专利检索 ap:("Daniel A. Dickman" OR "Bruce W. Horrom" OR "Brian A. Roden" OR "Sanjay R. Chemburkar") AND inv:"Daniel A. Dickman" 第 1 页

1.

发明授权
Process for the production of 2-acetylbenzo [.beta.]thiophenes 失效
标题翻译：用于生产2-乙酰基苯并噻吩的方法

公开(公告)号：US5169961A

公开(公告)日：1992-12-08

申请号：US796298

申请日：1991-11-22

申请人： Daniel A. Dickman , Bruce W. Horrom , Brian A. Roden , Sanjay R. Chemburkar

发明人： Daniel A. Dickman , Bruce W. Horrom , Brian A. Roden , Sanjay R. Chemburkar

IPC分类号： C07C313/08 , C07C319/14 , C07C319/24 , C07C323/22 , C07D333/56 , C07D497/08

CPC分类号： C07D497/08 , C07C313/08 , C07C319/14 , C07C319/24 , C07D333/56

摘要： A process for the production in high yield of 2-acetylbenzo[.beta.]thiophene and its alkyl and alkoxy substituted derivatives by converting a 2-halobenzaldehyde to a 2,2'-dithiobis(benzaldehyde) intermediate and reacting that intermediate successively with 2,4-pentanedione and chloroacetone in the presence of base.

摘要翻译： 通过将2-卤代苯甲醛转化为2,2'-二硫代双（苯甲醛）中间体并使该中间体依次与2,4和2二硫代双戊二酮和氯丙酮。

2.

发明授权
Process for the preparation of N-4-[(substituted phenyl)alkylheterocyclic]- N 失效
标题翻译：制备N-4 - [（取代苯基）烷基杂环基] -N-羟基脲化合物的方法

公开(公告)号：US5580989A

公开(公告)日：1996-12-03

申请号：US472448

申请日：1995-06-07

申请人： James D. Ratajczyk , Juliette K. Busse , Sanjay R. Chemburkar , Daniel A. Dickman , Yi-Yin Ku , Hemantkumar H. Patel , Ramesh R. Patel , David P. Sawick , John N. Starr , Bhadra Shelat , Harry O. Spiwek

发明人： James D. Ratajczyk , Juliette K. Busse , Sanjay R. Chemburkar , Daniel A. Dickman , Yi-Yin Ku , Hemantkumar H. Patel , Ramesh R. Patel , David P. Sawick , John N. Starr , Bhadra Shelat , Harry O. Spiwek

IPC分类号： A61K31/38 , A61K31/381 , A61P29/00 , A61P37/08 , A61P43/00 , B01J27/13 , B01J31/22 , C07D307/52 , C07D333/20 , C07D333/22 , C07D307/36

CPC分类号： C07D333/20 , C07D307/52

摘要： A process for preparing a compound of the structure I ##STR1## where A is oxygen and sulfur and R.sup.1 is selected from the group consisting of hydrogen, halogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, and trifluoromethyl, and R.sup.2 is alkyl of one to four carbon atoms, comprising coupling a compound of formula II: ##STR2## where X is bromine or iodine, with an N-hydroxyurea compound of formula III: ##STR3## in the presence of a palladium catalyst followed by reaction of the product thus formed with an alkali metal isocyante.The compounds of formula I are inhibitors of the enzyme 5-lipoxygenase and are thus useful as therapeutic agents for the treatment of allergic and inflammatory disease conditions.

摘要翻译： 制备结构I I的化合物的方法，其中A是氧和硫，R 1选自氢，卤素，1至6个碳原子的烷基，1至6个碳原子的烷氧基，以及三氟甲基，R 2为1-4个碳原子的烷基，其中包括式I化合物：其中X为溴或碘的式II化合物与式III的N-羟基脲化合物：钯催化剂，随后将由此形成的产物与碱金属异氰酸酯反应。式I化合物是5-脂氧合酶的抑制剂，因此可用作治疗过敏性和炎性疾病病症的治疗剂。

3.

发明授权
Process for the preparation of a renin inhibiting compound 失效
标题翻译：制备肾素抑制化合物的方法

公开(公告)号：US5275950A

公开(公告)日：1994-01-04

申请号：US15873

申请日：1993-02-10

申请人： Daniel A. Dickman , Bruce W. Horrom , Chi-Nung W. Hsiao , M. Robert Leanna , Hormoz Mazdiyasni , Howard E. Morton , Thomas M. Zydowsky , William R. Baker , Stephen L. Condon

发明人： Daniel A. Dickman , Bruce W. Horrom , Chi-Nung W. Hsiao , M. Robert Leanna , Hormoz Mazdiyasni , Howard E. Morton , Thomas M. Zydowsky , William R. Baker , Stephen L. Condon

IPC分类号： A61K38/00 , C07D277/28 , C07D277/46 , C07D295/26 , C07K5/065 , C12P13/04 , C07D241/04 , C12P11/00 , C12P17/12

CPC分类号： C07D277/28 , C07D295/26 , C07K5/06078 , A61K38/00

摘要： Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sulfonyl group, R.sub.6 is hydrogen, alkoxy, halogen or loweralkyl, R.sub.7 is loweralkyl having 2 to 7 carbon atoms, and R.sub.8 is loweralkyl, cycloalkyl, or aryl or a pharmaceutically acceptable acid addition salt thereof.

摘要翻译： 公开了中间体及其制备方法，其可用于制备下式的肾素抑制化合物：（*化学结构*）（I）其中R是通过氮原子与氮原子键合的含氮杂环磺酰基，R6是氢，烷氧基，卤素或低级烷基，R7是具有2-7个碳原子的低级烷基，R8是低级烷基，环烷基或芳基或其药学上可接受的酸加成盐。

4.

发明授权
Retroviral protease inhibiting compounds 有权
标题翻译：逆转录病毒蛋白酶抑制化合物

公开(公告)号：US07968707B2

公开(公告)日：2011-06-28

申请号：US11679227

申请日：2007-02-27

申请人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel

发明人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel

IPC分类号： C07D219/04 , C07D291/06 , C07D243/04 , C07D265/12 , C07D413/12 , C07D239/02

CPC分类号： C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12

摘要： A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

摘要翻译： 公开了下式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

5.

发明申请
APOPTOSIS PROMOTERS 有权
标题翻译： APOPTOSIS促销者

公开(公告)号：US20100234456A1

公开(公告)日：2010-09-16

申请号：US12787140

申请日：2010-05-25

申请人： Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri

发明人： Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri

IPC分类号： A61K31/255 , C07C39/24 , A61K31/055 , C07C39/04 , A61K31/05 , C07C305/22 , C07C47/52 , A61K31/11 , C07C63/00 , A61K31/192 , C07C211/44 , A61K31/135 , A61P35/00

CPC分类号： C07C311/41 , C07C63/48 , C07C63/49 , C07C65/26 , C07C65/28 , C07C205/58 , C07C229/52 , C07C229/56 , C07C233/81 , C07C311/13 , C07C311/18 , C07C311/21 , C07C311/37 , C07C311/44 , C07C323/20 , C07C323/25 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/18 , C07C2603/74 , C07D207/30 , C07D213/53 , C07D215/12 , C07D215/48 , C07D333/34

摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.

摘要翻译： 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物和治疗疾病的方法，其表达为Mcl-1蛋白。

6.

发明授权
Crystalline pharmaceutical 有权
标题翻译：结晶药物

公开(公告)号：US08796451B2

公开(公告)日：2014-08-05

申请号：US13107780

申请日：2011-05-13

申请人： Daniel A. Dickman , Sanjay Chemburkar , James J. Fort , Rodger F. Henry , David Lechuga-Ballesteros , Yuping Niu , William Porter

发明人： Daniel A. Dickman , Sanjay Chemburkar , James J. Fort , Rodger F. Henry , David Lechuga-Ballesteros , Yuping Niu , William Porter

IPC分类号： C07D239/36 , C07D239/10

CPC分类号： C07D239/10 , A61K9/4866 , A61K31/00 , A61K31/513 , A61K47/10 , A61K47/44 , A61K2300/00

摘要： New crystalline forms of lopinavir are disclosed.

摘要翻译： 公开了新的结晶形式的洛匹那韦。

7.

发明授权
Biaryl carboxylic acid apoptosis promoters 有权
标题翻译：双芳基羧酸凋亡启动子

公开(公告)号：US07989656B2

公开(公告)日：2011-08-02

申请号：US12787140

申请日：2010-05-25

申请人： Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri

发明人： Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri

IPC分类号： C07C63/00

CPC分类号： C07C311/41 , C07C63/48 , C07C63/49 , C07C65/26 , C07C65/28 , C07C205/58 , C07C229/52 , C07C229/56 , C07C233/81 , C07C311/13 , C07C311/18 , C07C311/21 , C07C311/37 , C07C311/44 , C07C323/20 , C07C323/25 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/18 , C07C2603/74 , C07D207/30 , C07D213/53 , C07D215/12 , C07D215/48 , C07D333/34

摘要： The present invention relates to biaryl carboxylic acid compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing these compounds and methods of treating diseases which express the Mcl-1 protein.

摘要翻译： 本发明涉及抑制抗细胞凋亡Mcl-1蛋白活性的联芳羧酸化合物，含有这些化合物的组合物和治疗表达Mcl-1蛋白的疾病的方法。