公开(公告)号：US07704753B2

公开(公告)日：2010-04-27

申请号：US11073028

申请日：2005-03-03

申请人： Zuifen Tang ,  Dengfeng Xiong ,  Shujiang Wu ,  Zhumin Guan

发明人： Zuifen Tang ,  Dengfeng Xiong ,  Shujiang Wu ,  Zhumin Guan

IPC分类号： G01N33/543

CPC分类号： G01N33/558 ,  Y10S435/805 ,  Y10S436/807 ,  Y10S436/823 ,  Y10T436/25125

摘要： The present invention provides devices, methods and kits for detecting the presence of an analyte in a liquid sample and indicating to the user the presence or absence of the analyte through the formation of a recognizable symbol during the assay. In one embodiment, the present invention provides test strips having a matrix including a sample application zone, a reagent zone, and a detection zone. Within the detection zone are located positive and negative control areas, and an analyte binding area. The positive control area contains one or more components that exhibit a first color when dry and a second color when wetted. When the assay is conducted, the positive control area is wetted by the assay fluids and turns to a second color, thereby functioning as a positive procedural control. When analyte is present in the sample, it binds at the analyte binding area, which interacts with the positive control area to form a second recognizable symbol at the detection zone.

摘要翻译： 本发明提供用于检测液体样品中分析物的存在并通过在测定期间形成可识别符号向用户指示分析物的存在或不存在的装置，方法和试剂盒。 在一个实施方案中，本发明提供具有包括样品施用区，试剂区和检测区的基质的测试条。 在检测区内设有正负控制区和分析物结合区。 阳性对照区域包含一种或多种在干燥时呈现第一颜色并且在润湿时呈现第二颜色的组分。 当进行测定时，阳性对照区域被测定流体润湿并变成第二种颜色，从而起到阳性程序控制的作用。 当分析物存在于样品中时，其在分析物结合区域处结合，分析物结合区域与阳性对照区域相互作用以在检测区域形成第二可识别符号。

公开(公告)号：US20100089529A1

公开(公告)日：2010-04-15

申请号：US11813835

申请日：2006-01-11

申请人： Claus Barholm-Hansen ,  Jacques Jonsmann ,  Thomas Rosleff Baekmark ,  Bent Overby ,  Christian Berendsen ,  Salim Bouaidat ,  Niels Kristian Bau-Madsen

发明人： Claus Barholm-Hansen ,  Jacques Jonsmann ,  Thomas Rosleff Baekmark ,  Bent Overby ,  Christian Berendsen ,  Salim Bouaidat ,  Niels Kristian Bau-Madsen

IPC分类号： B32B38/10

CPC分类号： F16K99/0017 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/165 ,  B01L2400/0406 ,  B01L2400/0688 ,  F16K99/0001 ,  F16K2099/0078

摘要： A method of producing a microfluidic device having at least one flow path may include providing a base substrate with a first surface and a top substrate with a second surface, hydrophilically treating at least one of the first and the second surfaces to provide a surface layer with a higher surface tension than the surface tension prior to the hydrophilic treatment, partly or totally removing the surface layer with a higher surface tension in a selected pattern of the hydrophilically treated first and/or second surfaces, to thereby provide the selected pattern with a lower surface tension than prior to the partly or totally removal of the surface layer with a higher surface tension in said selected pattern of the hydrophilic treated first and/or second surfaces, and joining said base substrate and top substrate to each other to provide a flow path between said first and second surfaces.

摘要翻译： 一种制造具有至少一个流路的微流体装置的方法可包括提供具有第一表面的基底基底和具有第二表面的顶部基底，亲水处理第一和第二表面中的至少一个以提供表面层 在亲水处理之前具有比表面张力更高的表面张力，部分地或全部地在亲水处理的第一和/或第二表面的选定图案中以更高的表面张力去除表面层，从而为所选择的图案提供较低的表面张力 表面张力比在亲水处理的第一和/或第二表面的所述选定图案中部分地或完全去除表面层之前具有更高表面张力的表面张力，以及将所述基底基板和顶部基板彼此接合以提供流动路径 在所述第一和第二表面之间。

公开(公告)号：US20100028981A1

公开(公告)日：2010-02-04

申请号：US12477107

申请日：2009-06-02

申请人： James T. RAMSEY ,  Larry Hartselle

发明人： James T. RAMSEY ,  Larry Hartselle

IPC分类号： C12M1/34 ,  G01N33/48

CPC分类号： B01L3/508 ,  A61B10/007 ,  A61B10/0096 ,  G01N33/558 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/81

摘要： The present invention includes but is not limited to a specimen collection device that includes a chamber capable of collecting a specimen, a specimen passage slot, a reservoir, a reservoir seal, and a test device. A sample or specimen added to the chamber flows through the specimen passage slot into the reservoir. Flow into the reservoir may be limited by the reservoir seal. The test device positioned within the reservoir detects the presence or concentration of an analyte within the sample or specimen.

摘要翻译： 本发明包括但不限于包括能够收集试样的室，样品通道槽，储存器，储存器密封件和测试装置的样本收集装置。 添加到室中的样品或样品流过样品通道槽进入储存器。 流入储存器的流量可能受到储存器密封的限制。 位于储存器内的测试装置检测样品或样品中分析物的存在或浓度。

公开(公告)号：US07591978B2

公开(公告)日：2009-09-22

申请号：US11502192

申请日：2006-08-10

申请人： Oren Shraga Dwir ,  Tomer Keren ,  Falk Fish

发明人： Oren Shraga Dwir ,  Tomer Keren ,  Falk Fish

IPC分类号： G01N21/00

CPC分类号： C12Q1/34 ,  C12Q2334/50 ,  C12Q2334/52 ,  G01N2333/195 ,  G01N2333/30 ,  G01N2333/36 ,  G01N2800/36

摘要： A solid-phase test device and a method for the detection of sialidase activity in a fluid sample. The test device includes a solid support provided with a pre-deposited dry form of a sialidase detecting composition. The sialidase detecting composition includes a sialidase substrate and a color-developing reagent. When the sialidase substrate is exposed to sialidase it yields an intermediate compound which reacts with the color-developing reagent to form a detectable color change.

摘要翻译： 固相试验装置和用于检测流体样品中唾液酸酶活性的方法。 测试装置包括具有预沉积干燥形式的唾液酸酶检测组合物的固体支持物。 唾液酸酶检测组合物包括唾液酸酶底物和显色剂。 当唾液酸酶底物暴露于唾液酸酶时，产生与显色剂反应形成可检测颜色变化的中间体化合物。

公开(公告)号：US20090232702A1

公开(公告)日：2009-09-17

申请号：US12360087

申请日：2009-01-26

申请人： Xin Wu ,  Fei Gao ,  Jielin Dai ,  Yinfei Wu

发明人： Xin Wu ,  Fei Gao ,  Jielin Dai ,  Yinfei Wu

IPC分类号： G01N31/22

CPC分类号： G01N33/558 ,  Y10S435/97

摘要： The present invention relates to test devices, and in particular devices capable of detecting the presence or absence of an analyte in a sample, such as a liquid sample. Also provided are methods of using such devices for quantitative or qualitative measurement of one or more analytes in a liquid sample.

摘要翻译： 本发明涉及测试装置，特别是能够检测样品（如液体样品）中分析物的存在或不存在的装置。 还提供了使用这种装置来定量或定性测量液体样品中一种或多种分析物的方法。

公开(公告)号：US20090031790A1

公开(公告)日：2009-02-05

申请号：US11845346

申请日：2007-08-27

申请人： Lijiang GUO ,  Jeilin DAI ,  Hsiaoho TUNG ,  Yuzhang Wu

发明人： Lijiang GUO ,  Jeilin DAI ,  Hsiaoho TUNG ,  Yuzhang Wu

IPC分类号： G01N1/10 ,  G01N33/50

CPC分类号： A61B10/0096 ,  A61B10/007 ,  B01L3/502 ,  B01L3/5023 ,  B01L2200/141 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/048 ,  B01L2300/0663 ,  B01L2300/0832 ,  B01L2300/0864 ,  B01L2400/0644 ,  G01N33/49 ,  G01N33/493

摘要： Medical and environmental diagnostic devices are described and claimed. Preferred embodiments feature cup (1) within cup configurations wherein one cup is dedicated, for the most part, to sample collection and another cup (2) is dedicated, for the most part, to assay performance. Communication between the cups is afforded by what is believed to be a unique valve assembly (3) and lid (7) tandem.

摘要翻译： 描述和要求保护医疗和环境诊断装置。 优选的实施方案在杯配置中具有杯（1），其中一个杯专用于大部分样品收集，另一个杯（2）主要用于测定性能。 杯子之间的通信由被认为是独特的阀组件（3）和盖（7）串联提供。

公开(公告)号：US07410768B2

公开(公告)日：2008-08-12

申请号：US09824587

申请日：2001-04-03

申请人： Lorraine D. Butlin ,  John Coley ,  Stephen J. Eida ,  Mohamed M. Gani

发明人： Lorraine D. Butlin ,  John Coley ,  Stephen J. Eida ,  Mohamed M. Gani

IPC分类号： G01N33/53

CPC分类号： C07K16/26 ,  G01N33/54306 ,  G01N33/76 ,  Y10S435/96 ,  Y10S436/806 ,  Y10S436/814 ,  Y10S436/815 ,  Y10S436/817 ,  Y10S436/818

摘要： A method and test device for differentiating between states of an analyte that can exist in different forms, such as follicle stimulating hormone (FSH). The method or test device uses a pair of specific binding agents, especially monoclonal antibodies, in two assays for the same analyte. The assays, applied to contemporaneous samples, differ from one another in format, one being a two step assay and the other being one step. A novel pair of anti-FSH monoclonal antibodies that can be used together in two such assays to differentiate pre-menopausal and post-menopausal FSH samples is disclosed.

摘要翻译： 用于区分可以不同形式存在的分析物的状态的方法和测试装置，例如促卵泡激素（FSH）。 该方法或测试装置在相同分析物的两个测定中使用一对特异性结合剂，特别是单克隆抗体。 应用于同期样品的测定法在格式上彼此不同，一种是两步测定，另一步是一步。 公开了一种新的一对抗FSH单克隆抗体，其可以在两种这样的测定中一起使用以区分绝经前和绝经后FSH样品。

公开(公告)号：USD570490S1

公开(公告)日：2008-06-03

申请号：US29285321

申请日：2007-03-26

申请人： Paul Laverack

设计人： Paul Laverack

公开(公告)号：US20070207548A1

公开(公告)日：2007-09-06

申请号：US11560824

申请日：2006-11-16

申请人： Gert Blankenstein

发明人： Gert Blankenstein

IPC分类号： G01N33/48

CPC分类号： B03C5/028 ,  B01D57/02 ,  B01J19/0093 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0421 ,  B01L2400/0424 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/084 ,  B03C1/035 ,  B03C5/026 ,  G01N15/1031 ,  G01N15/1056 ,  G01N15/1484 ,  G01N33/56966 ,  G01N2015/1006 ,  G01N2015/1081 ,  G01N2015/149

摘要： A micro flow system is provided for separating particles, comprising a microfabricated member having a flow channel (5) defined therein for guiding a flow of a fluid containing the particles through the flow channel, first inlet means (2) positioned at one end of the flow channel for entering the fluid into the flow channel, first outlet means (7) positioned at the other end of the flow channel for discharging the fluid from the flow channel, the flow of the fluid containing the particles being controlled in such a way that one particle at the time passes a cross section of the flow channel, the member being positioned in a field that is substantially perpendicular to a longitudinal axis of the flow channel so that particles residing in the flow channel and being susceptible to the field across the flow channel are deflected in the direction of the field. Further, a micro flow system is provided for analyzing components of a fluid comprising a microfabricated member having a flow channel defined therein for guiding a flow of a fluid through the flow channel, first inlet means for entering particles into the flow channel, first outlet means for discharging of fluid from the flow channel and a plurality of assay sites located in the flow channel and comprising immobilized reagents whereby the fluid may be analyzed for a plurality of components while residing in the flow channel.

摘要翻译： 提供微流量系统用于分离颗粒，包括微型构件，其具有限定在其中的流动通道（5），用于引导包含颗粒的流体通过流动通道，第一入口装置（2）位于 用于将流体进入流动通道的流动通道，位于流动通道的另一端的第一出口装置（7），用于从流动通道排出流体，包含颗粒的流体的流动被控制为使得 一个颗粒此时通过流动通道的横截面，该构件定位在基本上垂直于流动通道的纵向轴线的场中，使得位于流动通道中的颗粒易于流过流动的场 通道沿场的方向偏转。 此外，提供了一种微流量系统，用于分析流体的部件，该流体包括具有限定在其中的流动通道的微型构件，用于引导流体流过流动通道，用于将颗粒进入流动通道的第一入口装置，第一出口装置 用于从流动通道排放流体和位于流动通道中的多个测定位点，并且包括固定的试剂，由此可以在流体在流动通道中同时分析多种组分。

公开(公告)号：USRE39664E1

公开(公告)日：2007-05-29

申请号：US08561215

申请日：1995-11-21

申请人： Julian Gordon ,  Charles Stuart Gredell Pugh

发明人： Julian Gordon ,  Charles Stuart Gredell Pugh

IPC分类号： G01N33/58

CPC分类号： G01N33/558 ,  Y10T436/255

摘要： The present invention relates to improved specific binding assay devices comprising a chromatographic medium including a reaction site at which a specific binding reagent is immobilized, a sample application well located adjacent to the chromatographic medium and offset upstream from the reaction site, and liquid absorption blotter offset downstream from the reaction site.

摘要翻译： 本发明涉及改进的特异性结合测定装置，其包括色谱介质，其包括固定特异性结合试剂的反应位点，位于邻近色谱介质并偏离反应位点偏离的样品施加井，以及液体吸收吸墨纸偏移 在反应场所下游。