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21.发明申请NEAR-IR INDOCYANINE GREEN DOPED MULTIMODAL SILICA NANOPARTICLES AND METHODS FOR MAKING THE SAME 审中-公开近红外吲哚啉绿色多糖多元二氧化硅纳米颗粒及其制备方法公开(公告)号：US20130108552A1
公开(公告)日：2013-05-02
申请号：US13582226
申请日：2011-02-24
申请人： Parvesh Sharma , Scott Chang Brown , Niclas Bengtsson , Glenn A. Walter , Nobutaka Iwakuma , Edward W. Scott , Stephen R. Grobmyer , Swadeshmukul Santra , Brij M. Moudgil
发明人： Parvesh Sharma , Scott Chang Brown , Niclas Bengtsson , Glenn A. Walter , Nobutaka Iwakuma , Edward W. Scott , Stephen R. Grobmyer , Swadeshmukul Santra , Brij M. Moudgil
CPC分类号： A61N5/062 , A61K49/001 , B82Y5/00 , B82Y15/00 , C09K11/02 , C09K11/06 , G01N21/6486
摘要： The subject invention provides novel fluorescent core-shell nanoparticles comprising an encapsulated fluorescent core comprising an ionically bound fluorescent dye and a metal oxide shell. In one exemplary embodiment of the invention a core containing indocyanine green (ICG) with a silica shell that displays excellent photostability for generation of a near infrared fluorescence signal. The fluorescent core-shell nanoparticle can be further modified to act as an MRI, x-ray, or PAT contrast agent. The ICG nanoparticles can also be used as photodynamic therapeutic agent. Other embodiments of the invention directed to methods of making the novel core-shell nanoparticles and to the use of the core-shell nanoparticles for in vitro or in vivo imaging.
摘要翻译： 本发明提供了新颖的荧光核 - 壳纳米颗粒，其包含包含离子键的荧光染料和金属氧化物壳的包封的荧光核心。 在本发明的一个示例性实施方案中，含有具有二氧化硅壳的吲哚菁绿（ICG）的核心，其显示出用于产生近红外荧光信号的优异的光稳定性。 荧光核 - 壳纳米颗粒可进一步修饰为MRI，X射线或PAT造影剂。 ICG纳米颗粒也可以用作光动力治疗剂。 本发明的其它实施方案涉及制备新型核 - 壳纳米颗粒的方法以及使用核 - 壳纳米颗粒进行体外或体内成像。
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22.发明授权Materials and methods for identifying biointeractive nanostructures and/or nanoparticles 有权用于鉴定生物相互作用的纳米结构和/或纳米颗粒的材料和方法公开(公告)号：US07908908B2
公开(公告)日：2011-03-22
申请号：US11908515
申请日：2006-03-23
IPC分类号： G01B5/28
CPC分类号： G01N33/54373 , G01Q60/42
摘要： Disclosed herein are surface force microscope probes comprising living cells adhered thereto, as well as methods of making same. Also disclosed is a system for high throughput screening of nanostructures having biological relevance through use of surface force microscope probes comprising living cells. Further disclosed are methods of screening for biointeractive nanostructures.
摘要翻译： 本文公开了包括附着在其上的活细胞的表面力显微镜探针及其制造方法。 还公开了一种通过使用包含活细胞的表面力显微镜探针具有生物相关性的高通量筛选纳米结构的系统。 还公开了筛选生物相互作用的纳米结构的方法。
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23.发明申请Materials and Methods for Identifying Biointeractive Nanostructures and/or Nanoparticles 有权用于鉴定生物相互作用的纳米结构和/或纳米颗粒的材料和方法公开(公告)号：US20090000363A1
公开(公告)日：2009-01-01
申请号：US11908515
申请日：2006-03-23
CPC分类号： G01N33/54373 , G01Q60/42
摘要： Disclosed herein are surface force microscope probes comprising living cells adhered thereto, as well as methods of making same. Also disclosed is a system for high throughput screening of nanostructures having biological relevance through use of surface force microscope probes comprising living cells. Further disclosed are methods of screening for biointeractive nanostructures.
摘要翻译： 本文公开了包括附着在其上的活细胞的表面力显微镜探针及其制造方法。 还公开了一种通过使用包含活细胞的表面力显微镜探针具有生物相关性的高通量筛选纳米结构的系统。 还公开了筛选生物相互作用的纳米结构的方法。
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公开(公告)号：US5635089A
公开(公告)日：1997-06-03
申请号：US526633
申请日：1995-09-11
IPC分类号： B23K26/06 , B23K26/36 , B23K26/40 , B29C35/08 , B29C59/16 , C04B41/00 , C04B41/80 , C21D1/09 , C22F3/00 , H05K1/03 , H05K3/38 , B23K26/00
CPC分类号： C22F3/00 , A61F2/30771 , B23K26/0624 , B23K26/362 , B23K26/40 , B23K26/402 , B29C59/16 , C04B41/0036 , C04B41/009 , C04B41/80 , C21D1/09 , A61F2002/3097 , A61F2310/00011 , A61F2310/00179 , B23K2203/16 , B23K2203/42 , B23K2203/50 , B23K2203/52 , B29C2035/0827 , B29C2035/0838 , H05K1/0306 , H05K3/381 , H05K3/382
摘要： A method for increasing the surface area and roughness of metals, ceramics and composites on a micro-scale, and the surfaces themselves, is disclosed whereby a laser beam having a radiation wavelength of from UV to infrared is pulsed onto the surface of the material. The energy density of the radiation is between 0.01 to 15 J/cm.sup.2 and at least 50 pulses of radiation having duration of from 1 picosecond to 1 millisecond are used on each area. The surface structures formed are semi-periodic and are from 1/4 to several hundred microns in magnitude.
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公开(公告)号：US4208273A
公开(公告)日：1980-06-17
申请号：US897779
申请日：1978-04-19
CPC分类号： B03B1/04 , B03B13/04 , B07C5/3427
摘要： A method is disclosed for the separation of coal from run of mine (ROM) coal containing particles of coal and refuse, which comprises conditioning the ROM coal with a coupling agent capable of selectively coating the particulate coal to the substantial exclusion of coating the refuse, which coupling agent is at least one alcohol containing from about 6 to about 22 carbon atoms. Combined with said coupling agent is a fluorescent dye in a quantity to make the coated particles of coal fluoresce upon excitation to a degree sufficient to distinguish the coated coal particles from the substantially non-coated refuse. Exciting (e.g. as with ultraviolet light) the fluorescent dye coupled to the coal particles induces fluorescence and enables separating the fluorescing, coated coal particles from substantially non-fluorescing, non-coated refuse particles.
摘要翻译： 公开了一种用于从煤矿和含煤矿煤和垃圾颗粒的煤矿中分离煤的方法，其包括用能够选择性地涂覆颗粒状煤的偶联剂来调节ROM煤，以实质上排除涂覆垃圾， 该偶联剂是含有约6至约22个碳原子的至少一种醇。 与所述偶联剂组合是一定量的荧光染料，使得涂覆的煤颗粒在激发时发出足以将涂覆的煤颗粒与基本上未涂覆的垃圾区分开的程度。 激发（例如与紫外线一样），耦合到煤颗粒的荧光染料诱导荧光，并且能够将荧光涂覆的煤颗粒与基本上不发荧光的未涂覆的垃圾颗粒分离。
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26.发明授权
公开(公告)号：US4207175A
公开(公告)日：1980-06-10
申请号：US897780
申请日：1978-04-19
申请人： Brij M. Moudgil
发明人： Brij M. Moudgil
摘要： A method for the separation of magnesite from a particulate ore containing particles relatively rich in magnesite and particles relatively rich in dolomite and/or calcite, which comprises conditioning the ore with at least one coupling agent selected from saturated and unsaturated carboxylic acids containing from about 4 to about 22 carbon atoms, to selectively coat the calcite and/or dolomite in the ore to the substantial exclusion of the magnesite, in combination with providing at least one fluorescent dye to said coupling agent; radiating the conditioned ore to excite and induce fluorescence of the fluorescent dye to a degree sufficient to distinguish the coated particles from the non-coated particles and separating the fluorescing, coated particles from the non-fluorescing, non-coated particles.
摘要翻译： 一种用于从含有相对丰富的菱镁矿颗粒的颗粒矿石和相对富含白云石和/或方解石的颗粒中分离菱镁矿的方法，其包括用至少一种偶联剂调节矿石，所述偶联剂选自饱和和不饱和羧酸，其含有约4 至约22个碳原子，以选择性地将矿石中的方解石和/或白云石涂覆到基本排除菱镁矿，结合向所述偶联剂提供至少一种荧光染料; 辐射经调节的矿石以激发荧光染料的荧光，使荧光染料的荧光达到足以区分涂覆的颗粒与未涂覆颗粒的程度，并将荧光涂覆的颗粒与非发荧光的未涂覆颗粒分离。
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公开(公告)号：US20110020228A1
公开(公告)日：2011-01-27
申请号：US12865589
申请日：2009-02-02
IPC分类号： A61K49/00 , A61K31/765 , A61K31/20 , A61K31/201 , A61K31/23 , A61K31/231 , A61K36/47 , A61K36/889 , A61K36/899 , A61K31/341 , A61K31/08 , A61K31/355 , A61K31/7024 , A61K31/05 , A61K31/575 , A61K31/221 , A61K31/255 , A61P35/00
CPC分类号： A61K49/0017 , A61K31/765 , A61K47/543 , A61K47/60
摘要： A method for the treatment of cancer involves delivering a surface active agent to an organism, where the surface active agent selectively partitions to and kills cancer cells as opposed to healthy cells. The surface active agent can be an ionic or a non-ionic surfactant with a HLB of less than 29 or a mixture of surface active agents with a HLB of less than 40, where the hydrophobic portion is a lesser fraction of the surface active agent than the hydrophilic portion. A fluorescence method of detecting and locating cancer cells in an organism involves delivering a surface active agent, where the surface active agent includes a fluorescence moiety that upon selective partitioning of the surface active agent to the cancer cells and irradiation by a radiation source to excite the fluorescence moiety, a fluorescence emission is observed permitting the detection and location of the cancerous tissue by local volumes of relatively high intensity emission.
摘要翻译： 用于治疗癌症的方法涉及将表面活性剂递送到生物体，其中与健康细胞相反，表面活性剂选择性地分隔并杀死癌细胞。 表面活性剂可以是HLB小于29的离子或非离子表面活性剂或HLB小于40的表面活性剂的混合物，其中疏水部分是表面活性剂的较少部分， 亲水部分。 检测和定位生物体内的癌细胞的荧光方法包括递送表面活性剂，其中表面活性剂包括荧光部分，当将表面活性剂选择性分配到癌细胞时，通过辐射源照射以激发 观察到荧光发射，允许通过相当高强度发射的局部体积检测和定位癌组织。
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公开(公告)号：US4352731A
公开(公告)日：1982-10-05
申请号：US220656
申请日：1980-12-29
CPC分类号： B03B1/04 , B07C5/3427
摘要： Apparatus and method for selective wetting of particles includes sizing of particles to a preselected size for enabling optical discrimination between desired particles having a relatively large surface area receptive to coating by a preselected wetting agent and undesired particles having a relatively small surface area receptive to coating by the preselected wetting agent. The particles are fed into a conditioning zone defined by the spray of wetting agent from at least one spray means, the spray of wetting agent being in sufficient quantity to impact and coat substantially all of the surface areas of the particles receptive to coating by the wetting agent. The means for feeding the particles into the conditioning zone is disposed outside the conditioning zone and preferably feeds the particles in an unsupported state into the conditioning zone.
摘要翻译： 用于选择性润湿颗粒的装置和方法包括将颗粒的尺寸调整为预选尺寸，以使得能够对具有相当大的表面积的预期颗粒进行光学鉴别，所述表面积接受预选润湿剂的涂覆，以及具有相对较小的表面积的不期望的颗粒， 预选润湿剂。 将颗粒进料到由至少一种喷雾装置的润湿剂喷雾限定的调节区域中，润湿剂的喷雾量足以冲击和涂覆接受涂层的颗粒的基本上所有表面区域 代理商 用于将颗粒进料到调节区域的装置设置在调节区域的外部，并且优选将颗粒以无支撑状态进料到调节区域中。
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公开(公告)号：US4284499A
公开(公告)日：1981-08-18
申请号：US98363
申请日：1979-11-28
申请人： Brij M. Moudgil , Booker W. Morey
发明人： Brij M. Moudgil , Booker W. Morey
CPC分类号： B03D1/00 , B03D1/021 , B03D1/085 , B03D1/1406 , B03D1/1412 , B03D1/1475 , B03D1/24 , B03D1/028 , B03D1/06
摘要： An apparatus and a method for concentrating an ore to recover valuable minerals from the ore is disclosed. The apparatus is based upon flotation separation techniques and comprises a trough into which is fed a slurry of ore particles which have been conditioned with a flotation reagent. The trough has a side extending outwardly forming a downwardly sloping flat table. The slurry of conditioned ore particles flows out of the trough and downwardly along the sloping table. Positioned along the sloping table is a disperser for dispersing larger particles up and into the slurry, which larger particles are generally along the surface of the sloping table. The sloping table is equipped with at least one aerator positioned along the flow path of the slurry, downstream of the disperser which aerates the conditioned ore slurry. The particles coated with the flotation reagent form agglomerates with gas bubbles produced by the aerator. These agglomerates float at a higher level within the slurry than the non-coated, non-agglomerating ore particles. A splitter is positioned near an open end of the sloping table. The splitter height above the surface of the sloping table is adjustable for intersecting the conditioned ore slurry at differing levels. The splitter separates the agglomerative, coated particles floating at a higher level from the non-agglomerative, non-coated particles floating at a lower level in the slurry.
摘要翻译： 公开了一种用于浓缩矿石以从矿石中回收有价值矿物的装置和方法。 该设备基于浮选分离技术，并且包括槽，其中供给已经用浮选试剂调节的矿石颗粒的浆料。 槽具有向外延伸的一侧，形成向下倾斜的平台。 调节矿石颗粒的浆料从槽中流出并沿倾斜台向下流动。 沿着倾斜台定位的是用于将较大颗粒分散到浆料中的分散器，其中较大的颗粒通常沿着倾斜台的表面。 倾斜台配备有至少一个沿着浆料的流动路径定位的曝气器，在分散器的下游对调节的矿浆进行通气。 涂有浮选试剂的颗粒与曝气器产生的气泡形成附聚物。 这些附聚物在浆料内比未涂覆的非附聚矿石颗粒漂浮更高的水平。 分流器位于倾斜台的开口端附近。 倾斜台表面上方的分流器高度是可调节的，以便与不同水平的调节矿浆相交。 分流器将在较高水平上漂浮的凝聚的涂覆颗粒与在浆液中较低水平漂浮的非附聚的未涂覆颗粒分离。
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公开(公告)号：US06217706B1
公开(公告)日：2001-04-17
申请号：US09429397
申请日：1999-10-28
申请人： Hassan El-Shall , Brij M. Moudgil
发明人： Hassan El-Shall , Brij M. Moudgil
IPC分类号： D21B108
CPC分类号： D21C5/025 , Y02W30/648
摘要： A method of de-inking cellulosic fibrous materials comprising: a. admixing an alkaline reagent selected from the group consisting of ammonium hydroxide and hydrogen peroxide and mixtures thereof with an aqueous suspension of inked cellulosic fibrous material such that they react at the ink particle/cellulosic fiber interfaces to dislodge ink particles from the cellulosic materials; and b. removing the dislodged ink particles from the aqueous suspension.
摘要翻译： 一种脱墨纤维素纤维材料的方法，包括：a。 将选自氢氧化铵和过氧化氢的碱性试剂及其混合物与着色的纤维素纤维材料的水性悬浮液混合，使得它们在油墨颗粒/纤维素纤维界面反应以从纤维素材料上移除油墨颗粒; 安布 从水性悬浮液中除去脱落的墨颗粒。
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