公开(公告)号：US20180106704A1

公开(公告)日：2018-04-19

申请号：US15660004

申请日：2017-07-26

申请人： Lions VisionGift

发明人： Khoa D. Tran

IPC分类号： G01N1/28 ,  G01N21/03 ,  G01N15/10

CPC分类号： G01N1/28 ,  A61F2/0095 ,  A61F2/142 ,  B01L3/508 ,  B01L2200/185 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2300/0851 ,  C12N5/0621 ,  C12N5/0693 ,  C12N5/0697 ,  C12N2529/10 ,  G01N15/10 ,  G01N21/03 ,  G01N21/4795 ,  G01N21/55 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2021/0342

摘要： Assemblies for storing, handling, transporting, viewing, evaluating, and/or shipping corneal tissue are provided. The assemblies may include a viewing chamber and a corneal tissue carrier removably coupled to an inner portion of the viewing chamber. The assemblies may further include a corneal tissue sample disposed within the corneal tissue carrier. Methods of processing a corneal tissue sample and administering the corneal tissue sample to a subject are also provided.

公开(公告)号：US20160109357A1

公开(公告)日：2016-04-21

申请号：US14895107

申请日：2014-06-03

申请人： LASER ZENTRUM HANNOVER E.V. ,  LAVISION BIOTEC GmbH

发明人： Raoul Amadeus LORBEER ,  Marko HEINDRICH ,  Heiko Meyer ,  Heinrich SPIECKER

IPC分类号： G01N21/11 ,  G01N21/63 ,  G02B21/26 ,  G01N21/03 ,  G01N21/17

CPC分类号： G01N21/11 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/17 ,  G01N21/63 ,  G01N21/6458 ,  G01N2021/0342 ,  G01N2021/653 ,  G01N2201/02 ,  G01N2201/06113 ,  G02B21/26 ,  G02B21/33 ,  G02B21/34

摘要： The invention relates to a device for examining samples (1) in a liquid (5), comprising a movable shaft (2), to which the sample (1) is fastened, and a cuvette (4), wherein the device further comprises a bath (3), which surrounds the movable shaft (2), and wherein the bath (3) is fillable with the liquid (5), the movable shaft (2) is configured to receive the sample (1) at the upper side (24) thereof, the movable shaft (2) reaches into the cuvette (4) from below, wherein said cuvette is open at least toward the bottom and configured to be immersed into the liquid (5) in the bath (3) with the underside thereof, and, moreover, means are provided to generate a pressure difference between the interior of the cuvette (4) and the region outside of the cuvette (4) such that the fill level (21) of the liquid (5) in the cuvette (4) is adjustable.Moreover, the invention relates to a method for examining samples (1) in a liquid (5).

摘要翻译： 本发明涉及一种用于检查液体（5）中的样品（1）的装置，包括一个可移动的轴（2），样品（1）被固定到该容器上，以及一个试管（4），其中该装置还包括一个 （3），其包围所述可移动轴（2），并且其中所述浴（3）可以被所述液体（5）填充，所述可移动轴（2）构造成在所述上侧接纳所述样品（1） 24），可动轴（2）从下方到达比丘杯（4），其中所述比色杯至少朝向底部打开，并被构造成浸入浴槽（3）中的液体（5）中，底面 并且还提供了用于在反应杯（4）的内部和比色皿（4）外部的区域之间产生压力差的装置，使得比色皿中的液体（5）的填充液位（21） （4）可调。 此外，本发明涉及一种用于检查液体（5）中的样品（1）的方法。

公开(公告)号：US08098368B2

公开(公告)日：2012-01-17

申请号：US11990693

申请日：2006-08-21

申请人： Haim Shlezinger ,  Ran Ziskind ,  Adam Devir ,  Dan Sheffer

发明人： Haim Shlezinger ,  Ran Ziskind ,  Adam Devir ,  Dan Sheffer

IPC分类号： G01N21/00

CPC分类号： G01N21/87 ,  G01N2021/0342

摘要： A method of determining the position of inclusions in a gemstone, comprising: (a) placing the gemstone within a material having a refractive index within 0.5, optionally 0.2 or 0.1, of that of the gemstone; (b) illuminating the gemstone and imaging the illuminated gemstone; and (c) determining the position of inclusions based on images of the inclusions in the images.

摘要翻译： 一种确定宝石中夹杂物的位置的方法，包括：（a）将宝石放置在折射率在宝石的折射率的0.5，任选地0.2或0.1的材料内; （b）照亮宝石并对照明的宝石进行成像; 和（c）基于图像中的夹杂物的图像确定夹杂物的位置。

公开(公告)号：US07636161B1

公开(公告)日：2009-12-22

申请号：US11725603

申请日：2007-03-20

申请人： Thomas E. Tiwald

发明人： Thomas E. Tiwald

IPC分类号： G01J4/00

CPC分类号： G01N21/55 ,  G01N21/01 ,  G01N21/84 ,  G01N21/8422 ,  G01N2021/0342

摘要： A system for reducing reflections of a beam of electromagnetic from the back of a sample, including methodology of use.

摘要翻译： 用于减少来自样品背面的电磁波束反射的系统，包括使用方法。

公开(公告)号：US20050157386A1

公开(公告)日：2005-07-21

申请号：US11020387

申请日：2004-12-22

申请人： Roger Greenwald ,  James Zavislan

发明人： Roger Greenwald ,  James Zavislan

IPC分类号： B01L3/00 ,  G01N1/36 ,  G01N21/03 ,  G02B21/00 ,  G02B21/34 ,  A61D1/02 ,  A61B17/22

CPC分类号： G01N21/0303 ,  B01L3/508 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0822 ,  B01L2400/0683 ,  G01N1/36 ,  G01N2021/0339 ,  G01N2021/0342 ,  G01N2021/0364 ,  G02B21/0028 ,  G02B21/34

摘要： A tray or holder for tissue specimens, especially of excised tissue, such as biopsied specimens, is used with a confocal imaging system, especially a laser scanning confocal microscope system. The tray may be disposable after imaging of the specimen carried therein or may archive the specimen. A window supports the specimen. Clamps mounted inside the tray restrain the tissue. A compliant bag is mounted outside the tray on one side of a window of the tray on which the specimen is disposed. During imaging the specimen is immersed in a liquid contained in the tray having an index of refraction which closely matches the index of refraction of the tissue. The bag also contains an index matching liquid preferably having the same index as the liquid in the tray. A stabilizing plate is attached to a surface of the bag which faces the window. An objective lens of the confocal imaging system receives and supports the plate, preferably by a magnetic coupling ring around the plate which is magnetically attached to the barrel of the objective lens. The lens may be fixed and a mechanism for positioning the tray with respect to the lens in a direction along the optical axis of the lens and in orthogonal directions perpendicular to that axis shares a common support with the lens. Wavefront distortion which may result from an effectively corrugated surface of the specimen is minimized by selecting an immersion liquid which equals the refractive index of the near surface tissues. The tissue determines the index of the immersion fluid. The thicknesses and refractive indices of the window and plate are then determined to correct the residual aberration of the optical system. Different trays having different window and plate thicknesses and indices may be provided for different specimen species such as kidney, liver, cervix, et cetera. Thus, a generic confocal imaging system with a generic objective lens is corrected for image aberration and wavefront distortion due to the surface corrugations of the tissue. The correction is simplified since the bag is compliant and compresses so that the optical thickness along the axis between the objective lens and the focal plane in or at the specimen is substantially invariant whether the beam is focused at the interface between the specimen and the window or within the specimen over a focusing range which can extend over several millimeters.

公开(公告)号：US20050063046A1

公开(公告)日：2005-03-24

申请号：US10876776

申请日：2004-06-28

申请人： Ikuo Arata ,  Shigeru Sakamoto ,  Hirotoshi Terada

发明人： Ikuo Arata ,  Shigeru Sakamoto ,  Hirotoshi Terada

IPC分类号： G01N21/03 ,  G01N21/88 ,  G01N21/95 ,  G02B21/33 ,  G02B21/00 ,  G02B21/26

CPC分类号： G02B21/33 ,  G01N21/8806 ,  G01N21/9501 ,  G01N2021/0342

摘要： Optical contact liquid containing an amphipathic molecule is dripped onto a semiconductor device which is a sample as an inspection object (S104), and a solid immersion lens is set thereon (S105). The inserted position of the solid immersion lens is then adjusted (S106). The optical contact liquid is then dried (S108), and thereby the solid immersion lens is brought into optically-close contact with the semiconductor device. As a result, a sample observation method and a microscope or the like can be realized, in which the solid immersion lens can be easily aligned to a desired position on the sample, and the solid immersion lens can be securely brought into optically-close contact with the sample.

摘要翻译： 将含有两亲性分子的光学接触液滴在作为检查对象的样品的半导体器件上（S104），在其上设置固体浸没透镜（S105）。 然后调整固体浸没透镜的插入位置（S106）。 然后干燥光学接触液体（S108），从而将固体浸没透镜与半导体器件进行光学 - 紧密接触。 结果，可以实现样品观察方法和显微镜等，其中固体浸没透镜可以容易地对准样品上的期望位置，并且固体浸没透镜可以牢固地进行光学紧密接触 与样品。

公开(公告)号：US5594545A

公开(公告)日：1997-01-14

申请号：US306523

申请日：1994-11-17

申请人： Muneo Saito ,  Yasuyuki Kurosu ,  Toru Sasaki

发明人： Muneo Saito ,  Yasuyuki Kurosu ,  Toru Sasaki

IPC分类号： G01N21/03 ,  G01N21/05 ,  G01N21/64 ,  G01N27/447 ,  G01N30/74 ,  G01N1/10

CPC分类号： G01N21/05 ,  G01N27/44721 ,  G01N2021/0342 ,  G01N2021/0346 ,  G01N2021/6482

摘要： A microflow cell comprising an outer cylinder disposed on the outer periphery of a cylindrical flow cell and having a flat surface on at least a light-entering surface, and a filling material inserted between the outer cylinder and the flow cell and a capillary electrophoresis method using such a microflow cell. Since the outer cylinder is provided on the outer periphery of the cylindrical flow cell and the gap between the flow cell and the outer cylinder is filled up with a filling liquid, the quantity of scattered light is reduced, thereby enabling the adoption of fluorometry in the analysis of capillary electrophoresis.

摘要翻译： 一种微流通池，包括设置在圆筒形流通池的外周上的外筒，并且至少在光入口表面上具有平坦表面，以及插入在外筒和流动池之间的填充材料，以及使用 这样的微流通池。 由于外筒设置在圆筒形流动池的外周，并且流动池和外筒之间的间隙填充有填充液体，所以散射光的量减少，从而能够在 毛细管电泳分析。

公开(公告)号：US09127245B2

公开(公告)日：2015-09-08

申请号：US12738045

申请日：2008-11-27

申请人： Takeshi Miyazaki ,  Kohei Watanabe ,  Toshio Tanaka ,  Yasuhito Shimada ,  Norihiro Nishimura

发明人： Takeshi Miyazaki ,  Kohei Watanabe ,  Toshio Tanaka ,  Yasuhito Shimada ,  Norihiro Nishimura

IPC分类号： C12M3/00 ,  C12M1/12 ,  C12M1/42 ,  C12M1/32 ,  G01N21/64 ,  G01N21/03 ,  G01N21/17

CPC分类号： C12M21/06 ,  C12M23/12 ,  C12M25/01 ,  C12M25/06 ,  C12M35/08 ,  G01N21/6456 ,  G01N2021/0339 ,  G01N2021/0342 ,  G01N2021/0378 ,  G01N2021/174

摘要： A method of arranging a large number of living bodies, such as cells, embryos, or organisms rapidly, individually, and one by one, a holding sheet for the method, and a device for processing the living bodies. The method of holding living bodies includes using a sheet in which multiple through-holes with a size capable of holding one of the target living bodies, but not capable of holding two or more of the living bodies, are provided, to thereby arrange and hold the living bodies one by one in the multiple through-holes in the sheet together with a liquid.

摘要翻译： 快速，单独地，逐个地排列大量生物体如细胞，胚胎或生物的方法，用于该方法的保持片，以及用于处理活体的装置。 保持生物体的方法包括使用其中设置有能够容纳目标生物体之一但不能容纳两个或多个生物体的尺寸的多个通孔的片材，从而布置和保持 活体在片材中的多个通孔中一个一个地连同液体。

公开(公告)号：US07423816B2

公开(公告)日：2008-09-09

申请号：US10804194

申请日：2004-03-19

申请人： Hirotoshi Terada ,  Ikuo Arata ,  Shigeru Sakamoto

发明人： Hirotoshi Terada ,  Ikuo Arata ,  Shigeru Sakamoto

IPC分类号： G02B3/02

CPC分类号： G02B21/33 ,  G01N21/1717 ,  G01N21/8806 ,  G01N21/9501 ,  G01N2021/0342 ,  G02B3/06

摘要： A solid immersion lens 1 comprises a spherical portion 2 and a bottom surface portion 3. The bottom surface portion 3 is attached in close contact with a substrate 10 of a semiconductor device to be an observed object. The bottom surface portion 3 of this solid immersion lens 1 is formed in a cylindrical shape. Thereby, a solid immersion lens which can be easily separated from the observed object after an observation and can, during an observation, allow a light flux with a high NA to pass and a microscope using the same can be obtained.

摘要翻译： 固体浸没透镜1包括球形部分2和底面部分3。 底面部3与半导体装置的基板10紧密接触而成为观察对象物。 该固体浸没透镜1的底面部3形成为圆筒状。 因此，可以在观察后容易地从观察对象分离的固体浸没透镜，并且可以在观察期间允许具有高NA的光通量通过，并且可以获得使用其的显微镜。

公开(公告)号：US20080137064A1

公开(公告)日：2008-06-12

申请号：US12003592

申请日：2007-12-28

申请人： Ikuo Arata ,  Shigeru Sakamoto ,  Hirotoshi Terada

发明人： Ikuo Arata ,  Shigeru Sakamoto ,  Hirotoshi Terada

IPC分类号： G01N1/28

CPC分类号： G02B21/33 ,  G01N21/8806 ,  G01N21/9501 ,  G01N2021/0342 ,  G02B21/0004

摘要： Optical contact liquid containing an amphipathic molecule is dripped onto a semiconductor device which is a sample as an inspection object (S104), and a solid immersion lens is set thereon (S105). The inserted position of the solid immersion lens is then adjusted (S106). The optical contact liquid is then dried (S108), and thereby the solid immersion lens is brought into optically-close contact with the semiconductor device. As a result, a sample observation method and a microscope or the like can be realized, in which the solid immersion lens can be easily aligned to a desired position on the sample, and the solid immersion lens can be securely brought into optically-close contact with the sample.

摘要翻译： 将含有两亲性分子的光学接触液滴在作为检查对象的样品的半导体器件上（S104），在其上设置固体浸没透镜（S105）。 然后调整固体浸没透镜的插入位置（S106）。 然后干燥光学接触液体（S108），从而将固体浸没透镜与半导体器件进行光学 - 紧密接触。 结果，可以实现样品观察方法和显微镜等，其中固体浸没透镜可以容易地对准样品上的期望位置，并且固体浸没透镜可以牢固地进行光学紧密接触 与样品。