利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

245 records (took 0.04 seconds)

    LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD
    21.
    发明申请
    LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD 审中-公开
    无标签的高通量生物分子筛选系统和方法

    公开(公告)号：US20120010105A1

    公开(公告)日：2012-01-12

    申请号：US13237316

    申请日：2011-09-20

    Applicant: Stephen J. Caracci ,  Volker H.O. Eckelt ,  Anthony G. Frutos ,  Mark F. Krol ,  Thomas C. Moore ,  David A. Pastel ,  Gordon M. Shedd

    Inventor： Stephen J. Caracci ,  Volker H.O. Eckelt ,  Anthony G. Frutos ,  Mark F. Krol ,  Thomas C. Moore ,  David A. Pastel ,  Gordon M. Shedd

    IPC: C40B60/12 ,  C40B30/10 ,  C40B30/00

    CPC classification number: G01N35/028 ,  G01N2035/00158 ,  G01N2035/00356 ,  G01N2035/0097

    Abstract: A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.

    Abstract translation: 本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。 在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。 筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。 筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。

    AUTOMATIC ANALYZER
    22.
    发明申请
    AUTOMATIC ANALYZER 有权
    自动分析仪

    公开(公告)号：US20110293473A1

    公开(公告)日：2011-12-01

    申请号：US13145346

    申请日：2009-12-14

    Applicant: Michihiro Saito

    Inventor： Michihiro Saito

    IPC: G01N21/76

    CPC classification number: G01N21/6428 ,  G01N2021/6439 ,  G01N2035/0097

    Abstract: An analytic method uses a labeled antigen, labeled antibody, tracer, etc. in which a radio isotope, fluorescent dye, luminescent dye, enzyme, etc. is bonded to an antibody or an antigen bonded to a protein as an object of analysis for performing an assay of a trace amount of a substance such as a hormone, tumor marker, infective pathogen marker, infective antibody, etc., for blood, serum, plasma, or body fluid as a sample or specimen. The analysis is enabled at high sensitivity, with less generation of noises and at low background. When an assay is performed based on the antigen-antibody reaction for a sample in an analytic method by fluorometry or luminometry, detection or measurement of non-specific fluorescence or luminescence such as interference light is eliminated or removed effectively irrespective of the property of the sample or the level of the concentration of substances contained in the sample.

    Abstract translation: 分析方法使用标记的抗原，标记的抗体，示踪剂等，其中放射性同位素，荧光染料，发光染料，酶等与抗体或与蛋白质结合的抗原结合作为分析对象进行 作为样品或样品的血液，血清，血浆或体液的微量物质如激素，肿瘤标志物，感染性病原体标志物，感染性抗体等的测定。 该分析能够在高灵敏度下实现，噪声产生较少，背景较差。 当通过荧光测定或发光测定法在分析方法中基于样品的抗原 - 抗体反应进行测定时，检测或测量非特异性荧光或发光如干涉光，无论样品的性质如何，均可有效地消除或去除 或样品中所含物质的浓度水平。

    APPARATUS FOR MEASURING EFFECT OF TEST COMPOUNDS ON BIOLOGICAL OBJECTS
    26.
    发明申请
    APPARATUS FOR MEASURING EFFECT OF TEST COMPOUNDS ON BIOLOGICAL OBJECTS 审中-公开
    测试化合物对生物对象的影响的装置

    公开(公告)号：US20090186374A1

    公开(公告)日：2009-07-23

    申请号：US12035205

    申请日：2008-02-21

    Applicant: Alex Okun ,  Gregory Kaler ,  Ilya Okun

    Inventor： Alex Okun ,  Gregory Kaler ,  Ilya Okun

    IPC: C12Q1/02 ,  C12M1/34

    CPC classification number: G01N33/5008 ,  G01N2035/00534 ,  G01N2035/0097 ,  G01N2035/1032

    Abstract: An apparatus and method for real-time measurement of an effect of different concentrations of a test compound or series of test compounds on living cells, in which a flow of cell suspension is combined with a flow of the test compound and a cellular response of the living cells is repeatedly measured by a detector along a length of a detection zone where the cell suspension-test compound mixture is situated. The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test compounds and generation of three-dimensional dose/response/time profiles within a short timespan.

    Abstract translation: 用于实时测量不同浓度的测试化合物或一系列测试化合物对活细胞的影响的装置和方法，其中细胞悬液的流动与测试化合物的流动和细胞反应的结合 活细胞通过检测器沿着细胞悬浮液 - 测试化合物混合物所在的检测区域的长度重复测量。 该装置可用于化合物文库的自动筛选，并且能够在短时间内实时测定化合物浓度的变化和三维剂量/反应/时间曲线的产生。

    Incubator, schedule management method, and program
    28.
    发明申请
    Incubator, schedule management method, and program 有权
    孵化器，进度管理方法和程序

    公开(公告)号：US20090137030A1

    公开(公告)日：2009-05-28

    申请号：US12318903

    申请日：2009-01-12

    Applicant: Yoichi Wada

    Inventor： Yoichi Wada

    IPC: C12M1/34

    CPC classification number: G01N35/0092 ,  C12M23/50 ,  C12M41/14 ,  C12M41/36 ,  C12M41/48 ,  G01N35/028 ,  G01N2035/00356 ,  G01N2035/0094 ,  G01N2035/0096 ,  G01N2035/0097

    Abstract: An input section of an incubator accepts, from a user, a first input selecting a specified incubation container which registers an observing schedule, and a second input specifying an imaging condition of the specified incubation container in an observing sequence. A calculating section calculates, according to the above-mentioned imaging condition, an observing duration of the specified incubation container from a first data relating to a carrying period of an incubation container and a second data with regard to an imaging duration. A schedule management section extracts, based on a schedule data, a registrable time zone in which an observing sequence of the specified incubation container can be executed without overlapping with previously registered observing schedules, and outputs to display the registrable time zone for presentation to the user.

    Abstract translation: 孵化器的输入部分从用户接受选择注册观察时间表的指定培养容器的第一输入，以及以观察顺序指定所述培养容器的成像条件的第二输入。 计算部根据上述成像条件，根据与孵育容器的携带期间有关的第一数据和关于成像持续时间的第二数据，计算出指定培养容器的观察持续时间。 时间表管理部分根据时间表数据提取可注册的时间区域，在该时区可以执行指定孵化容器的观察序列而不与先前注册的观察时间表重叠，并且输出以显示用于呈现给用户的可注册时区 。

    Immunological assay system and method
    29.
    发明授权
    Immunological assay system and method 失效
    免疫测定系统和方法

    公开(公告)号：US07425309B2

    公开(公告)日：2008-09-16

    申请号：US10602981

    申请日：2003-06-24

    Applicant: John D. Roback ,  Christopher D. Hillyer

    Inventor： John D. Roback ,  Christopher D. Hillyer

    IPC: G01N33/00

    CPC classification number: G01N35/028 ,  B01L3/5025 ,  B01L3/50255 ,  B01L2200/16 ,  B01L2300/0829 ,  B01L2300/0851 ,  G01N2035/00356 ,  G01N2035/00485 ,  G01N2035/0097

    Abstract: An immunological or immunohematological assay system is disclosed that includes a vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition system, and a pipettor. The immunological assay system may also include a washer. Also disclosed is an immunological assay method that includes the steps of placing a immunological assay sample in a vessel, which may include a filter; adding testing reagents to the vessel; incubating the sample and reagent mixture in the vessel; separating the sample and reagent mixture in the vessel into components that have and have not reacted; and analyzing the vessel to determine the presence of interactions between the sample and reagents. The bottom of the vessel is preferably of a material that aids in spreading out the reacted components of the sample evenly over the bottom of the vessel so that interactions can more easily be analyzed.

    Abstract translation: 公开了免疫或免疫血液学测定系统，其包括能够包含测定样品，培养箱，样品分离系统，图像采集系统和移液器的容器。 免疫测定系统还可以包括洗衣机。 还公开了一种免疫测定方法，其包括将免疫测定样品置于容器中的步骤，容器可以包括过滤器; 向该容器加入测试试剂; 将样品和试剂混合物孵育在容器中; 将容器中的样品和试剂混合物分离成具有且没有反应的组分; 并分析血管以确定样品和试剂之间的相互作用的存在。 容器的底部优选是有助于将样品的反应组分均匀地扩散到容器底部的材料，使得可以更容易地分析相互作用。

    Method of Real-Time/Inline Detection of Ultratrace Metallic Element Contained in Sample Liquid and Apparatus Therefor
    30.
    发明申请
    Method of Real-Time/Inline Detection of Ultratrace Metallic Element Contained in Sample Liquid and Apparatus Therefor 审中-公开
    包含在样品液体中的超声金属元素的实时/在线检测方法及其设备

    公开(公告)号：US20080131319A1

    公开(公告)日：2008-06-05

    申请号：US11667155

    申请日：2005-11-04

    Applicant: Sayoko Haji ,  Masayuki Suzuki ,  Tadashi Saito

    Inventor： Sayoko Haji ,  Masayuki Suzuki ,  Tadashi Saito

    IPC: B01L1/00 ,  G01N33/20

    CPC classification number: G01N1/42 ,  G01N2035/00514 ,  G01N2035/0097

    Abstract: [Problems] In a method of real-time/inline detection of an ultratrace metallic element contained in a sample liquid, to provide a means for enabling detection based on new combinations of samples and pretreatment liquids, which has not been possible heretofore at a high sensitivity.[Means for Solving] A method of real-time/inline detection of an ultratrace metallic element contained in a sample liquid, comprising a sampling step of sampling from the sample liquid, a pretreatment step of treating the sample with a pretreatment liquid, and an analyzing step of analyzing the metallic element in a treated liquid that has passed through the pretreatment step, wherein the sample, the pretreatment liquid and/or the treated liquid are cooled, if an exothermic reaction is involved in the pretreatment step.

    Abstract translation: [问题]在包含在样品液体中的超精细金属元素的实时/在线检测方法中，提供了一种能够基于样品和预处理液体的新组合进行检测的手段，这在以前是不可能的 灵敏度。 [解决方法]一种实时/在线检测包含在样品液体中的超痕量金属元素的方法，包括从样品液体取样的取样步骤，用预处理液处理样品的预处理步骤，以及 如果预处理步骤中发生放热反应，则分析已经通过预处理步骤的处理液体中的金属元素的分析步骤，其中样品，预处理液体和/或处理液体被冷却。

Patent Agency Ranking