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44 条记录 (耗时 0.037 秒)

    Process for the preparation of enantiomerically pure .beta.-D-(-)-dioxolane-nucleosides
    22.
    发明授权
    Process for the preparation of enantiomerically pure .beta.-D-(-)-dioxolane-nucleosides 失效
    制备完全纯度（BETA）-D - （ - ） - 二氧杂环己烷的方法

    公开(公告)号：US5179104A

    公开(公告)日：1993-01-12

    申请号：US622762

    申请日：1990-12-05

    申请人： Chung K. Chu ,  Raymond F. Schinazi

    发明人： Chung K. Chu ,  Raymond F. Schinazi

    IPC分类号： C07D473/18 ,  A61K31/505 ,  A61K31/506 ,  A61K31/513 ,  A61K31/52 ,  A61K31/522 ,  A61K31/53 ,  A61K31/675 ,  A61K31/7076 ,  A61P31/12 ,  A61P31/18 ,  A61P37/04 ,  C07D327/04 ,  C07D405/04 ,  C07D411/04 ,  C07D473/00 ,  C07D473/30 ,  C07D473/34 ,  C07D473/40 ,  C07D497/08

    CPC分类号： A61K31/675 ,  C07D405/04

    摘要： An asymmetric process for the preparation of enantiomerically pure .beta.-D-(-)-dioxolane-nucleosides. The enantiomerically pure dioxolane nucleosides are active HIV agents, that are significantly more effective than the prior prepared racemic mixtures of the nucleosides. The anti-viral activity of the compounds is surprising in light of the generally accepted theory that moieties in the endo conformation, including these dioxolanes, are not effective antiviral agents. The toxicity of the enantiomerically pure dioxolane nucleosides is lower that that of the racemic mixture of the nucleosides, because the nonnaturally occurring .alpha.-isomer is not included.The product can be used as a research tool to study the inhibition of HIV in vitro or can be administered in a pharmaceutical composition to inhibit the growth of HIV in vivo.

    摘要翻译： 用于制备对映体纯的β-D（ - ） - 二氧戊环 - 核苷的不对称方法。 对映体纯的二氧戊环核苷是活性的HIV试剂，其显着比先前制备的核苷的外消旋混合物更有效。 根据普遍接受的理论，化合物的抗病毒活性是令人惊讶的，内在构象中的部分（包括这些二氧戊环）不是有效的抗病毒剂。 由于不包含非天然存在的α-异构体，对映体纯的二氧杂环戊烷核苷的毒性低于核苷的外消旋混合物的毒性。 该产品可用作研究HIV体外抑制的研究工具，或可以在药物组合物中施用以抑制体内HIV生长。

    Acrylate derivative, haloester derivative, polymer compound and photoresist composition
    30.
    发明授权
    Acrylate derivative, haloester derivative, polymer compound and photoresist composition 有权
    丙烯酸酯衍生物，卤代酯衍生物，高分子化合物和光致抗蚀剂组合物

    公开(公告)号：US08486606B2

    公开(公告)日：2013-07-16

    申请号：US13001738

    申请日：2009-06-30

    申请人： Junko Sato ,  Osamu Nakayama ,  Takashi Fukumoto

    发明人： Junko Sato ,  Osamu Nakayama ,  Takashi Fukumoto

    IPC分类号： G03F7/039 ,  C07D327/04 ,  C07D497/08 ,  C08F20/38

    CPC分类号： C07D327/04 ,  C07D497/18 ,  C08F220/38 ,  G03F7/0045 ,  G03F7/0397 ,  G03F7/085

    摘要： An acrylate derivative represented by the following general formula (1): (in the formula, R1 represents a hydrogen atom, a methyl group or a trifluoromethyl group; each of R2, R3, R5, R7, R8, R9 and R10 independently represents a hydrogen atom, an alkyl group, a cycloalkyl group or an alkoxy group; each of R4 and R6 independently represents a hydrogen atom, an alkyl group, a cycloalkyl group or an alkoxy group, or R4 and R6 are bonded to each other to represent an alkylene group, —O— or —S—; n represents 0, 1 or 2; and W represents an alkylene group or a cycloalkylene group); an intermediate thereof; a method for producing the same; a polymer compound which is obtainable from polymerization of a raw material containing the foregoing acrylate derivative and which is excellent in solubility in an organic solvent used for the preparation of a photoresist composition; and a photoresist composition containing the polymer compound, an organic solvent and a photo acid generator and having excellent adhesion to substrate and less pattern collapse, are provided.

    摘要翻译： 由以下通式（1）表示的丙烯酸酯衍生物：（式中，R1表示氢原子，甲基或三氟甲基; R2，R3，R5，R7，R8，R9和R10各自独立地表示 氢原子，烷基，环烷基或烷氧基; R 4和R 6各自独立地表示氢原子，烷基，环烷基或烷氧基，或者R 4和R 6相互键合，表示 亚烷基，-O-或-S-; n表示0,1或2; W表示亚烷基或亚环烷基）。 其中间体; 其制造方法; 可从含有上述丙烯酸酯衍生物的原料的聚合得到的聚合物化合物，其在用于制备光致抗蚀剂组合物的有机溶剂中的溶解性优异; 并且提供了含有高分子化合物，有机溶剂和光酸产生剂并且对基材具有优异粘附性和较少图案折叠的光致抗蚀剂组合物。