公开(公告)号：US10589267B2

公开(公告)日：2020-03-17

申请号：US15785394

申请日：2017-10-16

申请人： CUE HEALTH, INC.

发明人： Ayub Khattak ,  Clinton Sever

IPC分类号： B01L3/00 ,  G01N35/10 ,  G01N35/08 ,  G01N33/543 ,  H04M1/725 ,  G01N27/327 ,  G01N35/00 ,  G01N27/28 ,  B05D3/00 ,  F16K99/00 ,  C12Q1/6825 ,  G01N33/58 ,  G01N1/02

摘要： This system takes in raw cellular material collected using a provided swab, blood collection device, urine collection device, or other sample collection device and transforms that biological material into a digital result, identifying the presence, absence and/or quantity of nucleic acids, proteins, and/or other molecules of interest.

公开(公告)号：US10520461B2

公开(公告)日：2019-12-31

申请号：US15840347

申请日：2017-12-13

申请人： PHC HOLDINGS CORPORATION

发明人： Masaki Fujiwara

IPC分类号： G01N27/327 ,  C12Q1/54 ,  G01K7/00 ,  B01L3/00 ,  C12Q1/00 ,  G01N27/28 ,  G01N27/26 ,  G01N27/416

摘要： The concentration measurement method includes: introducing a predetermined amount of the biological sample into the capillary; measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured, the first voltage allowing the temperature measurement to be less affected by increase and reduction in an amount of the analyte contained in the biological sample; measuring the concentration of the analyte contained in the biological sample by applying a second voltage to the electrode unit; measuring an environmental temperature in a surrounding of the biological sample; and correcting the concentration of the measured analyte based on the measured temperature of the biological sample and the measured environmental temperature.

公开(公告)号：US20190285565A1

公开(公告)日：2019-09-19

申请号：US15923155

申请日：2018-03-16

申请人： Energy, United States Department of

发明人： Nathaniel C. Hoyt ,  Mark A. Williamson ,  James L. Willit

IPC分类号： G01N27/28 ,  G01N27/416 ,  G01N27/48

摘要： A multi electrode sensor that provides in-situ, real time measurements for molten salts and other process fluids such as real-time concentration and salt level measurements for nuclear systems such as molten salt reactors, nuclear reprocessing facilities utilizing molten salts and concentrated solar power systems. The sensor has multiple electrodes with unique lengths which are connected to a potentiostat. Measurements are taken when the electrodes are immersed in the process fluid.

公开(公告)号：US10195606B2

公开(公告)日：2019-02-05

申请号：US15368249

申请日：2016-12-02

申请人： CUE HEALTH INC.

发明人： Ayub Khattak ,  Clinton Sever

IPC分类号： G01N31/22 ,  B01L3/00 ,  G01N35/10 ,  G01N35/08 ,  G01N33/543 ,  H04M1/725 ,  G01N27/327 ,  G01N35/00 ,  G01N27/28 ,  B05D3/00 ,  F16K99/00 ,  C12Q1/6825 ,  G01N33/58 ,  G01N1/02

摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US10088448B2

公开(公告)日：2018-10-02

申请号：US15109943

申请日：2015-01-19

申请人： DENSO CORPORATION

发明人： Mitsunobu Nakatou ,  Keigo Mizutani ,  Takashi Araki

IPC分类号： G01N27/28 ,  G01N27/403 ,  G01N27/406 ,  G01N27/407 ,  G01N27/419 ,  G01N27/41

摘要： Provided is a gas sensor element that can increase detection accuracy of a specific gas component concentration by means of a sensor cell by reflecting changes in the operating temperature of a gas sensor element. The gas sensor element is provided with a solid electrolyte body having oxygen ion conductivity, a heater stacked to the solid electrolyte body via a reference gas space, a pump cell adjusting oxygen concentration in a measuring gas space, a sensor cell detecting specific gas component concentration in the measuring gas space, and an electronic conduction detector cell detecting current resulting from electronic conduction due to the heater. The electronic conduction detector cell includes an electronic conductor electrode which is provided to a measuring gas side surface of the solid electrolyte body and covered with an insulator.

公开(公告)号：US10006902B2

公开(公告)日：2018-06-26

申请号：US14311607

申请日：2014-06-23

申请人： Sophion Bioscience A/S

发明人： David Geraint Owen ,  Nicholas Gerard Byrne

IPC分类号： G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  B01L3/00 ,  G01N27/28 ,  G01N33/487

CPC分类号： G01N33/502 ,  B01L3/5025 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0893 ,  B01L2300/16 ,  G01N27/28 ,  G01N33/48728 ,  G01N33/5438 ,  G01N33/6872 ,  G01N2500/04 ,  G01N2500/10 ,  Y10T29/49826

摘要： The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. More particularly it relates to a structure comprising a biological membrane adhered to a porous or perforated substrate, a biological membrane capable of adhering with high resistance seals to a substrate such as perforated glass and the ability to form sheets having predominantly an ion channel or transporter of interest, a high throughput screen for determining the effect of test compounds on ion channel or transporter activity, methods for manufacture of the structure, membrane and substrate, and a method for monitoring ion channel or transporter activity in a membrane.

公开(公告)号：US09868930B2

公开(公告)日：2018-01-16

申请号：US15136188

申请日：2016-04-22

申请人： Rosemount Analytical Inc.

发明人： Michalle Jane Alleman Adkins ,  Chang-Dong Feng

IPC分类号： B01L9/00 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  C12M1/34 ,  C12M1/00 ,  G01N27/28

CPC分类号： C12M41/26 ,  C12M23/28 ,  G01N27/283

摘要： A single use pH sensor housing for a single use container is provided. The single use pH sensor housing includes a compartment configured to house a single use pH sensor. In one embodiment, the single use pH sensor housing comprises an actuator configured, when actuated, to transition the single use pH sensor from a storage position to a deployed position. In the storage position, the pH sensor is in fluidic contact with a buffer solution. In the deployed position, the single use pH sensor is in fluidic contact with an interior of the single use container. During the transition from the storage position to the deployed position, the buffer solution moves from a sensor portion of the compartment to a storage portion of the compartment such that the buffer solution is isolated from contact with the interior of the single use container.

公开(公告)号：US09863906B2

公开(公告)日：2018-01-09

申请号：US14887696

申请日：2015-10-20

申请人： MOLECULAR DEVICES, LLC

发明人： Lawrence Lee ,  Windsor Owens

IPC分类号： G01N27/28 ,  B01J19/08 ,  G01N33/487 ,  G01N27/327 ,  B01L9/00

CPC分类号： G01N27/283 ,  B01J19/08 ,  B01L9/523 ,  G01N27/327 ,  G01N33/48728

摘要： An apparatus for automatically conditioning a patch plate and a plenum of an electrophysiology measurement system is provided. An arm is linearly movable between a non-operative position and an operative position. An end effector mounted to one side of the arm is configured to condition the patch plate. Another end effector mounted to an opposite side of the arm is configured to condition the plenum. A linear actuator is coupled to the arm and is configured to drive movement of the arm between the operative position and the non-operative position. When the arm is positioned in the operative position, the arm is situated between the patch plate and the plenum.

公开(公告)号：US20170350847A1

公开(公告)日：2017-12-07

申请号：US15623662

申请日：2017-06-15

申请人： AgaMatrix, Inc.

发明人： Ian Harding ,  Sridhar G. Iyengar ,  Baoguo Wei ,  Steven Diamond ,  Martin Forest

IPC分类号： G01N27/28 ,  G01N27/403 ,  G01N27/327 ,  G01N33/50

CPC分类号： G01N27/28 ,  G01N27/3271 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/403 ,  G01N33/50

摘要： The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.

公开(公告)号：US20170273603A1

公开(公告)日：2017-09-28

申请号：US15731058

申请日：2015-03-12

申请人： GLUCOVATION, INC.

发明人： Jeff T. Suri ,  Robert Boock

IPC分类号： A61B5/1468 ,  G01N27/28 ,  G01N27/416 ,  G01N27/327

CPC分类号： A61B5/1468 ,  G01N27/28 ,  G01N27/327 ,  G01N27/3271 ,  G01N27/416

摘要： In some embodiments, an electrochemical sensing system includes a working electrode and a reference electrode. At least a portion of the working electrode includes rhodium. An electrical circuit is electronically coupled to the working electrode and the reference electrode. The electrical circuit is configured to bias the working electrode at voltage of less than about 0.4 V which is sufficient to electrochemically decompose a target analyte, and to measure a current corresponding to the concentration of the target analyte. In some embodiments, a biosensing molecule can be disposed on the working electrode and is operative to catalytically decompose a non-electroactive target analyte to yield and an electroactive by-product. In some embodiment, the reference electrode can include rhodium and its oxides.