公开(公告)号：US11739064B2

公开(公告)日：2023-08-29

申请号：US17099360

申请日：2020-11-16

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Alan Kozikowski ,  Irina Gaisina

IPC分类号： A61K31/4155 ,  C07D261/10 ,  A61K45/06 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  A61K31/422 ,  C07D261/18 ,  A61K31/42 ,  A61K31/427 ,  A61P35/00

CPC分类号： C07D261/10 ,  A61K31/4155 ,  A61K31/42 ,  A61K31/422 ,  A61K31/427 ,  A61K45/06 ,  A61P35/00 ,  C07D261/18 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  Y02A50/30 ,  A61K31/422 ,  A61K2300/00 ,  A61K31/42 ,  A61K2300/00 ,  A61K31/4155 ,  A61K2300/00 ,  A61K31/427 ,  A61K2300/00

摘要： Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

公开(公告)号：US20230218529A1

公开(公告)日：2023-07-13

申请号：US18091492

申请日：2022-12-30

申请人： INSMED INCORPORATED

发明人： Robert WORSHAM

IPC分类号： A61K9/127 ,  A61K31/4174 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/505 ,  A61K31/5025 ,  A61K31/65 ,  A61K31/7036 ,  A61K31/7048 ,  A61K38/14 ,  B01F23/41 ,  A61K31/145

CPC分类号： A61K9/1277 ,  A61K31/4174 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/505 ,  A61K31/5025 ,  A61K31/65 ,  A61K31/7036 ,  A61K31/7048 ,  A61K38/14 ,  B01F23/4105 ,  A61K31/145 ,  B01F2101/22

摘要： Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes. Also provided herein are liposomal API formulations manufactured by the disclosed methods.

公开(公告)号：US11679093B2

公开(公告)日：2023-06-20

申请号：US17251070

申请日：2019-06-11

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Kambez Hajipouran Benam

IPC分类号： C07C257/18 ,  A61K31/167 ,  A61K31/472 ,  A61K31/4725 ,  C07D217/26 ,  C07D217/12 ,  A61K31/245 ,  A61K31/194 ,  A61K31/195 ,  A61K31/4166 ,  A61K31/42 ,  A61K31/422 ,  A61K45/06 ,  C07C279/18 ,  C07D233/70 ,  C07D261/08

CPC分类号： A61K31/245 ,  A61K31/167 ,  A61K31/194 ,  A61K31/195 ,  A61K31/4166 ,  A61K31/42 ,  A61K31/422 ,  A61K45/06 ,  C07C257/18 ,  C07C279/18 ,  C07D233/70 ,  C07D261/08

摘要： The present invention relates in certain aspects to the discovery of novel 2-naphthimidamide compounds that are capable of binding Type II Transmembrane Serine Proteases (TTSPs). In certain embodiments, the compounds of the invention can be used to treat or prevent Influenza A viral infection in a mammal.

公开(公告)号：US20230159438A1

公开(公告)日：2023-05-25

申请号：US17832384

申请日：2022-06-03

申请人： Genzyme Corporation

发明人： Junkai Liao ,  Mark Munson ,  Zhongli Gao ,  Gregory Hurlbut ,  Hans Peter Nestler ,  Helen Yeoman ,  Martin Smrcina ,  Ronghua Li ,  Ryan Hartung ,  William Wire ,  Bertrand Vivet ,  Nina Ma

IPC分类号： C07C235/66 ,  C07D231/12 ,  C07D317/54 ,  C07C317/14 ,  C07C321/28 ,  C07D277/24 ,  C07D213/30 ,  C07D261/08 ,  C07D277/64 ,  C07D277/30 ,  C07D305/06 ,  A61K31/198 ,  A61K31/415 ,  A61K31/36 ,  A61K31/426 ,  A61K31/44 ,  A61K31/42 ,  A61K31/428 ,  A61K31/337 ,  A61K45/06

CPC分类号： C07C235/66 ,  C07D231/12 ,  C07D317/54 ,  C07C317/14 ,  C07C321/28 ,  C07D277/24 ,  C07D213/30 ,  C07D261/08 ,  C07D277/64 ,  C07D277/30 ,  C07D305/06 ,  A61K31/198 ,  A61K31/415 ,  A61K31/36 ,  A61K31/426 ,  A61K31/44 ,  A61K31/42 ,  A61K31/428 ,  A61K31/337 ,  A61K45/06 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/10

摘要： The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

公开(公告)号：US20230142714A1

公开(公告)日：2023-05-11

申请号：US17740260

申请日：2022-05-09

申请人： CORTEXYME, INC.

发明人： Andrei W. Konradi ,  Robert A. Galemmo, JR. ,  Stephen S. Dominy ,  Casey C. Lynch ,  Leslie J. Holsinger

IPC分类号： C07C233/62 ,  C07D401/12 ,  A61K31/655 ,  A61K31/165 ,  C07C245/08 ,  C07C323/42 ,  C07C247/18 ,  C07D261/12 ,  C07C237/42 ,  C07D213/82 ,  A61K31/513 ,  C07D239/34 ,  C07D239/36 ,  A61P31/04 ,  C07F5/02 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/4409 ,  C07D413/12 ,  C07C323/40 ,  A61K31/4406 ,  A61K31/505 ,  C07C233/78 ,  C07C235/50 ,  A61K31/44 ,  C07D257/04 ,  A61K45/06 ,  C07D239/38 ,  C07C317/28 ,  A61K31/42 ,  C07C381/00 ,  C07D213/81 ,  A61K31/41 ,  C07D213/65 ,  C07C247/16 ,  C07D213/70 ,  C07B59/00 ,  A61K31/167 ,  C07C235/10 ,  C07D213/68 ,  A61P25/00

CPC分类号： C07C233/62 ,  C07D401/12 ,  A61K31/655 ,  A61K31/165 ,  C07C245/08 ,  C07C323/42 ,  C07C247/18 ,  C07D261/12 ,  C07C237/42 ,  C07D213/82 ,  A61K31/513 ,  C07D239/34 ,  C07D239/36 ,  A61P31/04 ,  C07F5/02 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/4409 ,  C07D413/12 ,  C07C323/40 ,  A61K31/4406 ,  A61K31/505 ,  C07C233/78 ,  C07C235/50 ,  A61K31/44 ,  C07D257/04 ,  A61K45/06 ,  C07D239/38 ,  C07C317/28 ,  A61K31/42 ,  C07C381/00 ,  C07D213/81 ,  A61K31/41 ,  C07D213/65 ,  C07C247/16 ,  C07D213/70 ,  C07B59/001 ,  A61K31/167 ,  C07C235/10 ,  C07D213/68 ,  A61P25/00 ,  C07C2601/08

摘要： The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

公开(公告)号：US11634413B2

公开(公告)日：2023-04-25

申请号：US17445096

申请日：2021-08-16

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Melissa Fleury ,  Adam D. Hughes

IPC分类号： C07D405/12 ,  A61K31/415 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/421 ,  C07D231/14 ,  C07D231/20 ,  C07D249/04 ,  C07D261/18 ,  C07D263/38 ,  A61K45/06

摘要： In one aspect, the invention relates to compounds having the formula: where X, Ra, Rb, R2, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.

公开(公告)号：US20230116770A1

公开(公告)日：2023-04-13

申请号：US17875216

申请日：2022-07-27

申请人： Sanford Burnham Prebys Medical Discovery Institute

发明人： Stephen GARDELL ,  Anthony B. PINKERTON ,  Eduard SERGIENKO ,  Hampton SESSIONS

IPC分类号： A61K31/4409 ,  A61K31/196 ,  A61K31/245 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/417 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/5386 ,  C07C275/42 ,  C07D213/40 ,  C07D213/56 ,  C07D213/643 ,  C07D213/73 ,  C07D213/74 ,  C07D231/12 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D249/04 ,  C07D261/08 ,  C07D263/32 ,  C07D277/28 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D498/08

摘要： Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

公开(公告)号：US20230086469A1

公开(公告)日：2023-03-23

申请号：US17638770

申请日：2019-08-30

申请人： UNIVERSIDAD DE CHILE

发明人： Juan Carlos Aguillón Gutiérrez ,  Diego Francisco Catalán Martina ,  Lilian Andrea Soto Saez ,  Jaxaira Amilene Maggi Orellana ,  Octavio Alexis Aravena Madariaga ,  Katina Schinnerling

IPC分类号： A61K39/00 ,  A61K39/39 ,  A61P37/06 ,  A61K31/519 ,  A61K31/52 ,  A61K31/4706 ,  A61K38/13 ,  A61K31/65 ,  A61K31/42 ,  A61K31/5383 ,  A61K31/655 ,  A61K33/242 ,  A61K39/395

摘要： The present invention provides an immunomodulatory composition useful for treating or preventing joint damage comprising at least a set of peptides possessing an amino acid sequence having at least 80%, 85% and 90% sequence identity with the peptides corresponding to SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 and SEQ ID NO:4 and a method for the treatment or prevention of joint damage comprising the steps of a) extract monocytes from a patient with a rheumatological disease; b) culture the monocytes extracted in the previous step in AIM-V medium with GM-CSF and IL-4; c) wash the monocytes and add dexamethasone; d) load the tDCs with the immunomodulatory composition comprising autoantigenic peptides; e) add MPLA; and f) incorporate the tDCs loaded with autoantigenic peptides into the patient. The present invention includes methods for the treatment or prevention of rheumatological disease comprising a wide range of tDCs performed by different protocols.

公开(公告)号：US11596657B2

公开(公告)日：2023-03-07

申请号：US16337951

申请日：2017-07-11

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE ,  SORBONNE UNIVERSITE ,  ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

发明人： Harry Sokol ,  Jane Mea Natividad ,  Bruno Lamas ,  Henri Duboc ,  Mathias Lavie-Richard ,  Marie-Laure Michel ,  Philippe Langella

IPC分类号： A61K35/747 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10 ,  A61K35/745 ,  A61K35/744 ,  A61K31/138 ,  A61K31/167 ,  A61K31/40 ,  A61K31/42 ,  A61K31/44 ,  A61K36/258 ,  A61K31/404 ,  A61K31/4045 ,  A61K9/00

摘要： The present invention relates to the preventive or curative treatment of metabolic syndrome and the associated disorders with AhR agonist or microorganism producing AhR agonist.

公开(公告)号：US11571450B2

公开(公告)日：2023-02-07

申请号：US17697798

申请日：2022-03-17

申请人： PSILO SCIENTIFIC LTD

发明人： Benjamin Lightburn ,  Ryan Moss ,  Lisa Ranken

IPC分类号： A61K36/00 ,  A61K36/07 ,  A61K31/4045 ,  A61K31/675 ,  A61K31/48 ,  A61K31/404 ,  A61K31/42

摘要： This invention relates to the extraction of psychoactive compounds from psilocybin fungus for use in medicine. Raw psilocybin fungus is dried and ground. The solvent used for extraction is a lower aliphatic alcohol, water, a hydro-alcohol mixture, an acidic hydro-alcohol mixture, or an alkaline hydro-alcohol mixture. The extraction slurry is filtered and pH-adjusted if necessary. The solvent is then partially evaporated, or completely evaporated with water added back, to form a concentrated slurry. The concentrated slurry is then standardized to provide a known concentration of the psychoactive alkaloids that have been extracted. The standardized slurry may then be dried to result in a powdered psilocybin mushroom extract with a precisely defined purity.