公开(公告)号：US20090318703A1

公开(公告)日：2009-12-24

申请号：US12259012

申请日：2008-10-27

Applicant: Kousuke Tani ,  Masaki Asada ,  Kaoru Kobayashi ,  Masami Narita ,  Mikio Ogawa

Inventor： Kousuke Tani ,  Masaki Asada ,  Kaoru Kobayashi ,  Masami Narita ,  Mikio Ogawa

IPC: C07D213/62 ,  C07C229/34 ,  C07D307/02 ,  C07D231/10

CPC classification number: C07D231/12 ,  C07C59/68 ,  C07C69/734 ,  C07C69/736 ,  C07C69/738 ,  C07C229/34 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73 ,  C07C311/06 ,  C07C311/08 ,  C07C311/19 ,  C07C311/29 ,  C07C311/51 ,  C07C317/18 ,  C07C317/22 ,  C07C317/40 ,  C07C317/50 ,  C07C323/19 ,  C07C323/42 ,  C07C323/59 ,  C07C323/60 ,  C07D233/56 ,  C07D249/08

Abstract: A carboxylic acid derivative of formula (I): wherein R1 is —COOH, —COOR6, etc.; A is a single bond, alkylene, etc.; R2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a heterocyclic ring; Q is alkylnene-Cyc2, etc.; D is a linking chain; and R3 is alkyl, a carbocyclic ring or a heterocyclic ring, or a non-toxic salt thereof. The compound of formula (I) binds to PGE2 receptor, especially subtypes EP3 and/or EP4 and show the antagonizing activity, are useful for the prevention and/or treatment of diseases induced pain, itch, urticaria, allergy, urinary frequency, urinary disturbance, Alzheimer's disease, cancer, dysmenorrhea, endometriosis, etc.

Abstract translation: 式（I）的羧酸衍生物：其中R 1是-COOH，-COOR 6等; A是单键，亚烷基等; R2是烷基，烷氧基等; B是碳环或杂环; Q是亚烷基-Si 2等; D是连接链; 和R 3是烷基，碳环或杂环，或其无毒盐。 式（I）化合物与PGE2受体结合，特别是亚型EP3和/或EP4并显示拮抗活性，可用于预防和/或治疗疾病诱发的疼痛，瘙痒，荨麻疹，过敏，尿频，尿紊乱 ，阿尔茨海默病，癌症，痛经，子宫内膜异位症等

公开(公告)号：US07449599B2

公开(公告)日：2008-11-11

申请号：US11579049

申请日：2005-05-09

Applicant: Craig A. Coburn ,  Thomas G. Steele ,  Joseph P. Vacca ,  David Allen Annis, Jr. ,  Gergely M. Makara ,  Huw M. Nash ,  Praveen K. Tadikonda ,  Tong Wang

Inventor： Craig A. Coburn ,  Thomas G. Steele ,  Joseph P. Vacca ,  David Allen Annis, Jr. ,  Gergely M. Makara ,  Huw M. Nash ,  Praveen K. Tadikonda ,  Tong Wang

IPC: C07C233/05 ,  C07C233/65 ,  C07C305/18 ,  C07C255/50 ,  A61K31/16 ,  A61K31/255 ,  A61K31/275

CPC classification number: C07C235/84 ,  C07C255/57 ,  C07C309/67

Abstract: The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

Abstract translation: 本发明涉及作为β-分泌酶的抑制剂并且可用于治疗其中涉及β-分泌酶的疾病如阿尔茨海默氏病的苯甲酰胺化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。

公开(公告)号：US20040126639A1

公开(公告)日：2004-07-01

申请号：US10734194

申请日：2003-12-15

Applicant: JSR CORPORATION ,  HONDA MOTOR CO., LTD.

Inventor： Nagayuki Kanaoka ,  Masaru Iguchi ,  Naoki Mitsuta ,  Hiroshi Soma ,  Toshihiro Ohtsuki

IPC: H01M008/10 ,  C08J005/22 ,  C08G075/24

CPC classification number: C07C309/67 ,  C08G61/02 ,  C08G61/10 ,  C08G2261/312 ,  C08K5/42 ,  C08L65/00 ,  C08L65/02 ,  H01B1/122 ,  H01M8/1025 ,  H01M8/1027 ,  H01M8/1032 ,  H01M8/1039 ,  H01M2300/0082 ,  Y02P70/56

Abstract: Described herein is a production method of sulfonated polyarylene that is safe and enables easy control of the amount and position of sulfonic groups introduced in the polymer. The sulfonated polyarylene is also disclosed. The invention further provides a polyarylene and an aromatic sulfonate derivative that are suitably employed in the above production method. Also provided are a macromolecular solid electrolyte that comprises the sulfonated polyarylene, and a proton conductive membrane. The aromatic sulfonate derivative has the following formula (1): 1 wherein X is a halogen atom other than fluorine, a nullOSO3CH3 group or a nullOSO3CF3 group; Y is a divalent organic group; A is null(CH2)mnull or null(CF2)mnull (wherein m is an integer of 1 to 10); and R is a C4-20 hydrocarbon group. The production method of sulfonated polyarylene comprises coupling polymerization of an aromatic compound that includes at least the aromatic sulfonate derivative of the formula (1) and hydrolysis of the resultant polyarylene.

Abstract translation: 本文描述了磺化聚亚芳基的生产方法，它是安全的并且易于控制引入聚合物中的磺酸基的量和位置。 还公开了磺化聚亚芳基。 本发明还提供了适用于上述制备方法的聚亚芳基和芳族磺酸酯衍生物。 还提供了包含磺化聚亚芳基和质子传导膜的高分子固体电解质。 芳香族磺酸酯衍生物具有下式（1）：其中X是除氟以外的卤素原子，-OSO 3 CH 3基或-OSO 3 CF 3基; Y是二价有机基团; A是 - （CH 2）m - 或 - （CF 2）m - （其中m是1至10的整数）; 并且R是C 4-20烃基。 磺化聚亚芳基的制备方法包括至少包含式（1）的芳族磺酸酯衍生物和所得聚亚芳基的水解的芳族化合物的偶联聚合。

公开(公告)号：US4623703A

公开(公告)日：1986-11-18

申请号：US664342

申请日：1984-10-24

Applicant: Budalur S. Thyagarajan

Inventor： Budalur S. Thyagarajan

IPC: C08F8/48 ,  C08G75/02 ,  C08G75/20 ,  H01B1/12 ,  C08F38/00

CPC classification number: H01B1/128 ,  C07C309/67 ,  C08F8/48 ,  C08G75/02 ,  C08G75/20

Abstract: A two-step method is disclosed for chemically synthesizing substituted butadiene polymers from 1,4-disubstituted butynes. The first step in the synthesis of the butadiene polymer is the polymerization of 1,4-disubstituted butyne monomers. The substituted butyne polymer which results is then isomerized to the corresponding substituted butadiene polymer by subjecting the butyne to a weak organic base such as triethylamine. The isomerization reaction can be performed under very mild conditions and proceeds at ambient temperature.

Abstract translation: 公开了用于从1,4-二取代的丁炔化学合成取代的丁二烯聚合物的两步法。 合成丁二烯聚合物的第一步是1,4-二取代的丁炔单体的聚合。 然后将所得的取代丁炔聚合物通过使丁炔经受弱有机碱如三乙胺而异构化为相应的取代的丁二烯聚合物。 异构化反应可以在非常温和的条件下进行，并在环境温度下进行。

公开(公告)号：US4394387A

公开(公告)日：1983-07-19

申请号：US279918

申请日：1981-07-02

Applicant: Leonard G. Copping ,  John C. Kerry ,  Thomas I. Watkins ,  Robert J. Willis ,  Bryan H. Palmer

Inventor： Leonard G. Copping ,  John C. Kerry ,  Thomas I. Watkins ,  Robert J. Willis ,  Bryan H. Palmer

IPC: A01N33/26 ,  A01N31/08 ,  A01N37/28 ,  A01N39/04 ,  A01N41/04 ,  A01N41/10 ,  A01N43/08 ,  A01N43/10 ,  A01N47/24 ,  A01N47/34 ,  A01N53/00 ,  A01P7/04 ,  C07C67/00 ,  C07C241/02 ,  C07C301/00 ,  C07C303/28 ,  C07C303/30 ,  C07C309/63 ,  C07C309/65 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73 ,  C07C309/76 ,  C07C311/03 ,  C07C313/00 ,  C07C315/00 ,  C07C315/04 ,  C07C317/32 ,  C07C319/20 ,  C07C323/32 ,  C07C323/48 ,  C07D295/30 ,  C07D307/68 ,  C07D333/38 ,  A01N41/02 ,  A01N43/40 ,  A01N47/10 ,  A01N47/28

CPC classification number: C07D295/30 ,  A01N37/28 ,  A01N39/04 ,  A01N41/04 ,  A01N41/10 ,  A01N43/08 ,  A01N43/10 ,  A01N47/24 ,  A01N47/34 ,  A01N53/00 ,  C07C309/65 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73 ,  C07C311/03 ,  C07C323/32 ,  C07D307/68 ,  C07D333/38 ,  C07C2101/02 ,  C07C2101/04 ,  C07C2101/08

Abstract: Novel compounds are described which are substituted benzophenone hydrazones. They have pesticidal activity, especially against insects and acarids, and pesticidal compositions and methods are described. Methods of making the compounds, and novel intermediates, are also described.

公开(公告)号：US4344893A

公开(公告)日：1982-08-17

申请号：US124183

申请日：1980-02-25

Applicant: Leonard G. Copping ,  John C. Kerry ,  Thomas I. Watkins ,  Robert J. Willis ,  Bryan H. Palmer

Inventor： Leonard G. Copping ,  John C. Kerry ,  Thomas I. Watkins ,  Robert J. Willis ,  Bryan H. Palmer

IPC: A01N33/26 ,  A01N31/08 ,  A01N37/28 ,  A01N39/04 ,  A01N41/04 ,  A01N41/10 ,  A01N43/08 ,  A01N43/10 ,  A01N47/24 ,  A01N47/34 ,  A01N53/00 ,  A01P7/04 ,  C07C67/00 ,  C07C241/02 ,  C07C301/00 ,  C07C303/28 ,  C07C303/30 ,  C07C309/63 ,  C07C309/65 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73 ,  C07C309/76 ,  C07C311/03 ,  C07C313/00 ,  C07C315/00 ,  C07C315/04 ,  C07C317/32 ,  C07C319/20 ,  C07C323/32 ,  C07C323/48 ,  C07D295/30 ,  C07D307/68 ,  C07D333/38 ,  C07C143/68 ,  C07C133/04 ,  C07C133/08 ,  C07C143/74

CPC classification number: C07D295/30 ,  A01N37/28 ,  A01N39/04 ,  A01N41/04 ,  A01N41/10 ,  A01N43/08 ,  A01N43/10 ,  A01N47/24 ,  A01N47/34 ,  A01N53/00 ,  C07C309/65 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73 ,  C07C311/03 ,  C07C323/32 ,  C07D307/68 ,  C07D333/38 ,  C07C2101/02 ,  C07C2101/04 ,  C07C2101/08

Abstract: Novel compounds are described which are substituted benzophenone hydrazones. They have pesticidal activity, especially against insects and acarids, and pesticidal compositions and methods are described. Methods of making the compounds, and novel intermediates, are also described.

Abstract translation: 描述了取代的二苯甲酮腙的新型化合物。 它们具有杀虫活性，特别是针对昆虫和螨虫，并描述了杀虫剂组合物和方法。 还描述了制备化合物和新型中间体的方法。

公开(公告)号：US4116873A

公开(公告)日：1978-09-26

申请号：US682073

申请日：1976-05-10

Applicant: Louis DE Vries

Inventor： Louis DE Vries

IPC: C07C309/67 ,  C07F1/00 ,  C07F3/00 ,  C10M1/40 ,  C10M3/34 ,  C10M5/22 ,  C10M7/38

CPC classification number: C07F1/005 ,  C07C309/67 ,  C07F3/003 ,  C10M2205/026 ,  C10M2207/027 ,  C10M2211/02 ,  C10M2211/08 ,  C10M2215/086 ,  C10M2215/28 ,  C10M2219/022 ,  C10M2219/024 ,  C10M2219/044 ,  C10M2219/046 ,  C10M2219/068 ,  C10M2219/083 ,  C10M2223/04 ,  C10M2223/042 ,  C10M2223/045 ,  C10N2210/01 ,  C10N2210/02 ,  C10N2210/04 ,  C10N2270/02

Abstract: Oil-soluble detergent-dispersant Group I and Group II metal or lead salts of substantially saturated hydrocarbyl-substituted ethylsulfonic acids, processes for preparing these salts, lubricating oil additive concentrates and lubricating oil compositions containing them are disclosed.

Abstract translation: 油溶性洗涤剂分散剂I组和II族金属或基本饱和的烃基取代的乙基磺酸的铅盐，制备这些盐的方法，润滑油添加剂浓缩物和含有它们的润滑油组合物。

公开(公告)号：US2727057A

公开(公告)日：1955-12-13

申请号：US27451352

申请日：1952-03-01

Applicant: MONSANTO CHEMICALS

Inventor： PARK HAROLD F

IPC: C07C303/26 ,  C07C303/32 ,  C07C309/20 ,  C07C309/67

CPC classification number: C07C303/26 ,  C07C303/32 ,  C07C309/67 ,  C07C309/20

公开(公告)号：US11876177B2

公开(公告)日：2024-01-16

申请号：US16606972

申请日：2018-08-24

Applicant: LG Chem, Ltd.

Inventor： Sung Hoon Yu ,  Chul Haeng Lee ,  Hyun Seung Kim

IPC: H01M10/0567 ,  C07C69/96 ,  C07C305/14 ,  C07C305/18 ,  C07C309/67 ,  H01M10/0525 ,  H01M10/0568

CPC classification number: H01M10/0567 ,  C07C69/96 ,  C07C305/14 ,  C07C305/18 ,  C07C309/67 ,  H01M10/0525 ,  H01M10/0568 ,  H01M2300/0025

Abstract: A non-aqueous electrolyte solution for a lithium secondary battery and a lithium secondary battery including the same are disclosed herein. In some embodiments, a non-aqueous electrolyte solution for a lithium secondary battery, includes an additive having metal ion adsorbability and capable of forming a stable ion conductive film on the surface of an electrode. In some embodiments, a lithium secondary battery including the same has an improved an abnormal voltage drop phenomenon.

公开(公告)号：US20170246096A1

公开(公告)日：2017-08-31

申请号：US15594154

申请日：2017-05-12

Applicant: KAO CORPORATION

Inventor： Yasuhiro DOI

IPC: A61K8/46 ,  A61Q19/10 ,  A61K45/06 ,  C11D1/14 ,  C07C309/67 ,  C11D3/50 ,  C11D3/43 ,  C11D3/00 ,  C11D3/37 ,  A61Q5/02 ,  C11D3/48

CPC classification number: C11D1/143 ,  A61K8/466 ,  A61K45/06 ,  A61K2800/48 ,  A61K2800/51 ,  A61K2800/5426 ,  A61K2800/596 ,  A61Q5/02 ,  A61Q19/10 ,  C07C309/67 ,  C11D3/0089 ,  C11D3/3796 ,  C11D3/43 ,  C11D3/48 ,  C11D3/50

Abstract: The present invention provides a cleansing composition for skin or hair which can provide a good durability of foam and rinse feel, give good combability and softness from during rinsing to after drying while imparting manageability to hair when the cleansing composition is applied to hair, and give good moist feeling to skin when the cleansing composition is applied to skin.The cleansing composition for skin or hair is a cleansing composition comprising an internal olefin sulfonate (A) having 12 or more and 24 or less carbon atoms.