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公开(公告)号：US12116603B2
公开(公告)日：2024-10-15
申请号：US17091735
申请日：2020-11-06
Inventor： Yunwei Charles Cao , Tian Jiang
CPC classification number: C12N9/22 , C12N15/01 , C12N15/102 , C12N2310/52 , C12Y301/27005
Abstract: Disclosed herein are improved nanozymes for targeting RNA. The disclosed nanozymes are synthesized using recombinant RNase A with site-specific cysteine-substituted mutations that can be covalently functionalized with a length-tunable multi-thiol tether and then loaded onto gold particles through multiple gold-sulfur bonds. This new RNase A loading mechanism is site specific, and it allows high-density loading of alkylthiol modified DNA oligonucleotides. The disclosed nanozymes can also include additional capturer strands and/or involve DNA-recombinant-RNase-A unibodies to further increase the nanozyme's enzymatic activity and target selectivity. Also disclosed are functional on-off switchable nanozymes to control nanozyme activity. In some embodiments, the disclosed nanozyme are core-free hollow forms. The removal of the inorganic nanoparticle cores from nanozymes can effectively eliminate the potential long-term toxicity induced by the core, and also creates a cavity for loading and delivery of small molecule drugs.
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公开(公告)号：US12091827B2
公开(公告)日：2024-09-17
申请号：US18515663
申请日：2023-11-21
Inventor： Timothy G. Townsend , Justin G. Roessler , Christopher C. Ferraro
IPC: C04B18/00 , C04B18/04 , C04B20/02 , C04B26/26 , C04B28/04 , C08L95/00 , E01C3/00 , C04B111/00 , C04B111/10
CPC classification number: E01C3/003 , C04B18/049 , C04B20/02 , C04B26/26 , C04B28/04 , C08L95/005 , C04B2111/0075 , C04B2111/10 , Y02W30/91 , C04B28/04 , C04B14/28 , C04B18/06 , C04B18/08 , C04B20/0076 , C04B26/26 , C04B14/28 , C04B18/06 , C04B18/08 , C04B20/0076 , C04B20/02 , C04B18/06
Abstract: Described herein are compositions and methods for waste-to-energy ash in engineered aggregate in road construction.
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公开(公告)号：US12088245B2
公开(公告)日：2024-09-10
申请号：US17503993
申请日：2021-10-18
Inventor： Jiangeng Xue , Wei David Wei
IPC: H02S40/22 , B32B3/08 , B32B7/04 , B32B17/00 , B32B27/06 , B32B27/18 , B32B27/20 , B32B27/30 , B32B27/36 , B32B27/40 , H02S20/26
CPC classification number: H02S40/22 , B32B3/08 , B32B7/04 , B32B17/00 , B32B27/06 , B32B27/18 , B32B27/20 , B32B27/308 , B32B27/365 , B32B27/40 , H02S20/26 , B32B2250/03 , B32B2250/40 , B32B2264/105 , B32B2307/304 , B32B2307/40 , B32B2307/4026 , B32B2307/412 , B32B2307/558 , B32B2307/706 , B32B2307/732 , B32B2457/12 , Y02B10/10 , Y02E10/52
Abstract: A photovoltaic system is formed as a window that is constructed of at least one polymer layer that is filled or decorated with metal nanoparticles and a window frame that includes one or more photovoltaic cells. The metal nanoparticles have a shape and size such that they display surface plasmon resonance frequencies in the near-infrared and/or the near-ultraviolet. The near-infrared and/or the near-ultraviolet radiations are scattered such that they are transmitted parallel to the face of the window to the photovoltaic cells, where an electrical current is generated.
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公开(公告)号：US20240296509A1
公开(公告)日：2024-09-05
申请号：US18662631
申请日：2024-05-13
Inventor： Ravi Shankar Srinivasan , Nawari O. Nawari
IPC: G06Q50/16 , G06F30/20 , G06Q10/0631
CPC classification number: G06Q50/165 , G06F30/20 , G06Q10/06313
Abstract: The present disclosure describes system and methods for determination of building code performance. One such method comprises transforming a building code regulation into a computable record that defines a building design and/or engineering rule for the building code regulation; performing design model validation, wherein design model validation comprises entering building permit application file information and checking the building permit application file information against relevant codes and regulations, using a taxonomy or neural natural language processing techniques or artificial Intelligence; performing exchange model code checking; performing code conformance checking, wherein the code conformance checking comprises receiving a request from the exchange models and passing the building permit application file information to code checking modules; performing verification reporting based on input provided from the code checking modules; and performing results reporting based on findings of the verification reporting.
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公开(公告)号：US20240294278A1
公开(公告)日：2024-09-05
申请号：US18383215
申请日：2023-10-24
Inventor： Peter G. Ifju , Andrew Everette Ortega , Henry Tingle , Antonio Diaz
IPC: B64U10/60 , B63B35/00 , B63B39/06 , B63B79/15 , B64U101/32 , B64U101/35
CPC classification number: B64U10/60 , B63B39/061 , B63B79/15 , B63B2035/006 , B63B2211/02 , B64U2101/32 , B64U2101/35
Abstract: Various examples are provided related to autonomous unmanned drone-tethered sonar systems. In one embodiment, a bathy-drone system includes an unmanned payload vessel and an unmanned drone tethered to the payload vessel through the tether attachment point. The unmanned payload vessel can include a sensor or sensor suite coupled to a bottom of the payload vessel and a tether attachment point through which propulsive force can be applied to the payload vessel. The drone can autonomously transport the payload vessel to and from a survey location and autonomously propel the payload vessel along a survey path at the survey location.
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Patent Agency Ranking
公开(公告)号：US12059454B2
公开(公告)日：2024-08-13
申请号：US17591151
申请日：2022-02-02
Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Inventor： Henry Daniell , Qiuhong Li , Mohan K. Raizada
IPC: C12N15/82 , A61K9/00 , A61K9/16 , A61K9/19 , A61K9/50 , A61K36/23 , A61K36/28 , A61K36/31 , A61K38/16 , A61K38/22 , A61K38/48 , A61K47/64 , A61K47/65 , C07K14/28 , C12N9/48
CPC classification number: A61K38/4813 , A61K9/0053 , A61K9/1664 , A61K9/19 , A61K9/5063 , A61K36/23 , A61K36/28 , A61K36/31 , A61K38/164 , A61K38/22 , A61K47/6415 , A61K47/65 , C07K14/28 , C12N9/485 , C12N15/8214 , C12N15/8257 , C12Y304/15001 , C12Y304/17023 , C07K2319/55 , Y02A50/30
Abstract: Emerging evidence indicates that diminished activity of the vasoprotective axis of the renin-angiotensin system, constituting angiotensin converting enzyme2 (ACE2) and its enzymatic product, angiotensin-(1-7) [Ang-(1-7)] contribute to pulmonary hypertension (PH). However, clinical success for long-term delivery of ACE2 or Ang-(1-7) would require stability and ease of administration to increase patient compliance. Chloroplast expression of therapeutic proteins enables their bioencapsulation within plant cells to protect from acids and gastric enzymes; fusion to a transmucosal carrier facilitates effective systemic absorption. Oral feeding of rats with bioencapsulated ACE2 or Ang-(1-7) attenuated monocrotaline (MCT)-induced increase in right ventricular systolic pressure, decreased pulmonary vessel wall thickness and improved right heart function in both prevention and reversal protocols. Furthermore, combination of ACE2 and Ang-(1-7) augmented the beneficial effects against cardio-pulmonary pathophysiology induced by MCT administration.
Experiments have also been performed which indicate that this approach is also suitable for the treatment or inhibition of experimental uveitis and autoimmune uveoretinitis These studies provide proof-of-concept for a novel low-cost oral ACE2 or Ang-(1-7) delivery system using transplastomic technology for pulmonary and ocular disease therapeutics.-
公开(公告)号：US20240261139A1
公开(公告)日：2024-08-08
申请号：US18640036
申请日：2024-04-19
Inventor： Anuj Chauhan , Keith G. Christopher
CPC classification number: A61F9/0017 , A61N1/0436 , A61N1/044 , A61N1/303
Abstract: In one aspect, the disclosure relates to drug delivery devices for the ionophoretic delivery of a therapeutic agent(s) to the eye. In some aspects, the disclosed ionophoretic ocular delivery device is configured for delivery of a therapeutic agent to the anterior portion of the eye. In various aspects, the present disclosure provides methods for treatment of an ophthalmological disorder, disease, or clinical condition by delivering a therapeutic agent(s) to the eye using a disclosed ionophoretic ocular delivery device. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US20240233049A1
公开(公告)日：2024-07-11
申请号：US18408124
申请日：2024-01-09
Inventor： Deepak Balakrishnan , Ravi Shankar Srinivasan
IPC: G06Q50/08
CPC classification number: G06Q50/08
Abstract: The present disclosure presents systems and methods for generating digital or electronic building construction forms using Building Information Modeling (BIM) data. One such method comprises providing an add-in application on a computing device; retrieving, by the add-in application of the computing device, a building construction form template; extracting, by the add-in application of the computing device, building design data from a Building Information Model (BIM) file of a building construction project, wherein the BIM file is generated from an external application to the add-in application; calculating, by the add-in application of the computing device, one or more of the building design metrics using the extracted building design data; and/or inputting, by the add-in application of the computing device, the extracted building design data and the calculated metrics in the specified fields of the building construction form template and generating a populated version of the building construction form.
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公开(公告)号：US12024201B2
公开(公告)日：2024-07-02
申请号：US17392376
申请日：2021-08-03
Inventor： Prabuddha Chakraborty , Reiner Dizon , Christopher Vega , Joel B. Harley , Sandip Ray , Swarup Bhunia , Patanjali Sristi Lakshmiprasanna Sriramakumara
CPC classification number: B60W60/0025 , G05D1/101
Abstract: Disclosed are various embodiments related to coordinated monitoring and responding to an emergency situation at a building structure as a supplement to a traditional emergency response. In some embodiments, a system comprises a computing device that is configured to receive sensor data from a sensor network. The sensor network includes monitoring units that monitor various locations of an infrastructure. The computing device determines an occurrence of an emergency event at a location in the infrastructure using an anomaly detector model based at least in part on the sensor data. A hybrid mobile unit is instructed by the computing device to navigate to the location of the emergency event. The hybrid mobile unit is configured to provide mobile sensor data associated with the location to confirm the emergency event.
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公开(公告)号：US20240207420A1
公开(公告)日：2024-06-27
申请号：US18555956
申请日：2022-04-20
Inventor： Christine E. Schmidt , Mary M. Kasper
CPC classification number: A61K47/61 , A61K9/06 , A61K38/363 , A61K47/46
Abstract: Disclosed herein is a hydrogel comprising hyaluronic acid polymers that are at least partially crosslinked with fibrinogen molecules. Also disclosed is a composition comprising a glycidyl methacrylate hyaluronic acid monomer chemically conjugated to a fibrinogen molecule. Also disclosed is a method for producing a hydrogel that involves combining the disclosed composition containing GMHA-Fib precursors with an effective amount of a photoinitiator and light (e.g. UV light) to crosslink unconjugated methacrylate sites through free-radical polymerization. Also disclosed is a method for treating a subject with a peripheral nerve injury that involves implanting the disclosed hydrogel at the site of the injury to promote neural regeneration.
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