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公开(公告)号：US20150247016A1
公开(公告)日：2015-09-03
申请号：US14700387
申请日：2015-04-30
Applicant: Yosry A. Attia
Inventor： Yosry A. Attia
IPC: C08J9/00
CPC classification number: C08J9/00 , C08J9/28 , C08J9/33 , C08J2201/0482 , C08J2201/0524 , C08J2205/026 , C08J2323/04 , C08J2323/06 , C08J2323/08
Abstract: A method for making polyethylene aerogels, including high molecular weight aerogels, commences by in a hydrocarbon solvent (e.g., toluene or benzene) in which polyethylene is insoluble at room temperature, adding polyethylene to the solvent heated to a temperature at which said polyethylene is soluble to form a reaction mixture. A free-radical catalyst is added to the reaction mixture and the reaction mixture is held until the desired gelation of the polyethylene has been achieved. The reaction mixture is cooled to about room temperature; and the hydrocarbon solvent is replaced with a gas (e.g., CO2 or air) to form the polyethylene aerogel. Optionally, the cooled reaction mixture can be contacted with an anti-solvent for polyethylene to replace the hydrocarbon solvent with the anti-solvent. Silica aerogel particles can be encapsulated in polyethylene aerogel by adding the particles to the polyethylene gelation reaction mixture.
Abstract translation: 制造聚乙烯气凝胶的方法，包括高分子量气凝胶，在烃溶剂（如甲苯或苯）中开始，其中聚乙烯在室温下不溶解，加入聚乙烯加热到所述聚乙烯可溶的温度 以形成反应混合物。 向反应混合物中加入自由基催化剂，并保持反应混合物，直至达到所需的聚乙烯凝胶化。 将反应混合物冷却至约室温; 并且用气体（例如CO 2或空气）代替烃溶剂以形成聚乙烯气凝胶。 任选地，冷却的反应混合物可与用于聚乙烯的反溶剂接触以用抗溶剂代替烃溶剂。 通过将颗粒加入到聚乙烯凝胶化反应混合物中，可以将二氧化硅气凝胶颗粒包封在聚乙烯气凝胶中。
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公开(公告)号：US20150158995A1
公开(公告)日：2015-06-11
申请号：US14413579
申请日：2013-07-10
Applicant: Cellutech AB , Cellutech AB
Inventor： Nicholas Tchang Cervin , Lennart Bergström , Lars-Erik Wågberg
CPC classification number: C08K5/19 , B82Y30/00 , C08B11/12 , C08B11/20 , C08B15/06 , C08J9/0028 , C08J9/28 , C08J2201/0482 , C08J2301/00 , C08K5/17 , C08L1/286 , C08L1/288 , C08L2205/16 , D21H11/18 , D21H11/20 , D21H21/56 , D21H27/10
Abstract: A hydrophobized nanofibrillated cellulose foam comprising a charged hydrophobic amine, a method for providing such foam and its use.
Abstract translation: 包含带电疏水性胺的疏水化纳米纤维素纤维素泡沫，提供这种泡沫的方法及其用途。
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公开(公告)号：US06838493B2
公开(公告)日：2005-01-04
申请号：US10082954
申请日：2002-02-26
Applicant: Simon F. Williams , David P. Martin , Frank A. Skraly
Inventor： Simon F. Williams , David P. Martin , Frank A. Skraly
IPC: A61B17/58 , A61F2/84 , A61K45/00 , A61L15/64 , A61L17/00 , A61L17/12 , A61L27/00 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/14 , C08G63/06 , C08K5/00 , C12P7/62 , C08L67/04 , A61F13/00
CPC classification number: A61L27/58 , A61F2/07 , A61F2210/0004 , A61K31/715 , A61L17/12 , A61L27/18 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/00 , C08G63/06 , C08J9/26 , C08J2201/0444 , C08J2201/0482 , C08J2367/04 , C08K5/0033 , C08L67/04 , C12P7/625 , Y10S606/911
Abstract: Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.
Abstract translation: 由生物相容性聚羟基链烷酸酯形成或包括生物相容性聚羟基链烷酸酯的设备具有受控的降解速率，优选在生理条件下小于一年。 优选的装置包括缝线，缝线紧固件，弯液面修复装置，铆钉，钉，钉，螺钉（包括干涉螺钉），骨板和骨电镀系统，外科手术网，修复贴片，吊索，心血管贴片，矫形针 材料），粘附屏障，支架，引导组织修复/再生装置，关节软骨修复装置，神经导管，肌腱修复装置，房间隔缺损修复装置，心包块，填充剂和填充剂，静脉瓣，骨髓支架，半月板再生 装置，韧带和腱移植物，眼细胞植入物，脊髓融合笼，皮肤替代物，硬脑膜替代物，骨移植物替代物，骨榫，伤口敷料和止血剂。 聚羟基链烷酸酯可以含有由单体的混合物形成的添加剂，或者在其主链中包括侧基或修饰，或者可以化学改性，以改变降解速率。 聚羟基链烷酸酯组合物还在生理条件下的期望时间范围内提供有利的机械性能，生物相容性和降解时间。
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24.发明申请公开(公告)号：US20030236320A1
公开(公告)日：2003-12-25
申请号：US10403942
申请日：2003-03-28
Applicant: Metabolix, Inc.
Inventor： David P. Martin , Frank Skraly , Simon F. Williams
IPC: C08K003/00
CPC classification number: C08G63/912 , A61K9/1647 , A61K47/593 , A61K47/6957 , A61L15/26 , A61L17/10 , A61L17/12 , A61L24/0042 , A61L26/0019 , A61L26/009 , A61L27/18 , A61L27/34 , A61L27/58 , A61L29/06 , A61L31/06 , A61L31/148 , C08G63/06 , C08G63/64 , C08G63/6852 , C08G63/6882 , C08J9/26 , C08J2201/0444 , C08J2201/0482 , C08J2367/04 , C08K5/0033 , C12N5/0068 , C12N2533/30 , C12P7/625 , C08L67/04
Abstract: Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physioogical conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.
Abstract translation: 已经开发了具有受控降解速率的生物相容性聚羟基链烷酸酯组合物。 在一个实施方案中，聚羟基链烷酸酯含有改变降解速率的添加剂。 在另一个实施方案中，聚羟基链烷酸酯由单体的混合物形成或包括侧链基团或其主链中的修饰以改变其降解速率。 在另一个实施方案中，聚羟基链烷酸酯被化学改性。 用于制造增加孔隙率或暴露表面积的装置的方法可用于改变降解性。 例如，如通过实施例所证明的，多孔聚羟基链烷酸酯可以使用产生孔，空隙或间隙的方法，例如乳液或喷雾干燥技术，或者在聚合物内含有可浸出或可冷冻干燥的颗粒。 实例描述了包括泡沫，涂层，网格和微粒的聚（4HB）组合物。 如实施例所示，这些聚羟基链烷酸酯组合物具有非常有利的机械性能，并且在生理条件下在期望的时间范围内是生物相容的和降解的。 这些聚羟基链烷酸酯材料提供比目前可获得的更广泛的聚羟基链烷酸酯降解速率。 还描述了用于处理这些材料的方法，特别是用于治疗，预防或诊断应用，或可植入或注射的装置。
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25.发明授权Method for production of expansible macromolecular material and porous macromolecular membrane 失效生产可膨胀大分子材料和多孔高分子膜的方法
公开(公告)号：US4753761A
公开(公告)日：1988-06-28
申请号：US102853
申请日：1987-09-30
Applicant: Makoto Suzuki
Inventor： Makoto Suzuki
CPC classification number: C08J9/28 , A61F2/08 , A61F2/68 , B25J9/0012 , B25J9/1095 , A61F2002/0894 , C08J2201/0482 , C08J2201/0484 , C08J2201/0502
Abstract: An expansible macromolecular material is produced by a method which comprises mixing an aqueous polyvinyl alcohol solution, an acidic aqueous macromolecular electrolyte solution, and a basic aqueous macromolecular electrolyte solution thereby preparing a composite polymer and subjecting this composite polymer to at least one cycle of alternate freezing and defrosting treatments. A macromolecular membrane constituted of said expansible macromolecular material and containing numerous through holes is obtained by mixing, freezing, and defrosting the aforementioned three mixed aqueous solutions under specific conditions.
Abstract translation: 通过包括将聚乙烯醇水溶液，酸性高分子电解质水溶液和碱性高分子电解质水溶液混合从而制备复合聚合物并使该复合聚合物经受至少一个交替冷冻循环的方法制备可膨胀的高分子材料 和除霜治疗。 通过在特定条件下混合，冷冻和除霜上述三种混合水溶液，获得由所述可膨胀大分子材料构成并含有许多通孔的高分子膜。
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Patent Agency Ranking
公开(公告)号：US09963571B2
公开(公告)日：2018-05-08
申请号：US15616458
申请日：2017-06-07
Applicant: BLUESHIFT INTERNATIONAL MATERIALS, INC.
Inventor： Alan D. Sakaguchi , Garrett D. Poe , David J. Irvin , Alysa M. Joaquin , Janae D. Manning
CPC classification number: C08J9/28 , B01J13/0091 , C08G73/10 , C08G73/1071 , C08J2201/0482 , C08J2201/0502 , C08J2205/024 , C08J2205/026 , C08J2205/028 , C08J2205/042 , C08J2205/044 , C08J2205/05 , C08J2207/00 , C08J2207/10 , C08J2300/202 , C08J2379/08
Abstract: Aerogel compositions that include polyamic amides, methods for preparing the aerogel compositions, and articles of manufacture that include or manufactured from the aerogel compositions are described.
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公开(公告)号：US20170121483A1
公开(公告)日：2017-05-04
申请号：US15297276
申请日：2016-10-19
Applicant: BLUESHIFT INTERNATIONAL MATERIALS, INC.
Inventor： Garrett POE , Alan SAKAGUCHI , Nicole LAMBDIN , Kenneth KOLDAN
CPC classification number: C08J9/286 , B01D71/64 , C08G73/10 , C08G73/1046 , C08J9/26 , C08J9/28 , C08J2201/048 , C08J2201/0482 , C08J2201/0502 , C08J2205/026 , C08J2205/05 , C08J2300/202 , C08J2379/08
Abstract: Aerogel compositions, methods for preparing the aerogel compositions, articles of manufacture that include or are made from the aerogel compositions are described and uses thereof. The aerogels include a branched polyimide matrix with little to no crosslinked polymers.
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公开(公告)号：US09562141B2
公开(公告)日：2017-02-07
申请号：US14950522
申请日：2015-11-24
Applicant: NeXolve Corporation
Inventor： David L. Rodman , Garrett D. Poe , Brandon S. Farmer , Joseph C. Smith
CPC classification number: C08J9/286 , C08J9/28 , C08J2201/0482 , C08J2201/0502 , C08J2201/0543 , C08J2205/026 , C08J2379/08
Abstract: The present disclosure provides a method for producing an aerogel, the method comprising reacting at least one acid monomer with at least one diamino monomer in a first solvent under conditions appropriate to form a polyimide polymer; conducting a solvent exchange wherein the first solvent is exchanged for a second solvent, said second solvent having a freezing point, wherein said solvent exchange further comprises (1) submersing the polyimide polymer in the second solvent in a pressure vessel and (2) creating a high pressure environment inside the pressure vessel for a first period of time; cooling the polyimide polymer to a first temperature below the freezing point of the second solvent; and subjecting cooled polyimide polymer to a first vacuum for a second period of time at a second temperature.
Abstract translation: 本公开提供了一种制备气凝胶的方法，该方法包括使至少一种酸单体与至少一种二氨基单体在第一溶剂中在适于形成聚酰亚胺聚合物的条件下反应; 进行溶剂交换，其中第一溶剂被更换为第二溶剂，所述第二溶剂具有凝固点，其中所述溶剂交换还包括（1）将聚酰亚胺聚合物浸入第二溶剂中的压力容器中，和（2） 压力容器内的高压环境第一个时间段; 将聚酰亚胺聚合物冷却至低于第二溶剂凝固点的第一温度; 并在第二温度下将冷却的聚酰亚胺聚合物经受第一个真空第二个时间段。
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公开(公告)号：US09206298B2
公开(公告)日：2015-12-08
申请号：US13901453
申请日：2013-05-23
Applicant: NeXolve Corporation
Inventor： David L. Rodman , Garrett D. Poe , Brandon S. Farmer , Joseph C. Smith
CPC classification number: C08J9/286 , C08J9/28 , C08J2201/0482 , C08J2201/0502 , C08J2201/0543 , C08J2205/026 , C08J2379/08
Abstract: The present disclosure provides a method for producing an aerogel, the method comprising reacting at least one acid monomer with at least one diamino monomer in a first solvent under conditions appropriate to form a polyimide polymer; conducting a solvent exchange wherein the first solvent is exchanged for a second solvent, said second solvent having a freezing point, wherein said solvent exchange further comprises (1) submersing the polyimide polymer in the second solvent in a pressure vessel and (2) creating a high pressure environment inside the pressure vessel for a first period of time; cooling the polyimide polymer to a first temperature below the freezing point of the second solvent; and subjecting cooled polyimide polymer to a first vacuum for a second period of time at a second temperature.
Abstract translation: 本公开提供了一种制备气凝胶的方法，该方法包括使至少一种酸单体与至少一种二氨基单体在第一溶剂中在适于形成聚酰亚胺聚合物的条件下反应; 进行溶剂交换，其中第一溶剂被更换为第二溶剂，所述第二溶剂具有凝固点，其中所述溶剂交换还包括（1）将聚酰亚胺聚合物浸入第二溶剂中的压力容器中，和（2） 压力容器内的高压环境第一个时间段; 将聚酰亚胺聚合物冷却至低于第二溶剂凝固点的第一温度; 并在第二温度下将冷却的聚酰亚胺聚合物经受第一个真空第二个时间段。
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公开(公告)号：US20140350134A1
公开(公告)日：2014-11-27
申请号：US13901453
申请日：2013-05-23
Applicant: David L. Rodman , Garrett D. Poe , Brandon S. Farmer , Joseph C. Smith
Inventor： David L. Rodman , Garrett D. Poe , Brandon S. Farmer , Joseph C. Smith
IPC: C08J9/28
CPC classification number: C08J9/286 , C08J9/28 , C08J2201/0482 , C08J2201/0502 , C08J2201/0543 , C08J2205/026 , C08J2379/08
Abstract: The present disclosure provides a method for producing an aerogel, the method comprising reacting at least one acid monomer with at least one diamino monomer in a first solvent under conditions appropriate to form a polyimide polymer; conducting a solvent exchange wherein the first solvent is exchanged for a second solvent, said second solvent having a freezing point, wherein said solvent exchange further comprises (1) submersing the polyimide polymer in the second solvent in a pressure vessel and (2) creating a high pressure environment inside the pressure vessel for a first period of time; cooling the polyimide polymer to a first temperature below the freezing point of the second solvent; and subjecting cooled polyimide polymer to a first vacuum for a second period of time at a second temperature.
Abstract translation: 本公开提供了一种制备气凝胶的方法，该方法包括使至少一种酸单体与至少一种二氨基单体在第一溶剂中在适于形成聚酰亚胺聚合物的条件下反应; 进行溶剂交换，其中第一溶剂被更换为第二溶剂，所述第二溶剂具有凝固点，其中所述溶剂交换还包括（1）将聚酰亚胺聚合物浸入第二溶剂中的压力容器中，和（2） 压力容器内的高压环境第一个时间段; 将聚酰亚胺聚合物冷却至低于第二溶剂凝固点的第一温度; 并在第二温度下将冷却的聚酰亚胺聚合物经受第一个真空第二个时间段。
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