公开(公告)号：US3282983A

公开(公告)日：1966-11-01

申请号：US46684665

申请日：1965-06-24

Applicant: TEXACO INC

Inventor： LACHOWICZ DONALD R ,  KREUZ KENNETH L

IPC: C07C201/12 ,  C07C205/40 ,  C07C409/40 ,  C10L1/23

CPC classification number: C10L1/231 ,  C07C201/10 ,  C07C201/12 ,  C07C407/00 ,  C07C205/40 ,  C07C409/40

公开(公告)号：US3141040A

公开(公告)日：1964-07-14

申请号：US18038762

申请日：1962-02-19

Applicant: PENNSALT CHEMICALS CORP

Inventor： INMAN CHARLES E ,  OESTERLING ROBERT E ,  TYCZKOWSKI EDWARD A

IPC: C07B39/00 ,  C07C17/10 ,  C07C45/63 ,  C07C49/167 ,  C07C201/12 ,  C07C205/51

CPC classification number: C07C17/10 ,  C07B39/00 ,  C07C45/63 ,  C07C49/167 ,  C07C205/51

公开(公告)号：US3064058A

公开(公告)日：1962-11-13

申请号：US10135661

申请日：1961-04-07

Applicant: NEPERA CHEMICAL CO INC

Inventor： DUESEL BERNARD F ,  KADESCH RICHARD G

IPC: C07C17/20 ,  C07C201/12 ,  C07C205/12 ,  C07D213/61

CPC classification number: C07D213/61 ,  C07C17/208 ,  C07C201/12 ,  C07C25/00 ,  C07C205/12

公开(公告)号：US20250059132A1

公开(公告)日：2025-02-20

申请号：US18933603

申请日：2024-10-31

Applicant: MAXUNITECH INC.

Inventor： Bangchi CHEN ,  Yinwei SUN ,  Zhongyuan WANG ,  Yi ZHONG

IPC: C07C253/30 ,  C07C45/64 ,  C07C201/12 ,  C07D249/08 ,  C07D301/02

Abstract: A method for preparing 2-substituted arylacetonitrile compound of formula (1), in which a substituted aromatic compound of formula (2) and a 2-cyanocarboxylate compound of formula (3) are directly reacted in the presence of a base to obtain the 2-substituted arylacetonitrile compound (1), as shown in the following reaction scheme: An application of the compound of formula (1) in the preparation of a triazole fungicide is also provided.

公开(公告)号：US12180175B2

公开(公告)日：2024-12-31

申请号：US17475486

申请日：2021-09-15

Applicant: Xi'an Easy Peptide Biotechnology Co., Ltd.

Inventor： Junfeng Zhao ,  Tao Liu

IPC: C07D317/28 ,  C07C67/03 ,  C07C67/08 ,  C07C201/12 ,  C07C231/02 ,  C07C269/06 ,  C07C327/22 ,  C07C327/26 ,  C07C329/04 ,  C07D213/81 ,  C07D213/83 ,  C07D215/48 ,  C07D295/185 ,  C07D333/70 ,  C07J1/00 ,  C07K5/06

Abstract: The present disclosure discloses a water-soluble ynamide coupling reagent and a method for using the water-soluble ynamide coupling reagent in the synthesis of amide, polypeptide, ester and thioester compound. The ynamide coupling reagent has the structure represented by the following formula (I): and in the formula (I), R is one selected from the group consisting of methylsulfonyl, benzenesulfonyl, p-toluenesulfonyl, trifluoroacetyl and other electron withdrawing groups.

公开(公告)号：US20240409498A1

公开(公告)日：2024-12-12

申请号：US18409063

申请日：2024-01-10

Applicant: Nogra Pharma Limited

Inventor： Salvatore Demartis ,  Francesca Viti ,  Marie McNulty

IPC: C07C231/10 ,  C07C201/12 ,  C07C205/56 ,  C07C227/04 ,  C07C231/02 ,  C07C231/18 ,  C07C233/54 ,  C07C303/28

Abstract: The disclosure provides a process for the preparation of 3-(4′-annitophenyl)-2-metlioxypropionic acid, and analogs and intermediates thereof, contemplated to be capable of modulating the activity of receptors, e.g., PPARs receptors.

公开(公告)号：US20240327326A1

公开(公告)日：2024-10-03

申请号：US17619922

申请日：2021-11-17

Applicant: SUN YAT-SEN UNIVERSITY

Inventor： Guangqin LI ,  QINGLIN LIU

IPC: C07C45/62 ,  B01J23/89 ,  B01J31/18 ,  B01J37/00 ,  B01J37/02 ,  B01J37/03 ,  B01J37/04 ,  B01J37/06 ,  B01J37/34 ,  C07C29/141 ,  C07C201/12 ,  C07C209/36

CPC classification number: C07C45/62 ,  B01J23/8906 ,  B01J23/8913 ,  B01J23/892 ,  B01J31/18 ,  B01J37/009 ,  B01J37/0236 ,  B01J37/035 ,  B01J37/04 ,  B01J37/06 ,  B01J37/343 ,  C07C29/141 ,  C07C201/12 ,  C07C209/36 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2231/763 ,  B01J2531/828 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07C2601/16

Abstract: The present disclosure relates to the technical field of molecular biology, and in particular to a method for preparing a Pt-based alloy/MOFs catalyst with high hydrogenation selectivity, and a preparation method thereof. The present disclosure prepares a Pt-based alloy/MOFs structure with Pt alloy particles uniformly supported on the surface of MOFs in one step through a simple solvothermal method, the preparation method of the present disclosure is simple, the reaction environment is not harsh and does not require a special atmosphere. The resulting product has a unique structure, with small metal particles, uniform distribution and not easy to lose, and it will not affect the catalytic activity of the metal. In terms of catalytic performance, the obtained Pt alloy/MOFs catalyst can catalytically hydrogenate cinnamaldehyde under normal temperature and pressure, and has excellent performance. In addition, the catalyst can also catalyze the selective hydrogenation of 3-nitrostyrene, catalyze the dehydrogenation of tetrahydroquinoline, which proves that the catalyst of the present disclosure has a wide range of applications.

公开(公告)号：US20240294455A1

公开(公告)日：2024-09-05

申请号：US18571275

申请日：2022-06-16

Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.

Inventor： Stefan GLÖGGLER ,  Sergey KORCHAK ,  Anil P. JATAP ,  Philip SAUL ,  Denis MOLL

IPC: C07C67/31 ,  C07B59/00 ,  C07C67/307 ,  C07C67/317 ,  C07C69/63 ,  C07C69/732 ,  C07C201/12 ,  C07C205/34 ,  C07C227/18 ,  C07C229/08

CPC classification number: C07C67/31 ,  C07B59/001 ,  C07C67/307 ,  C07C67/317 ,  C07C69/63 ,  C07C69/732 ,  C07C201/12 ,  C07C205/34 ,  C07C227/18 ,  C07C229/08 ,  C07B2200/05

Abstract: The present invention relates to a method for preparing a compound suitable for signal enhanced magnetic resonance imaging comprising the steps of vinylating a mono-, di- or tricarboxylic acid comprising a moiety -Q-Z with Q being O or N and Z being a protecting group by using vinyl acetate, cleaving Z, and if Z has not already been converted into an alcohol upon cleavage, converting Q into an alcohol either by using nitrite or by converting Q into bromine followed by hydrolysis yielding a vinyl hydroxy ester. The compounds used may be partly or fully deuterated. Furthermore, the present invention relates to a vinyl hydroxy ester as well as an intermediate of its synthesis, wherein the vinyl moiety of the vinyl hydroxy ester and of the intermediate is partly or fully deuterated.

公开(公告)号：US20240239730A1

公开(公告)日：2024-07-18

申请号：US18618449

申请日：2024-03-27

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPPALI

IPC: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07B2200/07 ,  C07C2601/16

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US11820724B2

公开(公告)日：2023-11-21

申请号：US17296544

申请日：2020-09-10

Applicant: ACCELA CHEMBIO CO., LTD. ,  QIDONG ACCELA CHEMBIO CO., LTD.

Inventor： Yang Liu ,  Duoqing Xue ,  Yong Wu ,  Lihuang Chen ,  Lianhua Zhai

IPC: C07C201/08 ,  C07C201/12

CPC classification number: C07C201/08 ,  C07C201/12

Abstract: The present disclosure provides a method for preparing 2-ethyl-4-fluoro-1-nitrobenzene, including: (1) nitrifying 3-fluoroacetophenone with a nitration reagent, to obtain 1-(5-fluoro-2-nitrophenyl)ethanone; (2) reducing 1-(5-fluoro-2-nitrophenyl)ethanone with a reducing agent, to obtain 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene; (3) iodinating 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene, to obtain 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene; and (4) reducing 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene with a reducing agent, to obtain 2-ethyl-4-fluoro-1-nitrobenzene.