 , A61K31/235
CPC分类号： C07D213/42 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/088 , C07D295/13 , C07D295/185 , C07D303/36
摘要： Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1-R6, R7, R7′, R8, R30-R34, X′, Y, Y′, t, x, and n are as defined herein, are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译： 下式的琥珀酰氨基羟基氨基磺酰脲衍生物：其中R 1，R 6，R 7，R 7， R 8，R 30，R 34，X'，Y，Y'，t，x和n如本文所定义， 作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。
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28.发明申请Method of preparing intermediates useful in synthesis of retroviral protease inhibitors 失效制备可用于合成逆转录病毒蛋白酶抑制剂的中间体的方法公开(公告)号：US20050171366A1
公开(公告)日：2005-08-04
申请号：US10962746
申请日：2004-10-13
申请人： John Ng , Claire Przybyla , Richard Mueller , Michael Vazquez , Daniel Getman
发明人： John Ng , Claire Przybyla , Richard Mueller , Michael Vazquez , Daniel Getman
IPC分类号： A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/00 , C07C213/02 , C07C213/08 , C07C215/28 , C07C269/06 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号： C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C04B35/632 , C07B2200/07 , C07C213/00 , C07C213/02 , C07C213/08 , C07C269/06 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , C07C215/08 , C07C215/28 , C07C271/16
摘要： A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
摘要翻译： 对于易于大规模制备基于羟基脲的手性HIV蛋白酶抑制剂的中间体描述了合成。 该方法包括由手性α氨基醛形成非对映选择性环氧化物。
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29.发明授权Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效可用作逆转录病毒蛋白酶抑制剂的琥珀酰氨基羟乙基氨基磺酰胺公开(公告)号：US06727282B2
公开(公告)日：2004-04-27
申请号：US10237184
申请日：2002-09-09
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： C07C30702
CPC分类号： C07C311/05 , C07C311/18 , C07C311/29
摘要： Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译： 琥珀酰氨基羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶抑制剂。
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30.发明授权Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效可用作逆转录病毒蛋白酶抑制剂的琥珀酰氨基羟乙基氨基磺酰胺公开(公告)号：US06313345B1
公开(公告)日：2001-11-06
申请号：US09419816
申请日：1999-10-18
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： C07C30702
CPC分类号： C07C311/05 , C07C311/18 , C07C311/29
摘要： Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译： 琥珀酰氨基羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶抑制剂。
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