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公开(公告)号：US20240102174A1
公开(公告)日：2024-03-28
申请号：US18536762
申请日：2023-12-12
发明人： Douglas P. Riemer , Peter F. Ladwig
CPC分类号： C23F1/16 , C09K13/06 , C23F1/02 , G11B5/484 , H05K1/0277 , H05K3/067 , H05K2203/0779
摘要： An etch chemistry solution for treating metallic surfaces in which the etch chemistry solution includes an oxidizing agent and gluconic acid. The etch chemistry solution may also include an oxidizing agent and a short-chained polyethylene polymer glycol or a short-chained polyethylene copolymer glycol. The metallic surfaces are usually used in circuits such as flexible circuits.
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22.发明公开公开(公告)号：US20240094209A1
公开(公告)日：2024-03-21
申请号：US18509663
申请日：2023-11-15
发明人： Evan Greene , Greg Finak , Raphael Gottardo
IPC分类号： G01N33/574 , G16B5/00 , G16B25/10
CPC分类号： G01N33/5743 , G16B5/00 , G16B25/10
摘要： Disclosed herein are to markers, methods and systems for identifying cell populations, diagnosing, monitoring and treating cancer, including biomarkers predictive of response to immunotherapy treatment in Merkel cell carcinoma.
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公开(公告)号：US11932691B2
公开(公告)日：2024-03-19
申请号：US17157810
申请日：2021-01-25
IPC分类号： C07K16/28 , G01N33/574
CPC分类号： C07K16/2803 , G01N33/57492 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/92 , G01N2333/70503
摘要： The present disclosure relates to anti-ROR1 binding proteins, including those that bind to a ROR1 or portion thereof such as an intracellular C terminal portion of a ROR1 protein, and the use of such binding proteins in immunohistochemical and diagnostic methods. Related kits and methods of using the binding proteins are also provided, as are methods of treatment of subjects having diseases or conditions determined to be candidates for such treatments by the binding proteins or methods of this disclosure.
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24.发明授权公开(公告)号：US11898264B2
公开(公告)日：2024-02-13
申请号：US17479569
申请日：2021-09-20
摘要： Treatment solutions and methods for improving adhesion of gold electroplating onto metal surfaces are provided herein. More specifically, the disclosure relates to micro-etching stainless steel surfaces using to remove any organic contamination and chromium oxide formed on the surface, neutralize and strip the surface of any iron content, and repassivate the surface with a thin chromium oxide layer, prior to gold electroplating of the stainless steel surfaces.
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25.发明授权公开(公告)号：US11872195B2
公开(公告)日：2024-01-16
申请号：US16222942
申请日：2018-12-17
IPC分类号： A61K48/00 , C12N9/22 , C07K14/705 , C12N15/88 , A61K35/14
CPC分类号： A61K48/005 , C07K14/705 , C12N9/22 , C12N15/88 , A61K35/14
摘要： Compositions and methods that rapidly and selectively modify hematopoietic stem cells (or cells derived therefrom) to achieve therapeutic objectives by providing for transient expression of nucleic acids are described. The transient expression leads to permanent therapeutic changes in the modified cells, referred to herein as “hit and run” effects.
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公开(公告)号：US11867575B2
公开(公告)日：2024-01-09
申请号：US17587865
申请日：2022-01-28
发明人： Michael W. Davis , Peter F. Ladwig , Matthew S. Lang , Dean E. Myers , Clark T. Olsen , Douglas P. Riemer
CPC分类号： G01L1/2268 , G01L1/146
摘要： A pressure/force sensor comprises a diaphragm structure including a sensing element and a lead structure extending from the diaphragm structure and including first and second traces electrically coupled to the sensing element. The diaphragm structure and the lead structure include a circuit assembly comprising a common insulating layer and a common conductor layer on the insulating layer. The conductor layer includes at least a portion of the sensing element and at least the first trace.
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公开(公告)号：US11867329B2
公开(公告)日：2024-01-09
申请号：US16925761
申请日：2020-07-10
申请人： HUTCHINSON
发明人： Stéphane Ully , Julien Mongendre
IPC分类号： F16L33/035 , H01M10/613 , H01M10/625 , H01M10/6568
CPC分类号： F16L33/035 , H01M10/613 , H01M10/625 , H01M10/6568 , H01M2220/20
摘要： A fluid connection device comprising a body formed of one single part and comprising a first tubular nozzle comprising a male part, and at least two elastically-deformable tabs provided to retain the male part in a female part, wherein the device further comprises a lock mounted on the body and mobile in translation from a first position wherein the tabs are released, allowing their elastic deformation, to a second position wherein the tabs are blocked, preventing their elastic deformation.
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公开(公告)号：US11821111B2
公开(公告)日：2023-11-21
申请号：US17097853
申请日：2020-11-13
发明人： Jesse Bloom , Allison Greaney , Andrea Loes , Adam S. Dingens
CPC分类号： C40B50/06 , C12N7/00 , C12N15/1065 , C12N2760/16021
摘要： Methods to create barcoded influenza viruses without disrupting the function of the viral proteins and the proper packaging of the viral genome segments are described. The barcoded influenza viruses can be used within deep mutational scanning libraries to map influenza resistance mutations to therapeutic treatments. The libraries can also be used to predict influenza strains that may become resistant to therapeutic treatments and/or more easily evolve to infect new species. The libraries include features that allow efficient collection and assessment of informative data, obviating bottlenecks of previous approaches.
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29.发明授权公开(公告)号：US11820891B2
公开(公告)日：2023-11-21
申请号：US16952290
申请日：2020-11-19
申请人： HUTCHINSON
CPC分类号： C08L77/10 , B29C45/0001 , C08L77/02 , F16F15/00 , B29K2077/10 , C08K3/40 , C08K7/14
摘要： The invention relates to a thermoplastic polymer composition comprising polyamides, its preparation method and a device for a motor vehicle capable of damping vibrations. The composition (I1, I2, I3, I4) comprises
an aliphatic polyamide
a polyphthalamide coming from a C6-C12 aliphatic diamine and from an aromatic diacid comprising terephthalic acid, the aliphatic polyamide/polyphthalamide weight ratio being >1 and
a reinforcing filler comprising glass fibers.
The composition has, after “RH50” conditioning, maximum tan delta values according to ISO 6721-5 between 60-90° C. and 1-3000 Hz, with
(i) tan delta >4.20% at 60° C. and/or
(ii) tan delta >4.00% at 80° C. and/or
(iii) tan delta >3.80% at 90° C.-
公开(公告)号：US11803925B1
公开(公告)日：2023-10-31
申请号：US16850013
申请日：2020-04-16
申请人： Danielle Hutchinson
发明人： Danielle Hutchinson
CPC分类号： G06Q50/182 , G06N5/027 , G06N5/04 , G06N20/00
摘要： A system and method for procedure selection for dispute resolution according to a plurality of factors, wherein the factors include but are not limited to characteristics of the people (or parties) involved, the nature of the dispute and its context, and the goals of the parties involved. Optionally the characteristics of the parties are determined according to their goals.
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